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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:antineoplastic drug pathway
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Accession:PW:0002367 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of drugs used in the treatment of various cancers. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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aromatase inhibitor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A3 cytochrome P450 19A3 ISO RGD PMID:18695261 RGD:5130880 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899 		JBrowse link
axitinib pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT1 fms related receptor tyrosine kinase 1 ISO RGD PMID:22170007 RGD:6907361 NCBI chr11:5,620,698...5,797,095
Ensembl chr11:5,621,212...5,795,264 		JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 ISO RGD PMID:22170007 RGD:6907361 NCBI chr 2:78,076,008...78,115,137
Ensembl chr 2:78,076,080...78,115,126 		JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:22170007 RGD:6907361 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
axitinib pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO RGD PMID:22170007 RGD:6907361 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 ISO RGD PMID:22170007 RGD:6907361 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100 		JBrowse link
G CYP2C49 cytochrome P450 2C49 ISO RGD PMID:22170007 RGD:6907361 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455 		JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO RGD PMID:22170007 RGD:6907361 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
bevacizumab pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT1 fms related receptor tyrosine kinase 1 ISO SMPDB SMP:00420 NCBI chr11:5,620,698...5,797,095
Ensembl chr11:5,621,212...5,795,264 		JBrowse link
G KDR kinase insert domain receptor ISO SMPDB SMP:00420 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO SMPDB SMP:00420 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
capecitabine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDA cytidine deaminase ISO SMPDB SMP:00469 NCBI chr 6:78,824,248...78,849,154
Ensembl chr 6:78,824,270...78,849,547 		JBrowse link
G LOC110255234 liver carboxylesterase-like ISO SMPDB SMP:00469
G SLC28A1 solute carrier family 28 member 1 ISO SMPDB SMP:00469 NCBI chr 7:52,606,428...52,652,928
Ensembl chr 7:52,605,289...52,652,876 		JBrowse link
G TYMS thymidylate synthetase ISO SMPDB SMP:00469 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
capecitabine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDA cytidine deaminase ISO SMPDB SMP:00607 NCBI chr 6:78,824,248...78,849,154
Ensembl chr 6:78,824,270...78,849,547 		JBrowse link
G LOC110255234 liver carboxylesterase-like ISO SMPDB SMP:00607
G SLC28A1 solute carrier family 28 member 1 ISO SMPDB SMP:00607 NCBI chr 7:52,606,428...52,652,928
Ensembl chr 7:52,605,289...52,652,876 		JBrowse link
G TYMS thymidylate synthetase ISO SMPDB SMP:00607 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
cetuximab pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor ISO SMPDB SMP:00474 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
cisplatin drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATOX1 antioxidant 1 copper chaperone ISO RGD PMID:23936210 RGD:8548474 NCBI chr16:71,299,321...71,314,598
Ensembl chr16:71,299,321...71,314,597 		JBrowse link
G ATP7A ATPase copper transporting alpha ISO RGD PMID:22796517 RGD:8548473 NCBI chr  X:61,972,544...62,110,058
Ensembl chr  X:61,972,991...62,110,048 		JBrowse link
G ATP7B ATPase copper transporting beta ISO RGD PMID:22796517 RGD:8548473 NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064 		JBrowse link
G HMGB1 high mobility group box 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr11:7,195,556...7,321,071 JBrowse link
G SLC31A1 solute carrier family 31 member 1 ISO RGD PMID:22796517 PMID:23123662 RGD:8548473 RGD:8549769 NCBI chr 1:253,868,389...253,893,135
Ensembl chr 1:253,868,332...253,894,449 		JBrowse link
G SSRP1 structure specific recognition protein 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr 2:13,619,666...13,629,233
Ensembl chr 2:13,619,716...13,629,227 		JBrowse link
G TBP TATA-box binding protein ISO RGD PMID:20046924 RGD:8548475 NCBI chr 1:5,669...23,675 JBrowse link
G UBTF upstream binding transcription factor ISO RGD PMID:20046924 RGD:8548475 NCBI chr12:18,989,833...19,006,145
Ensembl chr12:18,989,836...19,006,129 		JBrowse link
G YBX1 Y-box binding protein 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr 6:168,716,782...168,736,475
Ensembl chr 6:168,716,772...168,736,604 		JBrowse link
cyclophosphamide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO SMPDB SMP:00447 NCBI chr 1:226,163,347...226,217,342
Ensembl chr 1:226,161,299...226,217,308 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 ISO SMPDB SMP:00447 NCBI chr12:59,895,476...59,905,900
Ensembl chr12:59,897,496...59,905,897 		JBrowse link
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B ISO SMPDB SMP:00447 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334 		JBrowse link
G CYP2C49 cytochrome P450 2C49 ISO SMPDB SMP:00447 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455 		JBrowse link
cyclophosphamide pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO SMPDB SMP:00604 NCBI chr 1:226,163,347...226,217,342
Ensembl chr 1:226,161,299...226,217,308 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 ISO SMPDB SMP:00604 NCBI chr12:59,895,476...59,905,900
Ensembl chr12:59,897,496...59,905,897 		JBrowse link
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B ISO SMPDB SMP:00604 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334 		JBrowse link
G CYP2C49 cytochrome P450 2C49 ISO SMPDB SMP:00604 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455 		JBrowse link
docetaxel pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00435 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00435 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00435 NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898 		JBrowse link
G ABCG2A ATP binding cassette subfamily G member 2A ISO SMPDB SMP:00435 NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,775,444...130,945,393 		JBrowse link
G SLCO1B2 solute carrier organic anion transporter family member 1B2 ISO SMPDB SMP:00435 NCBI chr 5:52,137,454...52,206,236 JBrowse link
G TUBA1B tubulin alpha 1b ISO SMPDB SMP:00435 NCBI chr 5:15,150,229...15,153,620
