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Study IDStudyExperiment NameExperiment NotesStrain Ont IDStrainSexAge# of AnimalsSample NotesClinical Measurement Ont IDPhenotypeFormulaClinical Measurement NotesAverage TypeValueUnitsSEMSDMethod Ont IDMethodMethod SiteMethod DurationMethod NotesPost Insult TypePost Insult Time ValuePost Insult Time UnitConditionsRecord IDCondition 1aCondition 1bCondition 2aCondition 2bCondition 3aCondition 3bCondition 4
401PhysGen Biochemistry datablood alkaline phosphatase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000577serum alkaline phosphatase activity level299.5U/l10.565433.4107MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)36380air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood alkaline phosphatase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000577serum alkaline phosphatase activity level384.2U/l13.321542.1263MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)36384air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood sodium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000500serum sodium level141.8mmol/l0.57351.8135MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)36510control condition (for 14 days)
401PhysGen Biochemistry datablood sodium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000500serum sodium level142mmol/l0.64982.0548MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)36522control condition (for 14 days)
401PhysGen Biochemistry datablood creatinine amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000537plasma creatinine level0.24mg/dl0.03060.0966MMO:0000354automated plasma creatinine analysiscontrol condition (for 14 days)42666control condition (for 14 days)
401PhysGen Biochemistry datablood creatinine amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000537plasma creatinine level0.27mg/dl0.030.0949MMO:0000354automated plasma creatinine analysiscontrol condition (for 14 days)42678control condition (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000291mean corpuscular hemoglobin concentration32.21g/dl0.13450.4254MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)37348control condition (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000291mean corpuscular hemoglobin concentration32.39g/dl0.13120.4149MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)37360control condition (for 14 days)
401PhysGen Biochemistry datablood chloride amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000489serum chloride level105.2mmol/l0.82732.6162MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)39122air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataleukocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000365total white blood cell count5.29x 1000 cells/ul0.22480.7109MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)40927air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataleukocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000365total white blood cell count6.05x 1000 cells/ul0.35911.1355MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)40931air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood aspartate transaminase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days9CMO:0000581serum aspartate aminotransferase activity level99.5556U/l6.007218.0216MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)42771air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood aspartate transaminase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000581serum aspartate aminotransferase activity level93.1U/l5.848918.4959MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)42775air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood alkaline phosphatase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000577serum alkaline phosphatase activity level204.1U/l8.562827.0779MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)37470control condition (for 14 days)
401PhysGen Biochemistry datablood alkaline phosphatase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000577serum alkaline phosphatase activity level280.4U/l16.372951.7756MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)37482control condition (for 14 days)
401PhysGen Biochemistry dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000025red blood cell count9.06x 10E6 cells/ul0.12960.4098MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)39238air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000025red blood cell count9.546x 10E6 cells/ul0.17670.5589MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)39242air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood globulin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0002399serum globulin levelreplaced obsolete serum globulin level term, 1/19/20161.29g/dl0.04330.137MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)41047control condition (for 14 days)
401PhysGen Biochemistry datablood globulin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0002399serum globulin levelreplaced obsolete serum globulin level term, 1/19/20161.38g/dl0.04160.1317MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)41059control condition (for 14 days)
401PhysGen Biochemistry datablood bilirubin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000376serum total bilirubin level0.1mg/dl0.00.0MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)42903control condition (for 14 days)
401PhysGen Biochemistry datablood phosphate amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000542serum phosphate level7.9mg/dl0.18740.5925MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)37595air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood phosphate amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000542serum phosphate level8.19mg/dl0.27550.8711MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)37599air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood sodium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000500serum sodium level140.5mmol/l0.52171.6499MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)39389air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood sodium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000500serum sodium level140.5mmol/l0.67082.1213MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)39393air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood bilirubin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000376serum total bilirubin level0.12mg/dl0.01330.0422MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)42915control condition (for 14 days)
401PhysGen Biochemistry datablood bicarbonate amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000488serum bicarbonate level20.4mmol/l1.8755.9292MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)43010control condition (for 14 days)
401PhysGen Biochemistry datablood bicarbonate amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000488serum bicarbonate level20.8mmol/l2.15926.828MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)43022control condition (for 14 days)
401PhysGen Biochemistry datablood alanine transaminase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000575serum alanine aminotransferase activity level45.6U/l1.26674.0056MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)37727control condition (for 14 days)
401PhysGen Biochemistry datablood creatinine amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000537plasma creatinine level0.27mg/dl0.02130.0675MMO:0000354automated plasma creatinine analysisair oxygen content (12 %) (for 14 days)39577air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood glucose amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000543serum glucose level168mg/dl15.020747.4997MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)41214control condition (for 14 days)
401PhysGen Biochemistry datablood glucose amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000543serum glucose level177.9mg/dl26.110282.5677MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)41226control condition (for 14 days)
401PhysGen Biochemistry datablood potassium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000495serum potassium level4.71mmol/l0.31070.9826MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)43347control condition (for 14 days)
401PhysGen Biochemistry datablood potassium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000495serum potassium level4.96mmol/l0.25910.8195MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)43359control condition (for 14 days)
401PhysGen Biochemistry datablood alanine transaminase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000575serum alanine aminotransferase activity level55.5U/l2.91839.2286MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)37739control condition (for 14 days)
401PhysGen Biochemistry datablood phosphate amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000542serum phosphate level8.52mg/dl0.47021.4868MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)37847control condition (for 14 days)
401PhysGen Biochemistry datablood creatinine amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000537plasma creatinine level0.3mg/dl0.02110.0667MMO:0000354automated plasma creatinine analysisair oxygen content (12 %) (for 14 days)39581air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datamonocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000032blood monocyte count0.164x 1000 cells/ul0.05310.1679MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)39675air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datamonocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000032blood monocyte count0.255x 1000 cells/ul0.06070.1919MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)39679air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000037hematocrit40.77%1.21573.8445MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)41322control condition (for 14 days)
401PhysGen Biochemistry dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000037hematocrit43.8%1.21483.8416MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)41334control condition (for 14 days)
401PhysGen Biochemistry datablood phosphate amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000542serum phosphate level8.91mg/dl0.55851.766MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)37859control condition (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000291mean corpuscular hemoglobin concentration31.79g/dl0.09360.2961MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)39778air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000291mean corpuscular hemoglobin concentration32.34g/dl0.05620.1776MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)39782air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataeosinophil quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000033blood eosinophil count0.05x 1000 cells/ul0.0190.06MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)41424control condition (for 14 days)
401PhysGen Biochemistry dataeosinophil quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000033blood eosinophil count0.021x 1000 cells/ul0.0090.0285MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)41436control condition (for 14 days)
401PhysGen Biochemistry datalymphocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000031blood lymphocyte count4.477x 1000 cells/ul0.20170.6378MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)41504air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datalymphocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000031blood lymphocyte count4.911x 1000 cells/ul0.26430.8357MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)41508air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000026blood hemoglobin level16.81g/dl0.23640.7475MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)37969air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000026blood hemoglobin level17.39g/dl0.29040.9183MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)37973air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood potassium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000495serum potassium level4.45mmol/l0.18270.5778MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)38067air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood potassium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000495serum potassium level4.44mmol/l0.19620.6204MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)38071air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataleukocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000365total white blood cell count3.38x 1000 cells/ul0.3461.0942MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)39905control condition (for 14 days)
