Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
(+)-catechin monohydrate 
(-)-epigallocatechin 3-gallate +   
(-)-selegiline  
(E)-10-hydroxydec-2-enoic acid +   
(R)-pantothenic acid +   
(R)-rosmarinic acid 
(R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol 
(S)-malic acid +  
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose 
1,4-butanediammonium +  
1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine hydrochloride 
17alpha-estradiol +   
17beta-estradiol +   
1D-chiro-inositol +  
2'-deoxyadenosine 5'-monophosphate +  
2'-deoxyadenosine 5'-monophosphate(2-) +  
2,4-dinitrophenol +   
2,5-dihydroxycinnamic acid methyl ester  
2,5-dimethylcelecoxib  
2,6-di-tert-butyl-4-methylphenol  
2-(1,3-benzothiazol-2-yl)phenol 
2-(1,3-benzoxazol-2-yl)phenol 
2-(1H-benzimidazol-2-yl)aniline 
2-(2-amino-3-methoxyphenyl)chromen-4-one 
2-(4-hydroxyphenyl)ethanol +   
2-amino-2-deoxy-D-glucopyranose +   
2-amino-3-(3-oxoprop-1-enyl)but-2-enedioic acid +  
2-deoxy-D-glucose +   
2-deoxy-D-ribofuranose 1-phosphate +   
2-oxoglutarate(1-) 
2-oxoglutarate(2-) 
2-oxoglutaric acid +  
3,3-diethyl-2-pyrrolidinone 
3,4-dichloroisocoumarin 
3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol 
3-carboxyprop-2-enoyl group +  
3-phosphoglyceric acid +   
3-phosphonato-D-glycerate(3-) 
4'-O-methyl-(-)-epicatechin 
4,5-dianilinophthalimide  
4-phenyl-3-furoxancarbonitrile  
6,7-dimethyl-2-phenylquinoxaline 
6-phospho-D-gluconic acid +  
6-phosphonatooxy-D-gluconate 
7-amino-2-(ethylsulfanyl)-5-oxo-1-phenyl-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitrile 
acarbose +   
acetic acid +   
acetyl-CoA +   
acetylsalicylic acid +   
adenosine +   
adenosine 5'-monophosphate +   
adenosine 5'-monophosphate(1+) 
adenosine 5'-monophosphate(2-) +  
adipic acid +   
ADP +   
ADP(3-) +  
alanine +   
aldehydo-D-ribose 5-phosphate(2-) 
alpha,alpha-trehalose +   
alpha-D-glucose 1-phosphate(2-) 
alpha-D-glucose 6-phosphate(2-) 
alpha-D-mannose 6-phosphate(2-) 
alpha-L-galactose 1-phosphate(2-) 
ammonium acetate  
ammonium carbonate 
ammonium hydroxide  
AMN082 dihydrochloride 
amoxapine  
amperozide  
amperozide hydrochloride 
anthra[1,9-cd]pyrazol-6(2H)-one  
arabinose +  
arginine +   
aspartate(1-) +  
aspartate(2-) +  
aspartic acid +   
ATP +   
ATP(3-) 
ATP(4-) +  
AUTEN-67 
AUTEN-99 hydrobromide 
bacitracin  
baicalein +   
BAM15 
beauveriolide I 
berberine  
beta-alaninate 
beta-alanine +   
beta-D-fructofuranose 6-phosphate(2-) 
beta-D-glucose 1-phosphate(2-) 
beta-D-glucose 6-phosphate(2-) +  
beta-L-galactose 1-phosphate(2-) 
beta-maltose +   
bezafibrate  
biotin +   
BRL-50481 
buformin 
butein  
butenedioyl group +  
C60 fullerene  
caffeine +   
calciol +   
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  
carnosine +   
CCCP  
celecoxib  
chicoric acid  
chloramphenicol +   
chlorprothixene hydrochloride 
ciclopirox olamine 
cinnarizine  
cis-aconitic acid 
cis-flupenthixol dihydrochloride 
citrate(1-) +  
citrate(2-) +  
citrate(3-) +   
citric acid +   
clofibrate  
creatine +   
