Phenominer Database Results (1209 results)

 

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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Experiment Notes Record ID Study ID
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 0.19 IU/g 0.03 0.09 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50092 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 13 9.69 IU/g 1.44 5.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49829 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 4 6.52 IU/g 1.0 2.0 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49833 461
GH/OmrMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 18.6 IU/g 3.24 10.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49841 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 3 0.33 IU/g 0.14 0.24 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49620 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 3 0.31 IU/g 0.07 0.12 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49622 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 21 0.22 IU/g 0.03 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47464 461
FHH-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.58 IU/g 0.1 0.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47501 461
SS-Chr XBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 0.59 IU/g 0.08 0.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47507 461
FHH-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.39 IU/g 0.08 0.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47511 461
GH/OmrMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 5 0.26 IU/g 0.06 0.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47561 461
FHH/EurMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 6.34 ml/min/g 1.0 3.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46520 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.1 ml/min/g 0.64 1.91 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46527 461
FHH-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 23.16 IU/g 1.55 4.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48843 461
FHH-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 20.16 IU/g 1.41 4.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48847 461
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 18.48 IU/g 2.99 7.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48861 461
FHH-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 19.68 IU/g 2.85 9.02 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48890 461
SS-Chr XBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 21.82 IU/g 2.57 8.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48909 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 13 5.8 ml/min/g 0.47 1.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44704 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 3.16 ml/min/g 0.52 1.55 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44705 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.36 ml/min/g 0.47 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44709 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 2.59 ml/min/g 0.2 0.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44710 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 4.47 ml/min/g 0.63 1.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44713 461
FHH-Chr 10BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 5.2 ml/min/g 0.62 1.76 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44717 461
FHH-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 4.11 ml/min/g 0.41 1.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44734 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 3.38 ml/min/g 0.27 0.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44738 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 6.52 ml/min/g 0.72 2.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44745 461
FHH-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 4.99 ml/min/g 1.16 2.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44757 461
LEW/Crl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 87.57 % 5.32 16.83 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45853 461
WKY/NCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 70.91 % 6.22 19.67 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45860 461
F344/DuCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 71.83 % 10.26 30.79 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45862 461
LE/BluGill arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 11 5.08 ml/min/g 0.37 1.23 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45895 461
Crl:CD(SD) percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 63.54 % 2.82 8.92 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47884 461
F344/DuCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 56.39 % 7.12 22.52 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47892 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 3 9.49 IU/g 3.99 6.92 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45698 461
SS-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 15 7.93 IU/g 1.03 3.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45708 461
Hsd:SD percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 61.65 % 5.68 17.03 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45712 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 8.16 ml/min/g 0.54 1.42 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46636 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.42 ml/min/g 0.6 1.89 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46640 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 12.16 ml/min/g 0.6 1.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46651 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 10.01 ml/min/g 0.47 1.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46657 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.53 ml/min/g 0.91 2.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46659 461
SS-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.04 ml/min/g 0.79 2.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46695 461
FHH-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 20 11.54 ml/min/g 0.5 2.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46703 461
SS-Chr 1BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.45 ml/min/g 1.4 3.97 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46720 461
SS-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 11.57 ml/min/g 0.52 1.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46732 461
FHH/EurMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 76.81 % 2.82 6.92 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46835 461
FHH/EurMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 5.88 ml/min/g 0.7 1.71 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46838 461
SS-Chr 6BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 11.36 ml/min/g 1.18 3.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46903 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 10.2 ml/min/g 0.6 1.91 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46906 461
FHH-Chr 19BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 9.78 ml/min/g 0.99 2.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46926 461
FHH-Chr 9BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 10.23 ml/min/g 1.68 3.75 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46945 461
FHH-Chr 9BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 9.4 ml/min/g 1.75 4.94 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46950 461
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 20.8 IU/g 5.77 12.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45949 461
SS-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 41.21 IU/g 2.87 8.6 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45951 461
FHH-Chr 6BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 15.05 IU/g 0.99 3.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45956 461
FHH-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 18.72 IU/g 2.37 6.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45958 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 15.63 IU/g 1.38 3.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45962 461
SS-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 4 19.38 IU/g 0.42 0.83 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45968 461
FHH-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 19.42 IU/g 1.53 4.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45979 461
SS-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 17 32.71 IU/g 3.25 13.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45999 461
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 7 15.8 IU/g 1.18 3.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46003 461
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 12.22 IU/g 1.74 4.93 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46005 461
SS-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 8.76 IU/g 1.36 3.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46010 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 1 9.68 ml/min/g isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46840 461
FHH-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 43.09 % 4.94 15.64 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47107 461
SS-Chr 9BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 47.46 % 4.19 17.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47111 461
FHH-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 53.84 % 4.3 10.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47118 461
FHH-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 57.7 % 3.95 17.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47120 461
GH/OmrMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 53.44 % 5.49 14.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47121 461
SS-Chr 17BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 57.46 % 4.55 13.65 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47124 461
FHH-Chr 17BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 52.79 % 4.3 17.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47125 461
FHH-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 57.21 % 4.36 19.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47127 461