401PhysGen Biochemistry dataleukocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000365total white blood cell count4.49x 1000 cells/ul0.33481.0588MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)39917control condition (for 14 days)
401PhysGen Biochemistry dataeosinophil quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000033blood eosinophil count0.041x 1000 cells/ul0.01270.0401MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)41648air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood chloride amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000489serum chloride level105.6mmol/l0.52071.6465MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)40026control condition (for 14 days)
401PhysGen Biochemistry datablood chloride amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000489serum chloride level105.3mmol/l0.44851.4181MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)40038control condition (for 14 days)
401PhysGen Biochemistry dataeosinophil quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000033blood eosinophil count0.031x 1000 cells/ul0.01040.0328MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)41652air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataion homeostasis traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000066plasma anion gap17.9mmol/l0.50441.5951MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)38262air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataion homeostasis traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000066plasma anion gap19.4mmol/l0.58121.8379MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)38266air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000026blood hemoglobin level13.12g/dl0.37141.1745MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)40122control condition (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000026blood hemoglobin level14.2g/dl0.36181.1441MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)40134control condition (for 14 days)
401PhysGen Biochemistry datablood urea nitrogen amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000587serum urea nitrogen level17.2mg/dl1.20923.8239MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)41772control condition (for 14 days)
401PhysGen Biochemistry datablood urea nitrogen amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000587serum urea nitrogen level13.8mg/dl0.84062.6583MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)41784control condition (for 14 days)
401PhysGen Biochemistry datablood bilirubin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000376serum total bilirubin level0.115mg/dl0.0150.0474MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)41869air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood bilirubin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000376serum total bilirubin level0.11mg/dl0.010.0316MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)41873air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataion homeostasis traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000066plasma anion gap20.5mmol/l1.57944.9944MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)43151control condition (for 14 days)
401PhysGen Biochemistry dataion homeostasis traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000066plasma anion gap20.8mmol/l1.78145.6332MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)43163control condition (for 14 days)
401PhysGen Biochemistry dataneutrophil quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000030blood neutrophil count0.592x 1000 cells/ul0.08260.2611MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)43225air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataneutrophil quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000030blood neutrophil count0.851x 1000 cells/ul0.10990.3475MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)43229air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000290mean corpuscular hemoglobin17.51pg0.06570.2079MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)40218control condition (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000290mean corpuscular hemoglobin16.72pg0.04420.1398MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)40230control condition (for 14 days)
401PhysGen Biochemistry dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000025red blood cell count7.494x 10E6 cells/ul0.22770.72MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)41989control condition (for 14 days)
401PhysGen Biochemistry datablood calcium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000503serum calcium level9.36mg/dl0.1360.43MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)36625air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood calcium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000503serum calcium level9.64mg/dl0.13180.4169MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)36629air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood cholesterol amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000363serum total cholesterol level76.1mg/dl2.0416.4541MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)38453control condition (for 14 days)
401PhysGen Biochemistry datablood cholesterol amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000363serum total cholesterol level79.4mg/dl2.688.4748MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)38465control condition (for 14 days)
401PhysGen Biochemistry datablood glucose amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000543serum glucose level138.5mg/dl5.49617.3797MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)38531air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood glucose amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days9CMO:0000543serum glucose level147.8889mg/dl4.709514.1284MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)38535air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datamonocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000032blood monocyte count0.04x 1000 cells/ul0.01470.0464MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)40314control condition (for 14 days)
401PhysGen Biochemistry datamonocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000032blood monocyte count0.07x 1000 cells/ul0.03410.1077MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)40326control condition (for 14 days)
401PhysGen Biochemistry dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000025red blood cell count8.476x 10E6 cells/ul0.22030.6966MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)42001control condition (for 14 days)
401PhysGen Biochemistry datablood bicarbonate amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000488serum bicarbonate level20.5mmol/l0.90982.8771MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)42063air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood bicarbonate amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000488serum bicarbonate level20.4mmol/l0.87182.7568MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)42067air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood calcium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000503serum calcium level9.47mg/dl0.10860.3433MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)36779control condition (for 14 days)
401PhysGen Biochemistry datablood calcium amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000503serum calcium level9.39mg/dl0.1130.3573MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)36791control condition (for 14 days)
401PhysGen Biochemistry datablood albumin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000550serum albumin level3.76g/dl0.06360.2011MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)40427control condition (for 14 days)
401PhysGen Biochemistry datablood albumin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000550serum albumin level3.79g/dl0.10050.3178MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)40439control condition (for 14 days)
401PhysGen Biochemistry datalymphocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000031blood lymphocyte count2.847x 1000 cells/ul0.31250.9883MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)36889control condition (for 14 days)
401PhysGen Biochemistry datalymphocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000031blood lymphocyte count3.58x 1000 cells/ul0.33011.0438MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)36901control condition (for 14 days)
401PhysGen Biochemistry dataerythrocyte size traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000038mean corpuscular volume54.4fl0.15850.5011MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)38667control condition (for 14 days)
401PhysGen Biochemistry dataerythrocyte size traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000038mean corpuscular volume51.66fl0.24370.7706MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)38679control condition (for 14 days)
401PhysGen Biochemistry dataerythrocyte size traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000038mean corpuscular volume58.33fl0.1620.5122MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)38746air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataerythrocyte size traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000038mean corpuscular volume56.36fl0.26340.8329MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)38750air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood globulin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0002399serum globulin levelreplaced obsolete serum globulin level term, 1/19/20161.34g/dl0.02210.0699MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)40551air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood globulin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0002399serum globulin levelreplaced obsolete serum globulin level term, 1/19/20161.5g/dl0.03330.1054MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)40555air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood albumin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000550serum albumin level3.88g/dl0.03890.1229MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)42234air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood albumin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000550serum albumin level3.89g/dl0.05670.1792MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)42238air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood total protein amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000661serum total protein level5.22g/dl0.05120.1619MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)36963air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood total protein amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000661serum total protein level5.39g/dl0.08090.2558MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)36967air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood alanine transaminase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000575serum alanine aminotransferase activity level46.6U/l2.91819.228MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)40715air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood alanine transaminase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000575serum alanine aminotransferase activity level53.7U/l3.10579.8212MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)40719air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood aspartate transaminase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000581serum aspartate aminotransferase activity level96.7U/l6.441320.3691MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)42437control condition (for 14 days)
401PhysGen Biochemistry datablood aspartate transaminase amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000581serum aspartate aminotransferase activity level113U/l11.271435.6433MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)42449control condition (for 14 days)
401PhysGen Biochemistry datablood cholesterol amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000363serum total cholesterol level59.4mg/dl2.11976.7032MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)37098air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood cholesterol amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000363serum total cholesterol level75mg/dl2.16546.8475MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)37102air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataneutrophil quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000030blood neutrophil count0.438x 1000 cells/ul0.10610.3354MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)38916control condition (for 14 days)
