any structural anomaly of a CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions
abnormal CD4-positive T cell differentiation +
abnormal CD4-positive, alpha-beta intraepithelial T cell morphology
abnormal CD4-positive, alpha-beta memory T cell morphology +
abnormal CD4-positive, alpha-beta T cell number +
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology +