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Ontology Browser

Term:
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) (CMO:0000721)
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Parent Terms Term With Siblings Child Terms
concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (EC50) 
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) +  
A calculated value for the concentration of phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of PE is halfway between the baseline value and the highest achievable value of such PE-induced contractile energy.
concentration of potassium chloride at which the force of blood vessel contraction is half the maximum value (EC50) 
phenylephrine-induced blood vessel contractile force expressed as percent of contractile force generated by potassium chloride 
phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline 

Synonyms
Exact Synonyms: phenylephrine half maximal effective concentration (EC50)
Xrefs: CHEBI:8093
Definition Sources: Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/EC50 "Wikipedia" "Wikipedia", ISBN:978-1416049982

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