INTERLEUKIN-1 SIGNALING PATHWAY (PW:0000883)
Description
Interleukin 1 is a member of the interleukin-1 family of cytokines that plays important roles in innate and adaptive immunity and which has been associated with acute and chronic inflammation. Interleukin 1 (alpha and beta) signaling involves the same receptor but there are differences between the localization, processing and function of the two cytokines. Il1b is considered the more potent cytokine while 1a can be active in its precursor form, can be membrane-associated and active and can also translocate to the nucleus to affect gene expression. The receptors are characterized by the presence of an extracellular immunoglobulin domain and an intracellular Toll/IL-1 receptor (
TIR ) domain. It is the presence of TIR domain that confers the shared characteristics of Il1 and Toll-like receptors (TLR) signaling. Upon ligand binding, the receptor undergoes conformational changes leading to recruitment of a co-receptor which then allows the complex to assemble with Myd88 and Tollip adapters followed by recruitment of Irak kinases (Tollip may also be involved in the internalization of the receptor). Irak4 undergoes auto-phosphorylation and then phosphorylates Irak1 and 2 which is followed by recruitment of Traf6, a ubiquitin E3 ligase. Traf6 and its upstream Irak1 partner are important for the assembly of a complex containing Map3k7 (Tak1) which can prompt NF-kappaB and MAPK signaling. A three-step mechanism has been proposed: phosphorylated Irak1 recruits Traf6 to the receptor complex and the two then dissociate to interact with a pre-formed Map3k7-Tab(s) complex on the membrane. A Traf6-Map3k7-Tab1-Tab2 complex translocates to the cytoplasm where the E3 ligase activity of Traf6 along with the E2 Ube2n and Ube2v1 enzymes are involved in K63-linked poly-ubiquitination events followed by activation of Map3k7. The sequence of events and mechanisms of Traf6-dependent poly-ubiquitination are not fully resolved. Irak1 is also subject to K63-poly-ubiquitination by the Pellino family members which it phosphorylates. However, Irak1 is also subject to Il1 triggered proteosomal degradation which depends on K48-linked poly-ubiquitination. Activated Map3k7 phosphorylates members of IKK complex which in turn activates NF-kappaB signaling; Map3k7 is also the upper MAP3K tier of JNK and p38 MAPK cascades. Processing of Il-1beta is accomplished by caspase 1 within a complex known as the inflammasome which includes members of Nod-like receptor (NLR) family, intracellular sensors of bacterial and nonbacterial danger. To-date, the NLRP3 inflammasome is the better characterized one and several mechanisms have been proposed for its activation. NLRP1 inflammasome is another complex that may also contain caspase-5 and a third complex includes AIM2 - a member of the HIN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA. Il-1alpha is processed by calpain but it is not clear which member or members of the family are involved in the process. The actions of Il1 are tightly regulated; the mechanisms include the presence of an endogenous receptor antagonist and of a decoy receptor. Another regulator is SIGIRR, also a member of the family; it has broader roles as it controls signaling by interleukin-1 and the other members of the family as well as signaling by Toll-like receptors.
To see the ontology report for annotations, GViewer and downloads, click here
[click to see the ontology report for related GO term
GO:0070498 and entry at Reactome - REACT_22442.1 ]
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Pathway Diagram:
Genes in Pathway:
G
Aim2
absent in melanoma 2
ISO
RGD
PMID:20303873 RGD:5490211
NCBI chr13:85,865,206...85,906,996
G
Casp1
caspase 1
ISO
PID PMID:19302047 PMID:20303873 PID:200089, RGD:5490210 , RGD:5490211
NCBI chr 8:2,587,812...2,597,403
G
Chuk
component of inhibitor of nuclear factor kappa B kinase complex
ISO
PID PID:200089
NCBI chr 1:252,908,748...252,944,273
G
Erc1
ELKS/RAB6-interacting/CAST family member 1
ISO
PID PID:200089
NCBI chr 4:152,763,664...153,055,724
G
Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
ISO
PID PID:200089
NCBI chr16:76,021,968...76,075,717
G
Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
ISO
PID PID:200089
NCBI chr X:157,358,279...157,397,563
G
Il1a
interleukin 1 alpha
ISO
PID PMID:20081871 PID:200089, RGD:5490209
NCBI chr 3:136,979,804...136,990,236
G
Il1b
interleukin 1 beta
ISO
PID PMID:20081871 PID:200089, RGD:5490209
NCBI chr 3:137,030,200...137,036,581
G
Il1r1
interleukin 1 receptor type 1
ISO IMP
PID PMID:20081871 PMID:20967881 PID:200089, RGD:5490209 , RGD:5130945
NCBI chr 9:42,504,917...42,580,958
G
Il1r2
interleukin 1 receptor type 2
ISO
PID PMID:20081871 PID:200089, RGD:5490209
NCBI chr 9:42,384,280...42,424,726
G
Il1rap
interleukin 1 receptor accessory protein
ISO
RGD
PMID:20081871 RGD:5490209
NCBI chr11:74,062,999...74,199,530
G
Il1rn
interleukin 1 receptor antagonist
ISO
PID PMID:20081871 PID:200089, RGD:5490209
NCBI chr 3:7,111,567...7,127,451
G
Irak1
interleukin-1 receptor-associated kinase 1
ISO
PID PMID:20086235 PMID:18535784 PID:200089, RGD:5490215 , RGD:5490218
NCBI chr X:156,919,927...156,929,825
G
Irak2
interleukin-1 receptor-associated kinase 2
ISO
RGD
PMID:20086235 RGD:5490215
NCBI chr 4:146,786,004...146,842,615
G
Irak3
interleukin-1 receptor-associated kinase 3
ISO
PID PID:200089
NCBI chr 7:55,653,949...55,714,371
G
Irak4
interleukin-1 receptor-associated kinase 4
ISO
PID PMID:20086235 PMID:18535784 PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 7:125,682,502...125,708,294
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
PID PID:200089
NCBI chr 5:109,894,175...109,897,268
G
Map2k6
mitogen-activated protein kinase kinase 6
ISO
PID PID:200089
NCBI chr10:95,373,304...95,490,406
G
Map3k3
mitogen activated protein kinase kinase kinase 3
ISO
PID PID:200089
NCBI chr10:91,020,174...91,088,852
G
Map3k7
mitogen activated protein kinase kinase kinase 7
ISO
PID PMID:20086235 PMID:18535784 PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 5:46,356,973...46,415,597
G
Mapk8
mitogen-activated protein kinase 8
ISO
PID PID:200089
NCBI chr16:8,638,897...8,721,960
G
Myd88
MYD88, innate immune signal transduction adaptor
ISO
PID PMID:20086235 PMID:18535784 PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 8:119,074,439...119,078,508
G
Nfkb1
nuclear factor kappa B subunit 1
ISO
PID PID:200089
NCBI chr 2:224,016,214...224,132,135
G
Nlrp1a
NLR family, pyrin domain containing 1A
ISO
RGD
PMID:20303873 RGD:5490211
NCBI chr10:55,778,560...55,833,639
G
Nlrp3
NLR family, pyrin domain containing 3
ISO
RGD
PMID:19302047 PMID:20303873 RGD:5490210 , RGD:5490211
NCBI chr10:44,326,770...44,353,814
G
Peli1
pellino E3 ubiquitin protein ligase 1
ISO
RGD
PMID:20086235 RGD:5490215
NCBI chr14:95,254,274...95,309,168
G
Peli2
pellino E3 ubiquitin protein ligase family member 2
ISO
RGD
PMID:20086235 RGD:5490215
NCBI chr15:21,393,262...21,537,737
G
Peli3
pellino E3 ubiquitin protein ligase family member 3
ISO
RGD
PMID:20086235 RGD:5490215
NCBI chr 1:202,230,034...202,242,900
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO
PID PID:200089
NCBI chr 2:115,175,275...115,249,034
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
ISO
PID PID:200089
NCBI chr 2:34,612,946...34,697,660
G
Prkci
protein kinase C, iota
ISO
PID PID:200089
NCBI chr 2:112,321,919...112,382,305
G
Prkcz
protein kinase C, zeta
ISO
PID PID:200089
NCBI chr 5:171,101,774...171,212,694
G
Pycard
PYD and CARD domain containing
ISO
RGD
PMID:19302047 PMID:20303873 RGD:5490210 , RGD:5490211
NCBI chr 1:182,601,657...182,603,013
G
Rela
RELA proto-oncogene, NF-kB subunit
ISO
PID PID:200089
NCBI chr 1:202,925,001...202,935,484
G
Sigirr
single Ig and TIR domain containing
ISO
RGD
PMID:20081871 RGD:5490209
NCBI chr 1:196,195,363...196,208,692
G
Sqstm1
sequestosome 1
ISO
PID PID:200089
NCBI chr10:34,525,517...34,536,670
G
Tab1
TGF-beta activated kinase 1/MAP3K7 binding protein 1
ISO
PID PMID:20086235 PMID:18535784 PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 7:111,675,829...111,707,058
G
Tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
ISO
PID PMID:20086235 PMID:18535784 PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 1:2,375,026...2,425,115
G
Tab3
TGF-beta activated kinase 1 (MAP3K7) binding protein 3
ISO
RGD
PMID:18535784 RGD:5490218
NCBI chr X:53,923,473...53,995,777
G
Ticam2
TIR domain containing adaptor molecule 2
ISO
PID PID:200089
NCBI chr18:39,289,902...39,311,462
G
Tollip
toll interacting protein
ISO
PID PMID:18535784 PID:200089, RGD:5490218
NCBI chr 1:196,961,585...196,984,252
G
Traf6
TNF receptor associated factor 6
ISO IMP
PID PMID:20086235 PMID:18535784 PMID:20967881 PID:200089, RGD:5490215 , RGD:5490218 , RGD:5130945
NCBI chr 3:87,963,517...87,988,316
G
Ube2n
ubiquitin-conjugating enzyme E2N
ISO
PID PMID:20086235 PMID:18535784 PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 7:30,154,330...30,184,373
G
Ube2v1
ubiquitin conjugating enzyme E2 V1
ISO
PID PMID:20086235 PMID:18535784 PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 3:156,317,339...156,340,198
Pathway Gene Annotations
Disease Annotations Associated with Genes in the interleukin-1 signaling pathway