401PhysGen Biochemistry dataneutrophil quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000030blood neutrophil count0.821x 1000 cells/ul0.11720.3707MMO:0000146automated blood cell counting methodcontrol condition (for 14 days)38928control condition (for 14 days)
401PhysGen Biochemistry dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000037hematocrit52.84%0.79962.5286MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)38992air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000037hematocrit53.77%0.91642.8979MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)38996air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood urea nitrogen amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000587serum urea nitrogen level19.8mg/dl1.51884.8028MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)40829air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood urea nitrogen amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000587serum urea nitrogen level21mg/dl1.46824.6428MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)40833air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000290mean corpuscular hemoglobin18.56pg0.07020.2221MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)42546air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood hemoglobin amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000290mean corpuscular hemoglobin18.22pg0.07270.23MMO:0000146automated blood cell counting methodair oxygen content (12 %) (for 14 days)42550air oxygen content (12 %) (for 14 days)
401PhysGen Biochemistry datablood total protein amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000661serum total protein level5.05g/dl0.10250.324MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)37218control condition (for 14 days)
401PhysGen Biochemistry datablood total protein amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000661serum total protein level5.17g/dl0.11740.3713MMO:0000169standard blood chemistry panelcontrol condition (for 14 days)37230control condition (for 14 days)
401PhysGen Biochemistry datablood chloride amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000489serum chloride level106.6mmol/l0.7182.2706MMO:0000169standard blood chemistry panelair oxygen content (12 %) (for 14 days)39118air oxygen content (12 %) (for 14 days)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000531percent change in respiration rate139.2725%6.495621.5434MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)54328air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000531percent change in respiration rate128.5562%7.440522.3215MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)54332air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000532percent change in tidal volume146.5344%8.681228.7922MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)54427air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000532percent change in tidal volume141.9371%3.472610.9812MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)54431air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000222tidal volume0.2833ml0.02020.0669MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)13924air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000222tidal volume0.3328ml0.0280.0839MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)13928air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000288percent change in ventilation%change=VE during 2-3 min hypercapnia/control during standard conditions257.1314%13.946646.2557MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0 and 0.1 hours)19212air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000288percent change in ventilation%change=VE during 2-3 min hypercapnia/control during standard conditions240.82%16.682952.7559MMO:0000022stop flow air displacement plethysmography0air carbon dioxide content (7 %) (between 0 and 0.1 hours)19216air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000288percent change in ventilation%change=VE during 2-3 min hypoxia/control during standard conditions141.3502%16.258348.7748MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)13685air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory dataarterial blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days7CMO:0000009mean arterial blood pressure119.4943mmHg2.49156.5918MMO:0000013vascular fluid filled catheterair carbon dioxide content (7 %) (for 0.1 hours)13484air carbon dioxide content (7 %) (for 0.1 hours)
381PhysGen Respiratory dataarterial blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days7CMO:0000009mean arterial blood pressure123.4129mmHg4.679512.3809MMO:0000013vascular fluid filled catheterair carbon dioxide content (7 %) (for 0.1 hours)13494air carbon dioxide content (7 %) (for 0.1 hours)
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000015body temperature36.8364degrees C0.17490.5801MMO:0000034digital rectal thermometryair carbon dioxide content (7 %) (for 0.1 hours)13560air carbon dioxide content (7 %) (for 0.1 hours)
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000015body temperature36.14degrees C0.16070.5082MMO:0000034digital rectal thermometryair carbon dioxide content (7 %) (for 0.1 hours)13564air carbon dioxide content (7 %) (for 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000288percent change in ventilation%change=VE during7-9 min hypercapnia/control during standard conditions134.9358%11.261333.784MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)18548air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000288percent change in ventilation%change=VE during7-9 min hypercapnia/control during standard conditions121.4356%11.881739.4072MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)18544air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000288percent change in ventilation%change=VE during7-9 min hypercapnia/control during standard conditions208.6069%11.683236.9455MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)14203air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000288percent change in ventilation%change=VE during7-9 min hypercapnia/control during standard conditions233.6396%22.222773.7043MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)14199air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000532percent change in tidal volume96.7738%7.600425.2075MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0.1 and 0.1 hours)53988air oxygen content (12 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000532percent change in tidal volume106.8449%6.268218.8045MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0.1 and 0.1 hours)53992air oxygen content (12 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000531percent change in respiration rate156.6755%7.191923.8528MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)54221air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000531percent change in respiration rate146.3656%6.082819.2356MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)54225air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000532percent change in tidal volume153.2432%9.055530.0336MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0 and 0.1 hours)54087air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000532percent change in tidal volume151.9376%4.053812.8193MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0 and 0.1 hours)54091air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datablood acidity-alkalinity balance traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days6CMO:0000300absolute change in blood pH0.04670.01010.0247MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)19784air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory datablood acidity-alkalinity balance traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days6CMO:0000300absolute change in blood pH0.04980.00460.0112MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)19794air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000222tidal volume0.4014ml0.01930.064MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0 and 0.1 hours)16474air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000222tidal volume0.4538ml0.04140.1311MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0 and 0.1 hours)16478air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory dataarterial blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days7CMO:0000009mean arterial blood pressure119.3mmHg2.53636.7104MMO:0000013vascular fluid filled cathetercontrol condition19865control condition
381PhysGen Respiratory dataarterial blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days7CMO:0000009mean arterial blood pressure125.5043mmHg3.876810.257MMO:0000013vascular fluid filled cathetercontrol condition19875control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000132minute ventilation63.9918ml/min2.88639.5727MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0 and 0.1 hours)14501air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000132minute ventilation69.8785ml/min7.98625.254MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0 and 0.1 hours)14505air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000289respiration rate140.1305breaths/min7.449724.7078MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)18266air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000289respiration rate135.4833breaths/min3.05929.1775MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)18270air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000531percent change in respiration rate122.51%6.068920.1284MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0.1 and 0.1 hours)53755air oxygen content (12 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000531percent change in respiration rate126.9383%8.467425.4023MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0.1 and 0.1 hours)53759air oxygen content (12 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000532percent change in tidal volume103.8797%9.22130.5827MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)53887air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000532percent change in tidal volume108.5606%7.900923.7027MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)53891air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000015body temperature36.9degrees C0.17890.5933MMO:0000034digital rectal thermometryair oxygen content (12 %) (for 0.1 hours)16573air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000015body temperature36.8444degrees C0.08010.2404MMO:0000034digital rectal thermometryair oxygen content (12 %) (for 0.1 hours)16577air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days7CMO:0000002heart rate361.0329beats/min16.161942.7605MMO:0000013vascular fluid filled catheterair carbon dioxide content (7 %) (for 0.1 hours)14697air carbon dioxide content (7 %) (for 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000531percent change in respiration rate169.074%6.260420.7636MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0 and 0.1 hours)53636air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000531percent change in respiration rate157.4148%7.468523.6176MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0 and 0.1 hours)53640air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days7CMO:0000002heart rate309.1186beats/min11.150129.5004MMO:0000013vascular fluid filled catheterair carbon dioxide content (7 %) (for 0.1 hours)14707air carbon dioxide content (7 %) (for 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000289respiration rate122.3345breaths/min4.532715.0331MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0.1 and 0.1 hours)14795air oxygen content (12 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000289respiration rate133.4993breaths/min4.899214.6976MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0.1 and 0.1 hours)14799air oxygen content (12 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000015body temperature36.57degrees C0.11460.3622MMO:0000034digital rectal thermometrycontrol condition19074control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000132minute ventilation57.0715ml/min3.65412.1191MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)20762air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000132minute ventilation61.3436ml/min8.39526.5473MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)20766air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datablood oxygen amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days6CMO:0000299absolute change in partial pressure of blood oxygen-43.7083mmHg4.121610.0959MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)19463air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory datablood oxygen amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days6CMO:0000299absolute change in partial pressure of blood oxygen-44.8mmHg2.07975.0942MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)19474air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000222tidal volume0.2626ml0.02150.0712MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0.1 and 0.1 hours)15234air oxygen content (12 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000222tidal volume0.3291ml0.02510.0754MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0.1 and 0.1 hours)15238air oxygen content (12 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datablood acidity-alkalinity balance traitConversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeksRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days6CMO:0000379blood pH7.48840.01150.0282MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)17048air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory datablood acidity-alkalinity balance traitConversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeksRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days6CMO:0000379blood pH7.50060.00320.0079MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)17059air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory datablood carbon dioxide amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days8CMO:0000283partial pressure of blood carbon dioxide (Pco2)37.1938mmHg1.28733.6411MMO:0000036automated blood gas analysis using a Bayer analyzercontrol condition16067control condition
