SS-Mthfrem1Mcwi-/+ |
heart rate |
controlled sodium content diet (4 %) (for 12 days) |
PhysGen Knockout data |
heart pumping trait |
male |
70 days-77 days |
8 |
|
|
333.87 |
beats/min |
8.63 |
24.42 |
radiotelemetry |
carotid artery |
|
0 |
- |
67111 |
717 |
SS-Mthfrem1Mcwi-/+ |
heart rate |
controlled sodium content diet (4 %) (for 11 days) |
PhysGen Knockout data |
heart pumping trait |
male |
70 days-77 days |
8 |
|
|
353.57 |
beats/min |
9.89 |
27.96 |
radiotelemetry |
carotid artery |
|
0 |
- |
67173 |
717 |
SS-Mthfrem1Mcwi-/+ |
left kidney wet weight |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
kidney mass |
male |
70 days-77 days |
8 |
|
|
1.61 |
g |
0.08 |
0.23 |
post excision weight measurement |
|
|
0 |
- |
66807 |
717 |
SS-Mthfrem1Mcwi-/+ |
heart rate |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
heart pumping trait |
male |
70 days-77 days |
8 |
|
|
330.76 |
beats/min |
11.64 |
32.92 |
radiotelemetry |
carotid artery |
|
0 |
- |
66622 |
717 |
SS-Mthfrem1Mcwi-/+ |
mean arterial blood pressure |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
arterial blood pressure trait |
male |
70 days-77 days |
8 |
/3 systolic pressure + 2/3 diastolic pressure |
|
129.62 |
mmHg |
4.21 |
11.92 |
radiotelemetry |
carotid artery |
|
0 |
- |
66501 |
717 |
SS-Mthfrem1Mcwi-/+ |
urine sodium excretion rate |
controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
urine sodium amount |
male |
60 days-69 days |
0 |
|
|
9.7 |
mEq/d |
1.2 |
|
urine electrolyte analysis |
|
0.0 |
0 |
|
98448 |
2059 |
SS-Mthfrem1Mcwi-/+ |
mean arterial blood pressure |
controlled sodium content diet (4 %) (for 11 days) |
PhysGen Knockout data |
arterial blood pressure trait |
male |
70 days-77 days |
8 |
1/3 systolic pressure + 2/3 diastolic pressure |
|
125.22 |
mmHg |
4.78 |
13.52 |
radiotelemetry |
carotid artery |
|
0 |
- |
66684 |
717 |
SS-Mthfrem1Mcwi-/+ |
systolic blood pressure |
controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
arterial blood pressure trait |
male |
58 days-67 days |
0 |
|
serial mean |
152.0 |
mmHg |
6.0 |
|
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98415 |
2059 |
SS-Mthfrem1Mcwi-/+ |
mean arterial blood pressure |
controlled sodium chloride content diet (0.4 %) (between 56 and 63 days) then controlled sodium chloride content diet (4 %) (for 10 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
arterial blood pressure trait |
male |
58 days-67 days |
0 |
|
serial mean |
130.0 |
mmHg |
4.0 |
|
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98401 |
2059 |
SS-Mthfrem1Mcwi-/+ |
single kidney wet weight |
controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
kidney mass |
male |
60 days-69 days |
0 |
|
|
1.61 |
g |
0.08 |
|
digital scale post excision weight measurement |
|
0.0 |
0 |
|
98455 |
2059 |
SS-Mthfrem1Mcwi-/+ |
right kidney wet weight |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
kidney mass |
male |
70 days-77 days |
8 |
|
|
1.67 |
g |
0.09 |
0.25 |
post excision weight measurement |
|
|
0 |
- |
66259 |
717 |
SS-Mthfrem1Mcwi-/+ |
urine total protein excretion rate |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
total urine protein amount |
male |
70 days-77 days |
8 |
|
|
120.21 |
mg/d |
23.05 |
65.2 |
automated urine analysis |
|
|
0 |
- |
66562 |
717 |
SS-Mthfrem1Mcwi-/+ |
urine total protein excretion rate |
controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
total urine protein amount |
male |
60 days-69 days |
0 |
|
|
132.0 |
mg/d |
23.0 |
|
urine total protein analysis |
|
0.0 |
0 |
|
98434 |
2059 |
SS-Mthfrem1Mcwi-/+ |
