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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:antineoplastic drug pathway
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Accession:PW:0002367 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of drugs used in the treatment of various cancers. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.

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aromatase inhibitor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 ISO RGD PMID:18695261 RGD:5130880 NCBI chr26:32,074,260...32,164,926
Ensembl chr26:32,132,425...32,164,277 		JBrowse link
axitinib pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT1 fms related receptor tyrosine kinase 1 ISO RGD PMID:22170007 RGD:6907361 NCBI chr 3:7,412,506...7,608,122
Ensembl chr 3:7,412,172...7,607,967 		JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 ISO RGD PMID:22170007 RGD:6907361 NCBI chr23:82,328,257...82,373,785
Ensembl chr23:82,328,258...82,357,044 		JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:22170007 RGD:6907361 NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771 		JBrowse link
axitinib pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO RGD PMID:22170007 RGD:6907361 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 ISO RGD PMID:22170007 RGD:6907361 NCBI chr26:8,727,996...8,733,254 JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 ISO RGD PMID:22170007 RGD:6907361 NCBI chr 9:87,981,300...88,025,007 JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO RGD PMID:22170007 RGD:6907361 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO RGD PMID:22170007 RGD:6907361 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 ISO RGD PMID:22170007 RGD:6907361 NCBI chr11:20,992,353...21,091,761
Ensembl chr11:21,001,655...21,093,278 		JBrowse link
bevacizumab pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT1 fms related receptor tyrosine kinase 1 ISO SMPDB SMP:00420 NCBI chr 3:7,412,506...7,608,122
Ensembl chr 3:7,412,172...7,607,967 		JBrowse link
G KDR kinase insert domain receptor ISO SMPDB SMP:00420 NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO SMPDB SMP:00420 NCBI chr17:28,377,959...28,394,508 JBrowse link
capecitabine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDA cytidine deaminase ISO SMPDB SMP:00469 NCBI chr20:111,931,365...111,960,172
Ensembl chr20:111,931,364...111,960,036 		JBrowse link
G LOC103233018 liver carboxylesterase 1 ISO SMPDB SMP:00469 NCBI chr 5:41,710,500...41,745,483 JBrowse link
G SLC28A1 solute carrier family 28 member 1 ISO SMPDB SMP:00469 NCBI chr29:3,387,226...3,469,461
Ensembl chr29:3,403,685...3,468,626 		JBrowse link
G TYMP thymidine phosphorylase ISO SMPDB SMP:00469 NCBI chr19:32,997,337...33,001,558
Ensembl chr19:32,997,304...33,001,215 		JBrowse link
G TYMS thymidylate synthetase ISO SMPDB SMP:00469 NCBI chr18:60,030,640...60,043,297
Ensembl chr18:60,030,658...60,041,856 		JBrowse link
capecitabine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDA cytidine deaminase ISO SMPDB SMP:00607 NCBI chr20:111,931,365...111,960,172
Ensembl chr20:111,931,364...111,960,036 		JBrowse link
G LOC103233018 liver carboxylesterase 1 ISO SMPDB SMP:00607 NCBI chr 5:41,710,500...41,745,483 JBrowse link
G SLC28A1 solute carrier family 28 member 1 ISO SMPDB SMP:00607 NCBI chr29:3,387,226...3,469,461
Ensembl chr29:3,403,685...3,468,626 		JBrowse link
G TYMP thymidine phosphorylase ISO SMPDB SMP:00607 NCBI chr19:32,997,337...33,001,558
Ensembl chr19:32,997,304...33,001,215 		JBrowse link
G TYMS thymidylate synthetase ISO SMPDB SMP:00607 NCBI chr18:60,030,640...60,043,297
Ensembl chr18:60,030,658...60,041,856 		JBrowse link
cetuximab pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor ISO SMPDB SMP:00474 NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239 		JBrowse link
cisplatin drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATOX1 antioxidant 1 copper chaperone ISO RGD PMID:23936210 RGD:8548474 NCBI chr23:54,306,321...54,312,105 JBrowse link
G ATP7A ATPase copper transporting alpha ISO RGD PMID:22796517 RGD:8548473 NCBI chr  X:66,843,519...66,985,655
Ensembl chr  X:66,843,558...66,985,709 		JBrowse link
G ATP7B ATPase copper transporting beta ISO RGD PMID:22796517 RGD:8548473 NCBI chr 3:29,817,712...29,899,302
Ensembl chr 3:29,816,860...29,899,077 		JBrowse link
G HMGB1 high mobility group box 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G SLC31A1 solute carrier family 31 member 1 ISO RGD PMID:22796517 PMID:23123662 RGD:8548473 RGD:8549769 NCBI chr12:26,307,308...26,348,701
Ensembl chr12:26,311,334...26,348,694 		JBrowse link
G SSRP1 structure specific recognition protein 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr 1:15,907,874...15,918,376
Ensembl chr 1:15,908,495...15,918,596 		JBrowse link
G TBP TATA-box binding protein ISO RGD PMID:20046924 RGD:8548475 NCBI chr13:97,661,905...97,678,640
Ensembl chr13:97,660,864...97,681,497 		JBrowse link
G UBTF upstream binding transcription factor ISO RGD PMID:20046924 RGD:8548475 NCBI chr16:62,168,288...62,184,902
Ensembl chr16:62,171,666...62,182,320 		JBrowse link
G YBX1 Y-box binding protein 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr20:90,229,927...90,250,213 JBrowse link
cyclophosphamide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO SMPDB SMP:00447 NCBI chr12:83,949,529...84,092,452
Ensembl chr12:83,949,399...84,009,003 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 ISO SMPDB SMP:00447 NCBI chr16:18,302,145...18,312,768
Ensembl chr16:18,302,142...18,312,756 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO SMPDB SMP:00447 NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 ISO SMPDB SMP:00447 NCBI chr 9:87,981,300...88,025,007 JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 ISO SMPDB SMP:00447 NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 ISO SMPDB SMP:00447 NCBI chr 9:88,082,124...88,125,390 JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00447 NCBI chr28:13,297,566...13,330,023 JBrowse link
G GSTM1 glutathione S-transferase mu 1 ISO SMPDB SMP:00447 NCBI chr20:23,854,969...23,861,634 JBrowse link
cyclophosphamide pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO SMPDB SMP:00604 NCBI chr12:83,949,529...84,092,452
Ensembl chr12:83,949,399...84,009,003 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 ISO SMPDB SMP:00604 NCBI chr16:18,302,145...18,312,768
Ensembl chr16:18,302,142...18,312,756 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO SMPDB SMP:00604 NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 ISO SMPDB SMP:00604 NCBI chr 9:87,981,300...88,025,007 JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 ISO SMPDB SMP:00604 NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 ISO SMPDB SMP:00604 NCBI chr 9:88,082,124...88,125,390 JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00604 NCBI chr28:13,297,566...13,330,023 JBrowse link
