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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:capecitabine drug pathway
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Accession:PW:0002131 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of capecitabine, an agent used in the treatment of several cancers. Capecitabine is a prodrug that is enzymatically converted to 5-fluorouracil which inhibits the activity of thymidylate synthase necessary for the de novo DNA synthesis. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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capecitabine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cda cytidine deaminase ISO SMPDB SMP:00469 NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231 		JBrowse link
G Ces1d carboxylesterase 1D ISO SMPDB SMP:00469 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Slc28a1 solute carrier family 28 member 1 ISO SMPDB SMP:00469 NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464 		JBrowse link
G Tymp thymidine phosphorylase ISO SMPDB SMP:00469 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Tyms thymidylate synthetase ISO SMPDB SMP:00469 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
capecitabine pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cda cytidine deaminase ISO SMPDB SMP:00607 NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231 		JBrowse link
G Ces1d carboxylesterase 1D ISO SMPDB SMP:00607 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Slc28a1 solute carrier family 28 member 1 ISO SMPDB SMP:00607 NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464 		JBrowse link
G Tymp thymidine phosphorylase ISO SMPDB SMP:00607 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Tyms thymidylate synthetase ISO SMPDB SMP:00607 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      antineoplastic and immunomodulatory drug pathway 156
        antineoplastic drug pathway 154
          capecitabine drug pathway 5
            capecitabine pharmacodynamics pathway 5
            capecitabine pharmacokinetics pathway 5
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