Aim2 autoimmune interstitial lung, joint, and kidney disease , gastrointestinal stromal tumor , hereditary breast ovarian cancer syndrome , multiple sclerosis , parathyroid carcinoma Casp1 acute kidney failure , Albuminuria , allergic disease , Alzheimer's disease , amyotrophic lateral sclerosis type 1 , asthma , ataxia telangiectasia , Brain Hypoxia-Ischemia , Brain Injuries , chromosome 11 partial duplication syndrome , congestive heart failure , Dilatation, Pathologic , Endotoxemia , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , Experimental Seizures , Febrile Seizures , Human Influenza , hyperhomocysteinemia , in situ carcinoma , Inflammation , Insulin Resistance , intellectual disability , kidney disease , lung disease , multiple sclerosis , myocardial infarction , Myocardial Reperfusion Injury , obesity , Pain , pneumonia , prostate cancer , prostatic hypertrophy , Reperfusion Injury , rhinitis , Spinal Cord Injuries , status epilepticus , Tibial Fractures , Viral Bronchiolitis Chuk asthma , autistic disorder , bacterial pneumonia , Bartsocas-Papas Syndrome 2 , bone development disease , cleft palate , colitis , colon cancer , Congenital Limb Deformities , Fetal Diseases , fetal encasement syndrome , genetic disease , Inflammation , liver cancer , Multiple Abnormalities , muscular atrophy , Neoplasm Metastasis , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , Skin Abnormalities , skin cancer Erc1 Hyperphosphatemic Familial Tumoral Calcinosis 1 , Macrocephaly, Dysmorphic Facies, and Psychomotor Retardation Ikbkb Alzheimer's disease , breast cancer , Choroidal Neovascularization , colitis , colon cancer , dermatitis , Experimental Arthritis , Experimental Diabetes Mellitus , Experimental Melanoma , genetic disease , glucose intolerance , Hirschsprung's disease , Hyperplasia , hypertension , IMMUNODEFICIENCY 15 , immunodeficiency 15A , immunodeficiency 15B , Inflammation , inflammatory bowel disease , Insulin Resistance , Kidney Reperfusion Injury , liver cancer , middle cerebral artery infarction , muscular atrophy , Neonatal Hyperbilirubinemia , obesity , pancreatic ductal adenocarcinoma , Pancreatic Intraepithelial Neoplasia , pancreatitis , pneumonia , prostate adenocarcinoma , prostate cancer , psoriasis , severe combined immunodeficiency , torsion dystonia 6 , transient cerebral ischemia , Transplant Rejection , type 2 diabetes mellitus , vascular disease Ikbkg acute myocardial infarction , adrenoleukodystrophy , autistic disorder , autosomal hemophilia A , Barth syndrome , Behcet's disease , Bloch-Sulzberger syndrome , cerebral creatine deficiency syndrome 1 , colorectal cancer , common variable immunodeficiency , congenital nonspherocytic hemolytic anemia 1 , Coronary Disease , dyskeratosis congenita , ectodermal dysplasia and immune deficiency , ectodermal dysplasia and immunodeficiency 1 , Emery-Dreifuss muscular dystrophy , Experimental Arthritis , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Pancreatitis , factor VIII deficiency , favism , genetic disease , glucosephosphate dehydrogenase deficiency , hepatitis , hepatocellular carcinoma , hypomelanosis of Ito , immunodeficiency 33 , irritable bowel syndrome , learning disability , liver cancer , Liver Reperfusion Injury , Lung Neoplasms , malaria , metabolic dysfunction-associated steatotic liver disease , paraplegia , perinatal necrotizing enterocolitis , periventricular nodular heterotopia , severe congenital encephalopathy due to MECP2 mutation , Splenomegaly , steatotic liver disease , syndromic X-linked intellectual disability Lubs type , Systemic Autoinflammatory Disease, X-Linked Il1a acute kidney failure , acute myeloid leukemia , allergic bronchopulmonary aspergillosis , allergic contact dermatitis , Alzheimer's disease , amnestic disorder , Anorexia , anthracosis , Arsenic Poisoning , aspiration pneumonia , asthma , autoimmune thrombocytopenic purpura , B-Cell Chronic Lymphocytic Leukemia , beta thalassemia , Brain Injuries , brain ischemia , Burns , cardiomyopathy , Chemical and Drug Induced Liver Injury , Chemical Burns , cholestasis , cholesteatoma , cholesteatoma of middle ear , chorioamnionitis , chronic progressive external ophthalmoplegia , common cold , corneal edema , Craniocerebral Trauma , Creutzfeldt-Jakob disease , cystic fibrosis , dermatomyositis , diabetic retinopathy , diarrhea , Disease Progression , Drug-Induced Immune Thrombocytopenia , Drug-induced Neutropenia , end stage renal disease , endometritis , Endotoxemia , Enterocolitis , Experimental Arthritis , Experimental Diabetes Mellitus , Experimental Leukemia , Experimental Melanoma , extrinsic allergic alveolitis , Fabry disease , Femoral Fractures , Fetal Growth Retardation , Fever , glomerulonephritis , graft-versus-host disease , Graves ophthalmopathy , head and neck squamous cell carcinoma , Heat Stroke , hemolytic-uremic syndrome , Hemorrhage , Hemorrhagic Shock , HIV Wasting Syndrome , Human Influenza , Hyperalgesia , hyperglycemia , Hypotension , IgA glomerulonephritis , Inflammation , interstitial lung disease , Invasive Pulmonary Aspergillosis , iridocyclitis , juvenile rheumatoid arthritis , Kearns-Sayre syndrome , keratoconus , Knee Osteoarthritis , Leber hereditary optic neuropathy , Liver Reperfusion Injury , lung disease , lung non-small cell carcinoma , malignant mesothelioma , MELAS syndrome , MERRF Syndrome , mesenchymal chondrosarcoma , metabolic dysfunction-associated steatotic liver disease , Middle East respiratory syndrome , mitochondrial myopathy , multiple myeloma , Myocardial Ischemia , Myocardial Reperfusion Injury , Nasal Polyps , Oral Lichen Planus , osteoarthritis , osteoporosis , otitis media , pancreatic cancer , Perennial Allergic Rhinitis , periodontitis , pneumonia , Poisoning , polymyositis , pulmonary fibrosis , pulmonary tuberculosis , Radiation Injuries , Radiation Pneumonitis , Reperfusion Injury , respiratory allergy , Retina Reperfusion Injury , rheumatoid arthritis , Schnitzler syndrome , Sclerosis , severe acute respiratory syndrome , skin disease , Skin Neoplasms , tick infestation , type 1 diabetes mellitus , urinary tract infection , uveitis , varicocele , Venous Thrombosis , vitiligo , Wounds and Injuries Il1b abdominal aortic aneurysm , acute kidney failure , Acute Lung Injury , acute myocardial infarction , acute necrotizing pancreatitis , adenocarcinoma , adult respiratory distress syndrome , agranulocytosis , AIDS Dementia Complex , Albuminuria , alcohol use disorder , Alcoholic Liver Diseases , allergic conjunctivitis , allergic disease , allergic rhinitis , Alport syndrome , Alveolar Bone Loss , Alzheimer's disease , anemia , Animal Disease Models , Anorexia , anthracosis , anthrax disease , anti-basement membrane glomerulonephritis , antisynthetase syndrome , Arsenic Poisoning , arteriosclerosis , asbestosis , asthma , atherosclerosis , atopic dermatitis , atrophic gastritis , B-Cell Chronic Lymphocytic Leukemia , bacterial pneumonia , Behcet's disease , Binge Drinking , Brain Contusion , Brain Hypoxia-Ischemia , brain infarction , Brain Injuries , brain ischemia , breast cancer , Breast Neoplasms , Bronchial Hyperreactivity , bronchiectasis , bronchiolitis , bronchopulmonary dysplasia , Burns , Cachexia , calcinosis , Cardiomegaly , cardiomyopathy , Cardiotoxicity , Cerebral Hemorrhage , cerebral infarction , cervical cancer , cervix uteri carcinoma in situ , Chemical and Drug Induced Liver Injury , Chemical Burns , Chemically-Induced Disorders , Chemotherapy-Related Cognitive Impairment , cholangiocarcinoma , cholesteatoma , Chronic Experimental Pancreatitis , Chronic Intermittent Hypoxia , chronic kidney disease , chronic myeloid leukemia , chronic obstructive pulmonary disease , chronic progressive external ophthalmoplegia , cochlear disease , Cognitive Dysfunction , colitis , Colonic Neoplasms , common cold , congestive heart failure , Contrast-Induced Nephropathy , coronary artery disease , Coronary Disease , COVID-19 , crescentic glomerulonephritis , cutaneous leishmaniasis , cystic fibrosis , cystitis , degenerative disc disease , dental caries , depressive disorder , dermatomyositis , Diabetic Nephropathies , diabetic neuropathy , diabetic retinopathy , disease of cellular proliferation , Disease Progression , Drug Hypersensitivity Syndrome , Drug-Induced Agranulocytosis , Drug-Induced Immune Thrombocytopenia , dry eye syndrome , Eales Disease , Edema , encephalitis , end stage renal disease , endometriosis , endophthalmitis , Endotoxemia , Entamoebiasis , Enterocolitis , epididymitis , epilepsy , esophageal cancer , essential hypertension , Experimental Arthritis , Experimental Autoimmune Neuritis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Melanoma , Experimental Radiation Injuries , Experimental Seizures , extrahepatic cholestasis , extrinsic allergic alveolitis , Eye Burns , eye disease , familial Mediterranean fever , Febrile Seizures , Fever , Fibrosis , focal segmental glomerulosclerosis , Gallbladder Neoplasms , gastric adenocarcinoma , gastric dilatation , gastric ulcer , Genetic Predisposition to Disease , glioblastoma , glomerulonephritis , glomerulosclerosis , gout , Gram-Negative Bacterial Infections , Graves' disease , Heart Injuries , heart valve disease , Heat Stroke , Helicobacter Infections , hemolytic-uremic syndrome , Hemorrhagic Shock , hepatitis C , hepatocellular carcinoma , herpes simplex virus keratitis , HIV Wasting Syndrome , Human Influenza , hydronephrosis , Hyperalgesia , Hypercholesterolemia , Hyperemia , hyperglycemia , hyperhomocysteinemia , hypertension , hypoglycemia , hypolipoproteinemia , Hypotension , IgA glomerulonephritis , Inflammation , Insulin Resistance , Invasive Pulmonary Aspergillosis , Kawasaki disease , Kearns-Sayre syndrome , keratoconus , kidney failure , Kidney Reperfusion Injury , learning disability , Leber hereditary optic neuropathy , leptospirosis , Lethargy , Leukocytosis , liver cirrhosis , Liver Reperfusion Injury , lung disease , Lung Neoplasms , lung non-small cell carcinoma , Lung Reperfusion Injury , lupus nephritis , Lyme Neuroborreliosis , lymphopenia , Manganese Poisoning , MELAS syndrome , membranoproliferative glomerulonephritis , membranous glomerulonephritis , Memory Disorders , MERRF Syndrome , metabolic dysfunction-associated steatohepatitis , metabolic dysfunction-associated steatotic liver disease , middle cerebral artery infarction , Middle East respiratory syndrome , mitochondrial myopathy , mucositis , multiple myeloma , Multiple Organ Failure , multiple sclerosis , muscular disease , myelodysplastic syndrome , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , Necrosis , Neoplasm Invasiveness , nephrosis , nephrotic syndrome , neuroblastoma , neutropenia , Neutropenic Enterocolitis , obesity , obstructive sleep apnea , oral squamous cell carcinoma , osteoarthritis , osteoporosis , otitis media , Otitis Media with Effusion , Oxygen-Induced Retinopathy , pancreatic cancer , Pancreatic Cyst , pancreatitis , PAPA syndrome , paracoccidioidomycosis , Parkinson's disease , Parkinsonism , peptic ulcer disease , perinatal necrotizing enterocolitis , periodontitis , Peripheral Nerve Injuries , plague , pleural tuberculosis , pleurisy , pneumonia , polymyositis , polyneuropathy , portal hypertension , Postmenopausal Osteoporosis , Postoperative Cognitive Dysfunction , Presenile and Senile Dementia , primary biliary cholangitis , Pseudomonas Aeruginosa Keratitis , Pseudomonas Infections , psoriasis , pulmonary edema , pulmonary fibrosis , pulmonary hypertension , pulmonary tuberculosis , Radiation Pneumonitis , Reperfusion Injury , respiratory allergy , Retina Reperfusion Injury , retinal vein occlusion , retinitis , retinopathy of prematurity , rheumatoid arthritis , rhinitis , Rhinosinusitis , schizophrenia , sciatic neuropathy , Sepsis , severe acute respiratory syndrome , shigellosis , silicosis , sinusitis , skin disease , sleep disorder , Small-For-Size Syndrome , Spinal Cord Injuries , Spontaneous Abortions , Staphylococcal Pneumonia , status asthmaticus , status epilepticus , steatotic liver disease , stomach cancer , Stomach Neoplasms , Stroke , Subarachnoid Hemorrhage , Systemic Inflammatory Response Syndrome , systemic lupus erythematosus , systemic scleroderma , thalassemia , thrombocytopenia , thrombocytosis , Thyroid Neoplasms , toxic shock syndrome , transient cerebral ischemia , Transplant Rejection , traumatic brain injury , trigeminal neuralgia , type 1 diabetes mellitus , type 2 diabetes mellitus , ulcerative colitis , ureteral obstruction , urinary bladder cancer , urinary tract infection , urticaria , uveitis , varicocele , vascular dementia , Venous Thrombosis , Ventilator-Induced Lung Injury , viral pneumonia , visceral leishmaniasis , Vulvar Vestibulitis Il1r1 allergic disease , aortic dissection , Bacterial Keratitis , Brain Injuries , Chemical Burns , cholesteatoma of middle ear , chronic recurrent multifocal osteomyelitis , Chronic recurrent multifocal osteomyelitis 3 , COVID-19 , endometriosis , glomerulonephritis , Hyperalgesia , Hypoglossal Nerve Injuries , Nontuberculous Mycobacterium Infections , Ocular Onchocerciasis , Perennial Allergic Rhinitis , pneumonia , pulpitis , severe acute respiratory syndrome , skin disease , Spinal Cord Injuries , systemic scleroderma , type 1 diabetes mellitus , Ventilator-Induced Lung Injury Il1r2 aggressive periodontitis , allergic disease , ankylosing spondylitis , Chemical and Drug Induced Liver Injury , cholangiocarcinoma , esophageal cancer , liver disease , lung adenocarcinoma , lung cancer , Lung Neoplasms , organ system cancer , pneumonia , Presbycusis , ulcerative colitis Il1rap Disease Progression , head and neck squamous cell carcinoma , hepatocellular carcinoma , High Myopia , liver disease , schizophrenia Il1rn Abscess , acute kidney failure , Acute Liver Failure , Acute Lung Injury , acute necrotizing pancreatitis , adult respiratory distress syndrome , alcohol dependence , allergic conjunctivitis , alopecia areata , Anorexia , anterior uveitis , anthracosis , anti-basement membrane glomerulonephritis , Arsenic Poisoning , asthma , Atrophy , autistic disorder , autoimmune thrombocytopenic purpura , autosomal dominant polycystic kidney disease , B-Cell Chronic Lymphocytic Leukemia , bacterial pneumonia , Behcet's disease , Brain Injuries , brain ischemia , Bronchial Hyperreactivity , bronchiolitis , bronchiolitis obliterans , bronchopulmonary dysplasia , bronchus carcinoma , Cachexia , calcium oxalate nephrolithiasis , cardiovascular system disease , Carotid Artery Injuries , Cerebral Hemorrhage , cerebrovascular disease , Chediak-Higashi syndrome , Chronic Anterior Uveitis , chronic kidney disease , chronic myeloid leukemia , chronic obstructive pulmonary disease , Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis , Chronic Rhinosinusitis , Chronic Uveitis , cicatricial pemphigoid , Colonic Neoplasms , common cold , Corneal Graft Rejection , corneal neovascularization , COVID-19 , crescentic glomerulonephritis , Cryopyrin-Associated Periodic Syndromes , cystic fibrosis , dacryocystitis , depressive disorder , diabetic angiopathy , Diabetic Nephropathies , diarrhea , Drug Hypersensitivity Syndrome , Drug-Induced Agranulocytosis , Drug-Related Side Effects and Adverse Reactions , dry eye syndrome , encephalitis , end stage renal disease , endometriosis , Endotoxemia , Endotoxin-Induced Uveitis , exanthem , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Myocarditis , Experimental Autoimmune Uveitis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Extravasation of Diagnostic and Therapeutic Materials , Eye Manifestations , Febrile Seizures , Fever , fibromyalgia , Fibrosis , genetic disease , glomerulonephritis , gout , graft-versus-host disease , Graves ophthalmopathy , hairy cell leukemia , hemolytic-uremic syndrome , hepatocellular carcinoma , herpes simplex virus keratitis , Human Influenza , Hyperalgesia , hyperglycemia , hypertension , IgA glomerulonephritis , IgA vasculitis , Inflammation , inflammatory bowel disease , interstitial lung disease , interstitial lung disease 2 , juvenile rheumatoid arthritis , keratoconus , kidney disease , Kidney Reperfusion Injury , learning disability , Leukocytosis , Lichen Sclerosus et Atrophicus , listeriosis , Liver Reperfusion Injury , lung non-small cell carcinoma , lupus nephritis , Meibomian Gland Dysfunction , melanoma , metabolic dysfunction-associated steatotic liver disease , middle cerebral artery infarction , morbid obesity , Muckle-Wells syndrome , mucositis , multiple myeloma , Multiple Organ Failure , multiple sclerosis , myocardial infarction , Myocardial Reperfusion Injury , myositis , Necrosis , Neoplasm Invasiveness , nephrotic syndrome , nicotine dependence , obesity , Oligoanuria , osteoporosis , Pain , periodontitis , pleural disease , pleural tuberculosis , pleurisy , pneumonia , Postoperative Cognitive Dysfunction , pre-eclampsia , Proctocolitis , Prostatic Neoplasms , prostatitis , proteinuria , Pseudomonas Aeruginosa Keratitis , Pseudomonas Infections , pulmonary eosinophilia , pulmonary fibrosis , pulmonary hypertension , pulmonary sarcoidosis , pulmonary tuberculosis , pustular psoriasis 14 , pyelonephritis , renal cell carcinoma , respiratory allergy , rheumatoid arthritis , rhinitis , Schnitzler syndrome , sciatic neuropathy , Sclerosis , Sepsis , Serositis , silicosis , Sjogren's syndrome , skin disease , Spinal Cord Injuries , status epilepticus , stomach cancer , Stomach Neoplasms , Stroke , Subarachnoid Hemorrhage , systemic lupus erythematosus , toxic shock syndrome , transient cerebral ischemia , Transplant Rejection , type 1 diabetes mellitus , type 2 diabetes mellitus , ulcerative colitis , ureteral obstruction , urinary bladder cancer , Urinary Calculi , vascular disease , Venous Thrombosis , Ventilator-Induced Lung Injury , Viral Bronchiolitis , viral pneumonia Irak1 adrenoleukodystrophy , ankylosing spondylitis , autistic disorder , autosomal hemophilia A , Barth syndrome , Brain Hypoxia-Ischemia , brain ischemia , cardiomyopathy , cerebral creatine deficiency syndrome 1 , Chemical and Drug Induced Liver Injury , Chromosome Xq28 Duplication Syndrome , cognitive disorder , coronary artery disease , diffuse scleroderma , dyskeratosis congenita , Emery-Dreifuss muscular dystrophy , factor VIII deficiency , favism , frontometaphyseal dysplasia , immunodeficiency 33 , inguinal hernia , Juberg-Hayward Syndrome , Lentivirus Infections , Melnick-Needles syndrome , methylmalonic acidemia and homocysteinemia cblX type , Myocardial Reperfusion Injury , myocarditis , otopalatodigital syndrome type 2 , paraplegia , periventricular nodular heterotopia , Periventricular Nodular Heterotopia 4 , psoriasis , psoriatic arthritis , Rett syndrome , rheumatoid arthritis , severe congenital encephalopathy due to MECP2 mutation , Splenomegaly , squamous cell carcinoma , syndromic X-linked intellectual disability Lubs type Irak2 Atrioventricular Septal Defect 2 , familial erythrocytosis 2 , myoclonic-atonic epilepsy , Neurodevelopmental Disorders , von Hippel-Lindau disease Irak3 Acute Lung Injury , asthma , bacterial pneumonia , Carcinoma, Lewis Lung , Endotoxemia , Escherichia Coli Infections , Glandular and Epithelial Neoplasms , Haemophilus Infections , Hirschsprung's disease , Klebsiella pneumonia , lung adenocarcinoma , melioidosis , mucopolysaccharidosis