381PhysGen Respiratory databody massMoms and pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000012body weight183.5g5.217.2MMO:0000017whole body digital scalecontrol condition17818control condition
381PhysGen Respiratory databody massMoms and pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000012body weight250.1g6.219.6MMO:0000017whole body digital scalecontrol condition17822control condition
381PhysGen Respiratory dataarterial blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days8CMO:0000009mean arterial blood pressure116.7362mmHg5.818616.4575MMO:0000013vascular fluid filled catheterair oxygen content (12 %) (for 0.1 hours)14330air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory dataarterial blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days6CMO:0000009mean arterial blood pressure115.4283mmHg1.81854.4544MMO:0000013vascular fluid filled catheterair oxygen content (12 %) (for 0.1 hours)14341air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory datablood carbon dioxide amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days6CMO:0000283partial pressure of blood carbon dioxide (Pco2)36.3mmHg1.18432.901MMO:0000036automated blood gas analysis using a Bayer analyzercontrol condition16078control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000132minute ventilation32.0066ml/min2.66238.8299MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0.1 and 0.1 hours)20209air oxygen content (12 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000132minute ventilation43.8687ml/min3.544510.6335MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0.1 and 0.1 hours)20213air oxygen content (12 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datablood acidity-alkalinity balance traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days8CMO:0000379blood pH7.44020.00970.0274MMO:0000036automated blood gas analysis using a Bayer analyzercontrol condition20623control condition
381PhysGen Respiratory datablood acidity-alkalinity balance traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days6CMO:0000379blood pH7.45070.00430.0105MMO:0000036automated blood gas analysis using a Bayer analyzercontrol condition20633control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000132minute ventilation25.4455ml/min1.51825.0353MMO:0000022stop flow air displacement plethysmographycontrol condition16148control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000132minute ventilation29.1499ml/min2.73238.6401MMO:0000022stop flow air displacement plethysmographycontrol condition16152control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000132minute ventilation31.5082ml/min5.774719.1526MMO:0000022stop flow air displacement plethysmographycontrol condition16691control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000132minute ventilation34.6144ml/min4.301912.9056MMO:0000022stop flow air displacement plethysmographycontrol condition16695control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000288percent change in ventilation%change=VE during 2-3 min hypoxia/control during standard conditions148.0066%16.043753.2109MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)13681air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000289respiration rate101.5711breaths/min4.803915.9328MMO:0000022stop flow air displacement plethysmographycontrol condition18411control condition
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000289respiration rate107.9758breaths/min6.176118.5284MMO:0000022stop flow air displacement plethysmographycontrol condition18415control condition
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000289respiration rate148.0616breaths/min4.471114.8291MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17112air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000289respiration rate141.4958breaths/min3.943812.4715MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17116air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datablood carbon dioxide amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days6CMO:0000298absolute change in partial pressure of blood carbon dioxide-8.05mmHg0.57011.3964MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)19632air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory datablood oxygen amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days8CMO:0000381partial pressure of blood oxygen98.9312mmHg5.225414.7796MMO:0000036automated blood gas analysis using a Bayer analyzercontrol condition18867control condition
381PhysGen Respiratory datablood oxygen amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days6CMO:0000381partial pressure of blood oxygen95.8417mmHg2.79756.8523MMO:0000036automated blood gas analysis using a Bayer analyzercontrol condition18878control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000222tidal volume0.2968ml0.03760.1246MMO:0000022stop flow air displacement plethysmographycontrol condition17983control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000222tidal volume0.3137ml0.02610.0782MMO:0000022stop flow air displacement plethysmographycontrol condition17987control condition
381PhysGen Respiratory datablood carbon dioxide amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days6CMO:0000298absolute change in partial pressure of blood carbon dioxide-6.4333mmHg0.77721.9039MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)19643air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000699absolute change in body temperature0.0636degrees C0.24240.8041MMO:0000034digital rectal thermometryair oxygen content (12 %) (for 0.1 hours)20310air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000699absolute change in body temperature0.0667degrees C0.13540.4062MMO:0000034digital rectal thermometryair oxygen content (12 %) (for 0.1 hours)20314air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000289respiration rate95.6677breaths/min3.416711.3318MMO:0000022stop flow air displacement plethysmographycontrol condition14936control condition
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000289respiration rate97.5491breaths/min3.09429.7847MMO:0000022stop flow air displacement plethysmographycontrol condition14940control condition
381PhysGen Respiratory dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days8CMO:0000002heart rate413.0288beats/min15.54143.9567MMO:0000013vascular fluid filled cathetercontrol condition20921control condition
381PhysGen Respiratory dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days5CMO:0000002heart rate405.508beats/min33.442674.78MMO:0000013vascular fluid filled cathetercontrol condition20932control condition
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000015body temperature36.8364degrees C0.14220.4717MMO:0000034digital rectal thermometrycontrol condition16813control condition
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000015body temperature36.7778degrees C0.11150.3346MMO:0000034digital rectal thermometrycontrol condition16817control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000222tidal volume0.2665ml0.0120.0398MMO:0000022stop flow air displacement plethysmographycontrol condition15398control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000222tidal volume0.2977ml0.02480.0786MMO:0000022stop flow air displacement plethysmographycontrol condition15402control condition
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000699absolute change in body temperature-0.2182degrees C0.17930.5947MMO:0000034digital rectal thermometryair carbon dioxide content (7 %) (for 0.1 hours)15670air carbon dioxide content (7 %) (for 0.1 hours)
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000699absolute change in body temperature-0.43degrees C0.14070.4448MMO:0000034digital rectal thermometryair carbon dioxide content (7 %) (for 0.1 hours)15674air carbon dioxide content (7 %) (for 0.1 hours)
381PhysGen Respiratory datablood gas amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days6CMO:0000283partial pressure of blood carbon dioxide (Pco2)28.9583mmHg0.91142.2326MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)17240air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory datablood gas amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days6CMO:0000283partial pressure of blood carbon dioxide (Pco2)29.8667mmHg1.21822.9841MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)17251air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days8CMO:0000002heart rate394.4538beats/min17.928350.709MMO:0000013vascular fluid filled catheterair oxygen content (12 %) (for 0.1 hours)17503air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days6CMO:0000002heart rate395.9167beats/min8.614121.1002MMO:0000013vascular fluid filled catheterair oxygen content (12 %) (for 0.1 hours)17514air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory dataarterial blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days8CMO:0000009mean arterial blood pressure119.35mmHg2.41616.8337MMO:0000013vascular fluid filled cathetercontrol condition15092control condition
381PhysGen Respiratory dataarterial blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days5CMO:0000009mean arterial blood pressure122.624mmHg4.755510.6336MMO:0000013vascular fluid filled cathetercontrol condition15103control condition
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000289respiration rate160.5235breaths/min5.347917.7371MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0 and 0.1 hours)16912air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datarespiratory function traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000289respiration rate152.1659breaths/min5.115416.1763MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0 and 0.1 hours)16916air carbon dioxide content (7 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000132minute ventilation39.5638ml/min3.227610.7046MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)18663air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000222tidal volume0.3838ml0.01870.0621MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17371air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days10CMO:0000222tidal volume0.4261ml0.04450.1407MMO:0000022stop flow air displacement plethysmographyair carbon dioxide content (7 %) (between 0.1 and 0.1 hours)17375air carbon dioxide content (7 %) (between 0.1 and 0.1 hours)
381PhysGen Respiratory dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days7CMO:0000002heart rate395.6843beats/min10.876928.7774MMO:0000013vascular fluid filled cathetercontrol condition15927control condition
381PhysGen Respiratory dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days7CMO:0000002heart rate378.8014beats/min6.759617.8842MMO:0000013vascular fluid filled cathetercontrol condition15937control condition
381PhysGen Respiratory datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days9CMO:0000132minute ventilation45.2492ml/min4.158612.4758MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (between 0 and 0.1 hours)18667air oxygen content (12 %) (between 0 and 0.1 hours)
381PhysGen Respiratory datablood oxygen amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days6CMO:0000381partial pressure of blood oxygen54.3083mmHg2.77356.7937MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)20475air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory datablood oxygen amountMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale99 days to 82 days6CMO:0000381partial pressure of blood oxygen51.0417mmHg1.55283.8036MMO:0000036automated blood gas analysis using a Bayer analyzerair oxygen content (12 %) (for 0.1 hours)20486air oxygen content (12 %) (for 0.1 hours)
