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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:nitrogenous bisphosphonate pharmacodynamics pathway
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Accession:PW:0001624 term browser browse the term
Definition:The pathway of nitrogenous bisphosphonate-target interaction and of the biochemical or physiological responses to them. They include alendronate, ibandronate, pamidronate or risedronate. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00079;   SMP:00095;   SMP:00112;   SMP:00117


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nitrogenous bisphosphonate pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095 		JBrowse link
G Cyp51 cytochrome P450, family 51 ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr  X:16,971,372...16,977,782
Ensembl chr  X:16,971,405...16,977,781 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168 		JBrowse link
G Fdps farnesyl diphosphate synthase ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136 		JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr17:55,958,750...55,982,762
Ensembl chr17:55,958,755...55,971,709 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Lipa lipase A, lysosomal acid type ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740 		JBrowse link
G Lss lanosterol synthase ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366 		JBrowse link
G Mvk mevalonate kinase ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503 		JBrowse link
G Nsdhl NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr  X:155,817,301...155,848,224
Ensembl chr  X:155,817,340...155,848,220 		JBrowse link
G Pmvk phosphomevalonate kinase ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr 2:177,174,344...177,184,076
Ensembl chr 2:177,174,335...177,184,080 		JBrowse link
G Sc5d sterol-C5-desaturase ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277 		JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr13:71,105,178...71,147,776
Ensembl chr13:71,105,178...71,147,672 		JBrowse link
G Sqle squalene epoxidase ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 ISO SMPDB SMP:00079 SMP:00095 SMP:00112 SMP:00117 NCBI chr 1:212,785,217...212,789,572
Ensembl chr 1:212,785,217...212,789,557 		JBrowse link
alendronate pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 ISO SMPDB SMP:00095 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095 		JBrowse link
G Cyp51 cytochrome P450, family 51 ISO SMPDB SMP:00095 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase ISO SMPDB SMP:00095 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase ISO SMPDB SMP:00095 NCBI chr  X:16,971,372...16,977,782
Ensembl chr  X:16,971,405...16,977,781 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 ISO SMPDB SMP:00095 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168 		JBrowse link
G Fdps farnesyl diphosphate synthase ISO SMPDB SMP:00095 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136 		JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 ISO SMPDB SMP:00095 NCBI chr17:55,958,750...55,982,762
Ensembl chr17:55,958,755...55,971,709 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO SMPDB SMP:00095 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 ISO SMPDB SMP:00095 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 ISO SMPDB SMP:00095 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 ISO SMPDB SMP:00095 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Lipa lipase A, lysosomal acid type ISO SMPDB SMP:00095 NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740 		JBrowse link
G Lss lanosterol synthase ISO SMPDB SMP:00095 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 ISO SMPDB SMP:00095 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase ISO SMPDB SMP:00095 NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366 		JBrowse link
G Mvk mevalonate kinase ISO SMPDB SMP:00095 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503 		JBrowse link
G Nsdhl NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL ISO SMPDB SMP:00095 NCBI chr  X:155,817,301...155,848,224
Ensembl chr  X:155,817,340...155,848,220 		JBrowse link
G Pmvk phosphomevalonate kinase ISO SMPDB SMP:00095 NCBI chr 2:177,174,344...177,184,076
Ensembl chr 2:177,174,335...177,184,080 		JBrowse link
G Sc5d sterol-C5-desaturase ISO SMPDB SMP:00095 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277 		JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO SMPDB SMP:00095 NCBI chr13:71,105,178...71,147,776
Ensembl chr13:71,105,178...71,147,672 		JBrowse link
G Sqle squalene epoxidase ISO SMPDB SMP:00095 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 ISO SMPDB SMP:00095 NCBI chr 1:212,785,217...212,789,572
Ensembl chr 1:212,785,217...212,789,557 		JBrowse link
pamidronate pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 ISO SMPDB SMP:00117 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095 		JBrowse link
G Cyp51 cytochrome P450, family 51 ISO SMPDB SMP:00117 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase ISO SMPDB SMP:00117 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase ISO SMPDB SMP:00117 NCBI chr  X:16,971,372...16,977,782
Ensembl chr  X:16,971,405...16,977,781 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 ISO SMPDB SMP:00117 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168 		JBrowse link
G Fdps farnesyl diphosphate synthase ISO SMPDB SMP:00117 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136 		JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 ISO SMPDB SMP:00117 NCBI chr17:55,958,750...55,982,762
Ensembl chr17:55,958,755...55,971,709 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO SMPDB SMP:00117 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 ISO SMPDB SMP:00117 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 ISO SMPDB SMP:00117 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 ISO SMPDB SMP:00117 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Lipa lipase A, lysosomal acid type ISO SMPDB SMP:00117 NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740 		JBrowse link
G Lss lanosterol synthase ISO SMPDB SMP:00117 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 ISO SMPDB SMP:00117 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase ISO SMPDB SMP:00117 NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366 		JBrowse link
G Mvk mevalonate kinase ISO SMPDB SMP:00117 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503 		JBrowse link
G Nsdhl NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL ISO SMPDB SMP:00117 NCBI chr  X:155,817,301...155,848,224
Ensembl chr  X:155,817,340...155,848,220 		JBrowse link
G Pmvk phosphomevalonate kinase ISO SMPDB SMP:00117 NCBI chr 2:177,174,344...177,184,076
Ensembl chr 2:177,174,335...177,184,080 		JBrowse link
G Sc5d sterol-C5-desaturase ISO SMPDB SMP:00117 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277 		JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO SMPDB SMP:00117 NCBI chr13:71,105,178...71,147,776
Ensembl chr13:71,105,178...71,147,672 		JBrowse link
G Sqle squalene epoxidase ISO SMPDB SMP:00117 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 ISO SMPDB SMP:00117 NCBI chr 1:212,785,217...212,789,572
Ensembl chr 1:212,785,217...212,789,557 		JBrowse link
risedronate pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 ISO SMPDB SMP:00112 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095 		JBrowse link
G Cyp51 cytochrome P450, family 51 ISO SMPDB SMP:00112 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase ISO SMPDB SMP:00112 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase ISO SMPDB SMP:00112 NCBI chr  X:16,971,372...16,977,782
Ensembl chr  X:16,971,405...16,977,781 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 ISO SMPDB SMP:00112 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168 		JBrowse link
G Fdps farnesyl diphosphate synthase ISO SMPDB SMP:00112 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136 		JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 ISO SMPDB SMP:00112 NCBI chr17:55,958,750...55,982,762
Ensembl chr17:55,958,755...55,971,709 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO SMPDB SMP:00112 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 ISO SMPDB SMP:00112 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 ISO SMPDB SMP:00112 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 ISO SMPDB SMP:00112 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Lipa lipase A, lysosomal acid type ISO SMPDB SMP:00112 NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740 		JBrowse link
G Lss lanosterol synthase ISO SMPDB SMP:00112 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 ISO SMPDB SMP:00112 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase ISO SMPDB SMP:00112 NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366 		JBrowse link
G Mvk mevalonate kinase ISO SMPDB SMP:00112 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503 		JBrowse link
G Nsdhl NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL ISO SMPDB SMP:00112 NCBI chr  X:155,817,301...155,848,224
Ensembl chr  X:155,817,340...155,848,220 		JBrowse link
G Pmvk phosphomevalonate kinase ISO SMPDB SMP:00112 NCBI chr 2:177,174,344...177,184,076
Ensembl chr 2:177,174,335...177,184,080 		JBrowse link
G Sc5d sterol-C5-desaturase ISO SMPDB SMP:00112 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277 		JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO SMPDB SMP:00112 NCBI chr13:71,105,178...71,147,776
Ensembl chr13:71,105,178...71,147,672 		JBrowse link
G Sqle squalene epoxidase ISO SMPDB SMP:00112 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 ISO SMPDB SMP:00112 NCBI chr 1:212,785,217...212,789,572
Ensembl chr 1:212,785,217...212,789,557 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      musculo-skeletal system drug pathway 69
        bisphosphonate drug pathway 22
          nitrogenous bisphosphonate drug pathway 22
            nitrogenous bisphosphonate pharmacodynamics pathway 22
              alendronate pharmacodynamics pathway 22
              ibandronate pharmacokinetics pathway 0
              pamidronate pharmacodynamics pathway 22
              risedronate pharmacodynamics pathway 22
paths to the root