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Ontology Browser

thyroid hormone signaling pathway (PW:0000501)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
altered signaling pathway pertinent to the brain and nervous system +   
gasotransmitter mediated signaling pathway +  
melatonin signaling pathway 
neuron-to-neuron signaling pathways +    
neurotrophic factor signaling pathway +   
Reelin signaling pathway +    
sensory system signaling pathway +    
thyroid hormone signaling pathway 
Thyroid hormone (TH) signaling pathway plays important roles in glucose and lipid metabolism. The TH receptors are nuclear receptors that once activated act as transcription factors. Low levels of TH stimulate the release of thyrotropin-releasing hormone (TRH) from the hypothalamus, in turn stimulating the secretion of thyroid-stimulating hormone (TSH) from the pituitary whose signaling then triggers TH production. TRH, TSH and TH signaling pathways are part of the hypothalamic-pituitary-thyroid (HPT) axis for which TH itself provides a negative regulatory loop.

Exact Synonyms: TH signaling pathway
Definition Sources: PMID:20015660, PMID:20872316, PMID:22759379

paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.