FHH-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 45.03 % 1.57 4.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47129 461
SS-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 53.58 % 6.45 27.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47134 461
SS-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 48.99 % 3.5 11.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47137 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 11.82 % 11.82 23.65 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47170 461
F344/DuCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 5.03 IU/g 0.73 2.3 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47176 461
LEW/Crl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 13.76 ml/min/g 0.66 1.86 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45088 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 3 9.7 ml/min/g 0.85 1.47 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45090 461
F344/DuCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 17.24 ml/min/g 0.66 2.08 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45091 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 11.48 ml/min/g 0.81 2.81 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46020 461
FHH-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 66.78 % 5.28 23.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46057 461
FHH-Chr 20BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 64.74 % 4.52 14.29 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46075 461
FHH-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 64.56 % 4.81 14.42 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46076 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 80.0 % 2.9 11.23 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46080 461
FHH-Chr 1BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 55.37 % 3.7 11.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46081 461
SS-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 41.21 % 3.77 10.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46087 461
SS-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 50.28 % 4.11 15.91 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46089 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 21 7.38 ml/min/g 1.47 6.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44772 461
FHH-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.07 ml/min/g 1.07 3.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44774 461
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 6.38 ml/min/g 0.72 2.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44776 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.65 ml/min/g 0.58 1.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46228 461
FHH-Chr 5BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 5.34 ml/min/g 0.56 1.57 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46231 461
SS-Chr 9BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 16 7.27 ml/min/g 0.42 1.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46235 461
SS-Chr 9BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 7.36 ml/min/g 0.77 2.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46238 461
SS-Chr 6BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 5.96 ml/min/g 0.65 1.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46239 461
SS-Chr 17BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 6.97 ml/min/g 0.34 1.08 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46243 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.09 ml/min/g 0.36 1.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46247 461
FHH/EurMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 6.32 ml/min/g 0.83 3.62 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46253 461
FHH-Chr 19BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 6.71 ml/min/g 0.68 2.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46254 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 5.29 ml/min/g 0.76 2.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46257 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 4.33 ml/min/g 0.46 1.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46262 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.42 IU/g 0.03 0.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47308 461
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.46 IU/g 0.11 0.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47329 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 22 0.26 IU/g 0.04 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47366 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 0.43 IU/g 0.1 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47440 461
FHH-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 20 0.34 IU/g 0.03 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47444 461
FHH-Chr 8BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.51 IU/g 0.09 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47456 461
FHH-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.32 IU/g 0.05 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47458 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 0.12 IU/g 0.04 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47459 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 21 0.23 IU/g 0.02 0.1 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47460 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.89 ml/min/g 0.6 1.89 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46297 461
FHH-Chr 6BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.32 IU/g 0.05 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47287 461
FHH-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 57.81 % 17.38 45.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46105 461
SS-Chr 10BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 68.4 % 3.75 11.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46106 461
WKY/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 10.66 ml/min/g 0.63 1.9 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46150 461
LE/BluGill arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 9.29 ml/min/g 0.48 1.43 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46161 461
Crl:CD(SD) arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 12.7 ml/min/g 3.58 11.33 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46178 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 22 6.55 ml/min/g 0.57 2.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46186 461
FHH-Chr 10BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 6.06 ml/min/g 1.4 3.42 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46200 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 6.68 ml/min/g 0.27 0.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46205 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 41.68 % 4.12 15.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47063 461
FHH-Chr XBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 42.76 % 2.99 7.91 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47073 461
SS-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 54.4 % 2.4 10.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47084 461
SS-Chr 20BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 25 post-ischemic value/pre-ischemic value x 100% 39.15 % 3.37 16.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47088 461
FHH-Chr 1BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 47.68 % 2.98 9.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47092 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 10.41 IU/g 1.62 4.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45364 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 18.26 IU/g 3.41 9.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45368 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 14.25 IU/g 2.36 6.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45370 461
LEW/Crl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.27 IU/g 0.05 0.17 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45237 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 2 0.08 IU/g 0.01 0.01 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45239 461
LEW/Crl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.4 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48384 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 6.23 ml/min/g 0.45 1.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46210 461
SS-Chr 20BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 8.62 ml/min/g 1.25 5.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46212 461
FHH-Chr 20BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 44.31 % 4.08 12.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47083 461
FHH-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 51.44 % 4.07 12.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47085 461
SS-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 52.69 % 6.13 26.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47089 461
SS-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 61.26 % 4.99 22.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47131 461
SS-Chr YBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 29 post-ischemic value/pre-ischemic value x 100% 47.98 % 3.14 16.93 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47142 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 39.86 % 9.5 26.86 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47169 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 6.29 ml/min/g 0.78 1.75 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45094 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 8.02 IU/g 1.87 4.19 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45116 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 6.93 ml/min/g 0.58 1.82 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46283 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 8.1 ml/min/g 0.41 1.23 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46302 461
Crl:CD(SD) heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 0.28 IU/g 0.07 0.19 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45234 461
LE/BluGill heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 11 0.3 IU/g 0.03 0.11 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45236 461
