activation of plasma proteins involved in acute inflammatory response +
CAAX-box protein processing
dibasic protein processing +
mitochondrial protein processing +
negative regulation of protein processing +
Notch receptor processing, ligand-dependent
Notch receptor processing, ligand-independent
The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface.