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REELIN SIGNALING PATHWAY (PW:0000388)

View Ontology Report

Description

The Reelin signaling pathway controls neuronal migration and positioning in central nervous system (CNS) development, as well as synaptic plasticity and memory, operating through different receptors, probably depending on context. Defects in the Reelin gene lead to the reeler phenotype in mice, exhibiting neural positioning defects, and to lissencephaly in humans, with malformation of the cerebrum and cerebellum. Reelin signaling is also thought to be involved in Alzheimer's disease, autism and

Pathway Diagram:

Ariadne Genomics Inc. Src-related kinases --+> Grin2b Src-related kinases --+> Grin2a Src-related kinases Itga3 ---> integrin mediated signaling pathway P-tyrosine PAFAH1B3 PAFAH1B1 Dab1 ---- Vldlr Ca2+ ---> Gria1 phosphatidylinositol 3-kinase-Akt signaling pathway Grin2b ---- Vldlr Grin2a ---- Lrp8 Grin2a ---- Vldlr Grin2b ---- Lrp8 thyroid hormones Dab1 ---- Lrp8 Itgb1 ---- Reln Itga3 ---- Reln Reln ---- Vldlr Lrp8 ---- Reln Dab1 ---- PtdIns4P PAFAH1B1 ---> brain development PAFAH1B1 ---> neuronal migration Itgb1 ---> integrin mediated signaling pathway brain development Pik3r1 Ca2+ ---> learning and/or memory learning and/or memory neuronal migration PtdIns4P Reln Gria1 Grin2a Grin2b Lrp8 Vldlr Itga3 Itgb1 Pafah1b2 Grin2a --+> Ca2+ Grin2b --+> Ca2+ Itgb1 --+> Dab1 Itga3 --+> Dab1 Dab1 Dab1 --+> Src-related kinases Pik3r1 ---> phosphatidylinositol 3-kinase-Akt signaling pathway Fyn --+> Dab1 Fyn Dab1 --+> Fyn Src-related kinases --+> Dab1 integrin mediated signaling pathway Gria1 --+> synaptic transmission synaptic transmission thyroid hormones --+> Reln Pafah1b2 ---- Vldlr PAFAH1B3 ---- Vldlr Dab1 ---- PAFAH1B1 Dab1 ---- Gria1 Ca2+
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Genes in Pathway:

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Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200062 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 ISO PID PID:200062 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200062 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Cdk5 cyclin-dependent kinase 5 ISO PID PID:200062 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 ISO PID PID:200062 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein ISO PID PID:200062 NCBI chr11:87,338,606...87,356,644
Ensembl chr11:87,778,312...87,815,043
JBrowse link
G Dab1 DAB adaptor protein 1 TAS
ISO
PID PMID:12670697 PID:200062, RGD:727518 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO PID PMID:12778121 PID:200062, RGD:2324970 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 TAS RGD PMID:18237558 RGD:2325284 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A TAS
ISO
PID PMID:18237558 PID:200062, RGD:2325284 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B TAS
ISO
PID PMID:18237558 PID:200062, RGD:2325284 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO PID PID:200062 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:15583703 RGD:2325851 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itgb1 integrin subunit beta 1 ISO PID PMID:15583703 PID:200062, RGD:2325851 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Lrp8 LDL receptor related protein 8 ISO PID PMID:19846452 PID:200062, RGD:2324974 NCBI chr 5:127,404,348...127,476,636
Ensembl chr 5:127,404,450...127,476,641
JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 ISO PID PID:200062 NCBI chr14:80,911,281...80,923,290
Ensembl chr14:80,911,270...80,924,831
JBrowse link
G Map1b microtubule-associated protein 1B ISO PID PID:200062 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO PID PID:200062 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 ISO PID PID:200062 NCBI chr 1:221,043,119...221,056,420
Ensembl chr 1:221,043,119...221,056,417
