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Term:
phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200)
Annotations: Rat: (137) Mouse: (142) Human: (153) Chinchilla: (100) Bonobo: (144) Dog: (121) Squirrel: (141) Pig: (125) Naked Mole-rat: (133) Green Monkey: (148)
Parent Terms Term With Siblings Child Terms
adenylate cyclase-modulating G protein-coupled receptor signaling pathway +   
adrenergic receptor signaling pathway +   
angiotensin-activated signaling pathway +   
apelin receptor signaling pathway  
bombesin receptor signaling pathway  
calcitonin family receptor signaling pathway +   
cannabinoid signaling pathway +   
chemokine-mediated signaling pathway +   
cholecystokinin signaling pathway +   
complement component C5a signaling pathway  
endothelin receptor signaling pathway +   
follicle-stimulating hormone signaling pathway  
G protein-coupled acetylcholine receptor signaling pathway +   
G protein-coupled chemorepellent receptor signaling pathway 
G protein-coupled dopamine receptor signaling pathway +   
G protein-coupled glutamate receptor signaling pathway +   
G protein-coupled opioid receptor signaling pathway +   
G protein-coupled opsin signaling pathway +   
G protein-coupled purinergic receptor signaling pathway +   
G protein-coupled receptor signaling pathway involved in dauer larval development 
G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium 
G protein-coupled receptor signaling pathway involved in heart process +   
G protein-coupled receptor signaling pathway involved in social behavior 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +   
G protein-coupled serotonin receptor signaling pathway +   
gastric inhibitory peptide signaling pathway  
ion channel modulating, G protein-coupled receptor signaling pathway +   
leukotriene signaling pathway  
luteinizing hormone signaling pathway +   
negative regulation of G protein-coupled receptor signaling pathway +   
neuropeptide signaling pathway +   
octopamine or tyramine signaling pathway +  
phospholipase C-activating G protein-coupled receptor signaling pathway +   
A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors.
phospholipase C-inhibiting G protein-coupled receptor signaling pathway  
phospholipase D-activating G protein-coupled receptor signaling pathway  
positive regulation of G protein-coupled receptor signaling pathway +   
regulation of G protein-coupled receptor signaling pathway +   
Rho-activating G protein-coupled receptor signaling pathway 
somatostatin receptor signaling pathway +   
sphingosine-1-phosphate receptor signaling pathway  
tachykinin receptor signaling pathway +   
thrombin-activated receptor signaling pathway +   
thromboxane A2 signaling pathway  
thyroid-stimulating hormone signaling pathway  

Synonyms
Exact Synonyms: G protein signaling, coupled to IP3 second messenger (phospholipase C activating) ;   G protein signalling, coupled to IP3 second messenger (phospholipase C activating) ;   G-protein coupled receptor signaling pathway coupled to IP3 second messenger ;   PLC-activating GPCR signaling pathway ;   protein kinase C-activating G protein-coupled receptor signaling pathway
Related Synonyms: activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
Definition Sources: GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194

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