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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:vinca alkaloid drug pathway
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Accession:PW:0001672 term browser browse the term
Definition:Vinca alkaloids are anti-mitotic and anti-microtubule agents originally derived from plants and also produced as semisynthetic compounds. They have a hypoglycemic and cytotoxic effects and are widely used as cancer drugs.


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vinblastine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB SMP:00436 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00436 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00436 NCBI chr 9:22,154,811...22,174,743
Ensembl chr 9:14,657,264...14,677,178 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00436 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00436 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO SMPDB SMP:00436 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00436 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ralbp1 ralA binding protein 1 ISO SMPDB SMP:00436 NCBI chr 9:112,903,289...112,940,093
Ensembl chr 9:105,456,425...105,492,707 		JBrowse link
G Tp53 tumor protein p53 ISO SMPDB SMP:00436 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tuba1b tubulin, alpha 1B ISO SMPDB SMP:00436 NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tubb1 tubulin, beta 1 class VI ISO SMPDB SMP:00436 NCBI chr 3:183,666,189...183,675,656
Ensembl chr 3:163,247,967...163,256,063 		JBrowse link
vincristine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB SMP:00437 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00437 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00437 NCBI chr 9:22,154,811...22,174,743
Ensembl chr 9:14,657,264...14,677,178 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00437 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00437 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO SMPDB SMP:00437 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ralbp1 ralA binding protein 1 ISO SMPDB SMP:00437 NCBI chr 9:112,903,289...112,940,093
Ensembl chr 9:105,456,425...105,492,707 		JBrowse link
G Tp53 tumor protein p53 ISO SMPDB SMP:00437 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tuba1b tubulin, alpha 1B ISO SMPDB SMP:00437 NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tubb1 tubulin, beta 1 class VI ISO SMPDB SMP:00437 NCBI chr 3:183,666,189...183,675,656
Ensembl chr 3:163,247,967...163,256,063 		JBrowse link
vindesine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB SMP:00438 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00438 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00438 NCBI chr 9:22,154,811...22,174,743
Ensembl chr 9:14,657,264...14,677,178 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00438 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00438 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO SMPDB SMP:00438 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ralbp1 ralA binding protein 1 ISO SMPDB SMP:00438 NCBI chr 9:112,903,289...112,940,093
Ensembl chr 9:105,456,425...105,492,707 		JBrowse link
G Tp53 tumor protein p53 ISO SMPDB SMP:00438 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tuba1b tubulin, alpha 1B ISO SMPDB SMP:00438 NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tubb1 tubulin, beta 1 class VI ISO SMPDB SMP:00438 NCBI chr 3:183,666,189...183,675,656
Ensembl chr 3:163,247,967...163,256,063 		JBrowse link
vinorelbine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB SMP:00439 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00439 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 ISO SMPDB SMP:00439 NCBI chr 9:22,154,811...22,174,743
Ensembl chr 9:14,657,264...14,677,178 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00439 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO SMPDB SMP:00439 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO SMPDB SMP:00439 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00439 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ralbp1 ralA binding protein 1 ISO SMPDB SMP:00439 NCBI chr 9:112,903,289...112,940,093
Ensembl chr 9:105,456,425...105,492,707 		JBrowse link
G Tp53 tumor protein p53 ISO SMPDB SMP:00439 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tuba1b tubulin, alpha 1B ISO SMPDB SMP:00439 NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tubb1 tubulin, beta 1 class VI ISO SMPDB SMP:00439 NCBI chr 3:183,666,189...183,675,656
Ensembl chr 3:163,247,967...163,256,063 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      antineoplastic and immunomodulatory drug pathway 156
        antineoplastic drug pathway 154
          vinca alkaloid drug pathway 11
            vinblastine drug pathway + 11
            vincristine drug pathway + 10
            vindesine drug pathway + 10
            vinorelbine drug pathway + 11
paths to the root