Ensembl chr 5:15,149,099...15,153,620 		JBrowse link
G TUBB1 tubulin beta 1 class VI ISO SMPDB SMP:00435 NCBI chr17:59,161,420...59,168,385
Ensembl chr17:59,161,420...59,168,385 		JBrowse link
doxorubicin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TOP2A DNA topoisomerase II alpha ISO RGD PMID:25895646 RGD:10395260 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450 		JBrowse link
G TOP2B DNA topoisomerase II beta ISO RGD PMID:25895646 RGD:10395260 NCBI chr13:12,507,738...12,575,042
Ensembl chr13:12,507,138...12,575,583 		JBrowse link
doxorubicin pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB
RGD		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00650 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB
RGD		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO RGD PMID:21048526 RGD:10395261 NCBI chr12:26,920,764...26,978,389
Ensembl chr12:26,920,821...26,979,602 		JBrowse link
G ABCG2A ATP binding cassette subfamily G member 2A ISO SMPDB
RGD		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,775,444...130,945,393 		JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 ISO SMPDB
RGD		 PMID:19442138 PMID:21048526 RGD:10395261 RGD:10395262 SMP:00650 NCBI chr 6:165,811,245...165,825,168
Ensembl chr 6:165,811,247...165,824,896 		JBrowse link
G AKR1C1 aldo-keto reductase family 1, member C1 ISO SMPDB
RGD		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr10:65,580,297...65,594,998
Ensembl chr10:65,576,464...65,678,248 		JBrowse link
G CBR3 carbonyl reductase 3 ISO SMPDB
RGD		 PMID:19442138 PMID:21048526 RGD:10395261 RGD:10395262 SMP:00650 NCBI chr13:199,830,690...199,840,444
Ensembl chr13:199,830,668...199,840,442 		JBrowse link
G LOC110256483 carbonyl reductase [NADPH] 1-like ISO RGD
SMPDB		 PMID:19442138 PMID:21048526 RGD:10395261 RGD:10395262 SMP:00650 NCBI chr13:199,713,741...199,719,535 JBrowse link
G NDUFS2 NADH:ubiquinone oxidoreductase core subunit S2 ISO SMPDB SMP:00650 NCBI chr 4:89,246,958...89,257,090
Ensembl chr 4:89,246,960...89,257,085 		JBrowse link
G NDUFS3 NADH:ubiquinone oxidoreductase core subunit S3 ISO SMPDB SMP:00650 NCBI chr 2:15,031,147...15,036,880
Ensembl chr 2:15,031,149...15,036,880 		JBrowse link
G NDUFS7 NADH:ubiquinone oxidoreductase core subunit S7 ISO SMPDB SMP:00650 NCBI chr 2:77,080,311...77,087,141 JBrowse link
G NOS3 nitric oxide synthase 3 ISO SMPDB
RGD		 PMID:19442138 RGD:10395262 SMP:00650 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ISO SMPDB
RGD		 PMID:19442138 RGD:10395262 SMP:00650 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590 		JBrowse link
G POR cytochrome p450 oxidoreductase ISO SMPDB SMP:00650 NCBI chr 3:10,212,734...10,272,184
Ensembl chr 3:10,212,735...10,281,823 		JBrowse link
G RALBP1 ralA binding protein 1 ISO SMPDB
RGD		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr 6:98,550,925...98,598,945
Ensembl chr 6:98,550,933...98,598,206 		JBrowse link
G SLC22A16 solute carrier family 22 member 16 ISO SMPDB
RGD		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr 1:76,423,386...76,468,267
Ensembl chr 1:76,423,355...76,467,575 		JBrowse link
G XDH xanthine dehydrogenase ISO SMPDB
RGD		 PMID:19442138 RGD:10395262 SMP:00650 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
erlotinib pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00472 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCG2A ATP binding cassette subfamily G member 2A ISO SMPDB SMP:00472 NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,775,444...130,945,393 		JBrowse link
G EGFR epidermal growth factor receptor ISO SMPDB SMP:00472 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
etoposide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00442 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00442 NCBI chr12:26,920,764...26,978,389
Ensembl chr12:26,920,821...26,979,602 		JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO SMPDB SMP:00442 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00442 NCBI chr13:124,387,921...124,409,967
Ensembl chr13:124,390,970...124,413,200 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00442 NCBI chr14:39,687,028...39,695,748
Ensembl chr14:39,687,000...39,695,752 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00442 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00442 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00442 NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,933...46,276,995 		JBrowse link
G MPO myeloperoxidase ISO SMPDB SMP:00442 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00442 NCBI chr 3:41,394,267...41,397,547
Ensembl chr 3:41,394,058...41,397,687 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00442 NCBI chr 9:109,260,850...109,280,256
Ensembl chr 9:109,252,011...109,280,247 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00442 NCBI chr 3:125,752,079...125,774,225
Ensembl chr 3:125,751,978...125,776,077 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00442 NCBI chr 1:107,886,663...107,893,155
Ensembl chr 1:107,886,658...107,893,253 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00442 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00442 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00442 NCBI chr14:50,249,607...50,251,636
Ensembl chr14:50,246,710...50,251,642 		JBrowse link
G TOP2A DNA topoisomerase II alpha ISO SMPDB SMP:00442 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450 		JBrowse link
G TOP2B DNA topoisomerase II beta ISO SMPDB SMP:00442 NCBI chr13:12,507,738...12,575,042
Ensembl chr13:12,507,138...12,575,583 		JBrowse link
etoposide pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00601 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00601 NCBI chr12:26,920,764...26,978,389
Ensembl chr12:26,920,821...26,979,602 		JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO SMPDB SMP:00601 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00601 NCBI chr13:124,387,921...124,409,967
Ensembl chr13:124,390,970...124,413,200 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00601 NCBI chr14:39,687,028...39,695,748
Ensembl chr14:39,687,000...39,695,752 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00601 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00601 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00601 NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,933...46,276,995 		JBrowse link
G MPO myeloperoxidase ISO SMPDB SMP:00601 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00601 NCBI chr 3:41,394,267...41,397,547
