Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
kidney disease +     
scleroderma +     
skin disease +     
16q24.1 microdeletion syndrome 
Achenbach syndrome 
adenovirus renal infection 
Adult familial nephronophthisis - spastic quadriparesia 
allergic respiratory disease +   
Alopecia - epilepsy - pyorrhea - intellectual disability 
Alopecia - intellectual disability - hypergonadotropic hypogonadism 
alopecia areata  
Alopecia universalis 
Alopecia-intellectual disability syndrome 
alpha 1-antitrypsin deficiency 
Alternariosis 
altitude sickness +   
androgenetic alopecia +   
Anhidrotic ectodermal dysplasia - immunodeficiency - osteopetrosis - lymphedema 
anuria 
asphyxia neonatorum  
atheroembolism of kidney 
autoimmune interstitial lung disease-arthritis syndrome 
Autosomal dominant medullary cystic kidney disease with hyperuricemia 
autosomal dominant progressive nephropathy with hypertension 
Bazex-Dupre-Christol syndrome +  
Behcet's syndrome  
bronchogenic cyst 
bronchopulmonary dysplasia  
Cerebro-reno-digital syndrome 
chemotherapy-induced alopecia  
chloracne 
Cholestasis-lymphedema syndrome 
chronic kidney disease +   
cicatricial alopecia 
congenital lethal erythroderma 
congenital primary megaureter +  
congenital pulmonary lymphangiectasia 
cutaneous mucinosis +  
cystic fibrosis  
cystic kidney disease +   
Deafness - lymphedema - leukemia 
dermatitis +   
dermatological toxicity  
dermis disorder +   
diabetes insipidus +  
diabetic foot  
diaphragm disease +   
disorder of pharynx +   
duplication of urethra 
edema  
epidermal disease +   
erythema multiforme 
erythema palmare hereditarium 
erythematosquamous dermatosis  
exanthem +   
exstrophy-epispadias complex +   
facial dermatosis +  
familial primary pulmonary hypoplasia 
fetal lower urinary tract obstruction +   
Genetic respiratory or mediastinal malformation +  
glomerular disease +   
growth delay-hydrocephaly-lung hypoplasia syndrome 
hand dermatosis 
Hand-foot syndrome  
hantavirus hemorrhagic fever with renal syndrome +  
hemoglobinuria +  
hemorrhagic fever with renal syndrome  
Hepatic fibrosis - renal cysts - intellectual disability 
hereditary epidermal appendage anomaly +   
hereditary sclerosing poikiloderma with tendon and pulmonary involvement 
hereditary skin disorder +   
hydronephrosis +   
hyperglobulinemic purpura 
hypertensive nephropathy +   
Hypotrichosis - lymphedema - telangiectasia 
Ichthyosis-hypotrichosis syndrome 
impaired renal function disease +   
Infantile nephronophthisis 
inflammatory skin disease +   
inherited kidney disorder +   
Juvenile nephronophthisis 
keratosis +   
keratosis pilaris +  
kidney cortex necrosis 
kidney failure +   
kidney neoplasm +   
kidney papillary necrosis +  
Kimura disease 
laryngo-onycho-cutaneous syndrome 
Late-onset primary lymphedema +  
leg dermatosis 
lichen disease +   
lipodystrophy +  
Lissencephaly syndrome, Norman-Roberts type 
Livedo reticularis 
localised scleroderma 
lower respiratory tract disease +   
lung agenesis-heart defect-thumb anomalies syndrome 
Lymphedema - atrial septal defects - facial changes 
Lymphedema - cerebral arteriovenous anomaly 
Lymphedema - cleft palate 
Lymphedema - distichiasis 
lymphedema, hereditary, iii 
maculopapular eruption  
Middle East respiratory syndrome 
Milroy disease 
mongolian spot 
mucopolysaccharidosis-plus syndrome 
multiple benign circumferential skin creases on limbs +  
Müllerian derivatives - lymphangiectasia - polydactyly 
Nasal Septal Perforation 
Necrobiotic Xanthogranuloma 
neonatal erythema toxicum 
nephritis +   
nephrocalcinosis +  
nephrogenic fibrosing dermopathy 
nephrolithiasis +   
nephrosis +   
nevus +   
non-neoplastic nevus  
Obesity Hypoventilation Syndrome 
panniculitis +  
Parana hard-skin syndrome 
paranasal sinus disease +   
paronychia +  
PEHO-like syndrome 
perinephritis 
pigmentation disease +   
polymyositis +   
post-operative acute kidney injury  
primary ciliary dyskinesia +  
prurigo nodularis  
pulmonary arterial hypertension +   
pulmonary tuberculosis +   
Pulmonary veno-occlusive disease and/or pulmonary capillary haemangiomatosis +  
Pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 
Rare genetic respiratory disease +  
reactive cutaneous fibrous lesion +   
renal aminoaciduria 
renal artery disease +  
renal dysplasia +  
renal glycosuria 
renal hypertension +  
renal hypoplasia +  
renal nutcracker syndrome 
renal tuberculosis +  
renal tubular dysgenesis +  
renal tubular transport disease +  
renal tubule disease +  
respiratory aspiration 
respiratory or thoracic malformation +  
respiratory paralysis 
respiratory system benign neoplasm +  
respiratory system cancer +   
respiratory system neoplasm +   
respiratory toxicity 
respiratory tract infectious disorder +   
rhinoscleroma 
rosacea  
scalp dermatosis 
scarlet fever 
Scarring alopecia of scalp 
Scleroderma Polymyositis Overlap Syndrome 
Sclerodermatomyositis 
sebaceous gland disease +   
severe acute respiratory syndrome  
severe cutaneous adverse reaction +   
Siegler-Brewer-Carey syndrome 
skin atrophy 
skin disorder caused by infection +   
skin neoplasm +   
skin pigmentation disorder +  
skin reaction 
skin sarcoidosis 
skin vascular disease +   
sleep apnea +   
stricture or kinking of ureter  
sudden infant death-dysgenesis of the testes syndrome 
sunburn  
sweat gland disease +   
systemic lupus erythematosus +   
systemic scleroderma +   
A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension. A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA. A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.
Takayasu arteritis  
temporal arteritis  
toxic dermatosis +   
upper respiratory tract disorder +   
ureteral disorder +   
vesiculobullous skin disease +   
whooping cough 
X-linked diffuse leiomyomatosis-Alport syndrome 
Yellow Nail Syndrome 
Young syndrome 

Synonyms
Exact Synonyms: DOID:418 ;   NCIT:C72070 ;   Orphanet:90291 ;   PSS (progressive systemic sclerosis) ;   Progressive systemic sclerosis ;   SS - Systemic sclerosis ;   SSc ;   SSc, diffuse sclerosis ;   Scleroderma ;   Scleroderma (& [systemic sclerosis])
Synonyms: http://identifiers.org/meddra/10042953
Xrefs: DOID:418 ;   GARD:9748 ;   HP:0100324 ;   ICD10:M34 ;   ICD9:710.1 ;   MEDGEN:19897 ;   MESH:D012595 ;   MONDO:0005100 ;   MedDRA:10036814 ;   MedDRA:10042953
External Ontologys: has_disease_location EFO:UBERON:0000014
Definition Sources: NCIT:C72070

paths to the root