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Ontology Browser

Term:
Notch receptor processing, ligand-independent (GO:0035334)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0) Naked Mole-rat: (0) Green Monkey: (0)
Parent Terms Term With Siblings Child Terms
activation of plasma proteins involved in acute inflammatory response +   
CAAX-box protein processing  
dibasic protein processing +   
mitochondrial protein processing +   
negative regulation of protein processing +   
Notch receptor processing, ligand-dependent 
Notch receptor processing, ligand-independent 
The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface.
positive regulation of protein processing +   
protein autoprocessing  
protein processing in phagocytic vesicle +   
protein splicing +   
regulation of protein processing +   
signal peptide processing +   
signaling receptor ligand precursor processing +   
vacuolar protein processing  
zymogen activation +   

Synonyms
Narrow Synonyms: Notch S1 cleavage
Definition Sources: GOC:bf, PMID:12651094

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