G GSTM1 glutathione S-transferase mu 1 ISO SMPDB SMP:00604 NCBI chr20:23,854,969...23,861,634 JBrowse link
docetaxel pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00435 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00435 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00435 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB SMP:00435 NCBI chr 7:36,458,110...36,599,753 JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 ISO SMPDB SMP:00435 NCBI chr11:20,637,429...20,760,577
Ensembl chr11:20,648,582...20,761,161 		JBrowse link
G TUBA1B tubulin alpha 1b ISO SMPDB SMP:00435 NCBI chr11:45,365,071...45,368,807
Ensembl chr11:45,364,873...45,368,752 		JBrowse link
G TUBB1 tubulin beta 1 class VI ISO SMPDB SMP:00435 NCBI chr 2:5,115,488...5,123,089
Ensembl chr 2:5,117,326...5,122,845 		JBrowse link
doxorubicin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TOP2A DNA topoisomerase II alpha ISO RGD PMID:25895646 RGD:10395260 NCBI chr16:65,761,391...65,792,041
Ensembl chr16:65,761,416...65,792,701 		JBrowse link
G TOP2B DNA topoisomerase II beta ISO RGD PMID:25895646 RGD:10395260 NCBI chr15:70,266,267...70,332,079
Ensembl chr15:70,266,601...70,332,824 		JBrowse link
doxorubicin pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB
RGD		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00650 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO RGD
SMPDB		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO RGD PMID:21048526 RGD:10395261 NCBI chr16:42,646,316...42,703,124
Ensembl chr16:42,646,812...42,702,852 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB
RGD		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr 7:36,458,110...36,599,753 JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 ISO RGD
SMPDB		 PMID:19442138 PMID:21048526 RGD:10395261 RGD:10395262 SMP:00650 NCBI chr20:87,228,348...87,245,511
Ensembl chr20:87,228,189...87,245,466 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 ISO SMPDB
RGD		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr 9:5,237,176...5,254,772 JBrowse link
G CBR3 carbonyl reductase 3 ISO RGD
SMPDB		 PMID:19442138 PMID:21048526 RGD:10395261 RGD:10395262 SMP:00650 NCBI chr 2:80,158,842...80,164,208
Ensembl chr 2:80,158,806...80,164,248 		JBrowse link
G LOC103218526 carbonyl reductase [NADPH] 1 ISO RGD
SMPDB		 PMID:19442138 PMID:21048526 RGD:10395261 RGD:10395262 SMP:00650 NCBI chr 2:80,096,743...80,099,982 JBrowse link
G NDUFS2 NADH:ubiquinone oxidoreductase core subunit S2 ISO SMPDB SMP:00650 NCBI chr20:2,767,864...2,780,336
Ensembl chr20:2,768,064...2,780,704 		JBrowse link
G NDUFS3 NADH:ubiquinone oxidoreductase core subunit S3 ISO SMPDB SMP:00650 NCBI chr 1:17,735,040...17,740,508
Ensembl chr 1:17,733,645...17,745,677 		JBrowse link
G NDUFS7 NADH:ubiquinone oxidoreductase core subunit S7 ISO SMPDB SMP:00650 NCBI chr 6:1,152,380...1,163,488
Ensembl chr 6:1,152,540...1,164,175 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO RGD
SMPDB		 PMID:19442138 RGD:10395262 SMP:00650 NCBI chr21:119,174,829...119,196,840 JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ISO RGD
SMPDB		 PMID:19442138 RGD:10395262 SMP:00650 NCBI chr 5:57,676,547...57,695,434
Ensembl chr 5:57,675,981...57,716,599 		JBrowse link
G POR cytochrome p450 oxidoreductase ISO SMPDB SMP:00650 NCBI chr28:10,145,070...10,230,836
Ensembl chr28:10,197,503...10,230,468 		JBrowse link
G RALBP1 ralA binding protein 1 ISO RGD
SMPDB		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr18:68,353,823...68,415,221
Ensembl chr18:68,391,245...68,413,555 		JBrowse link
G SLC22A16 solute carrier family 22 member 16 ISO RGD
SMPDB		 PMID:21048526 RGD:10395261 SMP:00650 NCBI chr13:63,422,540...63,474,920
Ensembl chr13:63,442,867...63,474,874 		JBrowse link
G XDH xanthine dehydrogenase ISO SMPDB
RGD		 PMID:19442138 RGD:10395262 SMP:00650 NCBI chr14:76,084,693...76,162,840
Ensembl chr14:76,085,368...76,163,936 		JBrowse link
erlotinib pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00472 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB SMP:00472 NCBI chr 7:36,458,110...36,599,753 JBrowse link
G EGFR epidermal growth factor receptor ISO SMPDB SMP:00472 NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239 		JBrowse link
etoposide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00442 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00442 NCBI chr16:42,646,316...42,703,124
Ensembl chr16:42,646,812...42,702,852 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00442 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO SMPDB SMP:00442 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00442 NCBI chr15:2,841,377...2,858,192
Ensembl chr15:2,841,255...2,858,202 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00442 NCBI chr11:107,244,359...107,255,293
Ensembl chr11:107,244,335...107,256,499 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00442 NCBI chr11:99,119,268...99,139,988
Ensembl chr11:99,119,224...99,139,722 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00442 NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00442 NCBI chr 1:110,418,497...110,431,636
Ensembl chr 1:110,417,942...110,431,590 		JBrowse link
G MPO myeloperoxidase ISO SMPDB SMP:00442 NCBI chr16:35,120,194...35,130,851
Ensembl chr16:35,120,581...35,130,671 		JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00442 NCBI chr 5:229,523...233,298
Ensembl chr 5:229,607...233,200 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00442 NCBI chr21:117,574,932...117,601,896
Ensembl chr21:117,574,427...117,601,960 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00442 NCBI chr14:96,801,327...96,828,325
Ensembl chr14:96,801,349...96,828,716 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00442 NCBI chr26:19,380,496...19,399,596 JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00442 NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00442 NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00442 NCBI chr19:4,465,795...4,467,882
Ensembl chr19:4,465,797...4,467,761 		JBrowse link
G TOP2A DNA topoisomerase II alpha ISO SMPDB SMP:00442 NCBI chr16:65,761,391...65,792,041
Ensembl chr16:65,761,416...65,792,701 		JBrowse link
G TOP2B DNA topoisomerase II beta ISO SMPDB SMP:00442 NCBI chr15:70,266,267...70,332,079
Ensembl chr15:70,266,601...70,332,824 		JBrowse link
etoposide pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00601 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00601 NCBI chr16:42,646,316...42,703,124
Ensembl chr16:42,646,812...42,702,852 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00601 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO SMPDB SMP:00601 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00601 NCBI chr15:2,841,377...2,858,192
