F344/NCrl |
blood insulin level |
fasting (for 6 hours) then glucose solution (2 g/kg) |
Granhall C, et al., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1. |
blood insulin amount |
male |
95 days
| 12 |
180.85 |
mU/l |
74.32 |
257.45 |
intraperitoneal glucose tolerance test |
tail vein |
|
post glucose injection |
15 |
min |
micrograms/L |
13081 |
330 |
F344.GK-(D1Arb42a-D1Rat90)/Swe |
blood insulin level |
fasting (for 6 hours) then glucose solution (2 g/kg) |
Granhall C, et al., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1. |
blood insulin amount |
male |
95 days
| 12 |
136.25 |
mU/l |
14.86 |
51.49 |
intraperitoneal glucose tolerance test |
tail vein |
|
post glucose injection |
15 |
min |
micrograms/L |
13089 |
330 |
F344.GK-(D1Got250-D1Rat90)/Swe |
blood insulin level |
fasting (for 6 hours) then glucose solution (2 g/kg) |
Granhall C, et al., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1. |
blood insulin amount |
male |
95 days
| 12 |
185.8 |
mU/l |
19.82 |
68.65 |
intraperitoneal glucose tolerance test |
tail vein |
0 |
post glucose injection |
15 |
min |
micrograms/L |
13100 |
330 |
Crl:WI |
blood insulin level |
running on treadmill (0-10 m/min) (between 0.1 and 0.2 hours) then running on treadmill (15 m/min) (for 0.5 hours) then running on treadmill (15 m/min) (for 0.8 hours) |
Keller AC, et al., J Cardiovasc Pharmacol. 2015 Feb;65(2):137-47. doi: 10.1097/FJC.0000000000000170. |
blood insulin amount |
male |
147 days
| 6 |
56.47 |
mU/l |
7.06 |
17.29 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
103997 |
2885 |
GK/MolTac |
blood insulin level |
running on treadmill (0-10 m/min) (between 0.1 and 0.2 hours) then running on treadmill (15 m/min) (for 0.5 hours) then running on treadmill (15 m/min) (for 0.8 hours) |
Keller AC, et al., J Cardiovasc Pharmacol. 2015 Feb;65(2):137-47. doi: 10.1097/FJC.0000000000000170. |
blood insulin amount |
male |
147 days
| 6 |
51.18 |
mU/l |
5.88 |
14.41 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104000 |
2885 |
LE-Lrrk2em1Sage-/- |
blood insulin level |
control condition (for 91 days) |
Ness D, et al., PLoS One. 2013 Jun 14;8(6):e66164. doi: 10.1371/journal.pone.0066164. Print 2013. |
blood insulin amount |
male |
91 days
| 5 |
55.5 |
mU/l |
13.19 |
29.5 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104306 |
2947 |
SD-Lepem1Sage+/+ |
blood insulin level |
fasting (for 12 hours) then standard diet (for 1 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
female |
91 days
| 6 |
17.35 |
mU/l |
3.82 |
9.37 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104479 |
2949 |
SD-Lepem1Sage-/- |
blood insulin level |
fasting (for 12 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
female |
91 days
| 6 |
871.77 |
mU/l |
192.35 |
471.17 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104480 |
2949 |
GK/MolTac |
blood insulin level |
running on treadmill (0-10 m/min) (between 0.1 and 0.2 hours) then running on treadmill (15 m/min) (for 0.5 hours) then running on treadmill (15 m/min) (for 0.8 hours) |
Keller AC, et al., J Cardiovasc Pharmacol. 2015 Feb;65(2):137-47. doi: 10.1097/FJC.0000000000000170. |
blood insulin amount |
male |
147 days
| 12 |
55.59 |
mU/l |
5.0 |
17.32 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104002 |
2885 |
F344.GK-(D1Rat83-D1Rat376)/Swe |
blood insulin level |
fasting (for 6 hours) then glucose solution (2 g/kg) |
Granhall C, et al., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1. |
blood insulin amount |
male |
95 days
| 12 |
178.37 |
mU/l |
9.91 |
34.33 |
intraperitoneal glucose tolerance test |
tail vein |
0 |
post glucose injection |
15 |
min |
micrograms/L |
13109 |
330 |
GK/MolTac |
blood insulin level |
control condition |
Keller AC, et al., J Cardiovasc Pharmacol. 2015 Feb;65(2):137-47. doi: 10.1097/FJC.0000000000000170. |
blood insulin amount |
male |
147 days
| 6 |
57.65 |
mU/l |
11.47 |
28.1 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
103999 |
2885 |
GK/MolTac |
blood insulin level |
control condition then controlled saxagliptin content diet (10 mg/kg/d) (for 12 days) |
Keller AC, et al., J Cardiovasc Pharmacol. 2015 Feb;65(2):137-47. doi: 10.1097/FJC.0000000000000170. |
blood insulin amount |
male |
147 days
| 12 |
71.47 |
mU/l |
8.24 |
28.53 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104003 |
2885 |
GK/MolTac |
blood insulin level |
running on treadmill (0-10 m/min) (between 0.1 and 0.2 hours) then controlled saxagliptin content diet (10 mg/kg/d) (for 12 days) then running on treadmill (15 m/min) (for 0.5 hours) then running on treadmill (15 m/min) (for 0.8 hours) |
Keller AC, et al., J Cardiovasc Pharmacol. 2015 Feb;65(2):137-47. doi: 10.1097/FJC.0000000000000170. |
blood insulin amount |
