decreased CD4-positive, alpha-beta memory T cell number +
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number +
decreased KLRG1+ CD4 alpha-beta T cell number
decreased T follicular helper cell number
reduced number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production