curcumin +   
cyclosporin A +   
cyproterone acetate  
cysteamine +   
cysteine +   
D-aspartate(1-) +  
D-cysteinate(1-) 
D-cysteinate(2-) 
D-cysteinium 
D-cysteinyl radical +  
D-erythro-isocitrate(3-) 
D-fructofuranose 1,6-bisphosphate(4-) +  
D-fructofuranose 1-phosphate(2-) +  
D-fructofuranose 6-phosphate(2-) 
D-fructose 1,6-bisphosphate +   
D-fructose 6-phosphate +  
D-galactopyranose 1-phosphate +   
D-glucopyranose 1-phosphate +   
D-glucopyranose 1-phosphate(2-) 
D-glucose 6-phosphate +   
D-mannopyranose 6-phosphate(2-) 
D-mannose 1-phosphate +  
D-mannose 6-phosphate +   
D-pinitol 
D-ribose +   
D-ribose 5-phosphate +   
D-ribulose 5-phosphate(2-) 
D-threo-isocitrate(3-) 
DADLE  
dafadine A 
danazol  
demeclocycline +   
dGDP 
diazaborine +  
dibromoacetic acid  
dichloroacetate 
didanosine  
dihydroergocristine mesylate +  
dimethyl sulfoxide +   
disodium fumarate 
disodium malate 
doxazosin mesylate 
doxycycline +   
doxycycline HCl +  
dTMP +   
EDTA monocalcium diisodium salt 
eliprodil  
ellagic acid +   
enalapril +   
enol-oxaloacetic acid 
ethidium bromide 
ethosuximide +   
ethoxyquin  
ethylenediaminetetraacetic acid  
EUK-134  
EUK-8  
everolimus  
fasudil  
fenofibrate  
ferric ammonium citrate  
ferulsinaic acid 
fisetin +   
fructose +   
fructose 1-phosphate +  
fumarate(1-) +  
fumaric acid +   
A butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.
galactose +   
gallic acid +   
genistein +   
glaucarubinone 
glucose +   
glutamate(1-) +   
glutamate(2-) +   
glutamic acid +   
glutamine +   
glutathione +   
glyceraldehyde +   
glycerate +  
glyceric acid +   
glycerol +   
glycinate +   
glycine +   
glycine betaine +   
glycine betaine hydrate 
glycinium +  
glycolaldehyde +   
glycyl radical +  
Guanabenz acetate 
Guanfacine hydrochloride 
guanosine +   
homocysteinate +  
homocysteine +   
hypoxanthine +   
ibuprofen +   
IDP  
indirubin  
isocitric acid +   
isoliquiritigenin +   
juglone  
kaempferol +   
kanamycin A sulfate 
kenpaullone  
ketanserin tartrate 
keto-phenylpyruvic acid +   
kinetin +  
KN-93  
L-744,832 
L-alaninate +  
L-alanine +   
L-alaninium +  
L-ascorbic acid +   
L-aspartate(1-) +  
L-aspartate(2-) +  
L-cysteinate(1-) +  
L-cysteinate(2-) 
L-cysteinium +  
L-cysteinyl radical +  
L-erythro-isocitrate(3-) 
L-galactose 1-phosphate +  
L-galactose 1-phosphate(2-) +  
L-homocysteine zwitterion +  
L-methionine sulfoximine +  
L-ribulose 5-phosphate(2-) 
L-thioproline +  
L-threo-isocitrate(3-) 
L-tyrosinate(1-) 
L-tyrosinate(2-) +  
L-tyrosine +   
L-tyrosinium +  
L-xylulose 5-phosphate(2-) 
lamotrigine  
latrepirdine 
LFM-A13 
lipoate +  
lipoic acid +   
lithium chloride  
lithocholic acid +   
lonidamine +   
loratadine  
loxapine succinate 
LY-165163 
LY-367,265 
LY294002  
magnesium citrate 
magnesium(2+) +  
malate(2-) +  
maleic acid +   
malic acid +   
Malonoben  
mannose +   
melatonin +   
mercaptoethanol +   
metergoline  
metformin  
methiothepin  
Methylergonovine Maleate  
metoprolol  
mianserin +   
mianserin hydrochloride 
