dose of methacholine at which pulmonary conductance is half its pretreatment value - Ontology Browser

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dose of methacholine at which pulmonary conductance is half its pretreatment value (CMO:0000713)
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Parent Terms

Term With Siblings

Child Terms

airway reactivity measurement + is-a

methacholine response/sensitivity measurement + is-a

dose of methacholine at which pulmonary conductance is half its pretreatment value

The administered quantity of methacholine, a quaternary ammonium ion in which the nitrogen is substituted with three methyl groups and a 2-acetoxypropyl group and which acts as a parasympathomimetic bronchoconstrictor, at which the ability of the repiratory tract to allow airflow during breathing (inspration and expiration) is half its value in an untreated subject, or at which the resistance of the respiratory tract to airflow is doubled.

Synonyms
Broad Synonyms:	methacholine median effective dose (ED50)
Xrefs:	CHEBI:50142 ; CHEBI:6804
Definition Sources:	Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Airway_resistance "Wikipedia" "Wikipedia", ISBN:978-1416049982

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