Ensembl chr15:2,841,255...2,858,202 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00601 NCBI chr11:107,244,359...107,255,293
Ensembl chr11:107,244,335...107,256,499 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00601 NCBI chr11:99,119,268...99,139,988
Ensembl chr11:99,119,224...99,139,722 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00601 NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00601 NCBI chr 1:110,418,497...110,431,636
Ensembl chr 1:110,417,942...110,431,590 		JBrowse link
G MPO myeloperoxidase ISO SMPDB SMP:00601 NCBI chr16:35,120,194...35,130,851
Ensembl chr16:35,120,581...35,130,671 		JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00601 NCBI chr 5:229,523...233,298
Ensembl chr 5:229,607...233,200 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00601 NCBI chr21:117,574,932...117,601,896
Ensembl chr21:117,574,427...117,601,960 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00601 NCBI chr14:96,801,327...96,828,325
Ensembl chr14:96,801,349...96,828,716 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00601 NCBI chr26:19,380,496...19,399,596 JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00601 NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00601 NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00601 NCBI chr19:4,465,795...4,467,882
Ensembl chr19:4,465,797...4,467,761 		JBrowse link
G TOP2A DNA topoisomerase II alpha ISO SMPDB SMP:00601 NCBI chr16:65,761,391...65,792,041
Ensembl chr16:65,761,416...65,792,701 		JBrowse link
G TOP2B DNA topoisomerase II beta ISO SMPDB SMP:00601 NCBI chr15:70,266,267...70,332,079
Ensembl chr15:70,266,601...70,332,824 		JBrowse link
gefitinib pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor ISO SMPDB
RGD		 PMID:19733976 RGD:5135288 SMP:00473 NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239 		JBrowse link
gefitinib pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO RGD PMID:19733976 RGD:5135288 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) ISO RGD PMID:19733976 RGD:5135288 NCBI chr 7:36,458,110...36,599,753 JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO RGD PMID:19733976 RGD:5135288 NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO RGD PMID:19733976 RGD:5135288 NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO RGD PMID:19733976 RGD:5135288 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO RGD PMID:19733976 RGD:5135288 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
gemcitabine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00446 NCBI chr20:85,541,796...85,584,167
Ensembl chr20:85,541,205...85,584,068 		JBrowse link
G CTPS1 CTP synthase 1 ISO SMPDB SMP:00446 NCBI chr20:91,905,452...91,938,188
Ensembl chr20:91,901,771...91,937,819 		JBrowse link
G DCK deoxycytidine kinase ISO SMPDB SMP:00446 NCBI chr 7:19,503,855...19,535,355
Ensembl chr 7:19,504,038...19,535,674 		JBrowse link
G DCTD dCMP deaminase ISO SMPDB SMP:00446 NCBI chr 7:128,874,164...128,902,036
Ensembl chr 7:128,874,117...128,901,910 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00446 NCBI chr16:42,186,039...42,195,608
Ensembl chr16:42,185,260...42,195,616 		JBrowse link
G NT5C 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00446 NCBI chr16:46,531,820...46,533,763
Ensembl chr16:46,532,216...46,535,736 		JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO SMPDB SMP:00446 NCBI chr 1:62,606,112...62,649,979
Ensembl chr 1:62,604,486...62,650,200 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO SMPDB SMP:00446 NCBI chr14:97,512,690...97,519,734
Ensembl chr14:97,512,832...97,521,932 		JBrowse link
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B ISO SMPDB SMP:00446 NCBI chr 8:97,055,111...97,091,980 JBrowse link
G SLC28A1 solute carrier family 28 member 1 ISO SMPDB SMP:00446 NCBI chr29:3,387,226...3,469,461
Ensembl chr29:3,403,685...3,468,626 		JBrowse link
G SLC28A3 solute carrier family 28 member 3 ISO SMPDB SMP:00446 NCBI chr12:95,088,902...95,179,201
Ensembl chr12:95,091,301...95,127,745 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) ISO SMPDB SMP:00446 NCBI chr17:27,934,537...27,949,120
Ensembl chr17:27,931,945...27,949,006 		JBrowse link
G TYMS thymidylate synthetase ISO SMPDB SMP:00446 NCBI chr18:60,030,640...60,043,297
Ensembl chr18:60,030,658...60,041,856 		JBrowse link
gemcitabine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO SMPDB SMP:00603 NCBI chr20:85,541,796...85,584,167
Ensembl chr20:85,541,205...85,584,068 		JBrowse link
G CTPS1 CTP synthase 1 ISO SMPDB SMP:00603 NCBI chr20:91,905,452...91,938,188
Ensembl chr20:91,901,771...91,937,819 		JBrowse link
G DCK deoxycytidine kinase ISO SMPDB SMP:00603 NCBI chr 7:19,503,855...19,535,355
Ensembl chr 7:19,504,038...19,535,674 		JBrowse link
G DCTD dCMP deaminase ISO SMPDB SMP:00603 NCBI chr 7:128,874,164...128,902,036
Ensembl chr 7:128,874,117...128,901,910 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO SMPDB SMP:00603 NCBI chr16:42,186,039...42,195,608
Ensembl chr16:42,185,260...42,195,616 		JBrowse link
G NT5C 5', 3'-nucleotidase, cytosolic ISO SMPDB SMP:00603 NCBI chr16:46,531,820...46,533,763
Ensembl chr16:46,532,216...46,535,736 		JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO SMPDB SMP:00603 NCBI chr 1:62,606,112...62,649,979
Ensembl chr 1:62,604,486...62,650,200 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO SMPDB SMP:00603 NCBI chr14:97,512,690...97,519,734
Ensembl chr14:97,512,832...97,521,932 		JBrowse link
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B ISO SMPDB SMP:00603 NCBI chr 8:97,055,111...97,091,980 JBrowse link
G SLC28A1 solute carrier family 28 member 1 ISO SMPDB SMP:00603 NCBI chr29:3,387,226...3,469,461
Ensembl chr29:3,403,685...3,468,626 		JBrowse link
G SLC28A3 solute carrier family 28 member 3 ISO SMPDB SMP:00603 NCBI chr12:95,088,902...95,179,201
Ensembl chr12:95,091,301...95,127,745 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) ISO SMPDB SMP:00603 NCBI chr17:27,934,537...27,949,120
Ensembl chr17:27,931,945...27,949,006 		JBrowse link
G TYMS thymidylate synthetase ISO SMPDB SMP:00603 NCBI chr18:60,030,640...60,043,297
Ensembl chr18:60,030,658...60,041,856 		JBrowse link
ifosfamide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO SMPDB SMP:00448 NCBI chr12:83,949,529...84,092,452
Ensembl chr12:83,949,399...84,009,003 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 ISO SMPDB SMP:00448 NCBI chr16:18,302,145...18,312,768
Ensembl chr16:18,302,142...18,312,756 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO SMPDB SMP:00448 NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 ISO SMPDB SMP:00448 NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 ISO SMPDB SMP:00448 NCBI chr 9:88,082,124...88,125,390 JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00448 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO SMPDB SMP:00448 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
