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Ontology Browser

protease mediated signaling pathway (PW:0002606)
Annotations: Rat: (8) Mouse: (8) Human: (8) Chinchilla: (8) Bonobo: (8) Dog: (8) Squirrel: (7) Pig: (8)
Parent Terms Term With Siblings Child Terms
signaling pathway +      
acid and base sensing signaling pathway +  
altered signaling pathway +    
calcium/calcium-mediated signaling pathway +     
cell adhesion signaling pathway +    
chemical compound signaling pathway +    
cytokine and chemokine mediated signaling pathway +    
G protein mediated signaling pathway +   
glycoconjugated protein signaling pathway +    
growth factor signaling pathway +    
hormone signaling pathway +    
kinase mediated signaling pathway +    
lipid signaling pathway +   
mechanotransduction pathway +    
mitogen activated protein kinase signaling pathway +     
nucleoside and nucleotide mediated signaling pathway +   
phosphatase mediated signaling pathway +   
photosignal transduction pathway +    
protease mediated signaling pathway +   
Proteases, the vitamin K-dependent coagulation proteases in particular, can activate a specific class of G protein-coupled receptors harboring an internally tethered ligand. The four protease-activated receptors (PARs) are involved in numerous physiologically relevant processes and can also play a role in disease-related aspects. PARs can be cleaved at different sites by different proteases to elicit distinct signaling responses, referred to as biased signaling.
signaling pathway involving second messengers +    
signaling pathway pertinent to development +    
signaling pathway pertinent to immunity +    
signaling pathway pertinent to the brain and nervous system +    
transcription factor mediated signaling pathway +    
vitamin and vitamin metabolites signaling pathway +    

Definition Sources: PMID:24860547, PMID:24990498, PMID:27068977

paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.