type IIID , multisystem inflammatory syndrome in children , osteoporosis , Porcine Postweaning Multisystemic Wasting Syndrome , Porcine Reproductive and Respiratory Syndrome , Pseudomonas Infections , Reperfusion Injury , Staphylococcal Infections , Streptococcus pneumonia , Surgical Wound Infection , tuberculosis , type 1 diabetes mellitus Irak4 Animal Disease Models , Bacterial Infections and Mycoses , Brain Hypoxia-Ischemia , brain ischemia , congenital dyserythropoietic anemia , genetic disease , Hyperoxia , Immunodeficiency 67 , Prostatic Neoplasms , Sepsis , systemic lupus erythematosus Jun Alcohol-Related Disorders , angiosarcoma , Asphyxia , basal cell carcinoma , Brain Injuries , brain ischemia , breast cancer , Breast Neoplasms , chronic obstructive pulmonary disease , Colonic Neoplasms , colorectal adenocarcinoma , colorectal adenoma , COVID-19 , depressive disorder , endometrial adenocarcinoma , endometrial carcinoma , extrahepatic cholestasis , glaucoma , Heat Stroke , hepatocellular carcinoma , Hodgkin's lymphoma , hypertension , Intestinal Polyps , juvenile rheumatoid arthritis , Liver Neoplasms , Lung Neoplasms , Mercury Poisoning, Nervous System , Nasal Polyps , Neoplastic Cell Transformation , Optic Nerve Injuries , oral squamous cell carcinoma , osteopetrosis , osteosarcoma , peripheral nervous system disease , prostate adenocarcinoma , prostate carcinoma , Prostatic Neoplasms , pulmonary emphysema , pulmonary tuberculosis , renal carcinoma , renal cell carcinoma , Reperfusion Injury , silicosis , Spinal Cord Injuries , status epilepticus , Stomach Neoplasms , tongue squamous cell carcinoma Map2k6 allergic disease , Animal Mammary Neoplasms , Brain Death , Cardiomegaly , cervical cancer , Colonic Neoplasms , Edema , Experimental Diabetes Mellitus , Myocardial Reperfusion Injury , ovarian carcinoma , Pick's disease , progressive supranuclear palsy , prostate carcinoma in situ , Prostatic Neoplasms , restrictive cardiomyopathy Map3k3 Cerebral Cavernous Malformation 5 , Esophageal Neoplasms , verrucous keratotic hemangioma Map3k7 arteriosclerosis , benign hypertensive renal disease , brain edema , Brain Hypoxia-Ischemia , Brain Injuries , brain ischemia , Cachexia , Cardiac Fibrosis , Cardiomegaly , chronic kidney disease , chronic obstructive pulmonary disease , congestive heart failure , coronary artery disease , Diabetic Cardiomyopathies , dilated cardiomyopathy , Embryo Loss , extrahepatic cholestasis , Forney Robinson Pascoe Syndrome , frontometaphyseal dysplasia , frontometaphyseal dysplasia 2 , genetic disease , hypertrophic cardiomyopathy , Liver Reperfusion Injury , Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal Bones , myocardial infarction , Opsismodysplasia , pancreatic ductal carcinoma , prostate cancer , Prostatic Neoplasms , Pulmonary Arterial Hypertension , Stroke , Subarachnoid Hemorrhage , transient cerebral ischemia , Wolff-Parkinson-White syndrome Mapk8 abdominal aortic aneurysm , Acute Liver Failure , Acute Otitis Media , alcohol use disorder , Alzheimer's disease , Animal Disease Models , anogenital venereal wart , anti-basement membrane glomerulonephritis , Arenaviridae infectious disease , atopic dermatitis , bacterial pneumonia , brain ischemia , candidiasis , Cardiomegaly , chronic mucocutaneous candidiasis , chronic obstructive pulmonary disease , Cockayne syndrome B , Colonic Neoplasms , colorectal adenocarcinoma , colorectal adenoma , Contrast-Induced Nephropathy , dengue disease , endometriosis , Endotoxemia , extrahepatic cholestasis , Helicobacter Infections , hepatitis , hepatocellular carcinoma , Hyperalgesia , hypertension , Infectious Ectromelia , influenza A , Intestinal Neoplasms , Kuhnt-Junius degeneration , Liver Reperfusion Injury , megacolon , metabolic dysfunction-associated steatotic liver disease , myocardial infarction , Myocardial Reperfusion Injury , Neoplastic Cell Transformation , Oxygen-Induced Retinopathy , pancreatic adenocarcinoma , pancreatic ductal adenocarcinoma , Parkinsonism , pre-malignant neoplasm , Pseudomonas Infections , rectal benign neoplasm , Reperfusion Injury , schizophrenia , Sepsis , steatotic liver disease , Stomach Neoplasms , Stroke , trigeminal neuralgia , type 2 diabetes mellitus Myd88 Acute Lung Injury , anemia , anogenital venereal wart , asthma , Bacterial Keratitis , Binge Drinking , breast cancer , breast carcinoma , Brugada syndrome , Cachexia , Carcinoma, Lewis Lung , central nervous system lymphoma , Chemical and Drug Induced Liver Injury , Colitis-Associated Neoplasms , colon adenocarcinoma , colon cancer , colon carcinoma , Colonic Polyps , colorectal adenocarcinoma , colorectal adenoma , colorectal cancer , Colorectal Cancer 10 , colorectal carcinoma , Coronavirus infectious disease , diarrhea , diffuse large B-cell lymphoma , Eosinophilia , esophageal cancer , Experimental Arthritis , Experimental Colitis , extrahepatic cholestasis , follicular lymphoma , gastroenteritis , genetic disease , Helicobacter Infections , hepatitis B , hepatocellular carcinoma , hypertension , Immunodeficiency 68 , Inflammation , Intestinal Polyps , Liver Injury , Liver Reperfusion Injury , lung adenocarcinoma , lung cancer , lung non-small cell carcinoma , lymphoplasmacytic lymphoma , melanoma , metabolic dysfunction-associated steatohepatitis , monoclonal gammopathy of uncertain significance , Myocardial Reperfusion Injury , Neoplasm Invasiveness , Neoplastic Cell Transformation , pneumonia , pulmonary eosinophilia , Reperfusion Injury , severe acute respiratory syndrome , stomach cancer , Stomach Neoplasms , testicular lymphoma , visceral heterotaxy 4 Nfkb1 acute kidney failure , adenocarcinoma , alcoholic hepatitis , atrophic gastritis , beta-mannosidosis , brain ischemia , breast cancer , Cerebral Hemorrhage , Cerebral Toxoplasmosis , Chemical and Drug Induced Liver Injury , Chronic Hepatitis C , Colonic Neoplasms , colorectal cancer , common variable immunodeficiency , common variable immunodeficiency 12 , depressive disorder , end stage renal disease , Entamoebiasis , genetic disease , Heat Stroke , hepatocellular carcinoma , High Myopia , HTLV-1-associated myelopathy/tropical spastic paraparesis , Huntington's disease , Hyperoxaluria , Intestinal Helminthiasis , liver disease , lung cancer , lung non-small cell carcinoma , lymphocytic choriomeningitis , melanoma , metabolic dysfunction-associated steatohepatitis , Neoplasm Metastasis , Neoplastic Cell Transformation , ovarian cyst , pancreatic adenocarcinoma , primary biliary cholangitis , primary ciliary dyskinesia 3 , primary immunodeficiency disease , prion disease , prostate cancer , steatotic liver disease , stomach cancer , transient cerebral ischemia , type 2 diabetes mellitus , Viral Bronchiolitis Nlrp1a Autoinflammation with Arthritis and Dyskeratosis , developmental and epileptic encephalopathy 25 , genetic disease , Multiple Self-healing Palmoplantar Carcinoma , prostate cancer , Recurrent Respiratory Papillomatosis , vitiligo Nlrp3 acne , Acute Lung Injury , alcoholic hepatitis , Anaphylaxis , Arsenic Poisoning , arteriovenous malformations of the brain , asbestosis , Ataxia , atypical hemolytic-uremic syndrome , autosomal dominant nonsyndromic deafness 34 , Chediak-Higashi syndrome , CINCA syndrome , Crohn's disease , Cryopyrin-Associated Periodic Syndromes , developmental and epileptic encephalopathy 54 , drug allergy , familial cold autoinflammatory syndrome , familial cold autoinflammatory syndrome 1 , Febrile Seizures , Fever , focal segmental glomerulosclerosis , focal segmental glomerulosclerosis 1 , food allergy , gastrointestinal stromal tumor , genetic disease , Hearing Loss , hidradenitis suppurativa , Inflammation , Insulin Resistance , Keratitis Fugax Hereditaria , kidney disease , long COVID , lung adenocarcinoma , metabolic dysfunction-associated steatotic liver disease , Muckle-Wells syndrome , multiple sclerosis , myocardial infarction , parathyroid carcinoma , pulmonary edema , pyoderma gangrenosum , severe acute respiratory syndrome , squamous cell carcinoma , steatotic liver disease , toxic encephalopathy , urticaria , xanthomatosis Peli1 Arsenic Poisoning , Bardet-Biedl syndrome , colorectal cancer , Drug-Related Side Effects and Adverse Reactions , skin disease Peli2 basal cell carcinoma Peli3 Aicardi-Goutieres Syndrome 3 , Bardet-Biedl syndrome , congenital muscular dystrophy-dystroglycanopathy type A13 , glycogen storage disease V , immunodeficiency 90 , intellectual disability Pik3ca adenocarcinoma , adenoid cystic carcinoma , Agenesis of Corpus Callosum , arteriovenous malformation , autosomal recessive polycystic kidney disease , Bannayan-Riley-Ruvalcaba syndrome , basal cell carcinoma , Brain Neoplasms , breast adenocarcinoma , breast angiosarcoma , breast cancer , Breast Cancer, Familial , breast carcinoma , Breast Neoplasms , Capillary Malformation-Arteriovenous Malformation 1 , Cardiovascular Abnormalities , Cerebral Cavernous Malformation 4 , CLAPO Syndrome , CLOVES syndrome , colon adenocarcinoma , colon carcinoma , colorectal cancer , colorectal carcinoma , Colorectal Neoplasms , complex cortical dysplasia with other brain malformations , Cowden syndrome , Cowden syndrome 5 , Currarino syndrome , cutaneous Paget's disease , Developmental Disabilities , Diabetic Cardiomyopathies , diaphragmatic eventration , diffuse large B-cell lymphoma , Disease Progression , Down syndrome , endometrial carcinoma , Endometrial Neoplasms , epidermal nevus , esophageal cancer , esophageal carcinoma , esophagus adenocarcinoma , estrogen-receptor positive breast cancer , Facial Asymmetry , familial multiple nevi flammei , gallbladder cancer , gastric adenocarcinoma , Gastrointestinal Neoplasms , genetic disease , glioblastoma , glycogen storage disease II , Growth Disorders , head and neck squamous cell carcinoma , Hemifacial Myohyperplasia , Hemimegalencephaly , hepatocellular carcinoma , Hereditary Neoplastic Syndromes , high grade glioma , Hyperplasia , Hypertelorism , keratoacanthoma , Klippel-Trenaunay syndrome , liver cancer , lung adenocarcinoma , lung cancer , lung carcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung small cell carcinoma , lung squamous cell carcinoma , lymphangioma , Lymphatic Metastasis , Macrocephaly , medulloblastoma , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome , Megalodactyly , melanoma , Mouth Neoplasms , Neoplasm Metastasis , NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES , ovarian cancer , Ovarian Neoplasms , Penile Neoplasms , polycystic kidney disease , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , PTEN hamartoma tumor syndrome , rectal benign neoplasm , renal cell carcinoma , rosette-forming glioneuronal tumor , sarcoma , seborrheic keratosis , skin melanoma , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , Stroke , urinary bladder cancer , Vascular Malformations , Ventricular Dysfunction, Left , Weight Gain Pik3r1 agammaglobulinemia 7 , Alzheimer's disease , Animal Mammary Neoplasms , astroblastoma , Breast Neoplasms , Burkitt lymphoma , carcinoma , CLOVES syndrome , Colonic Neoplasms , colorectal cancer , endometrial adenocarcinoma , endometrial cancer , endometrial carcinoma , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , genetic disease , glucose intolerance , hepatocellular carcinoma , hypertension , hypoglycemia , immunodeficiency 14 , immunodeficiency 36 , Insulin Resistance , lung adenocarcinoma , lung small cell carcinoma , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , Nematode Infections , Neurodevelopmental Disorders , obesity , osteoarthritis , Ovarian Neoplasms , portal hypertension , primary immunodeficiency disease , prostate cancer , Prostatic Neoplasms , renal cell carcinoma , Reperfusion Injury , rheumatoid arthritis , Septic Peritonitis , SHORT syndrome , Smith-Kingsmore Syndrome , type 2 diabetes mellitus , Vascular Malformations , vitiligo , X-linked agammaglobulinemia Prkci abdominal obesity-metabolic syndrome , autistic disorder , autosomal dominant dyskeratosis congenita 1 , Experimental Diabetes Mellitus , Fanconi-Bickel syndrome , invasive ductal carcinoma , obesity , ovarian carcinoma , type 2 diabetes mellitus Prkcz autism spectrum disorder , Cardiomegaly , chromosome 1p36 deletion syndrome , congenital myasthenic syndrome 8 , dilated cardiomyopathy 1LL , Ehlers-Danlos syndrome spondylodysplastic type 2 , Goldberg-Shprintzen syndrome , Hyperalgesia , hyperglycemia , Idiopathic Generalized Epilepsy , immunodeficiency 16 , immunodeficiency 38 , Insulin Resistance , Joubert syndrome 25 , Left Ventricular Hypertrophy , leukemia , Neurodevelopmental Disorders , Peroxisome Biogenesis Disorder, Complementation Group 7 , Prostatic Neoplasms , Shprintzen-Goldberg Craniosynostosis , type 2 diabetes mellitus Pycard adenocarcinoma , Albuminuria , Brain Contusion , branched-chain keto acid dehydrogenase kinase deficiency , calcinosis , Colorectal Neoplasms , Experimental Liver Cirrhosis , heart valve disease , hepatocellular carcinoma , hyperhomocysteinemia , kidney disease , large cell carcinoma , Lung Neoplasms , lung non-small cell carcinoma , malignant mesothelioma , small cell carcinoma , squamous cell carcinoma , steatotic liver disease , Stomach Neoplasms , Weight Gain Rela acute necrotizing pancreatitis , adenocarcinoma , Aicardi-Goutieres Syndrome 3 , alcoholic liver cirrhosis , Alcoholic Liver Diseases , amphetamine abuse , anaplastic large cell lymphoma , arteriosclerosis , Autoinflammatory Disease, Familial, Behcet-Like-3 , Bardet-Biedl syndrome , Barrett's esophagus , Binge Drinking , Brain Injuries , brain ischemia , Brain Neoplasms , Breast Neoplasms , Cardiomegaly , Cerebral Hemorrhage , cervix uteri carcinoma in situ , Chemotherapy-Related Cognitive Impairment , Childhood Schizophrenia , cholestasis , cholesteatoma of middle ear , Chronic Intermittent Hypoxia , chronic obstructive pulmonary disease , colitis , Colonic Neoplasms , Crohn's disease , cryptorchidism , cystitis , diabetic angiopathy , Diabetic Nephropathies , Disease Progression , Drug Eruptions , Drug-Induced Dyskinesia , ductal carcinoma in situ , encephalitis , end stage renal disease , endocrine system disease , epilepsy , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , Experimental Neoplasms , extrahepatic cholestasis , glycogen storage disease V , Heat Stroke , Hemorrhagic Shock , Hepatic Insufficiency , Hepatomegaly , hypertension , immunodeficiency 90 , Insulin Resistance , intellectual disability , Intestinal Reperfusion Injury , laryngeal squamous cell carcinoma , Left Ventricular Hypertrophy , liver cirrhosis , Liver Reperfusion Injury , lung non-small cell carcinoma , Lymphatic Metastasis , lymphoma , mastoiditis , metabolic dysfunction and alcohol associated liver disease , Myocardial Reperfusion Injury , Neoplasm Invasiveness , Neoplastic Cell Transformation , neuroblastoma , obesity , obstructive sleep apnea , oral squamous cell carcinoma , otitis media , Ovarian Neoplasms , pancreatic cancer , pancreatic ductal carcinoma , Parkinsonism , Pneumococcal Meningitis , primary biliary cholangitis , prostate adenocarcinoma , prostate carcinoma in situ , prostatic hypertrophy , Prostatic Neoplasms , pulmonary hypertension , renal cell carcinoma , renovascular hypertension , Reperfusion Injury , Sepsis , severe acute respiratory syndrome , Skin Neoplasms , Spinal Cord Injuries , status epilepticus , steatotic liver disease , Stomach Neoplasms , Subarachnoid Hemorrhage , Transplant Rejection , traumatic brain injury , ulcerative colitis , ureteral obstruction , urinary bladder cancer , Uterine Cervical Neoplasms , uveitis Sigirr Beckwith-Wiedemann syndrome , COVID-19 , developmental and epileptic encephalopathy , early infantile epileptic encephalopathy , immunodeficiency 39 Sqstm1 acute myocardial infarction , alcoholic hepatitis , Alcoholic Liver Diseases , amyotrophic lateral sclerosis , Cerebral Hemorrhage , developmental coordination disorder , distal myopathy with rimmed vacuoles , Ehlers-Danlos syndrome dermatosparaxis type , frontotemporal dementia and/or amyotrophic lateral sclerosis 1 , frontotemporal dementia and/or amyotrophic lateral sclerosis 3 , genetic disease , glaucoma , glucose intolerance , GNE myopathy , hypertension , Insulin Resistance , macular degeneration , neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset , Paget's disease of bone , Paget's disease of bone 2 , Paget's disease of bone 3 , Sotos syndrome , Spinal Cord Injuries , Starvation Tab1 adenylosuccinase lyase deficiency , polycystic ovary syndrome , Rubinstein-Taybi syndrome Tab2 brain disease , cardiomyopathy , chronic obstructive pulmonary disease , Congenital Heart Defects, Multiple Types , Congenital Heart Defects, Multiple Types, 2 , congenital heart disease , dilated cardiomyopathy , Embryo Loss , genetic disease , latent autoimmune diabetes in adults , lung non-small cell carcinoma , migraine , ovary epithelial cancer , pulmonary fibrosis , rheumatoid arthritis , systemic lupus erythematosus , type 1 diabetes mellitus 5 Tab3 autistic disorder , Duchenne muscular dystrophy , Neurodevelopmental Disorders , ornithine carbamoyltransferase deficiency , rheumatoid arthritis , syndromic X-linked intellectual disability Lubs type , systemic lupus erythematosus , X-linked adrenal hypoplasia congenita Ticam2 autistic disorder , Brain Injuries , Coronavirus infectious disease , familial adenomatous polyposis 1 , Hereditary Neoplastic Syndromes , Neurodevelopmental Disorders , severe acute respiratory syndrome Tollip Beckwith-Wiedemann syndrome , chronic obstructive pulmonary disease , COVID-19 , delta beta-thalassemia , developmental and epileptic encephalopathy , early infantile epileptic encephalopathy , idiopathic pulmonary fibrosis , immunodeficiency 39 , interstitial lung disease 2 , neuronal ceroid lipofuscinosis , Segawa Syndrome, Autosomal Recessive Traf6 alcohol use disorder , coronary artery disease , hypertrophic cardiomyopathy , hypohidrotic ectodermal dysplasia , intellectual disability , Intestinal Reperfusion Injury , intrinsic cardiomyopathy , laryngeal carcinoma , rheumatoid arthritis Ube2n Embryo Loss
abdominal aortic aneurysm Il1b , Mapk8 abdominal obesity-metabolic syndrome Prkci Abscess Il1rn acne Nlrp3 acute kidney failure Casp1 , Il1a , Il1b , Il1rn , Nfkb1 Acute Liver Failure Il1rn , Mapk8 Acute Lung Injury Il1b , Il1rn , Irak3 , Myd88 , Nlrp3 acute myeloid leukemia Il1a acute myocardial infarction Ikbkg , Il1b , Sqstm1 acute necrotizing pancreatitis Il1b , Il1rn , Rela Acute Otitis Media Mapk8 adenocarcinoma Il1b , Nfkb1 , Pik3ca , Pycard , Rela adenoid cystic carcinoma Pik3ca adenylosuccinase lyase deficiency Tab1 adrenoleukodystrophy Ikbkg , Irak1 adult respiratory distress syndrome Il1b , Il1rn agammaglobulinemia 7 Pik3r1 Agenesis of Corpus Callosum Pik3ca aggressive periodontitis Il1r2 agranulocytosis Il1b Aicardi-Goutieres Syndrome 3 Peli3 , Rela AIDS Dementia Complex Il1b Albuminuria Casp1 , Il1b , Pycard alcohol dependence Il1rn alcohol use disorder Il1b , Mapk8 , Traf6 Alcohol-Related Disorders Jun alcoholic hepatitis Nfkb1 , Nlrp3 , Sqstm1 alcoholic liver cirrhosis Rela Alcoholic Liver Diseases Il1b , Rela , Sqstm1 allergic bronchopulmonary aspergillosis Il1a allergic conjunctivitis Il1b , Il1rn allergic contact dermatitis Il1a allergic disease Casp1 , Il1b , Il1r1 , Il1r2 , Map2k6 allergic rhinitis Il1b alopecia areata Il1rn Alport syndrome Il1b Alveolar Bone Loss Il1b Alzheimer's disease Casp1 , Ikbkb , Il1a , Il1b , Mapk8 , Pik3r1 amnestic disorder Il1a amphetamine abuse Rela amyotrophic lateral sclerosis Sqstm1 amyotrophic lateral sclerosis type 1 Casp1 Anaphylaxis Nlrp3 anaplastic large cell lymphoma Rela anemia Il1b , Myd88 angiosarcoma Jun Animal Disease Models Il1b , Irak4 , Mapk8 Animal Mammary Neoplasms Map2k6 , Pik3r1 ankylosing spondylitis Il1r2 , Irak1 anogenital venereal wart Mapk8 , Myd88 Anorexia Il1a , Il1b , Il1rn anterior uveitis Il1rn anthracosis Il1a , Il1b , Il1rn anthrax disease Il1b anti-basement membrane glomerulonephritis Il1b , Il1rn , Mapk8 antisynthetase syndrome Il1b aortic dissection Il1r1 Arenaviridae infectious disease Mapk8 Arsenic Poisoning Il1a , Il1b , Il1rn , Nlrp3 , Peli1 arteriosclerosis Il1b , Map3k7 , Rela arteriovenous malformation Pik3ca arteriovenous malformations of the brain Nlrp3 asbestosis Il1b , Nlrp3 Asphyxia Jun aspiration pneumonia Il1a asthma Casp1 , Chuk , Il1a , Il1b , Il1rn , Irak3 , Myd88 astroblastoma Pik3r1 Ataxia Nlrp3 ataxia telangiectasia Casp1 atherosclerosis Il1b atopic dermatitis Il1b , Mapk8 Atrioventricular Septal Defect 2 Irak2 atrophic gastritis Il1b , Nfkb1 Atrophy Il1rn atypical hemolytic-uremic syndrome Nlrp3 autism spectrum disorder Prkcz autistic disorder Chuk , Ikbkg , Il1rn , Irak1 , Prkci , Tab3 , Ticam2 autoimmune interstitial lung, joint, and kidney disease Aim2 autoimmune thrombocytopenic purpura Il1a , Il1rn Autoinflammation with Arthritis and Dyskeratosis Nlrp1a Autoinflammatory Disease, Familial, Behcet-Like-3 Rela autosomal dominant dyskeratosis congenita 1 Prkci autosomal dominant nonsyndromic deafness 34 Nlrp3 autosomal dominant polycystic kidney disease Il1rn autosomal hemophilia A Ikbkg , Irak1 autosomal recessive polycystic kidney disease Pik3ca B-Cell Chronic Lymphocytic Leukemia Il1a , Il1b , Il1rn Bacterial Infections and Mycoses Irak4 Bacterial Keratitis Il1r1 , Myd88 bacterial pneumonia Chuk , Il1b , Il1rn , Irak3 , Mapk8 Bannayan-Riley-Ruvalcaba syndrome Pik3ca Bardet-Biedl syndrome Peli1 , Peli3 , Rela Barrett's esophagus Rela Barth syndrome Ikbkg , Irak1 Bartsocas-Papas Syndrome 2 Chuk basal cell carcinoma Jun , Peli2 , Pik3ca Beckwith-Wiedemann syndrome Sigirr , Tollip Behcet's disease Ikbkg , Il1b , Il1rn benign hypertensive renal disease Map3k7 beta thalassemia Il1a beta-mannosidosis Nfkb1 Binge Drinking Il1b , Myd88 , Rela Bloch-Sulzberger syndrome Ikbkg bone development disease Chuk Brain Contusion Il1b , Pycard Brain Death Map2k6 brain disease Tab2 brain edema Map3k7 Brain Hypoxia-Ischemia Casp1 , Il1b , Irak1 , Irak4 , Map3k7 brain infarction Il1b Brain Injuries Casp1 , Il1a , Il1b , Il1r1 , Il1rn , Jun , Map3k7 , Rela , Ticam2 brain ischemia Il1a , Il1b , Il1rn , Irak1 , Irak4 , Jun , Map3k7 , Mapk8 , Nfkb1 , Rela Brain Neoplasms Pik3ca , Rela branched-chain keto acid dehydrogenase kinase deficiency Pycard breast adenocarcinoma Pik3ca breast angiosarcoma Pik3ca breast cancer Ikbkb , Il1b , Jun , Myd88 , Nfkb1 , Pik3ca Breast Cancer, Familial Pik3ca breast carcinoma Myd88 , Pik3ca Breast Neoplasms Il1b , Jun , Pik3ca , Pik3r1 , Rela Bronchial Hyperreactivity Il1b , Il1rn bronchiectasis Il1b bronchiolitis Il1b , Il1rn bronchiolitis obliterans Il1rn bronchopulmonary dysplasia Il1b , Il1rn bronchus carcinoma Il1rn Brugada syndrome Myd88 Burkitt lymphoma Pik3r1 Burns Il1a , Il1b Cachexia Il1b , Il1rn , Map3k7 , Myd88 calcinosis Il1b , Pycard calcium oxalate nephrolithiasis Il1rn candidiasis Mapk8 Capillary Malformation-Arteriovenous Malformation 1 Pik3ca carcinoma Pik3r1 Carcinoma, Lewis Lung Irak3 , Myd88 Cardiac Fibrosis Map3k7 Cardiomegaly Il1b , Map2k6 , Map3k7 , Mapk8 , Prkcz , Rela cardiomyopathy Il1a , Il1b , Irak1 , Tab2 Cardiotoxicity Il1b Cardiovascular Abnormalities Pik3ca cardiovascular system disease Il1rn Carotid Artery Injuries Il1rn central nervous system lymphoma Myd88 Cerebral Cavernous Malformation 4 Pik3ca Cerebral Cavernous Malformation 5 Map3k3 cerebral creatine deficiency syndrome 1 Ikbkg , Irak1 Cerebral Hemorrhage Il1b , Il1rn , Nfkb1 , Rela , Sqstm1 cerebral infarction Il1b Cerebral Toxoplasmosis Nfkb1 cerebrovascular disease Il1rn cervical cancer Il1b , Map2k6 cervix uteri carcinoma in situ Il1b , Rela Chediak-Higashi syndrome Il1rn , Nlrp3 Chemical and Drug Induced Liver Injury Il1a , Il1b , Il1r2 , Irak1 , Myd88 , Nfkb1 Chemical Burns Il1a , Il1b , Il1r1 Chemically-Induced Disorders Il1b Chemotherapy-Related Cognitive Impairment Il1b , Rela Childhood Schizophrenia Rela cholangiocarcinoma Il1b , Il1r2 cholestasis Il1a , Rela cholesteatoma Il1a , Il1b cholesteatoma of middle ear Il1a , Il1r1 , Rela chorioamnionitis Il1a Choroidal Neovascularization Ikbkb chromosome 11 partial duplication syndrome Casp1 chromosome 1p36 deletion syndrome Prkcz Chromosome Xq28 Duplication Syndrome Irak1 Chronic Anterior Uveitis Il1rn Chronic Experimental Pancreatitis Il1b Chronic Hepatitis C Nfkb1 Chronic Intermittent Hypoxia Il1b , Rela chronic kidney disease Il1b , Il1rn , Map3k7 chronic mucocutaneous candidiasis Mapk8 chronic myeloid leukemia Il1b , Il1rn chronic obstructive pulmonary disease Il1b , Il1rn , Jun , Map3k7 , Mapk8 , Rela , Tab2 , Tollip chronic progressive external ophthalmoplegia Il1a , Il1b chronic recurrent multifocal osteomyelitis Il1r1 Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis Il1rn Chronic recurrent multifocal osteomyelitis 3 Il1r1 Chronic Rhinosinusitis Il1rn Chronic Uveitis Il1rn cicatricial pemphigoid Il1rn CINCA syndrome Nlrp3 CLAPO Syndrome Pik3ca cleft palate Chuk CLOVES syndrome Pik3ca , Pik3r1 cochlear disease Il1b Cockayne syndrome B Mapk8 cognitive disorder Irak1 Cognitive Dysfunction Il1b colitis Chuk , Ikbkb , Il1b , Rela Colitis-Associated Neoplasms Myd88 colon adenocarcinoma Myd88 , Pik3ca colon cancer Chuk , Ikbkb , Myd88 colon carcinoma Myd88 , Pik3ca Colonic Neoplasms Il1b , Il1rn , Jun , Map2k6 , Mapk8 , Nfkb1 , Pik3r1 , Rela Colonic Polyps Myd88 colorectal adenocarcinoma Jun , Mapk8 , Myd88 colorectal adenoma Jun , Mapk8 , Myd88 colorectal cancer Ikbkg , Myd88 , Nfkb1 , Peli1 , Pik3ca , Pik3r1 Colorectal Cancer 10 Myd88 colorectal carcinoma Myd88 , Pik3ca Colorectal Neoplasms Pik3ca , Pycard common cold Il1a , Il1b , Il1rn common variable immunodeficiency Ikbkg , Nfkb1 common variable immunodeficiency 12 Nfkb1 complex cortical dysplasia with other brain malformations Pik3ca congenital dyserythropoietic anemia Irak4 Congenital Heart Defects, Multiple Types Tab2 Congenital Heart Defects, Multiple Types, 2 Tab2 congenital heart disease Tab2 Congenital Limb Deformities Chuk congenital muscular dystrophy-dystroglycanopathy type A13 Peli3 congenital myasthenic syndrome 8 Prkcz congenital nonspherocytic hemolytic anemia 1 Ikbkg congestive heart failure Casp1 , Il1b , Map3k7 Contrast-Induced Nephropathy Il1b , Mapk8 corneal edema Il1a Corneal Graft Rejection Il1rn corneal neovascularization Il1rn coronary artery disease Il1b , Irak1 , Map3k7 , Traf6 Coronary Disease Ikbkg , Il1b Coronavirus infectious disease Myd88 , Ticam2 COVID-19 Il1b , Il1r1 , Il1rn , Jun , Sigirr , Tollip Cowden syndrome Pik3ca Cowden syndrome 5 Pik3ca Craniocerebral Trauma Il1a crescentic glomerulonephritis Il1b , Il1rn Creutzfeldt-Jakob disease Il1a Crohn's disease Nlrp3 , Rela Cryopyrin-Associated Periodic Syndromes Il1rn , Nlrp3 cryptorchidism Rela Currarino syndrome Pik3ca cutaneous leishmaniasis Il1b cutaneous Paget's disease Pik3ca cystic fibrosis Il1a , Il1b , Il1rn cystitis Il1b , Rela dacryocystitis Il1rn degenerative disc disease Il1b delta beta-thalassemia Tollip dengue disease Mapk8 dental caries Il1b depressive disorder Il1b , Il1rn , Jun , Nfkb1 dermatitis Ikbkb dermatomyositis Il1a , Il1b developmental and epileptic encephalopathy Sigirr , Tollip developmental and epileptic encephalopathy 25 Nlrp1a developmental and epileptic encephalopathy 54 Nlrp3 developmental coordination disorder Sqstm1 Developmental Disabilities Pik3ca diabetic angiopathy Il1rn , Rela Diabetic Cardiomyopathies Map3k7 , Pik3ca Diabetic Nephropathies Il1b , Il1rn , Rela diabetic neuropathy Il1b diabetic retinopathy Il1a , Il1b diaphragmatic eventration Pik3ca diarrhea Il1a , Il1rn , Myd88 diffuse large B-cell lymphoma Myd88 , Pik3ca diffuse scleroderma Irak1 Dilatation, Pathologic Casp1 dilated cardiomyopathy Map3k7 , Tab2 dilated cardiomyopathy 1LL Prkcz disease of cellular proliferation Il1b Disease Progression Il1a , Il1b , Il1rap , Pik3ca , Rela distal myopathy with rimmed vacuoles Sqstm1 Down syndrome Pik3ca drug allergy Nlrp3 Drug Eruptions Rela Drug Hypersensitivity Syndrome Il1b , Il1rn Drug-Induced Agranulocytosis Il1b , Il1rn Drug-Induced Dyskinesia Rela Drug-Induced Immune Thrombocytopenia Il1a , Il1b Drug-induced Neutropenia Il1a Drug-Related Side Effects and Adverse Reactions Il1rn , Peli1 dry eye syndrome Il1b , Il1rn Duchenne muscular dystrophy Tab3 ductal carcinoma in situ Rela dyskeratosis congenita Ikbkg , Irak1 Eales Disease Il1b early infantile epileptic encephalopathy Sigirr , Tollip ectodermal dysplasia and immune deficiency Ikbkg ectodermal dysplasia and immunodeficiency 1 Ikbkg Edema Il1b , Map2k6 Ehlers-Danlos syndrome