ifosfamide pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO SMPDB SMP:00605 NCBI chr12:83,949,529...84,092,452
Ensembl chr12:83,949,399...84,009,003 		JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 ISO SMPDB SMP:00605 NCBI chr16:18,302,145...18,312,768
Ensembl chr16:18,302,142...18,312,756 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO SMPDB SMP:00605 NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 ISO SMPDB SMP:00605 NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 ISO SMPDB SMP:00605 NCBI chr 9:88,082,124...88,125,390 JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00605 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO SMPDB SMP:00605 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
irinotecan pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00433 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00433 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00433 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB SMP:00433 NCBI chr 7:36,458,110...36,599,753 JBrowse link
G BCHE butyrylcholinesterase ISO SMPDB SMP:00433 NCBI chr15:23,708,121...23,778,027
Ensembl chr15:23,708,155...23,778,286 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00433 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO SMPDB SMP:00433 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00433 NCBI chr15:2,841,377...2,858,192
Ensembl chr15:2,841,255...2,858,202 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00433 NCBI chr11:107,244,359...107,255,293
Ensembl chr11:107,244,335...107,256,499 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00433 NCBI chr11:99,119,268...99,139,988
Ensembl chr11:99,119,224...99,139,722 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00433 NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00433 NCBI chr 1:110,418,497...110,431,636
Ensembl chr 1:110,417,942...110,431,590 		JBrowse link
G LOC103233018 liver carboxylesterase 1 ISO SMPDB SMP:00433 NCBI chr 5:41,710,500...41,745,483 JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00433 NCBI chr 5:229,523...233,298
Ensembl chr 5:229,607...233,200 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00433 NCBI chr21:117,574,932...117,601,896
Ensembl chr21:117,574,427...117,601,960 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00433 NCBI chr14:96,801,327...96,828,325
Ensembl chr14:96,801,349...96,828,716 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00433 NCBI chr26:19,380,496...19,399,596 JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00433 NCBI chr19:4,465,795...4,467,882
Ensembl chr19:4,465,797...4,467,761 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 ISO SMPDB SMP:00433 NCBI chr11:20,992,353...21,091,761
Ensembl chr11:21,001,655...21,093,278 		JBrowse link
G TOP1 DNA topoisomerase I ISO SMPDB SMP:00433 NCBI chr 2:22,655,085...22,751,082
Ensembl chr 2:22,651,995...22,751,102 		JBrowse link
irinotecan pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00600 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00600 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00600 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB SMP:00600 NCBI chr 7:36,458,110...36,599,753 JBrowse link
G BCHE butyrylcholinesterase ISO SMPDB SMP:00600 NCBI chr15:23,708,121...23,778,027
Ensembl chr15:23,708,155...23,778,286 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00600 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO SMPDB SMP:00600 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00600 NCBI chr15:2,841,377...2,858,192
Ensembl chr15:2,841,255...2,858,202 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00600 NCBI chr11:107,244,359...107,255,293
Ensembl chr11:107,244,335...107,256,499 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00600 NCBI chr11:99,119,268...99,139,988
Ensembl chr11:99,119,224...99,139,722 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00600 NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00600 NCBI chr 1:110,418,497...110,431,636
Ensembl chr 1:110,417,942...110,431,590 		JBrowse link
G LOC103233018 liver carboxylesterase 1 ISO SMPDB SMP:00600 NCBI chr 5:41,710,500...41,745,483 JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00600 NCBI chr 5:229,523...233,298
Ensembl chr 5:229,607...233,200 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00600 NCBI chr21:117,574,932...117,601,896
Ensembl chr21:117,574,427...117,601,960 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00600 NCBI chr14:96,801,327...96,828,325
Ensembl chr14:96,801,349...96,828,716 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00600 NCBI chr26:19,380,496...19,399,596 JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00600 NCBI chr19:4,465,795...4,467,882
Ensembl chr19:4,465,797...4,467,761 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 ISO SMPDB SMP:00600 NCBI chr11:20,992,353...21,091,761
Ensembl chr11:21,001,655...21,093,278 		JBrowse link
G TOP1 DNA topoisomerase I ISO SMPDB SMP:00600 NCBI chr 2:22,655,085...22,751,082
Ensembl chr 2:22,651,995...22,751,102 		JBrowse link
mercaptopurine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00428 NCBI chr 3:73,821,887...74,106,617
Ensembl chr 3:73,821,134...74,106,579 		JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00428 NCBI chr15:5,409,921...5,505,334
Ensembl chr15:5,409,861...5,505,315 		JBrowse link
G ADA adenosine deaminase ISO SMPDB SMP:00428 NCBI chr 2:19,167,209...19,200,233 JBrowse link
G ADCY10 adenylate cyclase 10 ISO SMPDB SMP:00428 NCBI chr25:61,129,837...61,228,180
Ensembl chr25:61,140,293...61,230,117 		JBrowse link
G ADK adenosine kinase ISO SMPDB SMP:00428 NCBI chr 9:56,659,284...57,222,279
Ensembl chr 9:56,660,129...57,222,147 		JBrowse link
G ADSL adenylosuccinate lyase ISO SMPDB SMP:00428 NCBI chr19:22,920,971...22,940,468 JBrowse link
G ADSS2 adenylosuccinate synthase 2 ISO SMPDB SMP:00428 NCBI chr25:81,441,792...81,485,344
Ensembl chr25:81,442,787...81,485,292 		JBrowse link
G AK1 adenylate kinase 1 ISO SMPDB SMP:00428 NCBI chr12:10,251,793...10,261,635
Ensembl chr12:10,256,054...10,261,465 		JBrowse link
G AMPD1 adenosine monophosphate deaminase 1 ISO SMPDB SMP:00428 NCBI chr20:18,973,547...18,996,082
Ensembl chr20:18,974,204...18,996,293 		JBrowse link
G APRT adenine phosphoribosyltransferase ISO SMPDB SMP:00428 NCBI chr 5:74,196,858...74,199,789
Ensembl chr 5:74,194,013...74,199,891 		JBrowse link
G ATAD1 ATPase family AAA domain containing 1 ISO SMPDB SMP:00428 NCBI chr 9:81,197,332...81,285,279 JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO SMPDB SMP:00428 NCBI chr10:101,128,583...101,166,668 JBrowse link
G DGUOK deoxyguanosine kinase ISO SMPDB SMP:00428 NCBI chr14:33,320,957...33,356,088