Ensembl chr 3:41,394,058...41,397,687 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00601 NCBI chr 9:109,260,850...109,280,256
Ensembl chr 9:109,252,011...109,280,247 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00601 NCBI chr 3:125,752,079...125,774,225
Ensembl chr 3:125,751,978...125,776,077 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00601 NCBI chr 1:107,886,663...107,893,155
Ensembl chr 1:107,886,658...107,893,253 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00601 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00601 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00601 NCBI chr14:50,249,607...50,251,636
Ensembl chr14:50,246,710...50,251,642 		JBrowse link
G TOP2A DNA topoisomerase II alpha ISO SMPDB SMP:00601 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450 		JBrowse link
G TOP2B DNA topoisomerase II beta ISO SMPDB SMP:00601 NCBI chr13:12,507,738...12,575,042
Ensembl chr13:12,507,138...12,575,583 		JBrowse link
gefitinib pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor ISO SMPDB
RGD		 PMID:19733976 RGD:5135288 SMP:00473 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
gefitinib pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO RGD PMID:19733976 RGD:5135288 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCG2A ATP binding cassette subfamily G member 2A ISO RGD PMID:19733976 RGD:5135288 NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,775,444...130,945,393 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO RGD PMID:19733976 RGD:5135288 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO RGD PMID:19733976 RGD:5135288 NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,642 		JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO RGD PMID:19733976 RGD:5135288 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
gemcitabine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00446 NCBI chr 6:164,161,439...164,197,429
Ensembl chr 6:164,162,518...164,197,379 		JBrowse link
G CTPS1 CTP synthase 1 ISO SMPDB SMP:00446 NCBI chr 6:170,201,749...170,233,105
Ensembl chr 6:170,201,751...170,233,016 		JBrowse link
G DCK deoxycytidine kinase ISO SMPDB SMP:00446 NCBI chr 8:67,706,661...67,736,743 JBrowse link
G DCTD dCMP deaminase ISO SMPDB SMP:00446 NCBI chr15:44,466,312...44,492,594
Ensembl chr15:44,466,315...44,490,831 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00446 NCBI chr12:27,416,308...27,435,044
Ensembl chr12:27,416,346...27,436,140 		JBrowse link
G NT5C 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00446 NCBI chr12:6,162,420...6,164,143
Ensembl chr12:6,162,243...6,164,140 		JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO SMPDB SMP:00446 NCBI chr 9:6,026,151...6,065,211
Ensembl chr 9:6,025,073...6,065,143 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO SMPDB SMP:00446 NCBI chr 3:126,357,198...126,367,145
Ensembl chr 3:126,347,819...126,365,644 		JBrowse link
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B ISO SMPDB SMP:00446 NCBI chr 4:34,823,869...34,859,777
Ensembl chr 4:34,823,758...34,859,778 		JBrowse link
G SLC28A1 solute carrier family 28 member 1 ISO SMPDB SMP:00446 NCBI chr 7:52,606,428...52,652,928
Ensembl chr 7:52,605,289...52,652,876 		JBrowse link
G SLC28A3 solute carrier family 28 member 3 ISO SMPDB SMP:00446 NCBI chr10:30,663,060...30,730,766
Ensembl chr10:30,669,904...30,729,301 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 ISO SMPDB SMP:00446 NCBI chr 7:39,217,974...39,234,683
Ensembl chr 7:39,218,051...39,234,685 		JBrowse link
G TYMS thymidylate synthetase ISO SMPDB SMP:00446 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
gemcitabine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00603 NCBI chr 6:164,161,439...164,197,429
Ensembl chr 6:164,162,518...164,197,379 		JBrowse link
G CTPS1 CTP synthase 1 ISO SMPDB SMP:00603 NCBI chr 6:170,201,749...170,233,105
Ensembl chr 6:170,201,751...170,233,016 		JBrowse link
G DCK deoxycytidine kinase ISO SMPDB SMP:00603 NCBI chr 8:67,706,661...67,736,743 JBrowse link
G DCTD dCMP deaminase ISO SMPDB SMP:00603 NCBI chr15:44,466,312...44,492,594
Ensembl chr15:44,466,315...44,490,831 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00603 NCBI chr12:27,416,308...27,435,044
Ensembl chr12:27,416,346...27,436,140 		JBrowse link
G NT5C 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00603 NCBI chr12:6,162,420...6,164,143
Ensembl chr12:6,162,243...6,164,140 		JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO SMPDB SMP:00603 NCBI chr 9:6,026,151...6,065,211
Ensembl chr 9:6,025,073...6,065,143 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO SMPDB SMP:00603 NCBI chr 3:126,357,198...126,367,145
Ensembl chr 3:126,347,819...126,365,644 		JBrowse link
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B ISO SMPDB SMP:00603 NCBI chr 4:34,823,869...34,859,777
Ensembl chr 4:34,823,758...34,859,778 		JBrowse link
G SLC28A1 solute carrier family 28 member 1 ISO SMPDB SMP:00603 NCBI chr 7:52,606,428...52,652,928
Ensembl chr 7:52,605,289...52,652,876 		JBrowse link
G SLC28A3 solute carrier family 28 member 3 ISO SMPDB SMP:00603 NCBI chr10:30,663,060...30,730,766
Ensembl chr10:30,669,904...30,729,301 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 ISO SMPDB SMP:00603 NCBI chr 7:39,217,974...39,234,683
Ensembl chr 7:39,218,051...39,234,685 		JBrowse link
G TYMS thymidylate synthetase ISO SMPDB SMP:00603 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
ifosfamide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO SMPDB SMP:00448 NCBI chr 1:226,163,347...226,217,342
Ensembl chr 1:226,161,299...226,217,308 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 ISO SMPDB SMP:00448 NCBI chr12:59,895,476...59,905,900
Ensembl chr12:59,897,496...59,905,897 		JBrowse link
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B ISO SMPDB SMP:00448 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334 		JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO SMPDB SMP:00448 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
ifosfamide pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO SMPDB SMP:00605 NCBI chr 1:226,163,347...226,217,342
Ensembl chr 1:226,161,299...226,217,308 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 ISO SMPDB SMP:00605 NCBI chr12:59,895,476...59,905,900
Ensembl chr12:59,897,496...59,905,897 		JBrowse link
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B ISO SMPDB SMP:00605 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334 		JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO SMPDB SMP:00605 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