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200062 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapt microtubule-associated protein tau ISO PID PID:200062 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nck2 NCK adaptor protein 2 ISO PID PID:200062 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 ISO PID PMID:17330141 PID:200062, RGD:4107040 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 8:50,256,969...50,310,043
Ensembl chr 8:50,259,248...50,277,797
JBrowse link
G Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 1:82,163,733...82,166,259
Ensembl chr 1:82,163,595...82,166,363
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200062 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PMID:17167084 PID:200062, RGD:4108507 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO PID PID:200062 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO PID PID:200062 NCBI chr 3:8,189,594...8,307,077
Ensembl chr 3:8,192,575...8,304,976
JBrowse link
G Reln reelin TAS
ISO
PID PMID:12670697 PID:200062, RGD:727518 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:18237558 RGD:2325284 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Vldlr very low density lipoprotein receptor TAS
ISO
PID PMID:12670697 PID:200062, RGD:727518 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
altered Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dab1 DAB adaptor protein 1 TAS RGD PMID:12670697 RGD:727518 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:12778121 RGD:2324970 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:15583703 RGD:2325851 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itgb1 integrin subunit beta 1 ISO RGD PMID:15583703 RGD:2325851 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Lrp8 LDL receptor related protein 8 ISO RGD PMID:19846452 RGD:2324974 NCBI chr 5:127,404,348...127,476,636
Ensembl chr 5:127,404,450...127,476,641
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 ISO RGD PMID:17330141 RGD:4107040 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 8:50,256,969...50,310,043
Ensembl chr 8:50,259,248...50,277,797
JBrowse link
G Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 1:82,163,733...82,166,259
Ensembl chr 1:82,163,595...82,166,363
JBrowse link
G Reln reelin TAS RGD PMID:12670697 RGD:727518 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:18237558 RGD:2325284 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Vldlr very low density lipoprotein receptor ISS RGD PMID:12764038 RGD:1358468 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassSrc related Kinasesv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) related kinases

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Reelin signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmMapk8
Aberrant Crypt FociGsk3b
absence epilepsyReln
acute kidney failureGsk3b
Acute Liver FailureMapk8
Acute Lung InjuryAkt1
acute myeloid leukemiaCbl
acute myocardial infarctionGsk3b
acute promyelocytic leukemiaAkt1
adenocarcinomaPik3ca
adenoid cystic carcinomaPik3ca
adrenal carcinomaPik3ca
adrenocortical carcinomaPik3ca
adult hepatocellular carcinomaAkt1 , Pik3ca
adult T-cell leukemiaFyn
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
age related macular degeneration 1Vldlr
Agenesis of Corpus CallosumPik3ca
AlbuminuriaNck2
alcohol use disorderGrin2b
Alzheimer's diseaseAkt1 , Cdk5 , Cdk5r1 , Fyn , Grin2a , Grin2b , Gsk3b , Lrp8 , Lrpap1 , Mapk8 , Mapt , Pik3r1 , Reln , Vldlr
amenorrheaVldlr
amphetamine abuseAkt1
amyotrophic lateral sclerosisAkt1 , Cdk5 , Gsk3b
Animal Disease ModelsAkt1 , Mapk8 , Mapt
Animal Mammary NeoplasmsPik3r1
anti-basement membrane glomerulonephritisMapk8 , Rapgef1
anxiety disorderMapt
Aortic Valve, Calcification ofAkt1
Arachnoid CystsCbl
Arnold-Chiari MalformationReln
arteriosclerosisVldlr
astigmatismGrin2b
