Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:indometacin pharmacodynamics pathway
go back to main search page
Accession:PW:0002305 term browser browse the term
Definition:The pathway of indometacin-target interaction and of the biochemical or physiological responses to drug. Indometcin is an inhibitor of cyclooxygenase enzymes used in the treatment of pain and inflammation and to reduce fever. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00104


show annotations for term's descendants           Sort by:
indometacin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 ISO SMPDB SMP:00104 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00104 NCBI chr10:55,456,923...55,469,239
Ensembl chr10:55,456,928...55,469,199 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00104 NCBI chr10:54,361,898...54,373,776
Ensembl chr10:54,361,898...54,373,776 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00104 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B ISO SMPDB SMP:00104 NCBI chr10:54,391,331...54,400,648
Ensembl chr10:54,391,302...54,400,648 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00104 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126 		JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB SMP:00104 NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 ISO SMPDB SMP:00104 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 ISO SMPDB SMP:00104
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO SMPDB SMP:00104 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 ISO SMPDB SMP:00104 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042 		JBrowse link
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 ISO SMPDB SMP:00104 NCBI chr 2:222,523,516...222,541,055
Ensembl chr 2:222,523,518...222,541,124 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 ISO SMPDB SMP:00104 NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,740,001...17,838,958 		JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 ISO SMPDB SMP:00104 NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,680,806...12,708,402 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO SMPDB SMP:00104 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00104 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO SMPDB SMP:00104 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO SMPDB SMP:00104 NCBI chr 7:29,856,846...29,888,642
Ensembl chr 7:29,856,802...29,888,641 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO SMPDB SMP:00104 NCBI chr10:35,060,002...35,066,466
Ensembl chr10:35,061,437...35,063,768 		JBrowse link
G Pla2g2a phospholipase A2 group IIA ISO SMPDB SMP:00104 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297 		JBrowse link
G Pla2g4b phospholipase A2 group IVB ISO SMPDB SMP:00104 NCBI chr 3:127,458,022...127,467,637
Ensembl chr 3:127,459,273...127,467,637 		JBrowse link
G Prxl2b peroxiredoxin like 2B ISO SMPDB SMP:00104 NCBI chr 5:170,744,953...170,747,556
Ensembl chr 5:170,744,953...170,747,556 		JBrowse link
G Ptgds prostaglandin D2 synthase ISO SMPDB SMP:00104 NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978 		JBrowse link
G Ptges prostaglandin E synthase ISO SMPDB SMP:00104 NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO SMPDB SMP:00104 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00104 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00104 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Tbxas1 thromboxane A synthase 1 ISO SMPDB SMP:00104 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6090
    drug pathway 397
      musculo-skeletal system drug pathway 69
        indometacin drug pathway 28
          indometacin pharmacodynamics pathway 28
Path 2
Term Annotations click to browse term
  pathway 6090
    drug pathway 397
      nervous system drug pathway 183
        analgesic and/or antipyretic drug pathway 97
          indometacin drug pathway 28
            indometacin pharmacodynamics pathway 28
paths to the root