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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:naloxone pharmacodynamics pathway
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Accession:PW:0002284 term browser browse the term
Definition:The pathway of naloxone-target interaction and of the biochemical or physiological responses to drug. Naloxone is a mu-opioid receptor competitive antagonist. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00688


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naloxone pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISO SMPDB SMP:00688 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00688 NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO SMPDB SMP:00688 NCBI chr13:87,261,964...87,286,911
Ensembl chr13:87,261,968...87,286,911 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00688 NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:89,700,649...89,729,825 		JBrowse link
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 ISO SMPDB SMP:00688 NCBI chr13:87,216,139...87,252,155
Ensembl chr13:87,216,139...87,251,724 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00688 NCBI chr13:79,319,708...79,340,226
Ensembl chr13:79,319,706...79,340,549 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00688 NCBI chr10:54,817,473...54,823,708
Ensembl chr10:54,817,476...54,823,708 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00688 NCBI chr 8:105,789,824...105,821,151
Ensembl chr 8:65,253,361...65,254,304
Ensembl chr 8:65,253,361...65,254,304 		JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00688 NCBI chr  X:121,952,923...121,974,146
Ensembl chr  X:121,923,061...121,973,654 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO SMPDB SMP:00688 NCBI chr19:40,425,560...40,724,810
Ensembl chr19:40,425,560...40,724,599 		JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00688 NCBI chr 8:116,950,860...117,082,159
Ensembl chr 8:116,950,907...117,081,759 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00688 NCBI chr10:83,494,509...83,515,164
Ensembl chr10:83,494,509...83,515,146 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit ISO SMPDB SMP:00688 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO SMPDB SMP:00688 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326 		JBrowse link
G Drd1 dopamine receptor D1 ISO SMPDB SMP:00688 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166 		JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 ISO SMPDB SMP:00688 NCBI chr 8:54,609,658...54,616,788
Ensembl chr 8:54,609,658...54,616,957 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO SMPDB SMP:00688 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO SMPDB SMP:00688 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A ISO SMPDB SMP:00688 NCBI chr 5:68,802,333...69,001,880
Ensembl chr 5:68,804,970...69,001,558 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO SMPDB SMP:00688 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760 		JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 ISO SMPDB SMP:00688 NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:50,742,839...51,243,522 		JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00688 NCBI chr 1:254,590,172...254,614,437
Ensembl chr 1:254,590,175...254,613,898 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO SMPDB SMP:00688 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO SMPDB SMP:00688 NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:151,333,234...151,638,849 		JBrowse link
G Pomc proopiomelanocortin ISO SMPDB SMP:00688 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO SMPDB SMP:00688 NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:128,228,424...128,340,298 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 ISO SMPDB SMP:00688 NCBI chr 1:95,481,298...95,491,211
Ensembl chr 1:95,481,298...95,491,197 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 ISO SMPDB SMP:00688 NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO SMPDB SMP:00688 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO SMPDB SMP:00688 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      various drug pathway 30
        naloxone drug pathway 30
          naloxone pharmacodynamics pathway 30
paths to the root