Ensembl chr14:33,320,969...33,356,093 		JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) ISO SMPDB SMP:00428 NCBI chr24:51,176,137...51,234,575
Ensembl chr24:51,181,859...51,231,078 		JBrowse link
G ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 ISO SMPDB SMP:00428 NCBI chr12:752,258...758,148
Ensembl chr12:752,774...757,614 		JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO SMPDB SMP:00428 NCBI chr 2:58,641,566...58,682,014
Ensembl chr 2:58,643,877...58,683,023 		JBrowse link
G GDA guanine deaminase ISO SMPDB SMP:00428 NCBI chr12:83,195,746...83,305,181
Ensembl chr12:83,195,994...83,306,792 		JBrowse link
G GMPR guanosine monophosphate reductase ISO SMPDB SMP:00428 NCBI chr17:55,843,576...55,893,334
Ensembl chr17:55,840,978...55,893,361 		JBrowse link
G GMPS guanine monophosphate synthase ISO SMPDB SMP:00428 NCBI chr15:34,817,603...34,885,363
Ensembl chr15:34,815,066...34,885,228 		JBrowse link
G GUCY1A2 guanylate cyclase 1 soluble subunit alpha 2 ISO SMPDB SMP:00428 NCBI chr 1:98,108,081...98,439,453 JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 ISO SMPDB SMP:00428 NCBI chr 7:102,332,711...102,381,250
Ensembl chr 7:102,332,719...102,381,251 		JBrowse link
G GUK1 guanylate kinase 1 ISO SMPDB SMP:00428 NCBI chr25:1,579,382...1,587,623
Ensembl chr25:1,579,610...1,587,419 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO SMPDB SMP:00428 NCBI chr  X:109,629,674...109,671,409 JBrowse link
G IMPDH1 inosine monophosphate dehydrogenase 1 ISO SMPDB SMP:00428 NCBI chr21:97,188,835...97,231,871
Ensembl chr21:97,189,481...97,206,726 		JBrowse link
G ITPA inosine triphosphatase ISO SMPDB SMP:00428 NCBI chr 2:33,873,231...33,893,329
Ensembl chr 2:33,873,339...33,893,556 		JBrowse link
G NME6 NME/NM23 nucleoside diphosphate kinase 6 ISO SMPDB SMP:00428 NCBI chr22:9,685,583...9,692,993
Ensembl chr22:9,681,953...9,692,172 		JBrowse link
G NT5C2 5'-nucleotidase, cytosolic II ISO SMPDB SMP:00428 NCBI chr 9:96,133,873...96,325,122
Ensembl chr 9:96,135,400...96,219,956 		JBrowse link
G NUDT2 nudix hydrolase 2 ISO SMPDB SMP:00428 NCBI chr12:46,260,652...46,274,678 JBrowse link
G NUDT5 nudix hydrolase 5 ISO SMPDB SMP:00428 NCBI chr 9:12,218,466...12,247,129 JBrowse link
G PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase ISO SMPDB SMP:00428 NCBI chr 7:12,178,588...12,205,554 JBrowse link
G PDE10A phosphodiesterase 10A ISO SMPDB SMP:00428 NCBI chr13:93,012,027...93,684,349
Ensembl chr13:93,020,696...93,344,369 		JBrowse link
G PDE4D phosphodiesterase 4D ISO SMPDB SMP:00428 NCBI chr 4:55,148,012...56,665,684
Ensembl chr 4:55,153,563...55,390,027 		JBrowse link
G PFAS phosphoribosylformylglycinamidine synthase ISO SMPDB SMP:00428 NCBI chr16:7,618,952...7,639,700
Ensembl chr16:7,623,817...7,638,594 		JBrowse link
G PNP purine nucleoside phosphorylase ISO SMPDB SMP:00428 NCBI chr29:20,992,892...21,001,400
Ensembl chr29:20,993,280...21,001,606 		JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase ISO SMPDB SMP:00428 NCBI chr 7:12,201,434...12,242,418
Ensembl chr 7:12,191,784...12,243,488 		JBrowse link
G PRPS1L1 phosphoribosyl pyrophosphate synthetase 1 like 1 ISO SMPDB SMP:00428 NCBI chr21:40,120,251...40,121,975
Ensembl chr21:40,120,963...40,121,919 		JBrowse link
G RAC1 Rac family small GTPase 1 ISO SMPDB SMP:00428 NCBI chr28:15,583,609...15,610,753
Ensembl chr28:15,583,516...15,610,328 		JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO SMPDB SMP:00428 NCBI chr 1:62,606,112...62,649,979
Ensembl chr 1:62,604,486...62,650,200 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO SMPDB SMP:00428 NCBI chr14:97,512,690...97,519,734
Ensembl chr14:97,512,832...97,521,932 		JBrowse link
G SLC28A2 solute carrier family 28 member 2 ISO SMPDB SMP:00428 NCBI chr26:37,927,200...37,956,729 JBrowse link
G SLC28A3 solute carrier family 28 member 3 ISO SMPDB SMP:00428 NCBI chr12:95,088,902...95,179,201
Ensembl chr12:95,091,301...95,127,745 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) ISO SMPDB SMP:00428 NCBI chr17:27,934,537...27,949,120
Ensembl chr17:27,931,945...27,949,006 		JBrowse link
G SLC29A2 solute carrier family 29 member 2 ISO SMPDB SMP:00428 NCBI chr 1:7,904,813...7,914,344
Ensembl chr 1:7,905,297...7,917,309 		JBrowse link
G TPMT thiopurine S-methyltransferase ISO SMPDB SMP:00428 NCBI chr17:53,987,561...54,012,647
Ensembl chr17:53,987,559...54,014,650 		JBrowse link
G TXN thioredoxin ISO SMPDB SMP:00428 NCBI chr12:29,296,166...29,308,979 JBrowse link
G XDH xanthine dehydrogenase ISO SMPDB SMP:00428 NCBI chr14:76,084,693...76,162,840
Ensembl chr14:76,085,368...76,163,936 		JBrowse link
mercaptopurine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00609 NCBI chr 3:73,821,887...74,106,617
Ensembl chr 3:73,821,134...74,106,579 		JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00609 NCBI chr15:5,409,921...5,505,334
Ensembl chr15:5,409,861...5,505,315 		JBrowse link
G ADK adenosine kinase ISO SMPDB SMP:00609 NCBI chr 9:56,659,284...57,222,279
Ensembl chr 9:56,660,129...57,222,147 		JBrowse link
G GMPS guanine monophosphate synthase ISO SMPDB SMP:00609 NCBI chr15:34,817,603...34,885,363
Ensembl chr15:34,815,066...34,885,228 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO SMPDB SMP:00609 NCBI chr  X:109,629,674...109,671,409 JBrowse link
G IMPDH1 inosine monophosphate dehydrogenase 1 ISO SMPDB SMP:00609 NCBI chr21:97,188,835...97,231,871
Ensembl chr21:97,189,481...97,206,726 		JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase ISO SMPDB SMP:00609 NCBI chr 7:12,201,434...12,242,418
Ensembl chr 7:12,191,784...12,243,488 		JBrowse link
G RAC1 Rac family small GTPase 1 ISO SMPDB SMP:00609 NCBI chr28:15,583,609...15,610,753
Ensembl chr28:15,583,516...15,610,328 		JBrowse link
G SLC28A2 solute carrier family 28 member 2 ISO SMPDB SMP:00609 NCBI chr26:37,927,200...37,956,729 JBrowse link
G SLC28A3 solute carrier family 28 member 3 ISO SMPDB SMP:00609 NCBI chr12:95,088,902...95,179,201
Ensembl chr12:95,091,301...95,127,745 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) ISO SMPDB SMP:00609 NCBI chr17:27,934,537...27,949,120
Ensembl chr17:27,931,945...27,949,006 		JBrowse link
G SLC29A2 solute carrier family 29 member 2 ISO SMPDB SMP:00609 NCBI chr 1:7,904,813...7,914,344
Ensembl chr 1:7,905,297...7,917,309 		JBrowse link
G TPMT thiopurine S-methyltransferase ISO SMPDB SMP:00609 NCBI chr17:53,987,561...54,012,647
Ensembl chr17:53,987,559...54,014,650 		JBrowse link
G XDH xanthine dehydrogenase ISO SMPDB SMP:00609 NCBI chr14:76,084,693...76,162,840
Ensembl chr14:76,085,368...76,163,936 		JBrowse link
methotrexate pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO SMPDB SMP:00432 NCBI chr22:54,848,868...54,933,415
Ensembl chr22:54,848,901...54,934,629 		JBrowse link
G DHFR dihydrofolate reductase ISO SMPDB SMP:00432 NCBI chr 4:74,787,292...74,811,196
Ensembl chr 4:74,787,629...74,810,960 		JBrowse link
G FPGS folylpolyglutamate synthase ISO SMPDB SMP:00432 NCBI chr12:10,316,664...10,329,497
Ensembl chr12:10,317,137...10,335,271 		JBrowse link
G FTCD formimidoyltransferase cyclodeaminase ISO SMPDB SMP:00432 NCBI chr 2:89,761,600...89,778,572
Ensembl chr 2:89,761,248...89,782,238 		JBrowse link
G GGH gamma-glutamyl hydrolase ISO SMPDB SMP:00432 NCBI chr 8:58,908,524...58,932,885
Ensembl chr 8:58,908,417...58,932,685 		JBrowse link
G MTFMT mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00432 NCBI chr26:18,556,747...18,583,528
Ensembl chr26:18,556,791...18,583,446 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO SMPDB SMP:00432 NCBI chr24:41,590,655...41,663,551
Ensembl chr24:41,590,590...41,666,952 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO SMPDB SMP:00432 NCBI chr13:78,306,770...78,539,884
Ensembl chr13:78,306,821...78,477,200 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO SMPDB SMP:00432 NCBI chr14:33,063,485...33,080,703
Ensembl chr14:33,064,542...33,080,366 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO SMPDB SMP:00432 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTHFS methenyltetrahydrofolate synthetase ISO SMPDB SMP:00432 NCBI chr26:3,492,837...3,567,394
Ensembl chr26:3,514,899...3,568,958 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO SMPDB SMP:00432 NCBI chr16:22,164,661...22,173,376
Ensembl chr16:22,166,318...22,173,240 		JBrowse link
panitumumab pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor ISO SMPDB SMP:00475 NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239 		JBrowse link
sorafenib pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO SMPDB SMP:00648 NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 ISO SMPDB SMP:00648 NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 ISO SMPDB SMP:00648 NCBI chr 9:88,082,124...88,125,390 JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00648 NCBI chr28:13,297,566...13,330,023 JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00648 NCBI chr15:2,841,377...2,858,192
Ensembl chr15:2,841,255...2,858,202 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00648 NCBI chr11:107,244,359...107,255,293
Ensembl chr11:107,244,335...107,256,499 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00648 NCBI chr11:99,119,268...99,139,988
Ensembl chr11:99,119,224...99,139,722 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00648 NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00648 NCBI chr 1:110,418,497...110,431,636
Ensembl chr 1:110,417,942...110,431,590 		JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00648 NCBI chr 5:229,523...233,298
Ensembl chr 5:229,607...233,200 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00648 NCBI chr21:117,574,932...117,601,896
Ensembl chr21:117,574,427...117,601,960 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00648 NCBI chr14:96,801,327...96,828,325
Ensembl chr14:96,801,349...96,828,716 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00648 NCBI chr26:19,380,496...19,399,596 JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00648 NCBI chr19:4,465,795...4,467,882
Ensembl chr19:4,465,797...4,467,761 		JBrowse link
tamoxifen pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO SMPDB SMP:00471 NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO SMPDB SMP:00471 NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00471 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO SMPDB SMP:00471 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
G ESR1 estrogen receptor 1 ISO SMPDB
RGD		 PMID:19629072 RGD:5130191 SMP:00471 NCBI chr13:79,153,418...79,554,552
Ensembl chr13:79,270,265...79,554,549 		JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:19629072 RGD:5130191 NCBI chr24:41,426,333...41,513,802
Ensembl chr24:41,447,224...41,512,486 		JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 ISO SMPDB SMP:00471 NCBI chr25:57,781,273...57,819,787
Ensembl chr25:57,782,085...57,819,408 		JBrowse link
G FMO3 flavin containing dimethylaniline monoxygenase 3 ISO SMPDB SMP:00471 NCBI chr25:57,971,737...57,995,850
Ensembl chr25:57,969,234...57,995,613 		JBrowse link
G NCOA3 nuclear receptor coactivator 3 ISO RGD PMID:16822624 RGD:5130718 NCBI chr 2:16,270,218...16,423,381
Ensembl chr 2:16,273,717...16,423,318 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO RGD PMID:16822624 RGD:5130718 NCBI chr16:15,442,315...15,629,411
Ensembl chr16:15,462,640...15,628,512 		JBrowse link
G NCOR2 nuclear receptor corepressor 2 ISO RGD PMID:16822624 RGD:5130718 NCBI chr11:119,675,363...119,917,059
Ensembl chr11:119,676,345...119,917,000 		JBrowse link
G PHB2 prohibitin 2 ISO RGD PMID:16822624 RGD:5130718 NCBI chr11:6,998,517...7,004,437 JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 ISO SMPDB SMP:00471 NCBI chr 5:26,439,618...26,452,997 JBrowse link
tamoxifen pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO RGD PMID:21148080 RGD:5130188 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO RGD PMID:12971802 RGD:5129544 NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 ISO RGD PMID:12971802 RGD:5129544 NCBI chr26:8,727,996...8,733,254 JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO RGD
SMPDB		 PMID:12971802 RGD:5129544 SMP:00606 NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 ISO RGD PMID:12971802 RGD:5129544 NCBI chr 9:87,981,300...88,025,007 JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 ISO RGD PMID:12971802 RGD:5129544 NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 ISO RGD PMID:12971802 RGD:5129544 NCBI chr 9:88,082,124...88,125,390 JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO RGD
SMPDB		 PMID:12971802 RGD:5129544 SMP:00606 NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO RGD
SMPDB		 PMID:12971802 RGD:5129544 SMP:00606 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO RGD
SMPDB		 PMID:12971802 RGD:5129544 SMP:00606 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
G ESR1 estrogen receptor 1 ISO SMPDB SMP:00606 NCBI chr13:79,153,418...79,554,552
Ensembl chr13:79,270,265...79,554,549 		JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 ISO SMPDB SMP:00606 NCBI chr25:57,781,273...57,819,787
Ensembl chr25:57,782,085...57,819,408 		JBrowse link
G FMO3 flavin containing dimethylaniline monoxygenase 3 ISO SMPDB SMP:00606 NCBI chr25:57,971,737...57,995,850
Ensembl chr25:57,969,234...57,995,613 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 ISO RGD
SMPDB		 PMID:19250197 RGD:5129558 SMP:00606 NCBI chr 5:26,439,618...26,452,997 JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 ISO RGD PMID:16099924 PMID:19250197 RGD:5129555 RGD:5129558 NCBI chr 6:41,160,707...41,175,382
Ensembl chr 6:41,159,978...41,175,300 		JBrowse link