astroblastomaPik3r1
astrocytomaAkt1
AtaxiaGrin2b , Mapt , Reln
atherosclerosisAkt1
atopic dermatitisMapk8
atrial fibrillationMapt
attention deficit hyperactivity disorderCdk5r1 , Grin2b
autism spectrum disorderGrin2b , Map1b , Reln
autistic disorderCrkl , Dab1 , Gria1 , Grin2a , Grin2b , Reln , Vldlr
autosomal dominant non-syndromic intellectual disability 6Grin2b
autosomal recessive polycystic kidney diseaseAkt1 , Pik3ca , Src
B-Cell Chronic Lymphocytic LeukemiaCbl
B-lymphoblastic leukemia/lymphoma with hyperdiploidyCbl
Bannayan-Riley-Ruvalcaba syndromePik3ca
basal cell carcinomaPik3ca
benign epilepsy with centrotemporal spikesGrin2a , Reln
bipolar disorderAkt1 , Grin2a , Grin2b , Gsk3b , Reln
bladder urothelial carcinomaAkt1 , Pik3ca
brain diseaseCdk5r1
Brain InjuriesAkt1 , Gsk3b , Map1b
Brain Injuries, TraumaticItgb1 , Mapt
brain ischemiaAkt1 , Cdk5 , Mapk8 , Mapt , Src
Brain NeoplasmsPik3ca , Pik3r1
breast adenocarcinomaAkt1 , Pik3ca
breast cancerAkt1 , Mapt , Pik3ca
Breast Cancer, FamilialPik3ca
breast carcinomaAkt1
Breast NeoplasmsAkt1 , Crkl , Map2k7 , Pik3ca , Pik3r1 , Src
Burkitt lymphomaPik3r1
BurnsFyn , Gsk3b
calcinosisItgb1
cannabis abuseAkt1
CarcinogenesisPafah1b1
carcinomaPik3r1
cardiac arrestAkt1
CardiomegalyAkt1 , Gsk3b , Itga3 , Mapk8 , Src , Vldlr
cardiomyopathyAkt1 , Itgb1 , Mapt
Cardiovascular AbnormalitiesCbl
Carotid Artery InjuriesCbl
CatalepsyFyn
Central Nervous System Viral DiseasesGria1 , Grin2a
cerebellar ataxiaGrin2b , Reln
cerebellar ataxia, mental retardation and dysequlibrium syndromeVldlr
Cerebellar Ataxia, Mental Retardation, and Dysequilibrium Syndrome 1Vldlr
cerebellar hypoplasiaVldlr
Charcot-Marie-Tooth disease type 2Arhgef2
chronic myeloid leukemiaAkt1 , Crkl
chronic obstructive pulmonary diseaseMapk8
CLAPO SyndromePik3ca
Classical Lissencephalies and Subcortical Band HeterotopiasPafah1b1
CLOVES syndromePik3ca
Cocaine-Related DisordersCdk5 , Gria1
cognitive disorderCdk5r1 , Grin2a , Grin2b , Gsk3b , Mapt
colitisSrc
colon adenocarcinomaPik3ca
colon cancerAkt1 , Gsk3b , Pik3ca , Src
colon carcinomaAkt1 , Crkl , Pik3ca
Colonic NeoplasmsGsk3b , Mapk8 , Pik3r1 , Src
colorectal adenocarcinomaGsk3b , Mapk8
colorectal adenomaMapk8
colorectal cancerAkt1 , Pik3ca , Pik3r1 , Src
colorectal carcinomaPik3ca
Colorectal NeoplasmsAkt1 , Grin2a , Pik3ca , Pik3r1 , Src
complex cortical dysplasia with other brain malformationsPik3ca
congenital diaphragmatic herniaCbl
congenital disorder of glycosylation IjCbl
congenital myasthenic syndrome 13Cbl
congestive heart failureCbl , Gsk3b , Itgb1 , Map2k7
Contrast-Induced NephropathyMapk8
coronary artery diseaseAkt1 , Lrp8
COVID-19Cdk5
Cowden syndromePik3ca
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromePik3ca
cribriform carcinomaPik3ca
cryptorchidismCbl , Reln
Currarino syndromePik3ca
cutaneous Paget's diseasePik3ca
degenerative disc diseaseGsk3b
dementiaLrp8 , Lrpap1 , Mapt , Vldlr
developmental coordination disorderPafah1b1
Developmental DisabilitiesCbl , Grin2a , Grin2b , Map1b , Pafah1b1 , Reln
Diabetes Mellitus, Experimental Akt1 , Grin2b , Itga3 , Itgb1 , Mapt , Pik3r1 , Vldlr
diabetic encephalopathyGsk3b
Diabetic NephropathiesGsk3b
diaphragmatic eventrationPik3ca
diffuse large B-cell lymphomaPik3ca
DiGeorge syndromeCrkl
dilated cardiomyopathyItgb1
Dilated Cardiomyopathy with Left Ventricular NoncompactionCbl
disease of cellular proliferationPik3ca , Pik3r1 , Src
Disease ProgressionPik3ca
Down syndromeReln
Drug-Induced DyskinesiaGsk3b , Mapt
ductal carcinoma in situSrc
DwarfismCbl , Pafah1b2
dystoniaGrin2b
early infantile epileptic encephalopathy 27Grin2b
egg allergyGrin2b
Ehlers-Danlos syndrome classic type 1Rapgef1
endometrial adenocarcinomaPik3r1
endometrial cancerPik3r1
endometrial carcinomaGsk3b , Pik3ca , Pik3r1
Endometrial NeoplasmsGsk3b , Pik3ca
Endometrioid CarcinomasAkt1
endometriosisItgb1
