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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:protease mediated signaling via protease-activated receptor 1
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Accession:PW:0002607 term browser browse the term
Definition:Protease-activated receptor 1 (PAR1/F2R) is primarily a target of coagulation factor 2, thrombin, but other proteases can prompt or disarm it. PAR1 signaling plays many roles in the immune, cardiovascular and nervous system.
Synonyms:related_synonym: protease mediated signaling via F2R;   protease mediated signaling via PAR1


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protease mediated signaling via protease-activated receptor 1 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin ISO RGD PMID:27126649 RGD:11352286 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246 		JBrowse link
G F2r coagulation factor II (thrombin) receptor ISO RGD PMID:23809128 PMID:27126649 RGD:11352294, RGD:11352286 NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:28,604,066...28,620,579 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa ISO RGD PMID:23809128 RGD:11352294 NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964 		JBrowse link
G Procr protein C receptor ISO RGD PMID:23809128 RGD:11352294 NCBI chr 3:164,714,727...164,718,994
Ensembl chr 3:164,711,636...164,718,989 		JBrowse link
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Path 1
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  pathway 6090
    signaling pathway 2634
      protease mediated signaling pathway 8
        protease mediated signaling via protease-activated receptor 1 4
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