teniposide pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00443 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO SMPDB SMP:00443 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
G MPO myeloperoxidase ISO SMPDB SMP:00443 NCBI chr16:35,120,194...35,130,851
Ensembl chr16:35,120,581...35,130,671 		JBrowse link
G TOP2A DNA topoisomerase II alpha ISO SMPDB SMP:00443 NCBI chr16:65,761,391...65,792,041
Ensembl chr16:65,761,416...65,792,701 		JBrowse link
teniposide pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00602 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO SMPDB SMP:00602 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
G MPO myeloperoxidase ISO SMPDB SMP:00602 NCBI chr16:35,120,194...35,130,851
Ensembl chr16:35,120,581...35,130,671 		JBrowse link
G TOP2A DNA topoisomerase II alpha ISO SMPDB SMP:00602 NCBI chr16:65,761,391...65,792,041
Ensembl chr16:65,761,416...65,792,701 		JBrowse link
tioguanine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB SMP:00430 NCBI chr 3:73,821,887...74,106,617
Ensembl chr 3:73,821,134...74,106,579 		JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00430 NCBI chr15:5,409,921...5,505,334
Ensembl chr15:5,409,861...5,505,315 		JBrowse link
G ADA adenosine deaminase ISO SMPDB SMP:00430 NCBI chr 2:19,167,209...19,200,233 JBrowse link
G ADCY10 adenylate cyclase 10 ISO SMPDB SMP:00430 NCBI chr25:61,129,837...61,228,180
Ensembl chr25:61,140,293...61,230,117 		JBrowse link
G ADK adenosine kinase ISO SMPDB SMP:00430 NCBI chr 9:56,659,284...57,222,279
Ensembl chr 9:56,660,129...57,222,147 		JBrowse link
G ADSL adenylosuccinate lyase ISO SMPDB SMP:00430 NCBI chr19:22,920,971...22,940,468 JBrowse link
G ADSS2 adenylosuccinate synthase 2 ISO SMPDB SMP:00430 NCBI chr25:81,441,792...81,485,344
Ensembl chr25:81,442,787...81,485,292 		JBrowse link
G AK1 adenylate kinase 1 ISO SMPDB SMP:00430 NCBI chr12:10,251,793...10,261,635
Ensembl chr12:10,256,054...10,261,465 		JBrowse link
G AMPD1 adenosine monophosphate deaminase 1 ISO SMPDB SMP:00430 NCBI chr20:18,973,547...18,996,082
Ensembl chr20:18,974,204...18,996,293 		JBrowse link
G APRT adenine phosphoribosyltransferase ISO SMPDB SMP:00430 NCBI chr 5:74,196,858...74,199,789
Ensembl chr 5:74,194,013...74,199,891 		JBrowse link
G ATAD1 ATPase family AAA domain containing 1 ISO SMPDB SMP:00430 NCBI chr 9:81,197,332...81,285,279 JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO SMPDB SMP:00430 NCBI chr10:101,128,583...101,166,668 JBrowse link
G DGUOK deoxyguanosine kinase ISO SMPDB SMP:00430 NCBI chr14:33,320,957...33,356,088
Ensembl chr14:33,320,969...33,356,093 		JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) ISO SMPDB SMP:00430 NCBI chr24:51,176,137...51,234,575
Ensembl chr24:51,181,859...51,231,078 		JBrowse link
G ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 ISO SMPDB SMP:00430 NCBI chr12:752,258...758,148
Ensembl chr12:752,774...757,614 		JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO SMPDB SMP:00430 NCBI chr 2:58,641,566...58,682,014
Ensembl chr 2:58,643,877...58,683,023 		JBrowse link
G GDA guanine deaminase ISO SMPDB SMP:00430 NCBI chr12:83,195,746...83,305,181
Ensembl chr12:83,195,994...83,306,792 		JBrowse link
G GMPR guanosine monophosphate reductase ISO SMPDB SMP:00430 NCBI chr17:55,843,576...55,893,334
Ensembl chr17:55,840,978...55,893,361 		JBrowse link
G GMPS guanine monophosphate synthase ISO SMPDB SMP:00430 NCBI chr15:34,817,603...34,885,363
Ensembl chr15:34,815,066...34,885,228 		JBrowse link
G GUCY1A2 guanylate cyclase 1 soluble subunit alpha 2 ISO SMPDB SMP:00430 NCBI chr 1:98,108,081...98,439,453 JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 ISO SMPDB SMP:00430 NCBI chr 7:102,332,711...102,381,250
Ensembl chr 7:102,332,719...102,381,251 		JBrowse link
G GUK1 guanylate kinase 1 ISO SMPDB SMP:00430 NCBI chr25:1,579,382...1,587,623
Ensembl chr25:1,579,610...1,587,419 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO SMPDB SMP:00430 NCBI chr  X:109,629,674...109,671,409 JBrowse link
G IMPDH1 inosine monophosphate dehydrogenase 1 ISO SMPDB SMP:00430 NCBI chr21:97,188,835...97,231,871
Ensembl chr21:97,189,481...97,206,726 		JBrowse link
G ITPA inosine triphosphatase ISO SMPDB SMP:00430 NCBI chr 2:33,873,231...33,893,329
Ensembl chr 2:33,873,339...33,893,556 		JBrowse link
G NME6 NME/NM23 nucleoside diphosphate kinase 6 ISO SMPDB SMP:00430 NCBI chr22:9,685,583...9,692,993
Ensembl chr22:9,681,953...9,692,172 		JBrowse link
G NT5C2 5'-nucleotidase, cytosolic II ISO SMPDB SMP:00430 NCBI chr 9:96,133,873...96,325,122
Ensembl chr 9:96,135,400...96,219,956 		JBrowse link
G NUDT2 nudix hydrolase 2 ISO SMPDB SMP:00430 NCBI chr12:46,260,652...46,274,678 JBrowse link
G NUDT5 nudix hydrolase 5 ISO SMPDB SMP:00430 NCBI chr 9:12,218,466...12,247,129 JBrowse link
G PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase ISO SMPDB SMP:00430 NCBI chr 7:12,178,588...12,205,554 JBrowse link
G PDE10A phosphodiesterase 10A ISO SMPDB SMP:00430 NCBI chr13:93,012,027...93,684,349
Ensembl chr13:93,020,696...93,344,369 		JBrowse link
G PDE4D phosphodiesterase 4D ISO SMPDB SMP:00430 NCBI chr 4:55,148,012...56,665,684
Ensembl chr 4:55,153,563...55,390,027 		JBrowse link
G PFAS phosphoribosylformylglycinamidine synthase ISO SMPDB SMP:00430 NCBI chr16:7,618,952...7,639,700
Ensembl chr16:7,623,817...7,638,594 		JBrowse link
G PNP purine nucleoside phosphorylase ISO SMPDB SMP:00430 NCBI chr29:20,992,892...21,001,400
Ensembl chr29:20,993,280...21,001,606 		JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase ISO SMPDB SMP:00430 NCBI chr 7:12,201,434...12,242,418
Ensembl chr 7:12,191,784...12,243,488 		JBrowse link
G PRPS1L1 phosphoribosyl pyrophosphate synthetase 1 like 1 ISO SMPDB SMP:00430 NCBI chr21:40,120,251...40,121,975
Ensembl chr21:40,120,963...40,121,919 		JBrowse link
G RAC1 Rac family small GTPase 1 ISO SMPDB SMP:00430 NCBI chr28:15,583,609...15,610,753
Ensembl chr28:15,583,516...15,610,328 		JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO SMPDB SMP:00430 NCBI chr 1:62,606,112...62,649,979
Ensembl chr 1:62,604,486...62,650,200 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO SMPDB SMP:00430 NCBI chr14:97,512,690...97,519,734
Ensembl chr14:97,512,832...97,521,932 		JBrowse link
G SLC28A2 solute carrier family 28 member 2 ISO SMPDB SMP:00430 NCBI chr26:37,927,200...37,956,729 JBrowse link
G SLC28A3 solute carrier family 28 member 3 ISO SMPDB SMP:00430 NCBI chr12:95,088,902...95,179,201
Ensembl chr12:95,091,301...95,127,745 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) ISO SMPDB SMP:00430 NCBI chr17:27,934,537...27,949,120
Ensembl chr17:27,931,945...27,949,006 		JBrowse link
G SLC29A2 solute carrier family 29 member 2 ISO SMPDB SMP:00430 NCBI chr 1:7,904,813...7,914,344
Ensembl chr 1:7,905,297...7,917,309 		JBrowse link
G TPMT thiopurine S-methyltransferase ISO SMPDB SMP:00430 NCBI chr17:53,987,561...54,012,647
Ensembl chr17:53,987,559...54,014,650 		JBrowse link
G TXN thioredoxin ISO SMPDB SMP:00430 NCBI chr12:29,296,166...29,308,979 JBrowse link
G XDH xanthine dehydrogenase ISO SMPDB SMP:00430 NCBI chr14:76,084,693...76,162,840
Ensembl chr14:76,085,368...76,163,936 		JBrowse link
tioguanine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO SMPDB SMP:00647 NCBI chr  X:109,629,674...109,671,409 JBrowse link
trastuzumab pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor ISO SMPDB SMP:00476 NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239 		JBrowse link
vinblastine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00436 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00436 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G ABCC10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00436 NCBI chr17:28,705,134...28,730,198
Ensembl chr17:28,705,465...28,725,767 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00436 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00436 NCBI chr16:42,646,316...42,703,124
Ensembl chr16:42,646,812...42,702,852 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO SMPDB SMP:00436 NCBI chr17:35,445,668...35,454,334
Ensembl chr17:35,445,223...35,454,342 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00436 NCBI chr28:13,297,566...13,330,023 JBrowse link
G RALBP1 ralA binding protein 1 ISO SMPDB SMP:00436 NCBI chr18:68,353,823...68,415,221
Ensembl chr18:68,391,245...68,413,555 		JBrowse link
G TP53 tumor protein p53 ISO SMPDB SMP:00436 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
G TUBA1B tubulin alpha 1b ISO SMPDB SMP:00436 NCBI chr11:45,365,071...45,368,807
Ensembl chr11:45,364,873...45,368,752 		JBrowse link
G TUBB1 tubulin beta 1 class VI ISO SMPDB SMP:00436 NCBI chr 2:5,115,488...5,123,089
Ensembl chr 2:5,117,326...5,122,845 		JBrowse link
vincristine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00437 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00437 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G ABCC10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00437 NCBI chr17:28,705,134...28,730,198
Ensembl chr17:28,705,465...28,725,767 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00437 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00437 NCBI chr16:42,646,316...42,703,124
Ensembl chr16:42,646,812...42,702,852 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO SMPDB SMP:00437 NCBI chr17:35,445,668...35,454,334
Ensembl chr17:35,445,223...35,454,342 		JBrowse link
G RALBP1 ralA binding protein 1 ISO SMPDB SMP:00437 NCBI chr18:68,353,823...68,415,221
Ensembl chr18:68,391,245...68,413,555 		JBrowse link
G TP53 tumor protein p53 ISO SMPDB SMP:00437 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
G TUBA1B tubulin alpha 1b ISO SMPDB SMP:00437 NCBI chr11:45,365,071...45,368,807
Ensembl chr11:45,364,873...45,368,752 		JBrowse link
G TUBB1 tubulin beta 1 class VI ISO SMPDB SMP:00437 NCBI chr 2:5,115,488...5,123,089
Ensembl chr 2:5,117,326...5,122,845 		JBrowse link
vindesine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00438 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00438 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G ABCC10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00438 NCBI chr17:28,705,134...28,730,198
Ensembl chr17:28,705,465...28,725,767 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00438 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00438 NCBI chr16:42,646,316...42,703,124
Ensembl chr16:42,646,812...42,702,852 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO SMPDB SMP:00438 NCBI chr17:35,445,668...35,454,334
Ensembl chr17:35,445,223...35,454,342 		JBrowse link
G RALBP1 ralA binding protein 1 ISO SMPDB SMP:00438 NCBI chr18:68,353,823...68,415,221
Ensembl chr18:68,391,245...68,413,555 		JBrowse link
G TP53 tumor protein p53 ISO SMPDB SMP:00438 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
G TUBA1B tubulin alpha 1b ISO SMPDB SMP:00438 NCBI chr11:45,365,071...45,368,807
Ensembl chr11:45,364,873...45,368,752 		JBrowse link
G TUBB1 tubulin beta 1 class VI ISO SMPDB SMP:00438 NCBI chr 2:5,115,488...5,123,089
Ensembl chr 2:5,117,326...5,122,845 		JBrowse link
vinorelbine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00439 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00439 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567 		JBrowse link
G ABCC10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00439 NCBI chr17:28,705,134...28,730,198
Ensembl chr17:28,705,465...28,725,767 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00439 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00439 NCBI chr16:42,646,316...42,703,124
Ensembl chr16:42,646,812...42,702,852 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO SMPDB SMP:00439 NCBI chr17:35,445,668...35,454,334
Ensembl chr17:35,445,223...35,454,342 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00439 NCBI chr28:13,297,566...13,330,023 JBrowse link
G RALBP1 ralA binding protein 1 ISO SMPDB SMP:00439 NCBI chr18:68,353,823...68,415,221
Ensembl chr18:68,391,245...68,413,555 		JBrowse link
G TP53 tumor protein p53 ISO SMPDB SMP:00439 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
G TUBA1B tubulin alpha 1b ISO SMPDB SMP:00439 NCBI chr11:45,365,071...45,368,807
Ensembl chr11:45,364,873...45,368,752 		JBrowse link
G TUBB1 tubulin beta 1 class VI ISO SMPDB SMP:00439 NCBI chr 2:5,115,488...5,123,089
Ensembl chr 2:5,117,326...5,122,845 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4046
    drug pathway 388
      antineoplastic and immunomodulatory drug pathway 149
        antineoplastic drug pathway 148
          anti-estrogen drug pathway + 21
          axitinib drug pathway + 9
          bortezomib drug pathway + 0
          capecitabine drug pathway + 5
          cyclophosphamide drug pathway + 8
          docetaxel drug pathway + 7
          doxorubicin drug pathway + 20
          erlotinib drug pathway + 3
          etoposide drug pathway + 19
          everolimus drug pathway + 0
          gefitinib drug pathway + 7
          gemcitabine pathway + 13
          ifosfamide drug pathway + 7
          irinotecan drug pathway + 20
          mercaptopurine drug pathway + 46
          methotrexate drug pathway + 12
          monoclonal antibody drug pathway + 4
          pazopanib drug pathway + 0
          pemetrexed drug pathway + 0
          platinum (Pt) containing drug pathway + 9
          plevitrexed drug pathway + 0
          pralatrexate drug pathway + 0
          sorafenib drug pathway + 14
          sunitinib drug pathway + 0
          temsirolimus drug pathway + 0
          teniposide drug pathway + 4
          tioguanine drug pathway + 46
          vinca alkaloid drug pathway + 11
paths to the root