EndotoxemiaAkt1
epidermal nevusPik3ca
epilepsyAkt1 , Cbl , Gria1 , Grin2a , Grin2b , Map1b , Mapt , Reln
esophageal atresiaItgb1
esophageal carcinomaPik3ca
esophagus adenocarcinomaPik3ca
essential tremorMapt
estrogen-receptor positive breast cancerPik3ca
Experimental ArthritisAkt1 , Cbl , Gsk3b
Experimental Autoimmune EncephalomyelitisMapt
Experimental LeukemiaCbl
Experimental Liver CirrhosisFyn , Itgb1 , Reln
extrahepatic cholestasisMapk8
Facial AsymmetryPik3ca
Failure to ThriveReln
familial adenomatous polyposisAkt1
familial hemophagocytic lymphohistiocytosis 5Map2k7
familial hyperlipidemiaVldlr
familial temporal lobe epilepsy 1Grin2a , Reln
familial temporal lobe epilepsy 7Reln
fatty liver diseaseMapk8
fetal alcohol spectrum disorderGrin2b
Fetal Growth RetardationGria1 , Grin2a , Grin2b
FibrosisAkt1 , Map2k7
focal epilepsyGrin2a
Focal Epilepsy with Speech Disorder and with or without Mental RetardationGrin2a , Grin2b
focal segmental glomerulosclerosisVldlr
frontotemporal dementiaMapt
GABA aminotransferase deficiencyGrin2a
gallbladder carcinomaPik3ca
gastric adenocarcinomaAkt1 , Pik3ca
gastroesophageal reflux diseaseReln
Gastrointestinal NeoplasmsPik3ca
Generalized EpilepsyGrin2a , Grin2b
genetic diseaseCbl , Grin2a , Grin2b , Pafah1b1 , Pik3ca , Pik3r1 , Reln
glioblastomaAkt1 , Pik3ca , Pik3r1
GliosisItgb1 , Mapt
glomerulonephritisItga3 , Itgb1
Growth DisordersCbl , Pik3ca
Head and Neck NeoplasmsPik3ca
head and neck squamous cell carcinomaAkt1 , Pik3ca
Hearing Loss, Cisplatin-InducedGsk3b
Hearing Loss, Noise-InducedSrc
heart diseaseGsk3b
HeartburnReln
Hematologic NeoplasmsCbl
HemimegalencephalyPik3ca
hepatic encephalopathyGria1
hepatocellular carcinomaAkt1 , Mapt , Pafah1b1 , Pik3ca
Hereditary Neoplastic SyndromesGria1 , Pik3ca
Hirschsprung's diseaseItgb1
HIV EncephalitisCdk5
Huntington's diseaseGrin2a , Grin2b
hydrocephalusItgb1
HyperalgesiaGrin2a , Grin2b , Itga3 , Itgb1 , Mapk8
HypercholesterolemiaVldlr
hyperglycemiaCbl
hyperhomocysteinemiaGria1 , Grin2a , Grin2b
HyperkinesisGria1
HyperoxaluriaRap1a
HyperplasiaAkt1 , Pik3ca
HypertelorismGrin2a , Pik3ca
hypertensionAkt1 , Gsk3b , Mapk8 , Pik3r1 , Src
HypertriglyceridemiaVldlr
hypoglycemiaGrin2b , Pik3r1
HypotensionGria1 , Grin2b
hypothyroidismCdk5r1 , Map1b , Reln
HypoxiaGrin2b
Hypoxia-Ischemia, BrainCdk5r1 , Grin2a , Grin2b , Mapt
ichthyosisReln
immunodeficiency 36Pik3r1
impotenceAkt1
in situ carcinomaAkt1
InflammationAkt1 , Cdk5
inguinal herniaPik3r1 , Reln
Insulin ResistancePik3r1
intellectual disabilityGrin2a , Grin2b , Mapt , Pafah1b1 , Reln , Vldlr
intermediate coronary syndromeAkt1
Interstitial Lung Disease, Nephrotic Syndrome, and Epidermolysis Bullosa, CongenitalItga3
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsGsk3b , Mapk8
invasive ductal carcinomaAkt1 , Crkl
Iron OverloadMapt
Joint InstabilityCbl , Reln
juvenile myelomonocytic leukemiaCbl
kidney cancerPik3ca
Kidney NeoplasmsAkt1
Kidney Reperfusion InjurySrc
Koolen de Vries syndromeMapt
Kuhnt-Junius degenerationMapk8
Landau-Kleffner syndromeGrin2a
Language Development DisordersGrin2a , Map1b , Reln
LaryngomalaciaPafah1b1
late onset Parkinson's diseaseMapt
learning disabilityGria1 , Mapt , Pafah1b1
lissencephalyPafah1b1 , Reln
Lissencephaly 7 with Cerebellar HypoplasiaCdk5
liver cancerAkt1 , Pik3ca
liver cirrhosisReln
Liver Reperfusion InjuryGsk3b , Mapk8
long QT syndromeCdk5
long QT syndrome 10Cbl
lung adenocarcinomaAkt1 , Pik3ca , Pik3r1
lung cancerPik3ca
lung carcinomaCrkl
Lung NeoplasmsAkt1 , Map2k7 , Pik3ca
lung non-small cell carcinomaAkt1 , Cbl , Itgb1 , Pik3ca
lung small cell carcinomaAkt1 , Itgb1 , Pik3ca , Pik3r1
lung squamous cell carcinomaAkt1 , Pik3ca
Lymphatic MetastasisItgb1 , Pik3ca
lymphomaPafah1b2
lymphopeniaCbl
MacrocephalyPik3ca
Macrocephaly Mesodermal Hamartoma SpectrumAkt1
major depressive disorderReln
male infertilityCbl
