abnormal Leydig cell differentiation - Ontology Browser

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abnormal Leydig cell differentiation (MP:0013602)
Annotations: Rat: (2) Mouse: (14) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)

Parent Terms

Term With Siblings

Child Terms

abnormal Leydig cell morphology + is-a

abnormal Leydig cell differentiation +

atypical formation of or inability to produce the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone; in most mammals, normal Leydig cell (LC) development comprises two sequential but overlapping cell lineages known as the fetal and adult type LC populations, which display distinct functional characteristics reflected by different morphology, hormonal regulation, and steroidogenic output

decreased Leydig cell number +

ectopic Leydig cells

increased Leydig cell number

Leydig cell atrophy

Leydig cell hypertrophy

abnormal adult Leydig cell differentiation

abnormal fetal Leydig cell differentiation

Synonyms
Exact Synonyms:	abnormal LC differentiation
Definition Sources:	http://press.endocrine.org/doi/full/10.1210/en.2012-2273, MGI:anna

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