minocycline +   
minocycline hydrochloride 
mochimganine 
monosodium fumarate 
morphine +   
myricetin +   
myxothiazol  
N(5)-ethyl-L-glutamine  
N(6)-(1,2-dicarboxyethyl)-AMP 
N,N,N-trimethylglycinium +  
N,N-dimethylformamide +   
N-[3-(aminomethyl)benzyl]acetamidine  
N-acetyl-L-cysteine +   
N-nitrosodimethylamine  
N-ribosylnicotinamide  
NAD +   
NAD zwitterion  
NADH +  
NADP zwitterion +   
NADP(+) +   
NADPH +  
naphthalene-1,2,3,4-tetrone +  
naphthazarin  
nebivolol  
nicardipine hydrochloride 
nicotinamide +   
nitrendipine  
nitroflurbiprofen  
nomilin  
nordihydroguaiaretic acid +   
Nortriptyline hydrochloride 
oleoyl ethanolamide +   
oxalatosuccinate(3-) +  
oxaloacetic acid +   
oxalosuccinic acid +  
oxatomide  
paracetamol +   
paraquat +   
paxilline  
pergolide mesylate 
phenformin  
phosphoenolpyruvate  
phosphoenolpyruvic acid 
phosphonatoenolpyruvate 
phosphonoformic acid +   
piceatannol +   
pioglitazone +   
potassium acetate 
potassium bitartrate 
potassium hydrogencarbonate 
PP2 
promethazine hydrochloride 
pseudouridine +  
psora 4 
purine +   
putrescine +   
pyrrolidine dithiocarbamate  
pyruvate +  
pyruvic acid +   
quercetin +   
quercetin 3-O-beta-D-glucopyranoside  
quinidine sulfate 
rac-lactic acid +   
resveratrol +   
riboflavin +   
ribulose 5-phosphate +  
rifampicin +   
RK-24466 
S-adenosyl-L-homocysteinate 
S-adenosyl-L-homocysteine  
SB 203580  
serinate +  
serine +   
serinium +  
simvastatin  
sirolimus +   
sodium butyrate 
sodium ferrous citrate 
sodium lactate  
sodium phenylbutyrate 
sodium valproate +   
spermidine +   
spermidine(3+) +  
spermine +   
spermine(4+) +  
staurosporine +   
SU4312 
succinate(1-) 
succinic acid +   
tannic acid  
thiamine(1+) diphosphate +  
thioflavine T  
thioridazine hydrochloride 
trametinib +   
trans-aconitate(3-) 
trans-aconitic acid 
trans-caffeic acid +   
trans-piceid  
trichostatin A +   
trimethadione 
tris(picolinato)chromium  
tschimganine 
tyrphostin 1 
tyrphostin AG 1478  
tyrphostin B42  
UDP-alpha-D-glucose  
UDP-alpha-D-xylose 
uridine +   
Urolithin A  
ursolic acid +   
valpromide  
vincristine sulfate 
Vinpocetine  
wortmannin +   
xanthine +   
xylulose 5-phosphate +   

Synonyms
Related Synonyms: (2E)-2-butenedioic acid ;   (2E)-But-2-enedioic acid ;   (E)-2-butenedioic acid ;   E297 ;   Formula=C4H4O4 ;   Fumarsaeure ;   InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+ ;   InChIKey=VZCYOOQTPOCHFL-OWOJBTEDSA-N ;   SMILES=OC(=O)\\C=C\\C(O)=O ;   trans-1,2-ethylenedicarboxylic acid
Alternate IDs: CHEBI:24124 ;   CHEBI:42743 ;   CHEBI:5190
Xrefs: CAS:110-17-8 ;   DrugBank:DB01677 ;   Drug_Central:3229 ;   FooDB:FDB003291 ;   Gmelin:49855 ;   HMDB:HMDB0000134 ;   KEGG:C00122 ;   KEGG:D02308 ;   KNApSAcK:C00001183
Xref Mesh: MESH:C032005
Xrefs: MetaCyc:FUM ;   PDBeChem:FUM ;   PMID:17439666 ;   PMID:21414846 ;   PMID:22113915 ;   PMID:22217732 ;   PMID:22516248 ;   PMID:23472183 ;   PPDB:1347 ;   Reaxys:605763
Cyclic Relationships: is_conjugate_acid_of CHEBI:37154

paths to the root