malignant gliomaMap3k11 , Pik3ca
malignant ovarian germ cell neoplasmCbl
Mammary Neoplasms, ExperimentalAkt1 , Gsk3b , Map2k7 , Pik3r1
mantle cell lymphomaGsk3b
medulloblastomaPik3ca
Megalencephaly - Cutis Marmorata Telangiectatica CongenitaPik3ca
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus SyndromePik3ca
MegalodactylyPik3ca
melanomaAkt1 , Grin2a , Pik3ca , Pik3r1
membranous glomerulonephritisLrpap1
Memory DisordersMapt
Meningeal NeoplasmsAkt1
meningiomaAkt1
mental depressionCdk5 , Cdk5r1 , Gsk3b , Reln
mesangial proliferative glomerulonephritisRapgef1
Metabolic SyndromeLrpap1
microcephalyArhgef2 , Cbl , Grin2a , Vldlr
middle cerebral artery infarctionCdk5 , Gsk3b , Mapt , Reln
Miller-Dieker lissencephaly syndromePafah1b1
mitral valve prolapseCbl
Monoclonal B-Cell LymphocytosisRapgef1
morphine dependenceGria1 , Grin2a
Mouth NeoplasmsPik3ca
Multiple AbnormalitiesGsk3b
multiple myelomaCbl , Pik3ca
multiple system atrophyMapt
Muscle HypertoniaPafah1b1
Muscle HypotoniaMap1b , Reln
muscular atrophyAkt1 , Gsk3b
myelofibrosisSrc
myeloid neoplasmCbl
myocardial infarctionAkt1 , Gsk3b , Itga3 , Itgb1 , Lrp8 , Lrpap1
Myocardial Reperfusion InjuryAkt1 , Cbl , Gsk3b , Mapk8 , Rap1a
myopiaLrpap1
Myopia 23, Autosomal RecessiveLrpap1
MyotoniaPik3r1
Nasopharyngeal NeoplasmsPik3ca
Nematode InfectionsPik3r1
Neoplasm InvasivenessItgb1 , Src
Neoplasm MetastasisItgb1 , Pik3ca , Src
Neoplastic Cell TransformationGsk3b , Mapk8
nephrotic syndromeNck2 , Vldlr
Nerve DegenerationCdk5r1 , Lrp8
Nervous System MalformationsPafah1b1 , Reln
Nervous System TraumaGrin2b
neural tube defectItgb1
neuroblastomaMap2k7 , Pik3ca
neurodegenerative diseaseMapt
neurodevelopmental disorder with midbrain and hindbrain malformationsArhgef2
Neurodevelopmental DisordersCrkl , Grin2a , Grin2b , Map1b , Pik3r1
neuronal ceroid lipofuscinosis 6Gsk3b
non-alcoholic fatty liver diseaseMapk8 , Vldlr
non-Hodgkin lymphomaPik3ca
Noonan Like SyndromeCbl
Noonan syndromeCbl
Noonan syndrome 1Cbl
Noonan syndrome 8Arhgef2
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl
Norman-Roberts syndromeReln
obesityAkt1 , Mapt , Pik3r1 , Vldlr
Osteoarthritis, ExperimentalLrpap1
Osteoarthritis, HipMapt
osteogenesis imperfecta type 1Itga3
osteosarcomaAkt1
ovarian cancerAkt1 , Crkl , Pik3ca
Ovarian NeoplasmsAkt1 , Gsk3b , Map2k7 , Pik3ca , Pik3r1
ovarian serous cystadenocarcinomaPik3ca
ovary epithelial cancerPik3ca
Oxygen-Induced RetinopathyMapk8
PainAkt1
pancreatic adenocarcinomaPik3ca
pancreatic cancerAkt1
pancreatic ductal adenocarcinomaMapk8
pancreatic intraductal papillary-mucinous neoplasmAkt1
papillary renal cell carcinomaPik3ca
paraplegiaAkt1
ParaproteinemiasPik3ca
Parkinson's diseaseAkt1 , Gsk3b , Mapt
Parkinsonian DisordersMapt , Src
Penile NeoplasmsPik3ca
peripheral T-cell lymphomaFyn
peritonitisGsk3b
periventricular nodular heterotopiaMap1b
Periventricular Nodular Heterotopia 9Map1b
Peters anomalyDab1
phenylketonuriaGrin2b
Pick's diseaseMapt
placental insufficiencyGrin2a , Grin2b
plasma cell neoplasmPik3ca
plasmacytomaPik3ca
pleomorphic xanthoastrocytomaReln
Pneumonia, StaphylococcalAkt1
PoisoningGsk3b
polycystic kidney diseasePik3ca
portal hypertensionPik3r1
pre-malignant neoplasmAkt1 , Map2k7 , Mapk8
Premature AgingMapt
primary immunodeficiency diseasePik3r1
progressive supranuclear palsyMapt
Progressive Supranuclear Palsy AtypicalMapt
prostate adenocarcinomaAkt1 , Pik3ca
prostate cancerAkt1 , Lrpap1 , Mapt , Pik3ca , Pik3r1 , Src
prostate carcinomaCrkl
prostate carcinoma in situMap2k7
Prostatic NeoplasmsAkt1 , Gsk3b , Map2k7 , Pik3ca , Pik3r1
proteinuriaNck2
Proteus syndromeAkt1
Psychomotor AgitationMapt
PTEN hamartoma tumor syndromePik3ca
pulmonary fibrosisFyn
pulmonary tuberculosisAkt1
pyridoxine-dependent epilepsyGrin2a
RASopathyCbl
rectal benign neoplasmMapk8 , Pik3ca
renal carcinomaPik3ca
renal cell carcinomaAkt1 , Pik3ca , Pik3r1
