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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:docetaxel drug pathway
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Accession:PW:0001768 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of docetaxel - an antineoplastiic agent. It is an anti-mitotic drug whose cytotoxicity affects tumor cells but can also extend to other dividing cells. In some cases, the drug could cause severe side effects and deaths due to its toxicity have been reported. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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docetaxel pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB SMP:00435 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00435 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00435 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 ISO SMPDB SMP:00435 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 ISO SMPDB SMP:00435 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Tuba1b tubulin, alpha 1B ISO SMPDB SMP:00435 NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tubb1 tubulin, beta 1 class VI ISO SMPDB SMP:00435 NCBI chr 3:183,666,189...183,675,656
Ensembl chr 3:163,247,967...163,256,063 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      antineoplastic and immunomodulatory drug pathway 156
        antineoplastic drug pathway 154
          docetaxel drug pathway 7
            docetaxel pharmacodynamics pathway 7
            docetaxel pharmacokinetics pathway 0
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