SS-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.41 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47326 461
FHH-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.4 IU/g 0.05 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47334 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.4 IU/g 0.07 0.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47338 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 93 0.29 IU/g 0.02 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47347 461
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.29 IU/g 0.07 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47359 461
SS-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.46 IU/g 0.1 0.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47361 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 12 0.23 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47424 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.25 IU/g 0.04 0.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47426 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.38 IU/g 0.12 0.3 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48377 461
LE/BluGill heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 11 0.58 IU/g 0.13 0.43 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48383 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.42 IU/g 0.08 0.27 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48385 461
F344/DuCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.56 IU/g 0.05 0.17 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48387 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 5 6.93 IU/g 2.76 6.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45693 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 1.71 IU/g 1.07 2.83 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45695 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 11.83 IU/g 0.85 2.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45703 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 11.02 ml/min/g 0.65 1.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46648 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 10.67 ml/min/g 0.51 1.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46656 461
SS-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 25 12.28 ml/min/g 0.72 3.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46664 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 12 12.7 ml/min/g 1.05 3.65 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46677 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 9.9 ml/min/g 0.61 2.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46685 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 10.65 ml/min/g 0.51 2.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46689 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.47 ml/min/g 0.81 2.29 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46716 461
SS-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 18 10.83 ml/min/g 0.75 3.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46723 461
FHH-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.84 ml/min/g 1.67 5.29 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46733 461
FHH/EurMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 62.74 % 13.68 33.5 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46834 461
LEW/Crl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 86.75 % 3.18 10.05 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45859 461
LE/BluGill percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 58.14 % 2.51 7.54 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45863 461
LEW/Crl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.34 ml/min/g 0.48 1.5 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45890 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 3 8.8 ml/min/g 1.15 1.99 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45894 461
LEW/Crl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 8.5 ml/min/g 1.14 3.6 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45896 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 7.47 IU/g 1.32 3.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45953 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 26.61 IU/g 2.95 11.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45955 461
FHH-Chr 6BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 9.75 IU/g 0.99 2.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45957 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 19 27.87 IU/g 2.62 11.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45959 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 7.1 IU/g 0.77 2.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45963 461
FHH-Chr 8BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 22.8 IU/g 1.36 4.31 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45982 461
SS-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 12.57 IU/g 2.32 7.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46004 461
FHH-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 14.54 IU/g 2.21 6.64 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46009 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 10.06 ml/min/g 1.15 2.82 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46857 461
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 7.06 ml/min/g 0.69 2.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44733 461
FHH-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 5.18 ml/min/g 0.87 2.76 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44748 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 8.0 ml/min/g 1.54 5.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44750 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 5.44 ml/min/g 0.38 1.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44764 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 4.43 ml/min/g 0.67 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44771 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 5.33 ml/min/g 0.36 1.03 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44773 461
SS-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 29 5.8 ml/min/g 0.47 2.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44783 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 5.28 ml/min/g 0.35 0.92 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44901 461
LEW/Crl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 56.32 % 4.71 13.31 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47889 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 73.83 % 5.99 10.38 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47891 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 10.19 ml/min/g 0.83 2.33 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46867 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 9.96 ml/min/g 0.71 2.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46892 461
FHH-Chr 16BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 9.31 ml/min/g 0.56 1.6 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46921 461
LEW/Crl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 65.09 % 5.14 16.26 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47883 461
SHR/NCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 78.91 % 4.46 13.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46060 461
FHH-Chr XBN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 68.56 % 10.42 27.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46066 461
SS-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 24 post-ischemic value/pre-ischemic value x 100% 63.29 % 4.57 22.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46116 461
FHH-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 90.07 % 7.52 22.57 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46124 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 70.6 % 3.25 14.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46137 461
BN/NHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 54.05 % 4.54 19.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46143 461
SS-Chr XBN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 69.38 % 6.02 19.02 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46145 461
FHH-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 71.83 % 4.82 15.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46147 461
LEW/Crl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 8.55 ml/min/g 0.59 1.88 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46151 461
Crl:CD(SD) arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 13.27 ml/min/g 1.12 3.36 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46154 461
LE/BluGill arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 11 8.64 ml/min/g 0.64 2.12 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46156 461
F344/DuCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 11.31 ml/min/g 0.95 2.69 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46160 461
FHH-Chr XBN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.38 ml/min/g 0.97 2.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46197 461
LEW/Crl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 16.64 IU/g 0.93 2.93 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49619 461
LEW/Crl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 20.63 IU/g 4.52 14.3 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49621 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.22 IU/g 0.05 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49679 461
SS-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 19 0.27 IU/g 0.04 0.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47477 461
FHH-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.34 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47486 461
FHH-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.24 IU/g 0.05 0.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47488 461
SS-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 20 0.24 IU/g 0.03 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47490 461
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.41 IU/g 0.07 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47500 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.2 IU/g 0.03 0.08 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50089 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 0.31 IU/g 0.04 0.09 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50091 461