Renal Cell Carcinoma 1Pik3ca
Reperfusion InjuryAkt1 , Gria1 , Grin2a , Grin2b , Mapk8 , Pik3r1 , Src
respiratory failureMapt
retinitis pigmentosaGrin2b
rhabdomyosarcomaCbl
Right Ventricular HypertrophyAkt1
Rolandic Epilepsy, Mental Retardation, and Speech Dyspraxia, Autosomal DominantGrin2a
Sacroiliac ArthritisReln
sarcomaPik3ca
schizoaffective disorderGria1
schizophreniaAkt1 , Cbl , Crkl , Fyn , Grin2a , Grin2b , Gsk3b , Lrp8 , Map2k7 , Mapk8 , Pafah1b1 , Pafah1b3 , Reln
sciatic neuropathyGrin2b , Gsk3b
seborrheic keratosisPik3ca
sensorineural hearing lossSrc
SepsisFyn , Grin2a , Gsk3b
Septic PeritonitisPik3r1
sexual disorderGria1
SHORT syndromePik3r1
skin cancerCrkl
skin diseaseFyn
skin melanomaAkt1 , Pik3ca , Pik3r1
Skin NeoplasmsAkt1
skin squamous cell carcinomaFyn
Sleep DeprivationGrin2b
speech disorderGrin2a
Spinal Cord InjuriesAkt1 , Map1b , Mapt
Spinal Cord Reperfusion InjuryCdk5 , Cdk5r1
spinocerebellar ataxia type 37Dab1
SplenomegalyMapt
Sporadic Papillary Renal Cell CarcinomaPik3ca
squamous cell carcinomaAkt1 , Itgb1 , Pik3ca
status epilepticusDab1 , Gria1 , Grin2a , Gsk3b , Reln , Src
stomach cancerPik3ca
Stomach NeoplasmsFyn , Mapk8 , Pik3ca
strabismusReln
StrokeAkt1 , Mapk8 , Pik3ca , Src
Subarachnoid HemorrhageGsk3b
subcortical band heterotopiaPafah1b1
substance-induced psychosisAkt1
substance-related disorderGsk3b
syndromic intellectual disabilityMapt
T-Cell LymphomaAkt1
TachycardiaGsk3b
tauopathyCdk5 , Gsk3b , Mapt
temporal lobe epilepsyFyn , Grin2b , Mapt , Reln
THROMBOCYTOPENIA 6Src
thrombosisLrp8
Thyroid NeoplasmsAkt1 , Pik3ca
transient cerebral ischemiaCbl , Cdk5
transitional cell carcinomaAkt1 , Pik3ca
trigeminal neuralgiaCdk5 , Cdk5r1 , Mapk8
type 1 diabetes mellitusCbl
type 2 diabetes mellitusAkt1 , Gsk3b , Map1b , Mapk8 , Pik3r1 , Src
ureteral obstructionAkt1
urinary bladder cancerAkt1 , Src
uterine cancerPik3ca , Pik3r1
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsAkt1 , Pik3ca
vascular dementiaCdk5 , Grin2a , Grin2b , Gsk3b , Mapt
Vascular MalformationsPik3ca
vasculitisCbl
velocardiofacial syndromeCrkl
Ventilator-Induced Lung InjuryAkt1
Ventricular Dysfunction, LeftPik3ca
visual epilepsyCbl , Gria1 , Grin2a , Grin2b , Map1b , Pafah1b1 , Reln , Src
vitiligoPik3r1
vulva cancerAkt1
Weight GainMapt , Pik3ca
Weight LossMapt
Williams-Beuren syndromeSrc
withdrawal disorderGria1 , Grin2a
X-linked agammaglobulinemiaPik3r1
Pathway Annotations Associated with Genes in the Reelin signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Pik3ca , Pik3r1
adenosine signaling pathwayAkt1 , Map2k7 , Mapk8 , Pik3ca , Rap1a
aldosterone signaling pathwayPik3ca , Pik3r1
alfentanil pharmacodynamics pathwayGrin2a
altered integrin mediated signaling pathwayItgb1
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Pik3ca
altered Reelin signaling pathwayDab1 , Fyn , Itga3 , Itgb1 , Lrp8 , Pafah1b1 , Pafah1b2 , Pafah1b3 , Reln , Src , Vldlr
Alzheimer's disease pathwayCdk5 , Cdk5r1 , Grin2a , Grin2b , Gsk3b , Mapt
amyotrophic lateral sclerosis pathwayGria1 , Grin2a , Grin2b
apoptotic cell death pathwayAkt1 , Pik3ca , Pik3r1
arrhythmogenic right ventricular cardiomyopathy pathwayItgb1
B cell receptor signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
basal cell carcinoma pathwayGsk3b
Bone morphogenetic proteins signaling pathwayGsk3b
bupivacaine pharmacodynamics pathwayGrin2a
buprenorphine pharmacodynamics pathwayGrin2a
c-Jun N-terminal kinases MAPK signaling pathwayMap2k7 , Map3k11 , Mapk8 , Rapgef1
calcium/calcium-mediated signaling pathwayGrin2a
calcium/calmodulin dependent kinase 2 signaling pathwayGria1 , Grin2a , Grin2b
cell cycle pathway, mitoticGsk3b
cell-extracellular matrix signaling pathwayItgb1 , Reln
ceramide signaling pathwayAkt1 , Mapk8 , Pik3ca , Pik3r1
Chagas disease pathwayAkt1 , Mapk8 , Pik3ca , Pik3r1