381PhysGen Respiratory databody temperature traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 82 days11CMO:0000015body temperature37.0545degrees C0.15690.5203MMO:0000034digital rectal thermometrycontrol condition19070control condition
461PhysGen Cardiac dataheart massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000069heart wet weight0.927g0.03640.1151MMO:0000157digital scale post excision weight measurementair oxygen content (12 %) (for 14 days)45406air oxygen content (12 %) (for 14 days)
461PhysGen Cardiac dataheart massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000069heart wet weight1.014g0.02560.081MMO:0000157digital scale post excision weight measurementair oxygen content (12 %) (for 14 days)45410air oxygen content (12 %) (for 14 days)
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000198arterial blood flow rate6.699ml/min/g1.28024.0483MMO:0000114isolated perfused heart effluent collectionair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44719air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000198arterial blood flow rate4.773ml/min/g0.45531.4399MMO:0000114isolated perfused heart effluent collectionair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44723air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000007left ventricular systolic blood pressure96.6511mmHg7.806523.4195MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44816controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000007left ventricular systolic blood pressure108.5911mmHg6.376919.1308MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44820controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days2CMO:0000754percent change in left ventricular systolic blood pressurepost-ischemic value/pre-ischemic value x 100%73.194%30.60843.2862MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44919controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days6CMO:0000754percent change in left ventricular systolic blood pressurepost-ischemic value/pre-ischemic value x 100%106.7137%8.552920.9502MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)44923controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days7CMO:0000002heart rate182.8357beats/min19.783452.3418MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)45149air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000002heart rate196.96beats/min9.211727.635MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)45153air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days8CMO:0000018left ventricular developed pressure45.5238mmHg10.088128.5335MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)45271air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000018left ventricular developed pressure43.7811mmHg7.204321.6128MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)45275air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days8CMO:0000007left ventricular systolic blood pressure90.6938mmHg14.806941.8803MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)49889air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000007left ventricular systolic blood pressure77.9111mmHg11.127233.3816MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)49893air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart muscle contractility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days8CMO:0000665heart contraction pressure34mmHg5.596615.8294MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)49998air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac dataheart muscle contractility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000665heart contraction pressure29.6667mmHg2.98148.9443MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)50002air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac dataheart muscle contractility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000663time to onset of heart contraction980s37.0386111.1159MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)50120controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac dataheart muscle contractility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000663time to onset of heart contraction907.5556s18.355455.0661MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)50124controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days8CMO:0000664time to peak heart contraction1172.5s64.1291181.3844MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)50228air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000664time to peak heart contraction1155.2222s49.556148.6681MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)50232air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000012body weight136.1g3.09.5MMO:0000017whole body digital scaleair oxygen content (12 %) (for 14 days)49529air oxygen content (12 %) (for 14 days)
461PhysGen Cardiac databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000012body weight140g8.125.8MMO:0000017whole body digital scaleair oxygen content (12 %) (for 14 days)49541air oxygen content (12 %) (for 14 days)
461PhysGen Cardiac dataheart left ventricle integrity traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000695heart left ventricle infarction weight to total heart left ventricle weight ratio1.828%1.34684.2591MMO:0000157digital scale post excision weight measurementair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours)49699air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 3 hours)
461PhysGen Cardiac dataheart left ventricle integrity traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000695heart left ventricle infarction weight to total heart left ventricle weight ratio7.381%4.158213.1494MMO:0000157digital scale post excision weight measurementair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours)49703air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 3 hours)
461PhysGen Cardiac dataheart massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000069heart wet weight0.865g0.04520.143MMO:0000157digital scale post excision weight measurementcontrol condition49061control condition
461PhysGen Cardiac dataheart massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000069heart wet weight1.024g0.0350.1107MMO:0000157digital scale post excision weight measurementcontrol condition49065control condition
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days8CMO:0000006left ventricular diastolic blood pressure5.4038mmHg0.22530.6374MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)49178controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000006left ventricular diastolic blood pressure5.3989mmHg0.19310.5794MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)49182controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart muscle contractility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days8CMO:0000663time to onset of heart contraction902.75s95.2783269.4877MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)49300air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac dataheart muscle contractility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000663time to onset of heart contraction971.4444s41.3273123.982MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)49304air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac dataheart left ventricle integrity traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000695heart left ventricle infarction weight to total heart left ventricle weight ratio9.583%2.85819.038MMO:0000157digital scale post excision weight measurementcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours)49397controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 3 hours)
461PhysGen Cardiac dataheart left ventricle integrity traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000695heart left ventricle infarction weight to total heart left ventricle weight ratio10.873%3.351110.5971MMO:0000157digital scale post excision weight measurementcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours)49401controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 3 hours)
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000749percent change in arterial blood flow ratepost-ischemic value/pre-ischemic value x 100%83.3012%5.727917.1836MMO:0000114isolated perfused heart effluent collectioncontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46067controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000749percent change in arterial blood flow ratepost-ischemic value/pre-ischemic value x 100%65.4855%4.580214.484MMO:0000114isolated perfused heart effluent collectioncontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46071controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000198arterial blood flow rate13.0467ml/min/g0.85672.5701MMO:0000114isolated perfused heart effluent collectionair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)46654air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000198arterial blood flow rate12.968ml/min/g0.53791.701MMO:0000114isolated perfused heart effluent collectionair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)46658air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart lactate dehydrogenase activityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000775heart effluent lactate dehydrogenase activity level normalized to heart weight0.3402IU/g0.03940.1245MMO:0000114isolated perfused heart effluent collectioncontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)47319controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000012body weight154g1.96.1MMO:0000017whole body digital scalecontrol condition47824control condition
461PhysGen Cardiac databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000012body weight215.4g6.921.9MMO:0000017whole body digital scalecontrol condition47836control condition
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000018left ventricular developed pressure52.49mmHg8.936226.8087MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47912controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000018left ventricular developed pressure56.1578mmHg8.53525.605MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47916controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart muscle contractility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000665heart contraction pressure40.2222mmHg3.08129.2436MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)48034controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac dataheart muscle contractility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000665heart contraction pressure50mmHg1.54564.6368MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)48038controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000002heart rate216.7944beats/min15.195945.5876MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)48198controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000002heart rate255.5667beats/min10.716232.1485MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)48202controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days7CMO:0000742percent change in heart ratepost-ischemic value/pre-ischemic value x 100%73.3433%8.528122.5631MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48296air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000742percent change in heart ratepost-ischemic value/pre-ischemic value x 100%84.035%4.215812.6474MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48300air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days8CMO:0000742percent change in heart ratepost-ischemic value/pre-ischemic value x 100%106.215%10.505329.7136MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48407controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000742percent change in heart ratepost-ischemic value/pre-ischemic value x 100%102.1873%12.327636.9828MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48411controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days5CMO:0000751percent change in left ventricular developed pressurepost-ischemic value/pre-ischemic value x 100%35.7058%7.616817.0317MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48528air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days5CMO:0000751percent change in left ventricular developed pressurepost-ischemic value/pre-ischemic value x 100%44.3938%6.660114.8924MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48532air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days5CMO:0000018left ventricular developed pressure155.52mmHg6.966515.5776MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)48625air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days5CMO:0000018left ventricular developed pressure117.22mmHg7.37216.4843MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)48629air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days5CMO:0000754percent change in left ventricular systolic blood pressurepost-ischemic value/pre-ischemic value x 100%72.9376%4.892510.94MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48757air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days5CMO:0000754percent change in left ventricular systolic blood pressurepost-ischemic value/pre-ischemic value x 100%76.332%6.736515.0632MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48761air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart lactate dehydrogenase activityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000775heart effluent lactate dehydrogenase activity level normalized to heart weight25.7507IU/g1.34154.2423MMO:0000114isolated perfused heart effluent collectioncontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours)48868controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 1.5 hours)
