Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways

Ontology Browser

Term:
abnormal stratum corneum lipid matrix formation (MP:0009596)
Annotations: Rat: (0) Mouse: (8) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0) Naked Mole-rat: (0) Green Monkey: (0)
Parent Terms Term With Siblings Child Terms
abnormal corneocyte morphology +   
abnormal stratum corneum lipid matrix formation  
altered lipid composition or intercellular lipid matrix assembly in the stratum corneum, usually resulting in loss of epidermal barrier function; normally, the intercorneocyte lipid matrix consists of a complex lipid mixture of ceramides, cholesterol and long-chain saturated fatty acids that self-assembles into an ordered multilayer structure known as lipid lamellae
absent epidermis stratum corneum  
hyperkeratosis +   
impaired stratum corneum desquamation  

Synonyms
Exact Synonyms: abnormal intercorneocyte lamellar lipids ;   abnormal intercorneocyte lipid lamellae ;   abnormal stratum corneum extracellular lipid matrix ;   defective epidermal lipid matrix composition ;   epidermal lipid matrix defects
Definition Sources: MGI:anna

paths to the root