Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

general transcription initiation factor activity (GO:0140223)
Annotations: Rat: (46) Mouse: (48) Human: (58) Chinchilla: (32) Bonobo: (37) Dog: (41) Squirrel: (37) Pig: (44) Naked Mole-rat: (37) Green Monkey: (40)
Parent Terms Term With Siblings Child Terms
molecular function +     
antioxidant activity +   
ATP-dependent activity +   
binding +   
cargo receptor activity +   
catalytic activity +   
cytoskeletal motor activity +   
fusogenic activity +  
general transcription initiation factor activity +   
A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
membrane bending activity 
membrane destabilizing activity  
membrane grommet activity 
molecular adaptor activity +   
molecular carrier activity +   
molecular function regulator activity +   
molecular sequestering activity +   
molecular tag activity +   
molecular template activity +   
molecular transducer activity +   
nutrient reservoir activity  
pore-forming activity  
protein folding chaperone +   
protein-containing complex destabilizing activity +   
protein-containing complex stabilizing activity +   
RNA folding chaperone  
small molecule sensor activity +   
structural molecule activity +   
toxin activity 
transcription regulator activity +   
translation regulator activity +   
transporter activity +   

Exact Synonyms: GTF activity ;   basal transcription factor activity ;   general transcription factor activity
Never In Taxon: NCBITaxon:2 ! Bacteria
Definition Sources: GOC:txnOH-2018

paths to the root