461PhysGen Cardiac dataheart lactate dehydrogenase activityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000775heart effluent lactate dehydrogenase activity level normalized to heart weight27.4697IU/g1.80095.6951MMO:0000114isolated perfused heart effluent collectioncontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours)48879controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 1.5 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000002heart rate268.7822beats/min47.0506141.1517MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48950controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000002heart rate219.94beats/min39.931119.793MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)48946controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days2CMO:0000007left ventricular systolic blood pressure118.5mmHg2.53.5355MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)45505controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days6CMO:0000007left ventricular systolic blood pressure104.87mmHg5.33813.0754MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)45509controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000198arterial blood flow rate6.5422ml/min/g0.52971.5892MMO:0000114isolated perfused heart effluent collectioncontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46202controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000198arterial blood flow rate5.687ml/min/g0.16770.5302MMO:0000114isolated perfused heart effluent collectioncontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46206controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days2CMO:0000018left ventricular developed pressure112.65mmHg2.653.7477MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)46751controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days6CMO:0000018left ventricular developed pressure99.4367mmHg5.100212.4928MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)46755controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart lactate dehydrogenase activityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000775heart effluent lactate dehydrogenase activity level normalized to heart weight0.2595IU/g0.03880.1227MMO:0000114isolated perfused heart effluent collectioncontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)47330controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000074heart weight to body weight ratio6.823g/kg0.2610.825MMO:0000157digital scale post excision weight measurementair oxygen content (12 %) (for 14 days)45627air oxygen content (12 %) (for 14 days)
461PhysGen Cardiac dataheart massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000074heart weight to body weight ratio7.418g/kg0.3821.208MMO:0000157digital scale post excision weight measurementair oxygen content (12 %) (for 14 days)45639air oxygen content (12 %) (for 14 days)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days2CMO:0000751percent change in left ventricular developed pressurepost-ischemic value/pre-ischemic value x 100%37.0975%30.552543.2078MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46320controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days6CMO:0000751percent change in left ventricular developed pressurepost-ischemic value/pre-ischemic value x 100%60.114%10.366125.3916MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46324controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000198arterial blood flow rate7.894ml/min/g0.40191.2708MMO:0000114isolated perfused heart effluent collectioncontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)46871controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000198arterial blood flow rate8.999ml/min/g0.5611.7739MMO:0000114isolated perfused heart effluent collectioncontrolled oxygen content Kreb's solution perfusate (for 0.5 hours)46875controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart lactate dehydrogenase activityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000775heart effluent lactate dehydrogenase activity level normalized to heart weight0.5125IU/g0.09230.2769MMO:0000114isolated perfused heart effluent collectionair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47456air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart lactate dehydrogenase activityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000775heart effluent lactate dehydrogenase activity level normalized to heart weight0.5219IU/g0.06580.2081MMO:0000114isolated perfused heart effluent collectionair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47466air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days5CMO:0000007left ventricular systolic blood pressure161.54mmHg7.012815.6811MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)45730air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days5CMO:0000007left ventricular systolic blood pressure123.32mmHg7.432616.6198MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)45734air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days8CMO:0000006left ventricular diastolic blood pressure45.17mmHg9.970828.2017MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46418air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000006left ventricular diastolic blood pressure34.13mmHg5.419716.2592MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)46422air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000074heart weight to body weight ratio5.612g/kg0.2740.865MMO:0000157digital scale post excision weight measurementcontrol condition47002control condition
461PhysGen Cardiac dataheart massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000074heart weight to body weight ratio4.78g/kg0.1740.552MMO:0000157digital scale post excision weight measurementcontrol condition47014control condition
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000749percent change in arterial blood flow ratepost-ischemic value/pre-ischemic value x 100%44.0071%2.51397.9497MMO:0000114isolated perfused heart effluent collectionair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47078air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataarterial blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000749percent change in arterial blood flow ratepost-ischemic value/pre-ischemic value x 100%37.145%3.657811.5671MMO:0000114isolated perfused heart effluent collectionair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47082air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days7CMO:0000002heart rate251.7943beats/min5.922915.6705MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47583air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000002heart rate235.5222beats/min6.288218.8647MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47587air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000664time to peak heart contraction1199.7778s33.202699.6077MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)46549controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac dataheart pumping traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000664time to peak heart contraction1152.6667s25.955677.8669MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours)46553controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days6CMO:0000006left ventricular diastolic blood pressure5.95mmHg0.17650.4324MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47198air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days8CMO:0000006left ventricular diastolic blood pressure5.53mmHg0.33690.9528MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours)47202air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days9CMO:0000006left ventricular diastolic blood pressure44.1611mmHg4.033812.1013MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47702controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart left ventricular blood pressure traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days9CMO:0000006left ventricular diastolic blood pressure52.4333mmHg3.69911.0969MMO:0000029balloon tipped catheter with pressure transducer in isolated perfused heartcontrolled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours)47706controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 0.7 hours)
461PhysGen Cardiac dataheart lactate dehydrogenase activityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale63 days to 49 days10CMO:0000775heart effluent lactate dehydrogenase activity level normalized to heart weight22.8159IU/g3.464210.9549MMO:0000114isolated perfused heart effluent collectionair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours)45974air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 1.5 hours)
461PhysGen Cardiac dataheart lactate dehydrogenase activityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale63 days to 49 days10CMO:0000775heart effluent lactate dehydrogenase activity level normalized to heart weight22.8014IU/g1.36254.3087MMO:0000114isolated perfused heart effluent collectionair oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours)45982air oxygen content (12 %) (for 14 days)controlled oxygen content Kreb's solution perfusate (for 0.5 hours)perfusate suspended (for 0.4 hours)controlled oxygen content Kreb's solution perfusate (for 1.5 hours)
482PhysGen Renal B dataurine sodium amountMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 80 days7CMO:0000760urine sodium excretion rate18.5163mEq/d2.14365.6715MMO:0000039flame atomic emission spectrometrycontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52782controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B dataurine sodium amountMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwimale99 days to 80 days4CMO:0000760urine sodium excretion rate21.1452mEq/d6.388612.7773MMO:0000039flame atomic emission spectrometrycontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52793controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B datarenin activityMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 80 days2CMO:0000116plasma renin activity level3.48ng/ml/h1.031.4566MMO:0000073radioimmunoassaycontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52880controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B datarenin activityMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwimale99 days to 80 days2CMO:0000116plasma renin activity level2.105ng/ml/h0.6950.9829MMO:0000073radioimmunoassaycontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52891controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B datatotal urine protein amountMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 80 days7CMO:0000756urine total protein excretion rate65.0143mg/d9.001423.8155MMO:0000359automated urine total protein analysiscontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52096controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B datatotal urine protein amountMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwimale99 days to 80 days4CMO:0000756urine total protein excretion rate401.0062mg/d155.0138310.0276MMO:0000359automated urine total protein analysiscontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52107controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B datablood creatinine amountMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 80 days7CMO:0000537plasma creatinine level0.3271mg/dl0.01910.0506MMO:0000073radioimmunoassaycontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52245controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B datablood creatinine amountMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwimale99 days to 80 days3CMO:0000537plasma creatinine level0.31mg/dl0.0580.1004MMO:0000073radioimmunoassaycontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52256controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B dataurine potassium amountMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 80 days7CMO:0000761urine potassium excretion rate1.1866mEq/d0.08420.2229MMO:0000039flame atomic emission spectrometryurine potassium analysiscontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52294controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B dataurine potassium amountMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwimale99 days to 80 days4CMO:0000761urine potassium excretion rate1.174mEq/d0.0980.1961MMO:0000039flame atomic emission spectrometryurine potassium analysiscontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52305controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B dataglomerular filtration traitMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 80 days6CMO:0000765creatinine clearance1.3478ml/min0.1630.3992MMO:0000275urine creatinine analysiscontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52341controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B dataglomerular filtration traitMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwimale99 days to 80 days3CMO:0000765creatinine clearance1.881ml/min0.43170.7477MMO:0000275urine creatinine analysiscontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52352controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B dataurine albumin amountMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 80 days7CMO:0000757urine albumin excretion rate29.5891mg/d7.044718.6386MMO:0000073radioimmunoassaycontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52388controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B dataurine albumin amountMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwimale99 days to 80 days4CMO:0000757urine albumin excretion rate144.625mg/d56.9182113.8364MMO:0000073radioimmunoassaycontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52399controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B dataheart pumping traitMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 80 days8CMO:0000002heart rate429.9016beats/min7.774821.9906MMO:0000013vascular fluid filled cathetercontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52486controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B dataheart pumping traitMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwimale99 days to 80 days3CMO:0000002heart rate404.674beats/min22.743539.3929MMO:0000013vascular fluid filled cathetercontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52497controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B dataarterial blood pressure traitMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwifemale99 days to 80 days8CMO:0000009mean arterial blood pressure141.229mmHg4.543712.8516MMO:0000013vascular fluid filled cathetercontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52533controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
482PhysGen Renal B dataarterial blood pressure traitMoms were fed Teklad, pups used in studies were fed DyetsRS:0000337FHH-Chr 8BN/Mcwimale99 days to 80 days3CMO:0000009mean arterial blood pressure159.6053mmHg9.53116.5082MMO:0000013vascular fluid filled cathetercontrolled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)52544controlled sodium content diet (8 %) (between 19 and 22 days)controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days)
526PhysGen Lung dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000037hematocrit40.77%1.21573.8445MMO:0000215microhematocrit tube assay with visual assessmentcontrol condition (for 14 days)57507control condition (for 14 days)
526PhysGen Lung dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000037hematocrit43.8%1.21483.8416MMO:0000215microhematocrit tube assay with visual assessmentcontrol condition (for 14 days)57519control condition (for 14 days)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000710methylene blue metabolism-surface area product after auto-oxidation19.3371ml/min/kg0.64592.0425MMO:0000152isolated perfused lung vascular effluent collectionair oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours)57599air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)sample resting period (for 0.1 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000710methylene blue metabolism-surface area product after auto-oxidation16.452ml/min/kg0.90132.8502MMO:0000152isolated perfused lung vascular effluent collectionair oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours)57603air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)sample resting period (for 0.1 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000709methylene blue metabolism-surface area product without auto-oxidation28.922ml/min/kg0.92852.9363MMO:0000152isolated perfused lung vascular effluent collectionair oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours)57801air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000709methylene blue metabolism-surface area product without auto-oxidation24.5022ml/min/kg1.4974.7338MMO:0000152isolated perfused lung vascular effluent collectionair oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours)57805air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)
526PhysGen Lung datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days6CMO:0000713dose of methacholine at which pulmonary conductance is half its pretreatment value2.9423mg/kg0.88482.1674MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours)58911air oxygen content (12 %) (for 14 days)methacholine (0-11.06 mg/kg) drug dose time series (for 0.2 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days9CMO:0000708FAPGG metabolism-surface area product66.1666ml/min/kg6.723220.1696MMO:0000152isolated perfused lung vascular effluent collectionFAPGG (0.6 mmol/l) (between 0 and 0 hours)58246FAPGG (0.6 mmol/l) (between 0 and 0 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days8CMO:0000708FAPGG metabolism-surface area product49.8325ml/min/kg6.714118.9903MMO:0000152isolated perfused lung vascular effluent collectionFAPGG (0.6 mmol/l) (between 0 and 0 hours)58258FAPGG (0.6 mmol/l) (between 0 and 0 hours)
526PhysGen Lung databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000012body weight168.7g3.511.2MMO:0000017whole body digital scalecontrol condition (for 14 days)58358control condition (for 14 days)
526PhysGen Lung databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000012body weight221.8g6.420.2MMO:0000017whole body digital scalecontrol condition (for 14 days)58370control condition (for 14 days)
526PhysGen Lung dataheart right ventricle massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days9CMO:0000108heart right ventricle weight to left ventricle weight ratio0.41180.02450.0734MMO:0000157digital scale post excision weight measurementair oxygen content (12 %) (for 14 days)58734air oxygen content (12 %) (for 14 days)
526PhysGen Lung dataheart right ventricle massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000108heart right ventricle weight to left ventricle weight ratio0.37920.03480.1101MMO:0000157digital scale post excision weight measurementair oxygen content (12 %) (for 14 days)58738air oxygen content (12 %) (for 14 days)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days9CMO:0000710methylene blue metabolism-surface area product after auto-oxidation15.0472ml/min/kg0.73562.2069MMO:0000152isolated perfused lung vascular effluent collectionmethylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours)60014methylene blue (10 umol/l) (between 0 and 0 hours)sample resting period (for 0.1 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days8CMO:0000710methylene blue metabolism-surface area product after auto-oxidation12.9169ml/min/kg1.02942.9115MMO:0000152isolated perfused lung vascular effluent collectionmethylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours)60026methylene blue (10 umol/l) (between 0 and 0 hours)sample resting period (for 0.1 hours)
526PhysGen Lung databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000012body weight144.3g3.19.7MMO:0000017whole body digital scaleair oxygen content (12 %) (for 14 days)59063air oxygen content (12 %) (for 14 days)
526PhysGen Lung databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000012body weight168.4g2.88.8MMO:0000017whole body digital scaleair oxygen content (12 %) (for 14 days)59067air oxygen content (12 %) (for 14 days)
526PhysGen Lung datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days7CMO:0000713dose of methacholine at which pulmonary conductance is half its pretreatment value2.6144mg/kg0.3560.9419MMO:0000022stop flow air displacement plethysmographymethacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours)59184methacholine (0-11.06 mg/kg) drug dose time series (for 0.2 hours)
526PhysGen Lung datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days8CMO:0000713dose of methacholine at which pulmonary conductance is half its pretreatment value5.1409mg/kg1.04632.9594MMO:0000022stop flow air displacement plethysmographymethacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours)59196methacholine (0-11.06 mg/kg) drug dose time series (for 0.2 hours)
526PhysGen Lung dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000037hematocrit52.84%0.79962.5286MMO:0000215microhematocrit tube assay with visual assessmentair oxygen content (12 %) (for 14 days)59258air oxygen content (12 %) (for 14 days)
526PhysGen Lung dataerythrocyte quantityMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000037hematocrit53.77%0.91642.8979MMO:0000215microhematocrit tube assay with visual assessmentair oxygen content (12 %) (for 14 days)59262air oxygen content (12 %) (for 14 days)
526PhysGen Lung datablood vessel distensibility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days9CMO:0000714fractional change in blood vessel diameter per unit change in intravascular pressure0.0284mmHg-10.00380.0115MMO:0000203fluid-filled catheter with pressure transducer in isolated perfused lungKreb's solution perfusate (between 0.2 and 0.2 hours)59378Kreb's solution perfusate (between 0.2 and 0.2 hours)
526PhysGen Lung datablood vessel distensibility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days8CMO:0000714fractional change in blood vessel diameter per unit change in intravascular pressure0.0286mmHg-10.00560.0157MMO:0000203fluid-filled catheter with pressure transducer in isolated perfused lungKreb's solution perfusate (between 0.2 and 0.2 hours)59390Kreb's solution perfusate (between 0.2 and 0.2 hours)
526PhysGen Lung datalung massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000102lung dry weight to body weight ratio1.2585g/kg0.05020.1588MMO:0000157digital scale post excision weight measurementcontrol condition (for 14 days)59474control condition (for 14 days)
526PhysGen Lung datalung massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days9CMO:0000102lung dry weight to body weight ratio1.0552g/kg0.03750.1126MMO:0000157digital scale post excision weight measurementcontrol condition (for 14 days)59486control condition (for 14 days)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000703calculated pulmonary vascular resistance normalized to body weight0.1624mmHg x min x kg x ml-10.00760.0239MMO:0000203fluid-filled catheter with pressure transducer in isolated perfused lungair oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours)59548air oxygen content (12 %) (for 14 days)Kreb's solution perfusate (between 0.2 and 0.2 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000703calculated pulmonary vascular resistance normalized to body weight0.1606mmHg x min x kg x ml-10.010.0316MMO:0000203fluid-filled catheter with pressure transducer in isolated perfused lungair oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours)59552air oxygen content (12 %) (for 14 days)Kreb's solution perfusate (between 0.2 and 0.2 hours)
526PhysGen Lung datalung massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000102lung dry weight to body weight ratio1.7612g/kg0.03760.1189MMO:0000157digital scale post excision weight measurementair oxygen content (12 %) (for 14 days)59658air oxygen content (12 %) (for 14 days)
526PhysGen Lung datalung massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000102lung dry weight to body weight ratio1.544g/kg0.02560.0811MMO:0000157digital scale post excision weight measurementair oxygen content (12 %) (for 14 days)59662air oxygen content (12 %) (for 14 days)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days9CMO:0000711methylene blue to FAPGG metabolism-surface area product ratio0.35640.03040.0913MMO:0000152isolated perfused lung vascular effluent collectionmethylene blue (10 umol/l) (between 0 and 0 hours)59792methylene blue (10 umol/l) (between 0 and 0 hours)