irinotecan pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00433 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00433 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00433 NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898 		JBrowse link
G ABCG2A ATP binding cassette subfamily G member 2A ISO SMPDB SMP:00433 NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,775,444...130,945,393 		JBrowse link
G BCHE butyrylcholinesterase ISO SMPDB SMP:00433 NCBI chr13:104,946,732...105,007,568 JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO SMPDB SMP:00433 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00433 NCBI chr13:124,387,921...124,409,967
Ensembl chr13:124,390,970...124,413,200 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00433 NCBI chr14:39,687,028...39,695,748
Ensembl chr14:39,687,000...39,695,752 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00433 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00433 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00433 NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,933...46,276,995 		JBrowse link
G LOC110255234 liver carboxylesterase-like ISO SMPDB SMP:00433
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00433 NCBI chr 3:41,394,267...41,397,547
Ensembl chr 3:41,394,058...41,397,687 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00433 NCBI chr 9:109,260,850...109,280,256
Ensembl chr 9:109,252,011...109,280,247 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00433 NCBI chr 3:125,752,079...125,774,225
Ensembl chr 3:125,751,978...125,776,077 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00433 NCBI chr 1:107,886,663...107,893,155
Ensembl chr 1:107,886,658...107,893,253 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00433 NCBI chr14:50,249,607...50,251,636
Ensembl chr14:50,246,710...50,251,642 		JBrowse link
G TOP1 DNA topoisomerase I ISO SMPDB SMP:00433 NCBI chr17:43,710,270...43,799,700
Ensembl chr17:43,710,290...43,799,700 		JBrowse link
irinotecan pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00600 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00600 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00600 NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898 		JBrowse link
G ABCG2A ATP binding cassette subfamily G member 2A ISO SMPDB SMP:00600 NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,775,444...130,945,393 		JBrowse link
G BCHE butyrylcholinesterase ISO SMPDB SMP:00600 NCBI chr13:104,946,732...105,007,568 JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO SMPDB SMP:00600 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00600 NCBI chr13:124,387,921...124,409,967
Ensembl chr13:124,390,970...124,413,200 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00600 NCBI chr14:39,687,028...39,695,748
Ensembl chr14:39,687,000...39,695,752 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00600 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00600 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00600 NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,933...46,276,995 		JBrowse link
G LOC110255234 liver carboxylesterase-like ISO SMPDB SMP:00600
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00600 NCBI chr 3:41,394,267...41,397,547
Ensembl chr 3:41,394,058...41,397,687 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00600 NCBI chr 9:109,260,850...109,280,256
Ensembl chr 9:109,252,011...109,280,247 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00600 NCBI chr 3:125,752,079...125,774,225
Ensembl chr 3:125,751,978...125,776,077 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00600 NCBI chr 1:107,886,663...107,893,155
Ensembl chr 1:107,886,658...107,893,253 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00600 NCBI chr14:50,249,607...50,251,636
Ensembl chr14:50,246,710...50,251,642 		JBrowse link
G TOP1 DNA topoisomerase I ISO SMPDB SMP:00600 NCBI chr17:43,710,270...43,799,700
Ensembl chr17:43,710,290...43,799,700 		JBrowse link
mercaptopurine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00428 NCBI chr11:64,089,149...64,309,831 JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00428 NCBI chr13:121,868,614...121,957,901
Ensembl chr13:121,869,600...121,926,071 		JBrowse link
G ADA adenosine deaminase ISO SMPDB SMP:00428 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,497...47,072,245 		JBrowse link
G ADCY10 adenylate cyclase 10 ISO SMPDB SMP:00428 NCBI chr 4:83,103,768...83,205,015
Ensembl chr 4:83,098,290...83,205,454 		JBrowse link
G ADK adenosine kinase ISO SMPDB SMP:00428 NCBI chr14:76,836,072...77,320,586
Ensembl chr14:76,836,095...77,322,416 		JBrowse link
G ADSL adenylosuccinate lyase ISO SMPDB SMP:00428 NCBI chr 5:8,027,799...8,045,480
Ensembl chr 5:8,025,508...8,047,603 		JBrowse link
G ADSS2 adenylosuccinate synthase 2 ISO SMPDB SMP:00428 NCBI chr10:17,220,081...17,259,141
Ensembl chr10:17,220,207...17,259,182 		JBrowse link
G AK1 adenylate kinase 1 ISO SMPDB SMP:00428 NCBI chr 1:268,355,032...268,365,659
Ensembl chr 1:268,355,033...268,365,598 		JBrowse link
G AMPD1 adenosine monophosphate deaminase 1 ISO SMPDB SMP:00428 NCBI chr 4:105,868,834...105,892,171
Ensembl chr 4:105,868,897...105,893,769 		JBrowse link
G AOX1 aldehyde oxidase 1 ISO SMPDB SMP:00428 NCBI chr15:104,157,748...104,234,533
Ensembl chr15:104,157,527...104,236,006 		JBrowse link
G APRT adenine phosphoribosyltransferase ISO SMPDB SMP:00428 NCBI chr 6:890,272...893,278
Ensembl chr 6:890,831...893,276 		JBrowse link
G ATAD1 ATPase family AAA domain containing 1 ISO SMPDB SMP:00428 NCBI chr14:99,802,939...99,885,562
Ensembl chr14:99,815,203...99,885,160 		JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO SMPDB SMP:00428 NCBI chr15:117,617,584...117,649,063
Ensembl chr15:117,617,502...117,649,107 		JBrowse link
G DGUOK deoxyguanosine kinase ISO SMPDB SMP:00428 NCBI chr 3:69,054,749...69,091,366
Ensembl chr 3:69,054,761...69,091,341 		JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) ISO SMPDB SMP:00428 NCBI chr 7:97,270,698...97,316,578
Ensembl chr 7:97,266,824...97,306,981 		JBrowse link
G ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 ISO SMPDB SMP:00428
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO SMPDB SMP:00428 NCBI chr13:197,130,898...197,158,797
Ensembl chr13:197,130,904...197,161,891 		JBrowse link
G GDA guanine deaminase ISO SMPDB SMP:00428 NCBI chr 1:225,425,389...225,589,835
Ensembl chr 1:225,403,138...225,589,827 		JBrowse link
G GMPR guanosine monophosphate reductase ISO SMPDB SMP:00428 NCBI chr 7:12,254,393...12,298,802