dermatosparaxis type Sqstm1 Ehlers-Danlos syndrome spondylodysplastic type 2 Prkcz Embryo Loss Map3k7 , Tab2 , Ube2n Emery-Dreifuss muscular dystrophy Ikbkg , Irak1 encephalitis Il1b , Il1rn , Rela end stage renal disease Il1a , Il1b , Il1rn , Nfkb1 , Rela endocrine system disease Rela endometrial adenocarcinoma Jun , Pik3r1 endometrial cancer Pik3r1 endometrial carcinoma Jun , Pik3ca , Pik3r1 Endometrial Neoplasms Pik3ca endometriosis Il1b , Il1r1 , Il1rn , Mapk8 endometritis Il1a endophthalmitis Il1b Endotoxemia Casp1 , Il1a , Il1b , Il1rn , Irak3 , Mapk8 Endotoxin-Induced Uveitis Il1rn Entamoebiasis Il1b , Nfkb1 Enterocolitis Il1a , Il1b Eosinophilia Myd88 epidermal nevus Pik3ca epididymitis Il1b epilepsy Il1b , Rela Escherichia Coli Infections Irak3 esophageal cancer Il1b , Il1r2 , Myd88 , Pik3ca esophageal carcinoma Pik3ca Esophageal Neoplasms Map3k3 esophagus adenocarcinoma Pik3ca essential hypertension Il1b estrogen-receptor positive breast cancer Pik3ca exanthem Il1rn Experimental Arthritis Ikbkb , Ikbkg , Il1a , Il1b , Il1rn , Myd88 Experimental Autoimmune Encephalomyelitis Il1rn Experimental Autoimmune Myocarditis Il1rn Experimental Autoimmune Neuritis Il1b Experimental Autoimmune Uveitis Il1rn Experimental Colitis Il1b , Il1rn , Myd88 , Rela Experimental Diabetes Mellitus Casp1 , Ikbkb , Il1a , Il1b , Il1rn , Map2k6 , Pik3r1 , Prkci , Rela Experimental Leukemia Il1a Experimental Liver Cirrhosis Casp1 , Ikbkg , Il1b , Pycard , Rela Experimental Liver Neoplasms Ikbkg Experimental Mammary Neoplasms Casp1 , Il1rn , Pik3r1 , Rela Experimental Melanoma Ikbkb , Il1a , Il1b Experimental Neoplasms Rela Experimental Pancreatitis Ikbkg Experimental Radiation Injuries Il1b Experimental Seizures Casp1 , Il1b extrahepatic cholestasis Il1b , Jun , Map3k7 , Mapk8 , Myd88 , Rela Extravasation of Diagnostic and Therapeutic Materials Il1rn extrinsic allergic alveolitis Il1a , Il1b Eye Burns Il1b eye disease Il1b Eye Manifestations Il1rn Fabry disease Il1a Facial Asymmetry Pik3ca factor VIII deficiency Ikbkg , Irak1 familial adenomatous polyposis 1 Ticam2 familial cold autoinflammatory syndrome Nlrp3 familial cold autoinflammatory syndrome 1 Nlrp3 familial erythrocytosis 2 Irak2 familial Mediterranean fever Il1b familial multiple nevi flammei Pik3ca Fanconi-Bickel syndrome Prkci favism Ikbkg , Irak1 Febrile Seizures Casp1 , Il1b , Il1rn , Nlrp3 Femoral Fractures Il1a Fetal Diseases Chuk fetal encasement syndrome Chuk Fetal Growth Retardation Il1a Fever Il1a , Il1b , Il1rn , Nlrp3 fibromyalgia Il1rn Fibrosis Il1b , Il1rn focal segmental glomerulosclerosis Il1b , Nlrp3 focal segmental glomerulosclerosis 1 Nlrp3 follicular lymphoma Myd88 food allergy Nlrp3 Forney Robinson Pascoe Syndrome Map3k7 frontometaphyseal dysplasia Irak1 , Map3k7 frontometaphyseal dysplasia 2 Map3k7 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 Sqstm1 frontotemporal dementia and/or amyotrophic lateral sclerosis 3 Sqstm1 gallbladder cancer Pik3ca Gallbladder Neoplasms Il1b gastric adenocarcinoma Il1b , Pik3ca gastric dilatation Il1b gastric ulcer Il1b gastroenteritis Myd88 Gastrointestinal Neoplasms Pik3ca gastrointestinal stromal tumor Aim2 , Nlrp3 genetic disease Chuk , Ikbkb , Ikbkg , Il1rn , Irak4 , Map3k7 , Myd88 , Nfkb1 , Nlrp1a , Nlrp3 , Pik3ca , Pik3r1 , Sqstm1 , Tab2 Genetic Predisposition to Disease Il1b Glandular and Epithelial Neoplasms Irak3 glaucoma Jun , Sqstm1 glioblastoma Il1b , Pik3ca glomerulonephritis Il1a , Il1b , Il1r1 , Il1rn glomerulosclerosis Il1b glucose intolerance Ikbkb , Pik3r1 , Sqstm1 glucosephosphate dehydrogenase deficiency Ikbkg glycogen storage disease II Pik3ca glycogen storage disease V Peli3 , Rela GNE myopathy Sqstm1 Goldberg-Shprintzen syndrome Prkcz gout Il1b , Il1rn graft-versus-host disease Il1a , Il1rn Gram-Negative Bacterial Infections Il1b Graves ophthalmopathy Il1a , Il1rn Graves' disease Il1b Growth Disorders Pik3ca Haemophilus Infections Irak3 hairy cell leukemia Il1rn head and neck squamous cell carcinoma Il1a , Il1rap , Pik3ca Hearing Loss Nlrp3 Heart Injuries Il1b heart valve disease Il1b , Pycard Heat Stroke Il1a , Il1b , Jun , Nfkb1 , Rela Helicobacter Infections Il1b , Mapk8 , Myd88 Hemifacial Myohyperplasia Pik3ca Hemimegalencephaly Pik3ca hemolytic-uremic syndrome Il1a , Il1b , Il1rn Hemorrhage Il1a Hemorrhagic Shock Il1a , Il1b , Rela Hepatic Insufficiency Rela hepatitis Ikbkg , Mapk8 hepatitis B Myd88 hepatitis C Il1b hepatocellular carcinoma Ikbkg , Il1b , Il1rap , Il1rn , Jun , Mapk8 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Pycard Hepatomegaly Rela hereditary breast ovarian cancer syndrome Aim2 Hereditary Neoplastic Syndromes Pik3ca , Ticam2 herpes simplex virus keratitis Il1b , Il1rn hidradenitis suppurativa Nlrp3 high grade glioma Pik3ca High Myopia Il1rap , Nfkb1 Hirschsprung's disease Ikbkb , Irak3 HIV Wasting Syndrome Il1a , Il1b Hodgkin's lymphoma Jun HTLV-1-associated myelopathy/tropical spastic paraparesis Nfkb1 Human Influenza Casp1 , Il1a , Il1b , Il1rn Huntington's disease Nfkb1 hydronephrosis Il1b Hyperalgesia Il1a , Il1b , Il1r1 , Il1rn , Mapk8 , Prkcz Hypercholesterolemia Il1b Hyperemia Il1b hyperglycemia Il1a , Il1b , Il1rn , Prkcz hyperhomocysteinemia Casp1 , Il1b , Pycard Hyperoxaluria Nfkb1 Hyperoxia Irak4 Hyperphosphatemic Familial Tumoral Calcinosis 1 Erc1 Hyperplasia Ikbkb , Pik3ca Hypertelorism Pik3ca hypertension Ikbkb , Il1b , Il1rn , Jun , Mapk8 , Myd88 , Pik3r1 , Rela , Sqstm1 hypertrophic cardiomyopathy Map3k7 , Traf6 Hypoglossal Nerve Injuries Il1r1 hypoglycemia Il1b , Pik3r1 hypohidrotic ectodermal dysplasia Traf6 hypolipoproteinemia Il1b hypomelanosis of Ito Ikbkg Hypotension Il1a , Il1b Idiopathic Generalized Epilepsy Prkcz idiopathic pulmonary fibrosis Tollip IgA glomerulonephritis Il1a , Il1b , Il1rn IgA vasculitis Il1rn immunodeficiency 14 Pik3r1 IMMUNODEFICIENCY 15 Ikbkb immunodeficiency 15A Ikbkb immunodeficiency 15B Ikbkb immunodeficiency 16 Prkcz immunodeficiency 33 Ikbkg , Irak1 immunodeficiency 36 Pik3r1 immunodeficiency 38 Prkcz immunodeficiency 39 Sigirr , Tollip Immunodeficiency 67 Irak4 Immunodeficiency 68 Myd88 immunodeficiency 90 Peli3 , Rela in situ carcinoma Casp1 Infectious Ectromelia Mapk8 Inflammation Casp1 , Chuk , Ikbkb , Il1a , Il1b , Il1rn , Myd88 , Nlrp3 inflammatory bowel disease Ikbkb , Il1rn influenza A Mapk8 inguinal hernia Irak1 Insulin Resistance Casp1 , Ikbkb , Il1b , Nlrp3 , Pik3r1 , Prkcz , Rela , Sqstm1 intellectual disability Casp1 , Peli3 , Rela , Traf6 interstitial lung disease Il1a , Il1rn interstitial lung disease 2 Il1rn , Tollip Intestinal Helminthiasis Nfkb1 Intestinal Neoplasms Mapk8 Intestinal Polyps Jun , Myd88 Intestinal Reperfusion Injury Rela , Traf6 intrinsic cardiomyopathy Traf6 invasive ductal carcinoma Prkci Invasive Pulmonary Aspergillosis Il1a , Il1b iridocyclitis Il1a irritable bowel syndrome Ikbkg Joubert syndrome 25 Prkcz Juberg-Hayward Syndrome Irak1 juvenile rheumatoid arthritis Il1a , Il1rn , Jun Kawasaki disease Il1b Kearns-Sayre syndrome Il1a , Il1b Keratitis Fugax Hereditaria Nlrp3 keratoacanthoma Pik3ca keratoconus Il1a , Il1b , Il1rn kidney disease Casp1 , Il1rn , Nlrp3 , Pycard kidney failure Il1b Kidney Reperfusion Injury Ikbkb , Il1b , Il1rn Klebsiella pneumonia Irak3 Klippel-Trenaunay syndrome Pik3ca Knee Osteoarthritis Il1a Kuhnt-Junius degeneration Mapk8 large cell carcinoma Pycard laryngeal carcinoma Traf6 laryngeal squamous cell carcinoma Rela latent autoimmune diabetes in adults Tab2 learning disability Ikbkg , Il1b , Il1rn Leber hereditary optic neuropathy Il1a , Il1b Left Ventricular Hypertrophy Prkcz , Rela Lentivirus Infections Irak1 leptospirosis Il1b Lethargy Il1b leukemia Prkcz Leukocytosis Il1b , Il1rn Lichen Sclerosus et Atrophicus Il1rn listeriosis Il1rn liver cancer Chuk , Ikbkb , Ikbkg , Pik3ca liver cirrhosis Il1b , Rela liver disease Il1r2 , Il1rap , Nfkb1 Liver Injury Myd88 Liver Neoplasms Jun Liver Reperfusion Injury Ikbkg , Il1a , Il1b , Il1rn , Map3k7 , Mapk8 , Myd88 , Rela long COVID Nlrp3 lung adenocarcinoma Il1r2 , Irak3 , Myd88 , Nlrp3 , Pik3ca , Pik3r1 lung cancer Il1r2 , Myd88 , Nfkb1 , Pik3ca lung carcinoma Pik3ca lung disease Casp1 , Il1a , Il1b Lung Neoplasms Ikbkg , Il1b , Il1r2 , Jun , Pik3ca , Pycard lung non-small cell carcinoma Il1a , Il1b , Il1rn , Myd88 , Nfkb1 , Pik3ca , Pycard , Rela , Tab2 Lung Reperfusion Injury Il1b lung small cell carcinoma Pik3ca , Pik3r1 lung squamous cell carcinoma Pik3ca lupus nephritis Il1b , Il1rn Lyme Neuroborreliosis Il1b lymphangioma Pik3ca Lymphatic Metastasis Pik3ca , Rela lymphocytic choriomeningitis Nfkb1 lymphoma Rela lymphopenia Il1b lymphoplasmacytic lymphoma Myd88 Macrocephaly Pik3ca Macrocephaly, Dysmorphic Facies, and Psychomotor Retardation Erc1 macular degeneration Sqstm1 malaria Ikbkg malignant mesothelioma Il1a , Pycard Manganese Poisoning Il1b mastoiditis Rela medulloblastoma Pik3ca megacolon Mapk8 Megalencephaly - Cutis Marmorata Telangiectatica Congenita Pik3ca , Pik3r1 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome Pik3ca Megalodactyly Pik3ca Meibomian Gland Dysfunction Il1rn melanoma Il1rn , Myd88 , Nfkb1 , Pik3ca MELAS syndrome Il1a , Il1b melioidosis Irak3 Melnick-Needles syndrome Irak1 membranoproliferative glomerulonephritis Il1b membranous glomerulonephritis Il1b Memory Disorders Il1b Mercury Poisoning, Nervous System Jun MERRF Syndrome Il1a , Il1b mesenchymal chondrosarcoma Il1a metabolic dysfunction and alcohol associated liver disease Rela metabolic dysfunction-associated steatohepatitis Il1b , Myd88 , Nfkb1 metabolic dysfunction-associated steatotic