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Term:
Parent Terms Term With Siblings Child Terms
2,2,3,3-tetrahydroxy-2,3-dihydronaphthalene-1,4-dione 
actinodaphnine 
CP-115953 
EC 5.99.1.2 (DNA topoisomerase) inhibitor +   
A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor +   
topoisomerase II inhibitor +   
topoisomerase IV inhibitor +   

Synonyms
Related Synonyms: DNA topoisomerase inhibitor ;   DNA topoisomerase inhibitors ;   EC 5.99.1.2 (DNA topoisomerase) inhibitors ;   EC 5.99.1.2 (topoisomerase I) inhibitor ;   EC 5.99.1.2 inhibitor ;   EC 5.99.1.2 inhibitors ;   topoisomerase I (EC 5.99.1.2) inhibitors ;   topoisomerase I inhibitor ;   topoisomerase I inhibitors ;   type I DNA topoisomerase inhibitor

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