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VERTEBRATE TRAIT ONTOLOGY - ANNOTATIONS

The Vertebrate Trait Ontology (VT) is being developed as a collaborative effort between the Rat Genome Database at the Medical College of Wisconsin (RGD, http://rgd.mcw.edu), Mouse Genome Informatics at the Jackson Laboratory (http://www.informatics.jax.org/) and the Animal QTL database at Iowa State University (http://www.animalgenome.org/cgi-bin/QTLdb/index). For more information about this vocabulary, or to request additions or changes, please contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:follicular dendritic cell physiology trait
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Accession:VT:0008197 term browser browse the term
Definition:Any measurable or observable characteristic related to the function of or processes in a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response.
Comment:Annotations to this cell type have been erroneously made to dendritic cell morphology trait. These are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response. They are not derived from the hematopoietic lineage. Due to its unique lineage and distinct function (B cell vs. T cell presentation), this is NOT a type of dendritic cell.



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  vertebrate trait 2384
    organ system trait 1553
      immune system trait 28
        immune system physiology trait 3
          immune system cell physiology trait 2
            follicular dendritic cell physiology trait 0
              follicular dendritic cell antigen presentation trait 0
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