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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:glyoxalase metabolic pathway
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Accession:PW:0002615 term browser browse the term
Definition:The glyoxalase pathway is the main detoxifying route to protect against the harmful effects of methylglyoxal (MG). The highly reactive dicarbonyl compound is primarily a by-product of glycolysis, but it can also result as a by-product of fatty acid and protein metabolism. MG is also known as pyruvaldehyde or 2-oxopropanol.
Synonyms:related_synonym: 2-oxo propanol degradation pathway;   SMP:00459;   methylglyoxal degradation pathway;   pyruvaldehyde degradation pathway


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glyoxalase metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glo1 glyoxalase 1 ISO SMPDB SMP:00459 NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191 		JBrowse link
G Hagh hydroxyacyl glutathione hydrolase ISO SMPDB SMP:00459 NCBI chr10:14,379,400...14,394,046
Ensembl chr10:14,382,410...14,394,043 		JBrowse link
G Ldhd lactate dehydrogenase D ISO SMPDB SMP:00459 NCBI chr19:56,492,827...56,497,695
Ensembl chr19:56,482,924...56,509,197 		JBrowse link
Term paths to the root
Path 1
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  pathway 6091
    classic metabolic pathway 1852
      carbohydrate metabolic pathway 526
        glyoxylate and dicarboxylate metabolic pathway 19
          glyoxalase metabolic pathway 3
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