Ensembl chr 7:12,254,388...12,299,531 		JBrowse link
G GMPS guanine monophosphate synthase ISO SMPDB SMP:00428 NCBI chr13:95,742,342...95,820,903
Ensembl chr13:95,738,659...95,819,759 		JBrowse link
G GUCY1A2 guanylate cyclase 1 soluble subunit alpha 2 ISO SMPDB SMP:00428 NCBI chr 9:62,101,581...62,510,803
Ensembl chr 9:62,101,613...62,499,581 		JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 ISO SMPDB SMP:00428 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687 		JBrowse link
G GUK1 guanylate kinase 1 ISO SMPDB SMP:00428 NCBI chr 2:51,247,665...51,257,481
Ensembl chr 2:51,241,952...51,257,485 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO SMPDB SMP:00428 NCBI chr  X:110,321,144...110,357,902
Ensembl chr  X:110,321,204...110,357,894 		JBrowse link
G IMPDH1 inosine monophosphate dehydrogenase 1 ISO SMPDB SMP:00428 NCBI chr18:19,979,983...19,996,432
Ensembl chr18:19,979,983...19,996,429 		JBrowse link
G ITPA inosine triphosphatase ISO SMPDB SMP:00428 NCBI chr17:32,458,351...32,474,827
Ensembl chr17:32,455,459...32,474,784 		JBrowse link
G NME6 NME/NM23 nucleoside diphosphate kinase 6 ISO SMPDB SMP:00428 NCBI chr13:31,048,367...31,053,285
Ensembl chr13:31,046,948...31,053,130 		JBrowse link
G NT5C2 5'-nucleotidase, cytosolic II ISO SMPDB SMP:00428 NCBI chr14:114,062,451...114,167,460
Ensembl chr14:114,062,459...114,145,109 		JBrowse link
G NUDT2 nudix hydrolase 2 ISO SMPDB SMP:00428 NCBI chr10:32,450,986...32,466,893
Ensembl chr10:32,451,064...32,466,839 		JBrowse link
G NUDT5 nudix hydrolase 5 ISO SMPDB SMP:00428 NCBI chr10:59,765,444...59,787,773
Ensembl chr10:59,765,703...59,790,157 		JBrowse link
G PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase ISO SMPDB SMP:00428 NCBI chr 8:55,700,700...55,722,982
Ensembl chr 8:55,700,956...55,722,979 		JBrowse link
G PDE10A phosphodiesterase 10A ISO SMPDB SMP:00428 NCBI chr 1:3,120,418...3,394,236
Ensembl chr 1:2,829,411...3,392,651 		JBrowse link
G PDE4D phosphodiesterase 4D ISO SMPDB SMP:00428 NCBI chr16:37,897,300...39,406,534
Ensembl chr16:37,897,302...39,306,364 		JBrowse link
G PFAS phosphoribosylformylglycinamidine synthase ISO SMPDB SMP:00428 NCBI chr12:53,458,401...53,477,254 JBrowse link
G PNP purine nucleoside phosphorylase ISO SMPDB SMP:00428 NCBI chr 7:78,426,838...78,447,029
Ensembl chr 7:78,424,740...78,447,012 		JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase ISO SMPDB SMP:00428 NCBI chr 8:55,652,194...55,701,077
Ensembl chr 8:55,654,377...55,701,077 		JBrowse link
G PRPS1L1 phosphoribosyl pyrophosphate synthetase 1 like 1 ISO SMPDB SMP:00428 NCBI chr 9:87,161,863...87,164,314
Ensembl chr 9:87,163,252...87,164,208 		JBrowse link
G RAC1 Rac family small GTPase 1 ISO SMPDB SMP:00428 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543 		JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO SMPDB SMP:00428 NCBI chr 9:6,026,151...6,065,211
Ensembl chr 9:6,025,073...6,065,143 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO SMPDB SMP:00428 NCBI chr 3:126,357,198...126,367,145
Ensembl chr 3:126,347,819...126,365,644 		JBrowse link
G SLC28A2 solute carrier family 28 member 2 ISO SMPDB SMP:00428 NCBI chr 1:126,472,500...126,511,207
Ensembl chr 1:126,472,525...126,511,095 		JBrowse link
G SLC28A3 solute carrier family 28 member 3 ISO SMPDB SMP:00428 NCBI chr10:30,663,060...30,730,766
Ensembl chr10:30,669,904...30,729,301 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 ISO SMPDB SMP:00428 NCBI chr 7:39,217,974...39,234,683
Ensembl chr 7:39,218,051...39,234,685 		JBrowse link
G SLC29A2 solute carrier family 29 member 2 ISO SMPDB SMP:00428 NCBI chr 2:6,027,287...6,036,280
Ensembl chr 2:6,027,287...6,036,280 		JBrowse link
G TPMT thiopurine S-methyltransferase ISO SMPDB SMP:00428 NCBI chr 7:13,821,656...13,846,107
Ensembl chr 7:13,820,866...13,846,012 		JBrowse link
G TXN thioredoxin ISO SMPDB SMP:00428 NCBI chr 1:251,264,180...251,278,000
Ensembl chr 1:251,263,175...251,277,988 		JBrowse link
G XDH xanthine dehydrogenase ISO SMPDB SMP:00428 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
mercaptopurine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00609 NCBI chr11:64,089,149...64,309,831 JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00609 NCBI chr13:121,868,614...121,957,901
Ensembl chr13:121,869,600...121,926,071 		JBrowse link
G ADK adenosine kinase ISO SMPDB SMP:00609 NCBI chr14:76,836,072...77,320,586
Ensembl chr14:76,836,095...77,322,416 		JBrowse link
G AOX1 aldehyde oxidase 1 ISO SMPDB SMP:00609 NCBI chr15:104,157,748...104,234,533
Ensembl chr15:104,157,527...104,236,006 		JBrowse link
G GMPS guanine monophosphate synthase ISO SMPDB SMP:00609 NCBI chr13:95,742,342...95,820,903
Ensembl chr13:95,738,659...95,819,759 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO SMPDB SMP:00609 NCBI chr  X:110,321,144...110,357,902
Ensembl chr  X:110,321,204...110,357,894 		JBrowse link
G IMPDH1 inosine monophosphate dehydrogenase 1 ISO SMPDB SMP:00609 NCBI chr18:19,979,983...19,996,432
Ensembl chr18:19,979,983...19,996,429 		JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase ISO SMPDB SMP:00609 NCBI chr 8:55,652,194...55,701,077
Ensembl chr 8:55,654,377...55,701,077 		JBrowse link
G RAC1 Rac family small GTPase 1 ISO SMPDB SMP:00609 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543 		JBrowse link
G SLC28A2 solute carrier family 28 member 2 ISO SMPDB SMP:00609 NCBI chr 1:126,472,500...126,511,207
Ensembl chr 1:126,472,525...126,511,095 		JBrowse link
G SLC28A3 solute carrier family 28 member 3 ISO SMPDB SMP:00609 NCBI chr10:30,663,060...30,730,766
Ensembl chr10:30,669,904...30,729,301 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 ISO SMPDB SMP:00609 NCBI chr 7:39,217,974...39,234,683
Ensembl chr 7:39,218,051...39,234,685 		JBrowse link
G SLC29A2 solute carrier family 29 member 2 ISO SMPDB SMP:00609 NCBI chr 2:6,027,287...6,036,280
Ensembl chr 2:6,027,287...6,036,280 		JBrowse link
G TPMT thiopurine S-methyltransferase ISO SMPDB SMP:00609 NCBI chr 7:13,821,656...13,846,107
Ensembl chr 7:13,820,866...13,846,012 		JBrowse link
G XDH xanthine dehydrogenase ISO SMPDB SMP:00609 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
methotrexate pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO SMPDB SMP:00432 NCBI chr 7:53,748,585...53,794,777
Ensembl chr 7:53,748,653...53,794,706 		JBrowse link
G DHFR dihydrofolate reductase ISO SMPDB SMP:00432 NCBI chr 2:89,230,660...89,255,830 JBrowse link
G FPGS folylpolyglutamate synthase ISO SMPDB SMP:00432 NCBI chr 1:268,281,298...268,309,397
Ensembl chr 1:268,287,765...268,309,398 		JBrowse link
G FTCD formimidoyltransferase cyclodeaminase ISO SMPDB SMP:00432
G GGH gamma-glutamyl hydrolase ISO SMPDB SMP:00432 NCBI chr 4:70,996,730...71,020,513
Ensembl chr 4:70,996,755...71,021,838 		JBrowse link
G LOC102167410 5-formyltetrahydrofolate cyclo-ligase ISO SMPDB SMP:00432 NCBI chr 7:48,717,518...48,873,492
Ensembl chr 7:48,717,851...48,873,455 		JBrowse link
G MTFMT mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00432 NCBI chr 1:106,970,620...107,001,563
Ensembl chr 1:106,970,640...107,001,564 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO SMPDB SMP:00432 NCBI chr 7:88,471,317...88,533,690
Ensembl chr 7:88,471,414...88,537,387 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO SMPDB SMP:00432 NCBI chr 1:15,140,929...15,330,265
Ensembl chr 1:15,140,899...15,329,986 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO SMPDB SMP:00432 NCBI chr 3:68,819,171...68,833,641
Ensembl chr 3:68,818,119...68,833,600 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO SMPDB SMP:00432 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO SMPDB SMP:00432 NCBI chr12:44,677,499...44,686,277
Ensembl chr12:44,677,502...44,686,250 		JBrowse link
panitumumab pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor ISO SMPDB SMP:00475 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
sorafenib pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B ISO SMPDB SMP:00648 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00648 NCBI chr13:124,387,921...124,409,967
Ensembl chr13:124,390,970...124,413,200 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00648 NCBI chr14:39,687,028...39,695,748
Ensembl chr14:39,687,000...39,695,752 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00648 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00648 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00648 NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,933...46,276,995 		JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00648 NCBI chr 3:41,394,267...41,397,547
Ensembl chr 3:41,394,058...41,397,687 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00648 NCBI chr 9:109,260,850...109,280,256
Ensembl chr 9:109,252,011...109,280,247 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00648 NCBI chr 3:125,752,079...125,774,225
Ensembl chr 3:125,751,978...125,776,077 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00648 NCBI chr 1:107,886,663...107,893,155
Ensembl chr 1:107,886,658...107,893,253 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00648 NCBI chr14:50,249,607...50,251,636
Ensembl chr14:50,246,710...50,251,642 		JBrowse link
tamoxifen pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B ISO SMPDB SMP:00471 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO SMPDB SMP:00471 NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,642 		JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO SMPDB SMP:00471 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
G ESR1 estrogen receptor 1 ISO SMPDB
RGD		 PMID:19629072 RGD:5130191 SMP:00471 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:19629072 RGD:5130191 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565 		JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 ISO SMPDB SMP:00471 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076 		JBrowse link
G FMO3 flavin containing dimethylaniline monoxygenase 3 ISO SMPDB SMP:00471 NCBI chr 9:63,757,928...63,777,075
Ensembl chr 9:63,757,964...63,777,279 		JBrowse link
G NCOA3 nuclear receptor coactivator 3 ISO RGD PMID:16822624 RGD:5130718 NCBI chr17:49,528,275...49,660,471
Ensembl chr17:49,528,179...49,663,200 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO RGD PMID:16822624 RGD:5130718 NCBI chr12:59,256,868...59,392,564
Ensembl chr12:59,273,100...59,392,562 		JBrowse link
G NCOR2 nuclear receptor corepressor 2 ISO RGD PMID:16822624 RGD:5130718 NCBI chr14:28,642,774...28,819,404
Ensembl chr14:28,624,702...28,819,404 		JBrowse link
G PHB2 prohibitin 2 ISO RGD PMID:16822624 RGD:5130718 NCBI chr 5:63,751,566...63,756,480
Ensembl chr 5:63,751,558...63,756,478 		JBrowse link
tamoxifen pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO RGD PMID:21148080 RGD:5130188 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO RGD PMID:12971802 RGD:5129544 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 ISO RGD PMID:12971802 RGD:5129544 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100 		JBrowse link
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B ISO SMPDB
RGD		 PMID:12971802 RGD:5129544 SMP:00606 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334 		JBrowse link
G CYP2C49 cytochrome P450 2C49 ISO RGD PMID:12971802 RGD:5129544 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO SMPDB
RGD		 PMID:12971802 RGD:5129544 SMP:00606 NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,642 		JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO SMPDB
RGD		 PMID:12971802 RGD:5129544 SMP:00606 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
G ESR1 estrogen receptor 1 ISO SMPDB SMP:00606 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 ISO SMPDB SMP:00606 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076 		JBrowse link
G FMO3 flavin containing dimethylaniline monoxygenase 3 ISO SMPDB SMP:00606 NCBI chr 9:63,757,928...63,777,075
Ensembl chr 9:63,757,964...63,777,279 		JBrowse link
G LOC100623255 UDP-glucuronosyltransferase 2B31 ISO RGD PMID:19250197 RGD:5129558 NCBI chr 8:65,915,718...65,936,113 JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 ISO RGD PMID:16099924 PMID:19250197 RGD:5129555 RGD:5129558 NCBI chr 6:53,525,496...53,536,723
Ensembl chr 6:53,524,787...53,536,718 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 ISO RGD PMID:19250197 RGD:5129558 NCBI chr15:133,968,693...134,049,029 JBrowse link
teniposide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO SMPDB SMP:00443 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
G MPO myeloperoxidase ISO SMPDB SMP:00443 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G TOP2A DNA topoisomerase II alpha ISO SMPDB SMP:00443 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450 		JBrowse link
teniposide pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 ISO SMPDB SMP:00602 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817 		JBrowse link
G MPO myeloperoxidase ISO SMPDB SMP:00602 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G TOP2A DNA topoisomerase II alpha ISO SMPDB SMP:00602 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450 		JBrowse link
tioguanine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00430 NCBI chr11:64,089,149...64,309,831 JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00430 NCBI chr13:121,868,614...121,957,901
Ensembl chr13:121,869,600...121,926,071 		JBrowse link
G ADA adenosine deaminase ISO SMPDB SMP:00430 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,497...47,072,245 		JBrowse link
G ADCY10 adenylate cyclase 10 ISO SMPDB SMP:00430 NCBI chr 4:83,103,768...83,205,015
Ensembl chr 4:83,098,290...83,205,454 		JBrowse link
G ADK adenosine kinase ISO SMPDB SMP:00430 NCBI chr14:76,836,072...77,320,586
Ensembl chr14:76,836,095...77,322,416 		JBrowse link
G ADSL adenylosuccinate lyase ISO SMPDB SMP:00430 NCBI chr 5:8,027,799...8,045,480
Ensembl chr 5:8,025,508...8,047,603 		JBrowse link
G ADSS2 adenylosuccinate synthase 2 ISO SMPDB SMP:00430 NCBI chr10:17,220,081...17,259,141
Ensembl chr10:17,220,207...17,259,182 		JBrowse link
G AK1 adenylate kinase 1 ISO SMPDB SMP:00430 NCBI chr 1:268,355,032...268,365,659
Ensembl chr 1:268,355,033...268,365,598 		JBrowse link
G AMPD1 adenosine monophosphate deaminase 1 ISO SMPDB SMP:00430 NCBI chr 4:105,868,834...105,892,171
Ensembl chr 4:105,868,897...105,893,769 		JBrowse link
G AOX1 aldehyde oxidase 1 ISO SMPDB SMP:00430 NCBI chr15:104,157,748...104,234,533
Ensembl chr15:104,157,527...104,236,006 		JBrowse link
G APRT adenine phosphoribosyltransferase ISO SMPDB SMP:00430 NCBI chr 6:890,272...893,278
Ensembl chr 6:890,831...893,276 		JBrowse link
G ATAD1 ATPase family AAA domain containing 1 ISO SMPDB SMP:00430 NCBI chr14:99,802,939...99,885,562
Ensembl chr14:99,815,203...99,885,160 		JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO SMPDB SMP:00430 NCBI chr15:117,617,584...117,649,063
Ensembl chr15:117,617,502...117,649,107 		JBrowse link
G DGUOK deoxyguanosine kinase ISO SMPDB SMP:00430 NCBI chr 3:69,054,749...69,091,366
Ensembl chr 3:69,054,761...69,091,341 		JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) ISO SMPDB SMP:00430 NCBI chr 7:97,270,698...97,316,578
Ensembl chr 7:97,266,824...97,306,981 		JBrowse link
G ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 ISO SMPDB SMP:00430
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO SMPDB SMP:00430 NCBI chr13:197,130,898...197,158,797
Ensembl chr13:197,130,904...197,161,891 		JBrowse link
G GDA guanine deaminase ISO SMPDB SMP:00430 NCBI chr 1:225,425,389...225,589,835
Ensembl chr 1:225,403,138...225,589,827 		JBrowse link
G GMPR guanosine monophosphate reductase ISO SMPDB SMP:00430 NCBI chr 7:12,254,393...12,298,802
Ensembl chr 7:12,254,388...12,299,531 		JBrowse link
G GMPS guanine monophosphate synthase ISO SMPDB SMP:00430 NCBI chr13:95,742,342...95,820,903
Ensembl chr13:95,738,659...95,819,759 		JBrowse link
G GUCY1A2 guanylate cyclase 1 soluble subunit alpha 2 ISO SMPDB SMP:00430 NCBI chr 9:62,101,581...62,510,803
Ensembl chr 9:62,101,613...62,499,581 		JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 ISO SMPDB SMP:00430 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687 		JBrowse link
G GUK1 guanylate kinase 1 ISO SMPDB SMP:00430 NCBI chr 2:51,247,665...51,257,481
Ensembl chr 2:51,241,952...51,257,485 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO SMPDB SMP:00430 NCBI chr  X:110,321,144...110,357,902
Ensembl chr  X:110,321,204...110,357,894 		JBrowse link
G IMPDH1 inosine monophosphate dehydrogenase 1 ISO SMPDB SMP:00430 NCBI chr18:19,979,983...19,996,432
Ensembl chr18:19,979,983...19,996,429 		JBrowse link
G ITPA inosine triphosphatase ISO SMPDB SMP:00430 NCBI chr17:32,458,351...32,474,827
Ensembl chr17:32,455,459...32,474,784 		JBrowse link
G NME6 NME/NM23 nucleoside diphosphate kinase 6 ISO SMPDB SMP:00430 NCBI chr13:31,048,367...31,053,285
Ensembl chr13:31,046,948...31,053,130 		JBrowse link
G NT5C2 5'-nucleotidase, cytosolic II ISO SMPDB SMP:00430 NCBI chr14:114,062,451...114,167,460
Ensembl chr14:114,062,459...114,145,109 		JBrowse link
G NUDT2 nudix hydrolase 2 ISO SMPDB SMP:00430 NCBI chr10:32,450,986...32,466,893
Ensembl chr10:32,451,064...32,466,839 		JBrowse link
G NUDT5 nudix hydrolase 5 ISO SMPDB SMP:00430 NCBI chr10:59,765,444...59,787,773
Ensembl chr10:59,765,703...59,790,157 		JBrowse link
G PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase ISO SMPDB SMP:00430 NCBI chr 8:55,700,700...55,722,982
Ensembl chr 8:55,700,956...55,722,979 		JBrowse link
G PDE10A phosphodiesterase 10A ISO SMPDB SMP:00430 NCBI chr 1:3,120,418...3,394,236
Ensembl chr 1:2,829,411...3,392,651 		JBrowse link
G PDE4D phosphodiesterase 4D ISO SMPDB SMP:00430 NCBI chr16:37,897,300...39,406,534
Ensembl chr16:37,897,302...39,306,364 		JBrowse link
G PFAS phosphoribosylformylglycinamidine synthase ISO SMPDB SMP:00430 NCBI chr12:53,458,401...53,477,254 JBrowse link
G PNP purine nucleoside phosphorylase ISO SMPDB SMP:00430 NCBI chr 7:78,426,838...78,447,029
Ensembl chr 7:78,424,740...78,447,012 		JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase ISO SMPDB SMP:00430 NCBI chr 8:55,652,194...55,701,077
Ensembl chr 8:55,654,377...55,701,077 		JBrowse link
G PRPS1L1 phosphoribosyl pyrophosphate synthetase 1 like 1 ISO SMPDB SMP:00430 NCBI chr 9:87,161,863...87,164,314
Ensembl chr 9:87,163,252...87,164,208 		JBrowse link
G RAC1 Rac family small GTPase 1 ISO SMPDB SMP:00430 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543 		JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO SMPDB SMP:00430 NCBI chr 9:6,026,151...6,065,211
Ensembl chr 9:6,025,073...6,065,143 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO SMPDB SMP:00430 NCBI chr 3:126,357,198...126,367,145
Ensembl chr 3:126,347,819...126,365,644 		JBrowse link
G SLC28A2 solute carrier family 28 member 2 ISO SMPDB SMP:00430 NCBI chr 1:126,472,500...126,511,207
Ensembl chr 1:126,472,525...126,511,095 		JBrowse link
G SLC28A3 solute carrier family 28 member 3 ISO SMPDB SMP:00430 NCBI chr10:30,663,060...30,730,766
Ensembl chr10:30,669,904...30,729,301 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 ISO SMPDB SMP:00430 NCBI chr 7:39,217,974...39,234,683
Ensembl chr 7:39,218,051...39,234,685 		JBrowse link
G SLC29A2 solute carrier family 29 member 2 ISO SMPDB SMP:00430 NCBI chr 2:6,027,287...6,036,280
Ensembl chr 2:6,027,287...6,036,280 		JBrowse link
G TPMT thiopurine S-methyltransferase ISO SMPDB SMP:00430 NCBI chr 7:13,821,656...13,846,107
Ensembl chr 7:13,820,866...13,846,012 		JBrowse link
G TXN thioredoxin ISO SMPDB SMP:00430 NCBI chr 1:251,264,180...251,278,000