male |
147 days
| 12 |
58.24 |
mU/l |
5.88 |
20.38 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104004 |
2885 |
Crl:LE |
blood insulin level |
control condition (for 91 days) |
Ness D, et al., PLoS One. 2013 Jun 14;8(6):e66164. doi: 10.1371/journal.pone.0066164. Print 2013. |
blood insulin amount |
male |
91 days
| 5 |
29.1 |
mU/l |
4.7 |
10.5 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104305 |
2947 |
SD-Lepem1Sage+/+ |
blood insulin level |
fasting (for 12 hours) then standard diet (for 1 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
male |
91 days
| 6 |
16.18 |
mU/l |
4.12 |
10.09 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104475 |
2949 |
Crl:WI |
blood insulin level |
control condition |
Keller AC, et al., J Cardiovasc Pharmacol. 2015 Feb;65(2):137-47. doi: 10.1097/FJC.0000000000000170. |
blood insulin amount |
male |
147 days
| 6 |
77.65 |
mU/l |
21.76 |
53.31 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
103996 |
2885 |
GK/KyoSwe |
blood insulin level |
fasting (between 16 and 18 hours) then glucose solution, 2.8M (2 g/kg) |
Galli J, et al., NatGenet 1996 Jan;12(1):31-7. |
blood insulin amount |
not specified |
65 days
| 4 |
12.5 |
mU/l |
6.7 |
13.4 |
enzyme linked immunosorbent assay |
|
|
glucose injection |
0 |
min |
|
11389 |
82 |
GK/MolTac |
blood insulin level |
control condition |
Keller AC, et al., J Cardiovasc Pharmacol. 2015 Feb;65(2):137-47. doi: 10.1097/FJC.0000000000000170. |
blood insulin amount |
male |
147 days
| 12 |
65.29 |
mU/l |
8.82 |
30.57 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104001 |
2885 |
SD-Lepem1Sage-/- |
blood insulin level |
fasting (for 12 hours) then standard diet (for 1 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
male |
91 days
| 6 |
2198.55 |
mU/l |
95.59 |
234.14 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104477 |
2949 |
SD-Lepem1Sage+/+ |
blood insulin level |
fasting (for 12 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
female |
91 days
| 6 |
5.88 |
mU/l |
0.88 |
2.16 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104478 |
2949 |
F344.GK-(D1Mgh14-D1Rat90)/Swe |
blood insulin level |
fasting (for 6 hours) then glucose solution (2 g/kg) |
Granhall C, et al., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1. |
blood insulin amount |
male |
95 days
| 12 |
156.07 |
mU/l |
22.3 |
77.24 |
intraperitoneal glucose tolerance test |
tail vein |
0 |
post glucose injection |
15 |
min |
micrograms/L |
13105 |
330 |
F344/DuCrl |
blood insulin level |
fasting (between 16 and 18 hours) then glucose solution, 2.8M (2 g/kg) |
Galli J, et al., NatGenet 1996 Jan;12(1):31-7. |
blood insulin amount |
not specified |
65 days
| 3 |
23.6 |
mU/l |
4.9 |
8.49 |
enzyme linked immunosorbent assay |
|
|
glucose injection |
0 |
min |
|
11398 |
82 |
F344.GK-(D1Rat175-D1Rat90)/Swe |
blood insulin level |
fasting (for 6 hours) then glucose solution (2 g/kg) |
Granhall C, et al., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1. |
blood insulin amount |
male |
95 days
| 12 |
131.3 |
mU/l |
12.39 |
42.91 |
intraperitoneal glucose tolerance test |
tail vein |
|
post glucose injection |
15 |
min |
micrograms/L |
13095 |
330 |
SD-Lepem1Sage+/+ |
blood insulin level |
fasting (for 12 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
male |
91 days
| 6 |
5.88 |
mU/l |
2.06 |
5.04 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104474 |
2949 |
Crl:WI |
blood insulin level |
control condition then controlled saxagliptin content diet (10 mg/kg/d) (for 12 days) |
Keller AC, et al., J Cardiovasc Pharmacol. 2015 Feb;65(2):137-47. doi: 10.1097/FJC.0000000000000170. |
blood insulin amount |
male |
147 days
| 6 |
82.94 |
mU/l |
19.71 |
48.27 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
103998 |
2885 |
SD-Lepem1Sage-/- |
blood insulin level |
fasting (for 12 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
male |
91 days
| 6 |
372.94 |
mU/l |
50.29 |
123.2 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104476 |
2949 |
SD-Lepem1Sage-/- |
blood insulin level |
fasting (for 12 hours) then standard diet (for 1 hours) |
D'souza AM, et al., Endocrinology. 2014 Apr;155(4):1268-79. doi: 10.1210/en.2013-1523. Epub 2014 Jan 27. |
blood insulin amount |
female |
91 days
| 6 |
4727.1 |
mU/l |
1370.6 |
3357.27 |
blood insulin analysis |
|
0.0 |
|
0 |
|
|
104481 |
2949 |
F344.GK-(D1Swe4-D1Rat85)/Swe |
blood insulin level |
fasting (for 6 hours) then glucose solution (2 g/kg) |
Granhall C, et al., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1. |
blood insulin amount |
male |
95 days
| 12 |
230.39 |
mU/l |
24.77 |
85.82 |
intraperitoneal glucose tolerance test |
tail vein |
0 |
post glucose injection |
15 |
min |
micrograms/L |
13113 |
330 |