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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
aspartic-type endopeptidase activity +   
cysteine-type endopeptidase activity +   
glutamic-type endopeptidase activity 
metal-dependent deNEDDylase activity 
metal-dependent deubiquitinase activity  
metalloendopeptidase activity +   
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
metalloexopeptidase activity +   
oligopeptidase activity  
peptidoglycan endopeptidase activity +  
serine-type endopeptidase activity  
threonine-type endopeptidase activity  

Synonyms
Narrow Synonyms: metalloendoprotease activity ;   metalloendoproteinase activity
Xrefs: EC:3.4.24 ;   Reactome:R-HSA-181567 "botC LC cleaves target cell STX1" ;   Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25" ;   Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2" ;   Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25" ;   Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1" ;   Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1" ;   Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25" ;   Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14" ;   Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)"
Definition Sources: GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE

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