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Term:
negative regulation of signal transduction
(GO:0009968)
Annotations:
Rat: (1501)
Mouse: (1578)
Human: (1624)
Chinchilla: (1261)
Bonobo: (1379)
Dog: (1494)
Squirrel: (1341)
Pig: (1456)
Naked Mole-rat: (1321)
Green Monkey: (1468)
Parent Terms
Term With Siblings
Child Terms
negative regulation of cell communication
+
negative regulation of response to stimulus
+
negative regulation of signaling
+
regulation of signal transduction
+
signal transduction
+
adaptation of signaling pathway
+
apoptotic signaling pathway
+
bile acid signaling pathway
+
carbohydrate mediated signaling
+
cell surface receptor signaling pathway
+
extracellular ATP signaling
extracellular regulation of signal transduction
+
G protein-coupled receptor signaling pathway
+
granzyme-mediated programmed cell death signaling pathway
+
hormone-mediated signaling pathway
+
hydrogen peroxide mediated signaling pathway
immune response-regulating signaling pathway
+
intracellular signal transduction
+
ligand-gated ion channel signaling pathway
+
lipoprotein particle mediated signaling
+
modulation of excitatory postsynaptic potential
+
modulation of inhibitory postsynaptic potential
+
necroptotic signaling pathway
negative regulation of BMP secretion
negative regulation of c-di-GMP signaling
negative regulation of cell communication by chemical coupling
negative regulation of cell communication by electrical coupling
+
negative regulation of cellular response to alkaline pH
negative regulation of cellular response to caffeine
negative regulation of cellular response to growth factor stimulus
+
negative regulation of cellular response to heat
negative regulation of cellular response to hypoxia
+
negative regulation of cellular response to insulin stimulus
+
negative regulation of cellular response to manganese ion
negative regulation of cellular response to oxidopamine
negative regulation of cellular response to testosterone stimulus
negative regulation of cellular response to very-low-density lipoprotein particle stimulus
negative regulation of cellular response to X-ray
negative regulation of defense response
+
negative regulation of detection of glucose
negative regulation of DNA repair
+
negative regulation of establishment of competence for transformation
negative regulation of fear response
+
negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
negative regulation of filamentous growth of a population of unicellular organisms in response to heat
negative regulation of filamentous growth of a population of unicellular organisms in response to pH
+
negative regulation of hormone secretion
+
negative regulation of immune response
+
negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of long-day photoperiodism, flowering
negative regulation of muscle adaptation
+
negative regulation of neuron projection regeneration
+
negative regulation of photomorphogenesis
negative regulation of receptor recycling
negative regulation of response to acetate
+
negative regulation of response to alcohol
+
negative regulation of response to amylopectin
negative regulation of response to benzene
negative regulation of response to biotic stimulus
+
negative regulation of response to calcium ion
negative regulation of response to cycloalkane
negative regulation of response to cytokine stimulus
+
negative regulation of response to drug
+
negative regulation of response to endoplasmic reticulum stress
+
negative regulation of response to external stimulus
+
negative regulation of response to formic acid
negative regulation of response to furfural
negative regulation of response to gamma radiation
+
negative regulation of response to nutrient levels
+
negative regulation of response to oxidative stress
+
negative regulation of response to pullulan
negative regulation of response to salt stress
+
negative regulation of response to toluene
negative regulation of response to water deprivation
negative regulation of response to wounding
+
negative regulation of retrograde trans-synaptic signaling by neuropeptide
negative regulation of shade avoidance
negative regulation of short-day photoperiodism, flowering
negative regulation of signal transduction
+
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
negative regulation of stress response to copper ion
negative regulation of synaptic transmission
+
negative regulation of telomere maintenance in response to DNA damage
+
negative regulation of thermomorphogenesis
negative regulation of transmission of nerve impulse
+
negative regulation of trichome patterning
negative regulation of vernalization response
negative regulation of Wnt protein secretion
neuronal signal transduction
+
opioid growth factor receptor signaling pathway
phototransduction
+
positive regulation of signal transduction
+
postsynaptic signal transduction
+
presynaptic signal transduction
+
red or far-red light signaling pathway
+
regulation of abscisic acid-activated signaling pathway
+
regulation of antigen receptor-mediated signaling pathway
+
regulation of apolipoprotein A-I-mediated signaling pathway
+
regulation of apoptotic signaling pathway
+
regulation of auxin mediated signaling pathway
+
regulation of blood pressure by chemoreceptor signaling pathway
regulation of brain-derived neurotrophic factor receptor signaling pathway
+
regulation of brassinosteroid mediated signaling pathway
+
regulation of CD40 signaling pathway
+
regulation of cytokine-mediated signaling pathway
+
regulation of cytokinin-activated signaling pathway
+
regulation of ephrin receptor signaling pathway
+
regulation of ERBB signaling pathway
+
regulation of Fas signaling pathway
+
regulation of Fc receptor mediated stimulatory signaling pathway
+
regulation of fibroblast growth factor receptor signaling pathway
+
regulation of floral organ abscission by signal transduction
regulation of G protein-coupled receptor signaling pathway
+
regulation of gibberellic acid mediated signaling pathway
+
regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
+
regulation of glucose mediated signaling pathway
+
regulation of glutamate receptor signaling pathway
+
regulation of growth hormone receptor signaling pathway