chemokine mediated signaling pathwayAkt1 , Crkl , Gsk3b , Pik3ca , Pik3r1 , Rap1a
chloroprocaine pharmacodynamics pathwayGrin2a
chronic myeloid leukemia pathwayAkt1 , Cbl , Crkl , Pik3ca , Pik3r1
citalopram pharmacodynamics pathwayGrin2a
cocaine pharmacodynamics pathwayGrin2a
codeine and morphine pharmacodynamics pathwayGrin2a
colorectal cancer pathwayAkt1 , Gsk3b , Mapk8 , Pik3ca , Pik3r1
desipramine pharmacodynamics pathwayGrin2a
dilated cardiomyopathy pathwayItgb1
diphenoxylate pharmacodynamics pathwayGrin2a
dopamine signaling pathwayCdk5 , Src
E-cadherin signaling pathwayAkt1 , Fyn , Pik3ca , Pik3r1 , Rap1a , Rapgef1 , Src
eicosanoid signaling pathwayAkt1 , Fyn , Src
endocytosis pathwayCbl , Src
endometrial cancer pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
Endoplasmic Reticulum-associated degradation pathwayMap2k7 , Mapk8
endothelin signaling pathwayAkt1 , Mapk8 , Src
Entamoebiasis pathwayPik3ca , Pik3r1
ephrin - ephrin receptor bidirectional signaling axisCbl , Cdk5 , Crkl , Fyn , Gria1 , Mapk8 , Nck2 , Pik3ca , Pik3r1 , Rap1a , Src
epidermal growth factor/neuregulin signaling pathwayAkt1 , Cbl , Crkl , Gsk3b , Map2k7 , Mapk8 , Nck2 , Pik3ca , Pik3r1 , Src
erythropoietin signaling pathwayCbl , Crkl , Mapk8 , Pik3r1 , Rap1a , Rapgef1
escitalopram pharmacodynamics pathwayGrin2a
estrogen signaling pathwaySrc
ether lipid metabolic pathwayPafah1b1 , Pafah1b2 , Pafah1b3
ether lipid metabolic pathwayPafah1b1 , Pafah1b2 , Pafah1b3
ethylmorphine pharmacodynamics pathwayGrin2a
excitatory synaptic transmission pathwayGrin2a , Grin2b
FasL mediated signaling pathwayAkt1 , Map2k7 , Mapk8 , Pik3ca , Pik3r1 , Src
Fc epsilon receptor mediated signaling pathwayAkt1 , Fyn , Map2k7 , Mapk8 , Pik3ca , Pik3r1
Fc gamma receptor mediated signaling pathwayAkt1 , Crkl , Pik3ca , Pik3r1
fentanyl pharmacodynamics pathwayGrin2a
fibroblast growth factor signaling pathwayAkt1 , Cbl , Pik3ca , Pik3r1 , Src
fluoxetine pharmacodynamics pathwayGrin2a
forkhead class A signaling pathwayAkt1
glioma pathwayAkt1 , Pik3ca , Pik3r1
glomerulonephritis pathwayItgb1
glutamate signaling pathwayGria1 , Grin2a , Grin2b
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayFyn , Mapk8 , Src
gonadotropin-releasing hormone signaling pathwayMap2k7 , Mapk8 , Src
granulocyte-macrophage colony-stimulating factor signaling pathwayPik3ca , Pik3r1
Hedgehog signaling pathwayAkt1 , Gsk3b , Lrpap1 , Pik3ca , Pik3r1
hepatitis C pathwayAkt1 , Gsk3b , Mapk8 , Pik3ca , Pik3r1
heroin pharmacodynamics pathwayGrin2a
Huntington's disease pathwayGrin2b
hydrocodone pharmacodynamics pathwayGrin2a
hydromorphone pharmacodynamics pathwayGrin2a
hypertrophic cardiomyopathy pathwayItgb1
hypoxia inducible factor pathwayAkt1
imipramine pharmacodynamics pathwayGrin2a
inflammatory response pathwayMapk8
influenza A pathwayAkt1 , Gsk3b , Map2k7 , Mapk8 , Pik3ca , Pik3r1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Cbl , Gsk3b , Rapgef1
insulin signaling pathwayAkt1 , Cbl , Crkl , Gsk3b , Mapk8 , Nck2 , Pik3ca , Pik3r1 , Rapgef1
insulin-like growth factor signaling pathwayAkt1 , Crkl , Nck2 , Pik3ca , Pik3r1
integrin mediated signaling pathwayItga3 , Itgb1 , Nck2
interleukin-1 signaling pathwayMapk8 , Pik3ca , Pik3r1
interleukin-2 signaling pathwayFyn , Mapk8 , Pik3ca , Pik3r1
interleukin-23 signaling pathwayItga3 , Pik3ca , Pik3r1
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Cbl , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Pik3ca , Pik3r1
Jak-Stat signaling pathwayAkt1 , Cbl , Pik3ca , Pik3r1
Leishmaniasis pathwayItgb1
levacetylmethadol pharmacodynamics pathwayGrin2a
levobupivacaine phgarmacodynamics pathwayGrin2a
levorphanol pharmacodynamics pathwayGrin2a
lidocaine pharmacodynamics pathwayGrin2a
long term depressionGria1 , Grin2a , Gsk3b
long term potentiationGria1 , Grin2a , Grin2b , Rap1a
measles pathwayAkt1 , Fyn , Gsk3b , Pik3ca , Pik3r1
melanoma pathwayAkt1 , Pik3ca , Pik3r1
mepivacaine pharmacodynamics pathwayGrin2a
methadone pharmacodynamics pathwayGrin2a
methadone pharmacokinetics pathwayGrin2a
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayAkt1 , Crkl , Map2k7 , Map3k11 , Mapk8 , Mapt , Rap1a
mTOR signaling pathwayAkt1 , Pik3ca , Pik3r1
myocarditis pathwayFyn
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1
nalbuphine pharmacodynamics pathwayGrin2a
naloxone pharmacodynamics pathwayGrin2a
naltrexone pharmacodynamics pathwayGrin2a
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayAkt1 , Crkl , Gsk3b , Map2k7 , Mapk8 , Pik3ca , Pik3r1 , Rap1a , Rapgef1
nicotine pharmacodynamics pathwayGrin2a
NOD-like receptor signaling pathwayMapk8
non-small cell lung carcinoma pathwayAkt1 , Pik3ca , Pik3r1
Notch signaling pathwayCbl
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Src
nuclear factor, erythroid 2 like 2 signaling pathwayGsk3b
oxybuprocaine pharmacodynamics pathwayGrin2a
oxycodone pharmacodynamics pathwayGrin2a
oxymorphone pharmacodynamics pathwayGrin2a
p38 MAPK signaling pathwayMap3k11
p53 signaling pathwayAkt1 , Gsk3b , Mapk8
pancreatic cancer pathwayAkt1 , Mapk8 , Pik3ca , Pik3r1
pentazocine pharmacodynamics pathwayGrin2a
phagocytosis pathwayItgb1
phosphatidylinositol 3-kinase class I signaling pathwayFyn , Pik3ca , Pik3r1 , Rap1a , Src
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1 , Src
phosphoinositide metabolic pathwayPik3ca , Pik3r1
platelet-derived growth factor signaling pathwayCbl , Crkl , Fyn , Map2k7 , Mapk8 , Nck2 , Pik3ca , Pik3r1 , Rap1a , Rapgef1 , Src
prilocaine pharmacodynamics pathwayGrin2a
prion disease pathwayFyn
procaine pharmacodynamics pathwayGrin2a
prostate cancer pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
protein kinase C (PKC) signaling pathwayFyn
Reelin signaling pathwayAkt1 , Arhgef2 , Cbl , Cdk5 , Cdk5r1 , Crkl , Dab1 , Fyn , Gria1 , Grin2a , Grin2b , Gsk3b , Itga3 , Itgb1 , Lrp8 , Lrpap1 , Map1b , Map2k7 , Map3k11 , Mapk8 , Mapt , Nck2 , Pafah1b1 , Pafah1b2 , Pafah1b3 , Pik3ca , Pik3r1 , Rap1a , Rapgef1 , Reln , Src , Vldlr
remifentanil pharmacodynamics pathwayGrin2a
renal cell carcinoma pathwayAkt1 , Crkl , Pik3ca , Pik3r1 , Rap1a , Rapgef1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMapk8
Rho/Rac/Cdc42 mediated signaling pathwayCbl , Mapk8 , Rapgef1
ropivacaine pharmacodynamics pathwayGrin2a
scatter factor/hepatocyte growth factor signaling pathwayCbl , Crkl , Pik3r1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung carcinoma pathwayAkt1 , Itgb1 , Pik3ca , Pik3r1
somatostatin signaling pathwaySrc
sphingosine 1-phosphate signaling pathwayAkt1 , Mapk8 , Src
syndecan signaling pathwayFyn , Itgb1 , Mapk8 , Src
systemic lupus erythematosus pathwayGrin2a , Grin2b
T cell receptor signaling pathwayAkt1 , Cbl , Fyn , Gsk3b , Map2k7 , Nck2 , Pik3ca , Pik3r1
Toll-like receptor signaling pathwayAkt1 , Map2k7 , Mapk8 , Pik3ca , Pik3r1
toxoplasmosis pathwayAkt1 , Itgb1 , Mapk8 , Pik3ca , Pik3r1
Trail mediated signaling pathwayMapk8 , Pik3ca , Pik3r1
tramadol pharmacodynamics pathwayGrin2a
tuberculosis pathwayAkt1 , Mapk8 , Src
tumor necrosis factor mediated signaling pathwayMap2k7
type 2 diabetes mellitus pathwayMapk8 , Pik3ca , Pik3r1
type II interferon signaling pathwayAkt1 , Cbl , Crkl , Map3k11 , Pik3ca , Pik3r1 , Rap1a , Rapgef1
ubiquitin/proteasome degradation pathwayCbl , Src
vascular endothelial growth factor signaling pathwayAkt1 , Cbl , Fyn , Nck2 , Pik3ca , Pik3r1 , Src
Wnt signaling pathwayGsk3b , Mapk8
Wnt signaling, canonical pathwayGsk3b
Wnt signaling, non-canonical pathwayMapk8
Phenotype Annotations Associated with Genes in the Reelin signaling pathway

References Associated with the Reelin signaling pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio:


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.