urine creatinine excretion rate |
controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
urine creatinine amount |
male |
60 days-69 days |
0 |
|
|
12.1 |
mg/d |
0.4 |
|
urine creatinine analysis |
|
0.0 |
0 |
|
98441 |
2059 |
SS-Mthfrem1Mcwi-/+ |
urine sodium excretion rate |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
urine sodium amount |
male |
70 days-77 days |
8 |
|
|
9.69 |
mEq/d |
1.16 |
3.27 |
automated urine analysis |
|
|
0 |
- |
66868 |
717 |
SS-Mthfrem1Mcwi-/+ |
mean arterial blood pressure |
controlled sodium content diet (4 %) (for 12 days) |
PhysGen Knockout data |
arterial blood pressure trait |
male |
70 days-77 days |
8 |
1/3 systolic pressure + 2/3 diastolic pressure |
|
129.31 |
mmHg |
4.58 |
12.95 |
radiotelemetry |
carotid artery |
|
0 |
- |
66989 |
717 |
SS-Mthfrem1Mcwi-/+ |
urine albumin excretion rate |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
urine albumin amount |
male |
70 days-77 days |
8 |
|
|
73.13 |
mg/d |
19.06 |
53.91 |
automated urine analysis |
|
|
0 |
- |
66929 |
717 |
SS-Mthfrem1Mcwi-/+ |
heart rate |
controlled sodium content diet (4 %) (for 13 days) |
PhysGen Knockout data |
heart pumping trait |
male |
70 days-77 days |
8 |
|
|
324.0 |
beats/min |
11.63 |
32.9 |
radiotelemetry |
carotid artery |
|
0 |
- |
66381 |
717 |
SS-Mthfrem1Mcwi-/+ |
diastolic blood pressure |
controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
arterial blood pressure trait |
male |
58 days-67 days |
0 |
|
serial mean |
110.0 |
mmHg |
4.0 |
|
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98408 |
2059 |
SS-Mthfrem1Mcwi-/+ |
heart wet weight |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
heart mass |
male |
70 days-77 days |
8 |
|
|
1.24 |
g |
0.06 |
0.17 |
post excision weight measurement |
|
|
0 |
- |
67051 |
717 |
SS-Mthfrem1Mcwi-/+ |
heart rate |
controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 10 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
heart pumping trait |
male |
58 days-67 days |
0 |
|
serial mean |
330.0 |
beats/min |
12.0 |
|
intra-aortic abdominal radiotelemetry |
|
32400.0 |
0 |
|
98422 |
2059 |
SS-Mthfrem1Mcwi-/+ |
urine creatinine excretion rate |
controlled sodium content diet (4 %) (for 14 days) |
PhysGen Knockout data |
urine creatinine amount |
male |
70 days-77 days |
8 |
|
|
12.12 |
mg/d |
0.38 |
1.06 |
automated urine analysis |
|
|
0 |
- |
66745 |
717 |
SS-Mthfrem1Mcwi-/+ |
heart wet weight |
controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
heart mass |
male |
60 days-69 days |
0 |
|
|
1.24 |
g |
0.06 |
|
digital scale post excision weight measurement |
|
0.0 |
0 |
|
98462 |
2059 |
SS-Mthfrem1Mcwi-/+ |
body weight |
controlled sodium content diet (0.4 %) (between 56 and 63 days) then controlled sodium content diet (4 %) (for 12 days) |
Flister MJ, et al., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4. |
body mass |
male |
60 days-69 days |
0 |
|
|
333.0 |
g |
10.0 |
|
body weighing method |
|
0.0 |
0 |
|
98469 |
2059 |
SS-Mthfrem1Mcwi-/+ |
body weight |
controlled sodium content diet (4 %) (for 10 days) |
PhysGen Knockout data |
body mass |
male |
70 days-77 days |
8 |
|
|
333.2 |
g |
10.0 |
28.2 |
whole body digital scale |
|
|
0 |
- |
66321 |
717 |
SS-Mthfrem1Mcwi-/+ |
mean arterial blood pressure |
controlled sodium content diet (4 %) (for 13 days) |
PhysGen Knockout data |
arterial blood pressure trait |
male |
70 days-77 days |
8 |
1/3 systolic pressure + 2/3 diastolic pressure |
|
130.49 |
mmHg |
4.51 |
12.76 |
radiotelemetry |
carotid artery |
|
0 |
- |
66441 |
717 |