+
regulation of hepatocyte growth factor receptor signaling pathway
+
regulation of insulin receptor signaling pathway
+
regulation of insulin-like growth factor receptor signaling pathway
+
regulation of integrin-mediated signaling pathway
+
regulation of intracellular signal transduction
+
regulation of jasmonic acid mediated signaling pathway
regulation of lipopolysaccharide-mediated signaling pathway
+
regulation of netrin-activated signaling pathway
+
regulation of neuronal signal transduction
+
regulation of neurotrophin TRK receptor signaling pathway
+
regulation of Notch signaling pathway
+
regulation of pattern recognition receptor signaling pathway
+
regulation of platelet-derived growth factor receptor signaling pathway
+
regulation of postsynapse to nucleus signaling pathway
regulation of receptor signaling pathway via STAT
+
regulation of red or far-red light signaling pathway
+
regulation of Roundabout signaling pathway
+
regulation of salicylic acid mediated signaling pathway
+
regulation of semaphorin-plexin signaling pathway
+
regulation of sevenless signaling pathway
+
regulation of signal transduction
+
regulation of signal transduction by receptor internalization
+
regulation of signal transduction involved in conjugation with cellular fusion
+
regulation of signaling receptor activity
+
regulation of smoothened signaling pathway
+
regulation of sphingolipid mediated signaling pathway
+
regulation of Toll signaling pathway
+
regulation of torso signaling pathway
+
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
+
regulation of vascular endothelial growth factor receptor signaling pathway
+
regulation of vascular endothelial growth factor signaling pathway
+
regulation of Wnt signaling pathway
+
salicylic acid mediated signaling pathway
+
serotonin receptor signaling pathway
+
signal clustering
signal complex assembly
signal transduction in absence of ligand
+
signal transduction involved in cellular response to ammonium ion
signal transduction involved in filamentous growth
signal transduction involved in positive regulation of conjugation with cellular fusion
+
signal transduction involved in regulation of gene expression
sphingolipid mediated signaling pathway
+
extracellular negative regulation of signal transduction
+
negative adaptation of signaling pathway
+
negative regulation of abscisic acid-activated signaling pathway
negative regulation of antigen receptor-mediated signaling pathway
+
negative regulation of apolipoprotein A-I-mediated signaling pathway
negative regulation of apoptotic signaling pathway
+
negative regulation of auxin mediated signaling pathway
negative regulation of brain-derived neurotrophic factor receptor signaling pathway
negative regulation of brassinosteroid mediated signaling pathway
negative regulation of CD40 signaling pathway
negative regulation of corticotropin-releasing hormone receptor activity
negative regulation of cytokine activity
+
negative regulation of cytokine-mediated signaling pathway
+
negative regulation of cytokinin-activated signaling pathway
negative regulation of ephrin receptor signaling pathway
negative regulation of ERBB signaling pathway
+
negative regulation of Fas signaling pathway
negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
negative regulation of fibroblast growth factor receptor signaling pathway
+
negative regulation of G protein-coupled receptor signaling pathway
+
negative regulation of GDF15-GFRAL signaling pathway
negative regulation of gibberellic acid mediated signaling pathway
negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
negative regulation of glucose mediated signaling pathway
+
negative regulation of glutamate receptor signaling pathway
+
negative regulation of growth hormone receptor signaling pathway
negative regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of insulin receptor signaling pathway
+
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of integrin-mediated signaling pathway
negative regulation of intracellular signal transduction
+
negative regulation of lipopolysaccharide-mediated signaling pathway
+
negative regulation of netrin-activated signaling pathway
negative regulation of neuronal signal transduction
negative regulation of neurotrophin TRK receptor signaling pathway
negative regulation of Notch signaling pathway
+
negative regulation of peptidoglycan recognition protein signaling pathway
negative regulation of platelet-derived growth factor receptor signaling pathway
+
negative regulation of receptor signaling pathway via STAT
+
negative regulation of red or far-red light signaling pathway
negative regulation of Roundabout signaling pathway
+
negative regulation of semaphorin-plexin signaling pathway
negative regulation of sevenless signaling pathway
negative regulation of signal transduction by receptor internalization
+
negative regulation of signal transduction in absence of ligand
+
negative regulation of signal transduction involved in conjugation with cellular fusion
+
negative regulation of smoothened signaling pathway
+
negative regulation of sphingolipid mediated signaling pathway
negative regulation of Toll signaling pathway
negative regulation of toll-like receptor 1 signaling pathway
negative regulation of toll-like receptor 10 signaling pathway
negative regulation of toll-like receptor 15 signaling pathway
negative regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
negative regulation of toll-like receptor 5 signaling pathway
negative regulation of toll-like receptor 6 signaling pathway
negative regulation of toll-like receptor signaling pathway
+
negative regulation of torso signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
+
negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of Wnt signaling pathway
+
termination of signal transduction
+
Synonyms
Exact Synonyms:
down regulation of signal transduction ; downregulation of signal transduction
Narrow Synonyms:
inhibition of signal transduction
Related Synonyms:
negative regulation of signaling pathway ; negative regulation of signalling pathway
Alternate IDs:
GO:0035467
Xrefs:
Reactome:R-HSA-8849472 "PTK6 Down-Regulation"
Definition Sources:
GOC:sm