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.43 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47465 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.39 IU/g 0.03 0.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47467 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.15 IU/g 0.06 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47471 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 17.62 IU/g 1.46 3.85 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48841 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 31.97 IU/g 4.89 14.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48848 461
FHH-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 28.44 IU/g 2.1 6.31 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48856 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 11 0.24 IU/g 0.04 0.12 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48707 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 21.9 IU/g 2.48 7.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48860 461
SS-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 4 46.09 IU/g 4.96 9.92 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48891 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 24 29.51 IU/g 3.22 15.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48893 461
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 32.54 IU/g 1.66 5.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48910 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 13.94 IU/g 2.2 6.23 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49832 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 5.44 IU/g 0.84 2.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49840 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 6.43 IU/g 0.52 1.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49843 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 13.15 IU/g 2.12 6.69 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 50202 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 4 7.68 IU/g 0.46 0.93 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 50205 461
SHR/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 5.82 ml/min/g 0.91 2.03 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46522 461
FHH/EurMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 5.03 ml/min/g 0.34 0.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46525 461
SS-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.28 IU/g 0.07 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47484 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 14 0.29 IU/g 0.07 0.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47487 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 19 0.46 IU/g 0.12 0.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47491 461
FHH-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 0.15 IU/g 0.03 0.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47493 461
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.36 IU/g 0.06 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47499 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 19 0.78 IU/g 0.09 0.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47505 461
FHH-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.59 IU/g 0.09 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47509 461
SS-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.54 IU/g 0.09 0.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47510 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 45.79 % 11.92 39.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47512 461
SS-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 36.92 % 7.71 24.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47516 461
GH/OmrMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 54.46 % 9.53 28.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47519 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.26 IU/g 0.02 0.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47557 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 0.55 IU/g 0.14 0.36 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47559 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 17.99 IU/g 4.36 10.69 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45487 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 9.75 IU/g 1.75 5.24 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45488 461
SS-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 34.18 IU/g 5.29 17.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48840 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 9.1 IU/g 1.59 3.89 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48842 461
FHH-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 18.94 IU/g 2.28 6.46 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48855 461
SS-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 39.31 IU/g 3.65 10.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48857 461
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 1 6.31 IU/g isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48872 461
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 7 23.86 IU/g 3.38 8.94 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48882 461
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 35.54 IU/g 2.07 6.55 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48892 461
Crl:CD(SD) percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 67.84 % 7.4 23.42 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47886 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 0.18 IU/g 0.02 0.05 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47995 461
SS-Chr 12BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.63 ml/min/g 0.51 1.62 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46895 461
SS-Chr 10BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 8.82 ml/min/g 0.82 2.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46899 461
SS-Chr 6BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 9.54 ml/min/g 0.74 2.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46908 461
SS-Chr 10BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 8.45 ml/min/g 0.89 2.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46910 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 8.2 ml/min/g 0.63 2.36 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46924 461
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 9.24 ml/min/g 1.03 3.08 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46928 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 8.48 ml/min/g 0.81 2.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46930 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 10.35 ml/min/g 1.58 3.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46933 461
SS-Chr 1BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 7.4 ml/min/g 0.55 1.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46939 461
SS-Chr XBN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 8.82 ml/min/g 0.41 1.31 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46949 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 13.17 ml/min/g 0.66 1.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46663 461
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 14.88 ml/min/g 1.14 3.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46668 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 10.15 ml/min/g 0.61 2.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46672 461
SS-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.18 ml/min/g 0.54 1.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46674 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 14.1 ml/min/g 1.29 4.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46676 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.68 ml/min/g 0.99 3.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46680 461
SS-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 17 11.66 ml/min/g 0.62 2.57 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46690 461
FHH-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 9.99 ml/min/g 0.44 1.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46692 461
FHH-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 12.66 ml/min/g 1.06 2.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46694 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 10.3 ml/min/g 0.29 1.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46699 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 10.42 ml/min/g 0.33 1.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46701 461
SS-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 55.67 % 8.36 25.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45918 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 4 15.19 IU/g 1.83 3.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45952 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 13.84 IU/g 1.68 4.1 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45960 461
FHH-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 13.64 IU/g 2.07 5.85 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45997 461
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 11.3 IU/g 1.12 3.55 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46001 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 22 10.05 ml/min/g 0.55 2.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46855 461
FHH-Chr 6BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 8.37 ml/min/g 0.25 0.79 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46858 461
FHH-Chr XBN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 7.34 ml/min/g 0.55 1.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46870 461
FHH-Chr YBN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 8.45 ml/min/g 0.72 2.29 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46883 461
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.46 ml/min/g 0.9 2.85 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46885 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 10.53 ml/min/g 0.57 2.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46889 461
FHH-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.09 ml/min/g 0.58 1.82 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46705 461