liver disease Ikbkg , Il1a , Il1b , Il1rn , Mapk8 , Nlrp3 methylmalonic acidemia and homocysteinemia cblX type Irak1 middle cerebral artery infarction Ikbkb , Il1b , Il1rn Middle East respiratory syndrome Il1a , Il1b migraine Tab2 mitochondrial myopathy Il1a , Il1b Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal Bones Map3k7 monoclonal gammopathy of uncertain significance Myd88 morbid obesity Il1rn Mouth Neoplasms Pik3ca Muckle-Wells syndrome Il1rn , Nlrp3 mucopolysaccharidosis type IIID Irak3 mucositis Il1b , Il1rn Multiple Abnormalities Chuk multiple myeloma Il1a , Il1b , Il1rn Multiple Organ Failure Il1b , Il1rn multiple sclerosis Aim2 , Casp1 , Il1b , Il1rn , Nlrp3 Multiple Self-healing Palmoplantar Carcinoma Nlrp1a multisystem inflammatory syndrome in children Irak3 muscular atrophy Chuk , Ikbkb muscular disease Il1b myelodysplastic syndrome Il1b myocardial infarction Casp1 , Il1b , Il1rn , Map3k7 , Mapk8 , Nlrp3 Myocardial Ischemia Il1a , Il1b Myocardial Reperfusion Injury Casp1 , Il1a , Il1b , Il1rn , Irak1 , Map2k6 , Mapk8 , Myd88 , Rela myocarditis Irak1 myoclonic-atonic epilepsy Irak2 myositis Il1rn Nasal Polyps Il1a , Jun Necrosis Il1b , Il1rn Nematode Infections Pik3r1 Neonatal Hyperbilirubinemia Ikbkb Neoplasm Invasiveness Il1b , Il1rn , Myd88 , Rela Neoplasm Metastasis Chuk , Nfkb1 , Pik3ca Neoplastic Cell Transformation Jun , Mapk8 , Myd88 , Nfkb1 , Rela nephrosis Il1b nephrotic syndrome Il1b , Il1rn neuroblastoma Il1b , Rela neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset Sqstm1 NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES Pik3ca Neurodevelopmental Disorders Irak2 , Pik3r1 , Prkcz , Tab3 , Ticam2 neuronal ceroid lipofuscinosis Tollip neutropenia Il1b Neutropenic Enterocolitis Il1b nicotine dependence Il1rn Nontuberculous Mycobacterium Infections Il1r1 obesity Casp1 , Ikbkb , Il1b , Il1rn , Pik3r1 , Prkci , Rela obstructive sleep apnea Il1b , Rela Ocular Onchocerciasis Il1r1 Oligoanuria Il1rn Opsismodysplasia Map3k7 Optic Nerve Injuries Jun Oral Lichen Planus Il1a oral squamous cell carcinoma Il1b , Jun , Rela organ system cancer Il1r2 ornithine carbamoyltransferase deficiency Tab3 osteoarthritis Il1a , Il1b , Pik3r1 osteopetrosis Jun osteoporosis Il1a , Il1b , Il1rn , Irak3 osteosarcoma Jun otitis media Il1a , Il1b , Rela Otitis Media with Effusion Il1b otopalatodigital syndrome type 2 Irak1 ovarian cancer Pik3ca ovarian carcinoma Map2k6 , Prkci ovarian cyst Nfkb1 Ovarian Neoplasms Pik3ca , Pik3r1 , Rela ovary epithelial cancer Tab2 Oxygen-Induced Retinopathy Il1b , Mapk8 Paget's disease of bone Sqstm1 Paget's disease of bone 2 Sqstm1 Paget's disease of bone 3 Sqstm1 Pain Casp1 , Il1rn pancreatic adenocarcinoma Mapk8 , Nfkb1 pancreatic cancer Il1a , Il1b , Rela Pancreatic Cyst Il1b pancreatic ductal adenocarcinoma Ikbkb , Mapk8 pancreatic ductal carcinoma Map3k7 , Rela Pancreatic Intraepithelial Neoplasia Ikbkb pancreatitis Ikbkb , Il1b PAPA syndrome Il1b paracoccidioidomycosis Il1b paraplegia Ikbkg , Irak1 parathyroid carcinoma Aim2 , Nlrp3 Parkinson's disease Il1b Parkinsonism Il1b , Mapk8 , Rela Penile Neoplasms Pik3ca peptic ulcer disease Il1b Perennial Allergic Rhinitis Il1a , Il1r1 perinatal necrotizing enterocolitis Ikbkg , Il1b periodontitis Il1a , Il1b , Il1rn Peripheral Nerve Injuries Il1b peripheral nervous system disease Jun periventricular nodular heterotopia Ikbkg , Irak1 Periventricular Nodular Heterotopia 4 Irak1 Peroxisome Biogenesis Disorder, Complementation Group 7 Prkcz Pick's disease Map2k6 plague Il1b pleural disease Il1rn pleural tuberculosis Il1b , Il1rn pleurisy Il1b , Il1rn Pneumococcal Meningitis Rela pneumonia Casp1 , Ikbkb , Il1a , Il1b , Il1r1 , Il1r2 , Il1rn , Myd88 Poisoning Il1a polycystic kidney disease Pik3ca polycystic ovary syndrome Tab1 polymyositis Il1a , Il1b polyneuropathy Il1b Porcine Postweaning Multisystemic Wasting Syndrome Irak3 Porcine Reproductive and Respiratory Syndrome Irak3 portal hypertension Il1b , Pik3r1 Postmenopausal Osteoporosis Il1b Postoperative Cognitive Dysfunction Il1b , Il1rn pre-eclampsia Il1rn pre-malignant neoplasm Mapk8 Presbycusis Il1r2 Presenile and Senile Dementia Il1b primary biliary cholangitis Il1b , Nfkb1 , Rela primary ciliary dyskinesia 3 Nfkb1 primary immunodeficiency disease Nfkb1 , Pik3r1 prion disease Nfkb1 Proctocolitis Il1rn progressive supranuclear palsy Map2k6 prostate adenocarcinoma Chuk , Ikbkb , Jun , Pik3ca , Rela prostate cancer Casp1 , Chuk , Ikbkb , Map3k7 , Nfkb1 , Nlrp1a , Pik3ca , Pik3r1 prostate carcinoma Jun prostate carcinoma in situ Map2k6 , Rela prostatic hypertrophy Casp1 , Rela Prostatic Neoplasms Chuk , Il1rn , Irak4 , Jun , Map2k6 , Map3k7 , Pik3ca , Pik3r1 , Prkcz , Rela prostatitis Il1rn proteinuria Il1rn Pseudomonas Aeruginosa Keratitis Il1b , Il1rn Pseudomonas Infections Il1b , Il1rn , Irak3 , Mapk8 psoriasis Ikbkb , Il1b , Irak1 psoriatic arthritis Irak1 PTEN hamartoma tumor syndrome Pik3ca Pulmonary Arterial Hypertension Map3k7 pulmonary edema Il1b , Nlrp3 pulmonary emphysema Jun pulmonary eosinophilia Il1rn , Myd88 pulmonary fibrosis Il1a , Il1b , Il1rn , Tab2 pulmonary hypertension Il1b , Il1rn , Rela pulmonary sarcoidosis Il1rn pulmonary tuberculosis Il1a , Il1b , Il1rn , Jun pulpitis Il1r1 pustular psoriasis 14 Il1rn pyelonephritis Il1rn pyoderma gangrenosum Nlrp3 Radiation Injuries Il1a Radiation Pneumonitis Il1a , Il1b rectal benign neoplasm Mapk8 , Pik3ca Recurrent Respiratory Papillomatosis Nlrp1a renal carcinoma Jun renal cell carcinoma Il1rn , Jun , Pik3ca , Pik3r1 , Rela renovascular hypertension Rela Reperfusion Injury Casp1 , Il1a , Il1b , Irak3 , Jun , Mapk8 , Myd88 , Pik3r1 , Rela respiratory allergy Il1a , Il1b , Il1rn restrictive cardiomyopathy Map2k6 Retina Reperfusion Injury Il1a , Il1b retinal vein occlusion Il1b retinitis Il1b retinopathy of prematurity Il1b Rett syndrome Irak1 rheumatoid arthritis Il1a , Il1b , Il1rn , Irak1 , Pik3r1 , Tab2 , Tab3 , Traf6 rhinitis Casp1 , Il1b , Il1rn Rhinosinusitis Il1b rosette-forming glioneuronal tumor Pik3ca Rubinstein-Taybi syndrome Tab1 sarcoma Pik3ca schizophrenia Il1b , Il1rap , Mapk8 Schnitzler syndrome Il1a , Il1rn sciatic neuropathy Il1b , Il1rn Sclerosis Il1a , Il1rn seborrheic keratosis Pik3ca Segawa Syndrome, Autosomal Recessive Tollip Sepsis Il1b , Il1rn , Irak4 , Mapk8 , Rela Septic Peritonitis Pik3r1 Serositis Il1rn severe acute respiratory syndrome Il1a , Il1b , Il1r1 , Myd88 , Nlrp3 , Rela , Ticam2 severe combined immunodeficiency Ikbkb severe congenital encephalopathy due to MECP2 mutation Ikbkg , Irak1 shigellosis Il1b SHORT syndrome Pik3r1 Shprintzen-Goldberg Craniosynostosis Prkcz silicosis Il1b , Il1rn , Jun sinusitis Il1b Sjogren's syndrome Il1rn Skin Abnormalities Chuk skin cancer Chuk skin disease Il1a , Il1b , Il1r1 , Il1rn , Peli1 skin melanoma Pik3ca Skin Neoplasms Il1a , Rela sleep disorder Il1b small cell carcinoma Pycard Small-For-Size Syndrome Il1b Smith-Kingsmore Syndrome Pik3r1 Sotos syndrome Sqstm1 Spinal Cord Injuries Casp1 , Il1b , Il1r1 , Il1rn , Jun , Rela , Sqstm1 Splenomegaly Ikbkg , Irak1 Spontaneous Abortions Il1b squamous cell carcinoma Irak1 , Nlrp3 , Pik3ca , Pycard Staphylococcal Infections Irak3 Staphylococcal Pneumonia Il1b Starvation Sqstm1 status asthmaticus Il1b status epilepticus Casp1 , Il1b , Il1rn , Jun , Rela steatotic liver disease Ikbkg , Il1b , Mapk8 , Nfkb1 , Nlrp3 , Pycard , Rela stomach cancer Il1b , Il1rn , Myd88 , Nfkb1 , Pik3ca Stomach Neoplasms Il1b , Il1rn , Jun , Mapk8 , Myd88 , Pik3ca , Pycard , Rela Streptococcus pneumonia Irak3 Stroke Il1b , Il1rn , Map3k7 , Mapk8 , Pik3ca Subarachnoid Hemorrhage Il1b , Il1rn , Map3k7 , Rela Surgical Wound Infection Irak3 syndromic X-linked intellectual disability Lubs type Ikbkg , Irak1 , Tab3 Systemic Autoinflammatory Disease, X-Linked Ikbkg Systemic Inflammatory Response Syndrome Il1b systemic lupus erythematosus Il1b , Il1rn , Irak4 , Tab2 , Tab3 systemic scleroderma Il1b , Il1r1 testicular lymphoma Myd88 thalassemia Il1b thrombocytopenia Il1b thrombocytosis Il1b Thyroid Neoplasms Il1b Tibial Fractures Casp1 tick infestation Il1a tongue squamous cell carcinoma Jun torsion dystonia 6 Ikbkb toxic encephalopathy Nlrp3 toxic shock syndrome Il1b , Il1rn transient cerebral ischemia Ikbkb , Il1b , Il1rn , Map3k7 , Nfkb1 Transplant Rejection Ikbkb , Il1b , Il1rn , Rela traumatic brain injury Il1b , Rela trigeminal neuralgia Il1b , Mapk8 tuberculosis Irak3 type 1 diabetes mellitus Il1a , Il1b , Il1r1 , Il1rn , Irak3 type 1 diabetes mellitus 5 Tab2 type 2 diabetes mellitus Ikbkb , Il1b , Il1rn , Mapk8 , Nfkb1 , Pik3r1 , Prkci , Prkcz ulcerative colitis Il1b , Il1r2 , Il1rn , Rela ureteral obstruction Il1b , Il1rn , Rela urinary bladder cancer Il1b , Il1rn , Pik3ca , Rela Urinary Calculi Il1rn urinary tract infection Il1a , Il1b urticaria Il1b , Nlrp3 Uterine Cervical Neoplasms Rela uveitis Il1a , Il1b , Rela varicocele Il1a , Il1b vascular dementia Il1b vascular disease Ikbkb , Il1rn Vascular Malformations Pik3ca , Pik3r1 Venous Thrombosis Il1a , Il1b , Il1rn Ventilator-Induced Lung Injury Il1b , Il1r1 , Il1rn Ventricular Dysfunction, Left Pik3ca verrucous keratotic hemangioma Map3k3 Viral Bronchiolitis Casp1 , Il1rn , Nfkb1 viral pneumonia Il1b , Il1rn visceral heterotaxy 4 Myd88 visceral leishmaniasis Il1b vitiligo Il1a , Nlrp1a , Pik3r1 von Hippel-Lindau disease Irak2 Vulvar Vestibulitis Il1b Weight Gain Pik3ca , Pycard Wolff-Parkinson-White syndrome Map3k7 Wounds and Injuries Il1a X-linked adrenal hypoplasia congenita Tab3 X-linked agammaglobulinemia Pik3r1 xanthomatosis Nlrp3