Ensembl chr 1:251,263,175...251,277,988 		JBrowse link
G XDH xanthine dehydrogenase ISO SMPDB SMP:00430 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
tioguanine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO SMPDB SMP:00647 NCBI chr  X:110,321,144...110,357,902
Ensembl chr  X:110,321,204...110,357,894 		JBrowse link
trastuzumab pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor ISO SMPDB SMP:00476 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
vinblastine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00436 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00436 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G ABCC10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00436 NCBI chr 7:38,432,720...38,452,689
Ensembl chr 7:38,432,732...38,452,686 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00436 NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00436 NCBI chr12:26,920,764...26,978,389
Ensembl chr12:26,920,821...26,979,602 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO SMPDB SMP:00436 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,354,672...32,363,761 		JBrowse link
G RALBP1 ralA binding protein 1 ISO SMPDB SMP:00436 NCBI chr 6:98,550,925...98,598,945
Ensembl chr 6:98,550,933...98,598,206 		JBrowse link
G TP53 tumor protein p53 ISO SMPDB SMP:00436 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TUBA1B tubulin alpha 1b ISO SMPDB SMP:00436 NCBI chr 5:15,150,229...15,153,620
Ensembl chr 5:15,149,099...15,153,620 		JBrowse link
G TUBB1 tubulin beta 1 class VI ISO SMPDB SMP:00436 NCBI chr17:59,161,420...59,168,385
Ensembl chr17:59,161,420...59,168,385 		JBrowse link
vincristine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00437 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00437 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G ABCC10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00437 NCBI chr 7:38,432,720...38,452,689
Ensembl chr 7:38,432,732...38,452,686 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00437 NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00437 NCBI chr12:26,920,764...26,978,389
Ensembl chr12:26,920,821...26,979,602 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO SMPDB SMP:00437 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,354,672...32,363,761 		JBrowse link
G RALBP1 ralA binding protein 1 ISO SMPDB SMP:00437 NCBI chr 6:98,550,925...98,598,945
Ensembl chr 6:98,550,933...98,598,206 		JBrowse link
G TP53 tumor protein p53 ISO SMPDB SMP:00437 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TUBA1B tubulin alpha 1b ISO SMPDB SMP:00437 NCBI chr 5:15,150,229...15,153,620
Ensembl chr 5:15,149,099...15,153,620 		JBrowse link
G TUBB1 tubulin beta 1 class VI ISO SMPDB SMP:00437 NCBI chr17:59,161,420...59,168,385
Ensembl chr17:59,161,420...59,168,385 		JBrowse link
vindesine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00438 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00438 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G ABCC10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00438 NCBI chr 7:38,432,720...38,452,689
Ensembl chr 7:38,432,732...38,452,686 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00438 NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00438 NCBI chr12:26,920,764...26,978,389
Ensembl chr12:26,920,821...26,979,602 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO SMPDB SMP:00438 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,354,672...32,363,761 		JBrowse link
G RALBP1 ralA binding protein 1 ISO SMPDB SMP:00438 NCBI chr 6:98,550,925...98,598,945
Ensembl chr 6:98,550,933...98,598,206 		JBrowse link
G TP53 tumor protein p53 ISO SMPDB SMP:00438 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TUBA1B tubulin alpha 1b ISO SMPDB SMP:00438 NCBI chr 5:15,150,229...15,153,620
Ensembl chr 5:15,149,099...15,153,620 		JBrowse link
G TUBB1 tubulin beta 1 class VI ISO SMPDB SMP:00438 NCBI chr17:59,161,420...59,168,385
Ensembl chr17:59,161,420...59,168,385 		JBrowse link
vinorelbine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00439 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00439 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G ABCC10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00439 NCBI chr 7:38,432,720...38,452,689
Ensembl chr 7:38,432,732...38,452,686 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00439 NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00439 NCBI chr12:26,920,764...26,978,389
Ensembl chr12:26,920,821...26,979,602 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO SMPDB SMP:00439 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,354,672...32,363,761 		JBrowse link
G RALBP1 ralA binding protein 1 ISO SMPDB SMP:00439 NCBI chr 6:98,550,925...98,598,945
Ensembl chr 6:98,550,933...98,598,206 		JBrowse link
G TP53 tumor protein p53 ISO SMPDB SMP:00439 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TUBA1B tubulin alpha 1b ISO SMPDB SMP:00439 NCBI chr 5:15,150,229...15,153,620
Ensembl chr 5:15,149,099...15,153,620 		JBrowse link
G TUBB1 tubulin beta 1 class VI ISO SMPDB SMP:00439 NCBI chr17:59,161,420...59,168,385
Ensembl chr17:59,161,420...59,168,385 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4044
    drug pathway 384
      antineoplastic and immunomodulatory drug pathway 145
        antineoplastic drug pathway 144
          anti-estrogen drug pathway + 19
          axitinib drug pathway + 7
          bortezomib drug pathway + 0
          capecitabine drug pathway + 4
          cyclophosphamide drug pathway + 4
          docetaxel drug pathway + 7
          doxorubicin drug pathway + 20
          erlotinib drug pathway + 3
          etoposide drug pathway + 18
          everolimus drug pathway + 0
          gefitinib drug pathway + 6
          gemcitabine pathway + 13
          ifosfamide drug pathway + 4
          irinotecan drug pathway + 18
          mercaptopurine drug pathway + 47
          methotrexate drug pathway + 12
          monoclonal antibody drug pathway + 4
          pazopanib drug pathway + 0
          pemetrexed drug pathway + 0
          platinum (Pt) containing drug pathway + 9
          plevitrexed drug pathway + 0
          pralatrexate drug pathway + 0
          sorafenib drug pathway + 11
          sunitinib drug pathway + 0
          temsirolimus drug pathway + 0
          teniposide drug pathway + 3
          tioguanine drug pathway + 47
          vinca alkaloid drug pathway + 10
paths to the root