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 12.53 ml/min/g 0.5 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46711 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 25 11.17 ml/min/g 0.52 2.6 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46717 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 17 10.45 ml/min/g 0.56 2.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46724 461
FHH-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 12.26 ml/min/g 1.18 3.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46728 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.56 ml/min/g 0.59 1.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46734 461
FHH-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 6.22 ml/min/g 0.93 2.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44706 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 13 7.73 ml/min/g 0.51 1.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44708 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.28 ml/min/g 0.84 2.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44724 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 6.79 ml/min/g 0.39 1.6 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44730 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 6.73 ml/min/g 0.32 1.02 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44767 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 11.47 ml/min/g 0.89 2.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46301 461
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 21 0.4 IU/g 0.05 0.23 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47280 461
SS-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 0.25 IU/g 0.04 0.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47281 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 3 0.24 IU/g 0.08 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47284 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 11 12.69 ml/min/g 1.22 4.04 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45053 461
LEW/Crl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 13.25 ml/min/g 0.64 2.02 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45082 461
F344/DuCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 14.79 ml/min/g 1.06 3.37 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45084 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 6.1 ml/min/g 1.23 3.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45097 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 3.68 ml/min/g 0.63 1.4 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44900 461
FHH-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 22 post-ischemic value/pre-ischemic value x 100% 65.22 % 4.3 20.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46051 461
FHH-Chr 8BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 65.49 % 4.58 14.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46071 461
SS-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 48.23 % 5.55 17.55 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46073 461
FHH-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 60.02 % 6.32 18.97 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46074 461
SS-Chr 20BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 70.71 % 6.04 25.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46077 461
SS-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 post-ischemic value/pre-ischemic value x 100% 56.56 % 3.07 12.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46078 461
FHH-Chr 4BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 51.77 % 5.56 14.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46084 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 58.5 % 3.72 15.78 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46085 461
SS-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 58.82 % 5.59 16.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46088 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 12 0.41 IU/g 0.07 0.26 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45132 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 5.58 ml/min/g 0.38 1.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46224 461
FHH-Chr 16BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 7.67 ml/min/g 1.25 3.76 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46244 461
GH/OmrMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.86 ml/min/g 0.95 2.85 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46250 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 13 6.42 ml/min/g 0.55 1.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46256 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 6.88 ml/min/g 0.51 1.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46263 461
SS-Chr YBN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 24 6.19 ml/min/g 0.31 1.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46267 461
SS-Chr 1BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 3.96 ml/min/g 0.36 1.01 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46271 461
SS-Chr 4BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 8.5 ml/min/g 2.17 6.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46276 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 6.43 ml/min/g 0.5 1.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46278 461
BN/NHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 18 10.61 ml/min/g 1.14 4.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46280 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 10.96 ml/min/g 0.49 1.69 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46286 461
FHH-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 57.45 % 5.19 14.69 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46096 461
FHH-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 79.29 % 19.42 51.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46097 461
SS-Chr 6BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 57.8 % 7.98 23.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46099 461
SS-Chr 6BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 50.19 % 8.76 27.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46104 461
SS-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 47.3 % 2.58 7.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46121 461
FHH-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 75.89 % 7.26 19.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46125 461
BN/NHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 62.66 % 5.0 21.81 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46144 461
FHH-Chr 9BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 54.75 % 3.24 9.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46146 461
F344/DuCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 8.78 ml/min/g 0.3 0.94 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46153 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 5.44 ml/min/g 0.54 1.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46188 461
FHH-Chr 10BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 6.51 ml/min/g 2.47 6.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46194 461
FHH-Chr 8BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 6.54 ml/min/g 0.53 1.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46202 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 6.09 ml/min/g 0.36 1.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46213 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 15 7.61 ml/min/g 0.57 2.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46215 461
FHH-Chr 4BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.1 ml/min/g 0.53 1.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46217 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 48.49 % 4.72 17.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47067 461
SS-Chr 20BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 23 post-ischemic value/pre-ischemic value x 100% 42.33 % 5.42 25.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47079 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 57.19 % 4.21 15.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47094 461
SS-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 45.22 % 3.81 12.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47098 461
SS-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 52.52 % 3.24 10.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47100 461
SS-Chr 10BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 59.19 % 3.58 10.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47106 461
FHH-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 40.29 % 4.67 13.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47112 461
FHH-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 48.53 % 8.18 20.03 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47116 461
SS-Chr 10BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 54.19 % 3.53 9.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47117 461
SS-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 62.43 % 4.99 15.78 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47126 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 29.06 % 3.05 11.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47128 461
FHH-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 46.79 % 6.82 15.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47130 461
SS-Chr XBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 61.26 % 6.5 19.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47145 461
FHH-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 29.49 % 1.6 5.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47149 461
FHH-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 41.32 % 2.69 8.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47153 461
FHH-Chr 9BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 44.29 % 4.91 14.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47157 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 6.98 IU/g 0.65 2.04 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47174 461
LEW/Crl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 10.97 IU/g 0.93 2.95 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47178 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 22 5.57 ml/min/g 0.32 1.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44782 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.29 IU/g 0.05 0.15 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45230 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.47 IU/g 0.07 0.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47314 461
FHH-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.39 IU/g 0.05 0.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47316 461
FHH-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.38 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47327 461
SS-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 18 0.41 IU/g 0.08 0.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47337 461
FHH-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.61 IU/g 0.11 0.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47343 461
SS-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.09 IU/g 0.02 0.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47348 461
FHH-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.21 IU/g 0.04 0.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47350 461
SS-Chr XBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.25 IU/g 0.04 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47369 461
FHH-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.33 IU/g 0.1 0.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47373 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.32 IU/g 0.12 0.33 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47421 461
SS-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.3 IU/g 0.07 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47451 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.41 IU/g 0.1 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47453 461
FHH-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.53 IU/g 0.14 0.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47454 461
FHH-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 19 0.37 IU/g 0.06 0.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47455 461
F344/DuCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.38 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48380 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 4.8 ml/min/g 0.52 1.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46208 461
FHH-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 43.75 % 6.29 25.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47062 461
FHH-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 33.83 % 4.05 12.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47064 461
SHR/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 47.62 % 9.16 34.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47074 461
FHH-Chr 10BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 55.33 % 5.02 13.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47076 461
FHH-Chr 8BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 44.01 % 2.51 7.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47078 461
SS-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 49.61 % 2.41 6.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47081 461
FHH-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 59.55 % 8.38 26.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47133 461
SS-Chr 1BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 38.44 % 4.65 11.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47144 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 56.18 % 3.93 15.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47148 461
BN/NHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 23 post-ischemic value/pre-ischemic value x 100% 55.18 % 3.21 15.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47154 461
FHH-Chr 4BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 4.08 ml/min/g 0.37 0.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46219 461
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 7.15 ml/min/g 0.93 2.79 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46227 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 6.79 ml/min/g 0.24 0.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46266 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 6.4 ml/min/g 0.54 2.36 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46273 461
BN/NHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 18 8.39 ml/min/g 0.75 3.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46279 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 11.17 ml/min/g 1.07 2.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46285 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 49.04 % 6.43 21.32 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48117 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 13 12.15 ml/min/g 1.17 4.22 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45052 461
LE/BluGill arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 11.25 ml/min/g 0.8 2.25 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45092 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 12 10.31 IU/g 1.37 4.76 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47416 461
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 16 0.29 IU/g 0.06 0.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47422 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 0.31 IU/g 0.04 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47428 461
SS-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.21 IU/g 0.05 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47439 461
Crl:CD(SD) heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.45 IU/g 0.25 0.74 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48379 461
SS-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.25 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47297 461
SS-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.4 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47301 461
FHH-Chr XBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.42 IU/g 0.07 0.23 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47313 461
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 7 0.64 IU/g 0.07 0.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47342 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 14 0.4 IU/g 0.07 0.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47351 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 14 12.9 ml/min/g 0.79 2.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46639 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 9.67 ml/min/g 0.78 2.94 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46650 461
FHH-Chr 10BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 9.74 ml/min/g 1.07 3.02 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46652 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 12.26 ml/min/g 0.48 1.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46662 461
FHH-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 10.86 ml/min/g 1.0 3.33 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46666 461
FHH-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.26 ml/min/g 0.6 1.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46669 461
FHH-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 11.71 ml/min/g 0.45 1.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46671 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 11.35 ml/min/g 0.31 0.94 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46673 461
SS-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 11.6 ml/min/g 0.76 3.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46687 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 8.54 ml/min/g 0.65 1.45 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46635 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 4 8.04 ml/min/g 0.43 0.86 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46634 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 13.17 IU/g 2.67 6.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45369 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.41 ml/min/g 1.05 2.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46708 461
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.57 ml/min/g 0.53 1.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46712 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 23 11.44 ml/min/g 0.77 3.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46714 461
SS-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.86 ml/min/g 0.46 1.46 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46721 461
SS-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 18 11.25 ml/min/g 0.63 2.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46727 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 13.02 ml/min/g 0.59 1.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46729 461
Crl:CD(SD) heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 7 0.19 IU/g 0.07 0.19 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45232 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.36 IU/g 0.06 0.2 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45238 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 11.43 IU/g 0.72 1.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45697 461
GH/OmrMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 9.43 IU/g 1.35 4.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45699 461
SS-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 16 7.93 IU/g 1.33 5.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45701 461
FHH/EurMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 5.99 ml/min/g 0.06 0.15 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46839 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 6.62 ml/min/g 0.27 1.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44725 461
FHH-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 5.66 ml/min/g 0.47 1.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44731 461
SS-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 4.75 ml/min/g 0.39 1.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44756 461
WKY/NCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 72.19 % 4.69 14.82 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45852 461
F344/DuCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 58.95 % 4.3 13.59 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45855 461