526PhysGen Lung datablood vessel distensibility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000714fractional change in blood vessel diameter per unit change in intravascular pressure0.0292mmHg-10.00160.0049MMO:0000203fluid-filled catheter with pressure transducer in isolated perfused lungair oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours)58490air oxygen content (12 %) (for 14 days)Kreb's solution perfusate (between 0.2 and 0.2 hours)
526PhysGen Lung datablood vessel distensibility traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000714fractional change in blood vessel diameter per unit change in intravascular pressure0.0288mmHg-10.00280.0088MMO:0000203fluid-filled catheter with pressure transducer in isolated perfused lungair oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours)58494air oxygen content (12 %) (for 14 days)Kreb's solution perfusate (between 0.2 and 0.2 hours)
526PhysGen Lung datapulmonary ventilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days9CMO:0000713dose of methacholine at which pulmonary conductance is half its pretreatment value2.275mg/kg0.55221.6566MMO:0000022stop flow air displacement plethysmographyair oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours)58907air oxygen content (12 %) (for 14 days)methacholine (0-11.06 mg/kg) drug dose time series (for 0.2 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days8CMO:0000711methylene blue to FAPGG metabolism-surface area product ratio0.43880.05580.1579MMO:0000152isolated perfused lung vascular effluent collectionmethylene blue (10 umol/l) (between 0 and 0 hours)59804methylene blue (10 umol/l) (between 0 and 0 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days9CMO:0000703calculated pulmonary vascular resistance normalized to body weight0.1014mmHg x min x kg x ml-10.00560.0169MMO:0000203fluid-filled catheter with pressure transducer in isolated perfused lungKreb's solution perfusate (between 0.2 and 0.2 hours)59908Kreb's solution perfusate (between 0.2 and 0.2 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days8CMO:0000703calculated pulmonary vascular resistance normalized to body weight0.1201mmHg x min x kg x ml-10.00860.0242MMO:0000203fluid-filled catheter with pressure transducer in isolated perfused lungKreb's solution perfusate (between 0.2 and 0.2 hours)59920Kreb's solution perfusate (between 0.2 and 0.2 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days9CMO:0000709methylene blue metabolism-surface area product without auto-oxidation22.3148ml/min/kg1.48014.4403MMO:0000152isolated perfused lung vascular effluent collectionmethylene blue (10 umol/l) (between 0 and 0 hours)58643methylene blue (10 umol/l) (between 0 and 0 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days8CMO:0000709methylene blue metabolism-surface area product without auto-oxidation19.8204ml/min/kg1.21123.4259MMO:0000152isolated perfused lung vascular effluent collectionmethylene blue (10 umol/l) (between 0 and 0 hours)58655methylene blue (10 umol/l) (between 0 and 0 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000708FAPGG metabolism-surface area product54.6284ml/min/kg3.99712.6397MMO:0000152isolated perfused lung vascular effluent collectionair oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours)58000air oxygen content (12 %) (for 14 days)FAPGG (0.6 mmol/l) (between 0 and 0 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000708FAPGG metabolism-surface area product58.5749ml/min/kg4.446414.0606MMO:0000152isolated perfused lung vascular effluent collectionair oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours)58004air oxygen content (12 %) (for 14 days)FAPGG (0.6 mmol/l) (between 0 and 0 hours)
526PhysGen Lung dataheart right ventricle massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000108heart right ventricle weight to left ventricle weight ratio0.24330.01710.0542MMO:0000157digital scale post excision weight measurementcontrol condition (for 14 days)57921control condition (for 14 days)
526PhysGen Lung dataheart right ventricle massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000108heart right ventricle weight to left ventricle weight ratio0.21580.00950.03MMO:0000157digital scale post excision weight measurementcontrol condition (for 14 days)57933control condition (for 14 days)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale91 days to 77 days10CMO:0000711methylene blue to FAPGG metabolism-surface area product ratio0.5520.03910.1235MMO:0000152isolated perfused lung vascular effluent collectionair oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours)58114air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)
526PhysGen Lung datapulmonary blood flow traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale91 days to 77 days10CMO:0000711methylene blue to FAPGG metabolism-surface area product ratio0.4310.02890.0913MMO:0000152isolated perfused lung vascular effluent collectionair oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours)58118air oxygen content (12 %) (for 14 days)methylene blue (10 umol/l) (between 0 and 0 hours)
522PhysGen Vascular databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days10CMO:0000012body weight175.4g1.85.6MMO:0000017whole body digital scalecontrol condition (for 21 days)55426control condition (for 21 days)
522PhysGen Vascular databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days10CMO:0000012body weight236.5g5.116.1MMO:0000017whole body digital scalecontrol condition (for 21 days)55437control condition (for 21 days)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days10CMO:0000724concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)2.4364E-7mole0.97383.0794MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)56531controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days9CMO:0000724concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)5.3688E-7mole3.0129.0361MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)56543controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days9CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)-6.80660.04230.1269MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerphenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)55636phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days9CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)-6.92040.07350.2205MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerphenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)55648phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days9CMO:0000721concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)0.0264umol/l0.00820.0247MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerphenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)54685phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days10CMO:0000721concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)0.0137umol/l0.00210.0066MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerphenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)54697phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days10CMO:0000728maximum contractile force per wet weight of aorta1.226g/mg0.16640.5264MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerpotassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)55799potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days10CMO:0000728maximum contractile force per wet weight of aorta1.058g/mg0.1340.4237MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)57345controlled sodium content diet (4 %) (for 21 days)potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days10CMO:0000728maximum contractile force per wet weight of aorta0.947g/mg0.08880.2808MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)57357controlled sodium content diet (4 %) (for 21 days)potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days10CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel78.8%5.801918.3473MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)54791controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days9CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel61.7778%8.299624.8987MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)54803controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days10CMO:0000728maximum contractile force per wet weight of aorta0.803g/mg0.13210.4179MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerpotassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours)55811potassium ion (80 mmol/l) (for 0.2 hours)phenylephrine (10 umol/l) (for 0.2 hours)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days9CMO:0000724concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)1.6192E-7mole0.14760.4428MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerphenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)55905phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days9CMO:0000724concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)1.354E-7mole0.25110.7533MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerphenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)55917phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days10CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)-6.80580.11860.375MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)56926controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days9CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)-6.66640.18840.5652MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)56938controlled sodium content diet (4 %) (for 21 days)phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days9CMO:0000721concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)0.0193umol/l0.00550.0164MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)54917controlled sodium content diet (4 %) (for 21 days)phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days10CMO:0000721concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)0.0119umol/l0.00380.0121MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)54929controlled sodium content diet (4 %) (for 21 days)phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days9CMO:0000722logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)EC50 value is moles/liter-7.86890.13220.3967MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)56116controlled sodium content diet (4 %) (for 21 days)phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days10CMO:0000722logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)EC50 value is moles/liter-8.06840.10930.3457MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducercontrolled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)56128controlled sodium content diet (4 %) (for 21 days)phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)
522PhysGen Vascular databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days10CMO:0000012body weight179g4.414.0MMO:0000017whole body digital scalecontrolled sodium content diet (4 %) (for 21 days)55192controlled sodium content diet (4 %) (for 21 days)
522PhysGen Vascular databody massMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days10CMO:0000012body weight267.6g7.824.8MMO:0000017whole body digital scalecontrolled sodium content diet (4 %) (for 21 days)55203controlled sodium content diet (4 %) (for 21 days)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days9CMO:0000722logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)EC50 value is moles/liter-7.52680.21220.6367MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerphenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)55286phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)
522PhysGen Vascular datavasoconstriction traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days10CMO:0000722logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)EC50 value is moles/liter-7.90510.06250.1975MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerphenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours)55298phenylephrine (0-300 umol/l) drug dose time series (for 1.2 hours)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwifemale84 days to 70 days9CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel75.7778%6.054818.1644MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerphenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)57235phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)
522PhysGen Vascular datavasodilation traitMoms and pups used in studies were fed TekladRS:0000337FHH-Chr 8BN/Mcwimale84 days to 70 days9CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel76.6667%4.657713.9732MMO:0000208wire myography using a Digi-Med tissue force analysis system with force transducerphenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours)57247phenylephrine (1 umol/l) (for 0.2 hours)acetylcholine (0-30 umol/l) drug dose time series (for 1 hours)