high molecular weight B cell growth factor receptor activity
immune receptor activity +
leucokinin receptor activity
ligand-modulated transcription activator activity
ligand-modulated transcription repressor activity
neurotransmitter receptor activity +
neurotrophin receptor activity +
nuclear receptor activity +
A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.