FHH-Chr 6BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.5 ml/min/g 0.76 2.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46859 461
FHH-Chr 8BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 9.0 ml/min/g 0.56 1.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46875 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 10.15 ml/min/g 0.64 2.02 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46877 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 15 9.52 ml/min/g 0.63 2.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46884 461
FHH-Chr 15BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 8.2 ml/min/g 0.63 1.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46909 461
FHH-Chr 14BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 7.57 ml/min/g 0.52 1.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46911 461
SS-Chr 17BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 10.11 ml/min/g 0.72 2.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46917 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 9.69 ml/min/g 0.7 2.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46934 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 2 7.13 ml/min/g 0.64 0.91 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45898 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 16.71 IU/g 2.7 7.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45950 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 14 24.75 IU/g 3.07 11.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45980 461
FHH-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 20.03 IU/g 3.07 9.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45984 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 38 17.04 IU/g 1.18 7.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45990 461
FHH-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 17.9 IU/g 2.2 6.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45992 461
SS-Chr XBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 20.17 IU/g 2.03 6.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45996 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 23.2 IU/g 3.38 10.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46000 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 8.79 ml/min/g 0.5 1.72 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46854 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 54.99 % 5.6 21.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46056 461
FHH-Chr 17BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 73.52 % 6.79 17.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46114 461
FHH/EurMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 61.61 % 2.87 12.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46118 461
FHH-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 76.71 % 8.44 22.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46129 461
SS-Chr YBN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 26 post-ischemic value/pre-ischemic value x 100% 57.77 % 4.58 23.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46131 461
SS-Chr 1BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 49.55 % 4.23 11.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46133 461
FHH-Chr 9BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 62.0 % 5.11 12.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46141 461
WKY/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 11.15 ml/min/g 0.55 1.75 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46158 461
LEW/Crl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 8.74 ml/min/g 0.91 2.87 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46175 461
F344/DuCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 8.2 ml/min/g 0.66 2.1 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46177 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 14 6.16 ml/min/g 0.44 1.64 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46187 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 4.74 ml/min/g 0.44 1.33 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46199 461
FHH-Chr XBN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 4.24 ml/min/g 0.28 0.68 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46201 461
SS-Chr 20BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 5.86 ml/min/g 0.76 2.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46203 461
FHH-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 20 6.51 ml/min/g 0.59 2.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44768 461
SS/JrHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 9.05 ml/min/g 1.37 3.62 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46526 461
GH/OmrMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.93 ml/min/g 0.33 0.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46528 461
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 17 0.29 IU/g 0.13 0.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47475 461
FHH-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 0.48 IU/g 0.13 0.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47479 461
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 25 0.36 IU/g 0.12 0.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47481 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 19 0.73 IU/g 0.06 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47506 461
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.29 IU/g 0.04 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47508 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.26 IU/g 0.06 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47558 461
FHH-Chr 6BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 19.43 IU/g 2.09 6.62 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48846 461
SS-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 29.72 IU/g 1.37 4.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48854 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 32.53 IU/g 2.99 8.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48877 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 25.73 IU/g 1.59 4.76 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48883 461
SS-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 13.59 IU/g 1.45 4.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48897 461
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 23.38 IU/g 2.68 7.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48900 461
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 23.09 IU/g 2.6 7.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48902 461
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 29.8 IU/g 1.7 5.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48906 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 0.35 IU/g 0.06 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49676 461
GH/OmrMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 0.27 IU/g 0.04 0.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49678 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.37 IU/g 0.07 0.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49680 461
GH/OmrMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.32 IU/g 0.04 0.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49682 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 2 9.2 IU/g 6.45 9.12 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49814 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 42 10.45 IU/g 1.03 6.68 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49831 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 10.44 IU/g 1.18 4.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49835 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 9.56 IU/g 1.64 4.91 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49838 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 6.46 IU/g 0.89 2.68 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49839 461
SS-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 17 9.88 IU/g 2.03 8.36 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 49844 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 4 0.28 IU/g 0.05 0.1 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50090 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 11.67 IU/g 2.31 5.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 50209 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.13 IU/g 0.04 0.09 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48706 461
FHH-Chr 8BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.52 IU/g 0.07 0.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47466 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 49 0.27 IU/g 0.02 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47476 461
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.59 IU/g 0.09 0.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47478 461
GH/OmrMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 56.6 % 5.4 13.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47515 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 0.3 IU/g 0.05 0.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47555 461
SS-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 28.24 IU/g 1.49 4.73 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48859 461
FHH-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 18.13 IU/g 2.51 6.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48865 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 28.22 IU/g 2.45 6.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48870 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 7 16.25 IU/g 2.42 6.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48874 461
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 24.13 IU/g 1.73 5.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48878 461
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 28.96 IU/g 2.67 7.55 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48886 461
SS-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 30.61 IU/g 3.05 9.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48888 461
SS-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 21.29 IU/g 2.1 6.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48894 461
SS-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 25.28 IU/g 3.19 9.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48898 461
FHH-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 14.21 IU/g 2.31 6.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48911 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 5.93 ml/min/g 0.73 2.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44703 461
FHH-Chr 10BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 4 8.54 ml/min/g 1.1 2.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44711 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 5.44 ml/min/g 0.5 1.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44712 461
FHH-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 4.2 ml/min/g 0.25 0.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44718 461
SS-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 5.18 ml/min/g 0.28 1.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44720 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.45 ml/min/g 0.36 1.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44721 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 5.03 ml/min/g 0.53 1.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44722 461
FHH-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 5.03 ml/min/g 0.48 1.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44736 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.37 ml/min/g 0.83 2.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44741 461
SS-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 6.08 ml/min/g 0.45 1.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44765 461
Crl:CD(SD) percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 59.6 % 6.76 20.29 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45856 461
LE/BluGill percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 60.86 % 5.74 19.04 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45858 461
Crl:CD(SD) arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.57 ml/min/g 0.28 0.84 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45891 461
WKY/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.68 ml/min/g 0.54 1.72 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45897 461
F344/DuCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 10.67 ml/min/g 1.93 5.44 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45899 461
FHH/EurMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 64.47 % 2.8 7.93 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45919 461
SHR/NCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 54.02 % 8.16 25.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45921 461
FHH-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 13.79 IU/g 1.7 4.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45954 461
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 17 20.0 IU/g 2.15 8.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45970 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 22.98 IU/g 2.94 11.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45976 461
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 10.85 IU/g 1.15 2.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45977 461
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 26.68 IU/g 3.46 9.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45981 461
SS-Chr 20BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 11 8.66 ml/min/g 0.81 2.69 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46872 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 8.26 ml/min/g 0.51 1.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46878 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.7 ml/min/g 0.46 1.46 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46879 461
SS-Chr 20BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 16 9.55 ml/min/g 0.43 1.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46881 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.03 ml/min/g 0.24 0.68 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46633 461
FHH-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 9.89 ml/min/g 0.58 1.65 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46642 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 13 11.23 ml/min/g 0.85 3.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46670 461
SS-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 11.92 ml/min/g 0.54 1.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46686 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 9.03 IU/g 1.64 3.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45700 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 3 10.97 IU/g 0.8 1.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45702 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 8.52 ml/min/g 0.42 1.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46916 461
FHH/EurMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 49 7.93 ml/min/g 0.24 1.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46932 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 8.48 ml/min/g 0.61 1.92 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46942 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 8.3 ml/min/g 0.6 1.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46943 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 12.26 ml/min/g 2.57 8.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46946 461
BN/NHsdMcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 18 14.68 ml/min/g 0.67 2.85 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46948 461
SS-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 28 11.9 ml/min/g 0.51 2.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46718 461
SS-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 65.55 % 4.53 16.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47109 461
SS-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 59.4 % 3.47 15.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47113 461
SS-Chr 6BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 32.47 % 4.43 14.01 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47115 461
FHH-Chr 17BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 post-ischemic value/pre-ischemic value x 100% 53.38 % 3.75 15.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47123 461
FHH-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 51.0 % 4.82 13.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47135 461
SS-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 22 post-ischemic value/pre-ischemic value x 100% 52.71 % 3.79 17.78 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47141 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 97 post-ischemic value/pre-ischemic value x 100% 46.49 % 1.74 17.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47143 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 56.79 % 10.41 29.44 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47172 461
SS-Chr 9BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 post-ischemic value/pre-ischemic value x 100% 65.65 % 4.87 20.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46100 461
FHH-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 47.17 % 2.87 9.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46101 461
FHH-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 66.87 % 2.91 8.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46117 461
SS-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 65.72 % 6.09 17.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46127 461
FHH/EurMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 48 post-ischemic value/pre-ischemic value x 100% 63.61 % 2.61 18.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46128 461
SS-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 72.36 % 4.16 13.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46130 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 92 post-ischemic value/pre-ischemic value x 100% 62.8 % 2.23 21.36 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46132 461
SS-Chr XBN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 80.44 % 10.93 34.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46134 461
Hsd:SD arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 2 10.98 ml/min/g 0.1 0.13 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46159 461
Crl:CD(SD) arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 9.37 ml/min/g 0.51 1.62 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46176 461
LE/BluGill arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.44 ml/min/g 0.97 3.06 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46180 461
F344/DuCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 11.01 ml/min/g 0.8 2.41 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46184 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 6.32 ml/min/g 0.69 3.0 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46192 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.84 ml/min/g 0.95 2.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46204 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 5.89 ml/min/g 0.27 0.81 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46211 461
FHH-Chr 6BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 49.05 % 4.74 14.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47065 461
SHR/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 58.26 % 4.16 13.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47071 461
SS-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 41.53 % 2.44 7.73 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47080 461
SS-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 30.25 % 1.7 4.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47097 461
WKY/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 53.59 % 3.91 11.74 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47882 461
LE/BluGill percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 57.9 % 5.02 15.07 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47888 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 4.3 ml/min/g 0.16 0.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44778 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 3.1 ml/min/g 0.18 0.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44790 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 3.78 ml/min/g 0.3 0.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44791 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.29 ml/min/g 0.35 1.11