PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: doxorubicin pharmacokinetics pathway
Accession: PW:0001565
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Definition: The pathway of processing - absorption, distribution, metabolism or elimination - of doxorubicin. Doxorubicin is used as a chemotherapeutic agent for the treatment of various cancers. Its use is limited by the serious cardiotoxic side effects it exerts. Genetic variations can result in changes in the availability of the drug.
Synonyms: related_synonym: SMP:00650
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Abcb1
ATP binding cassette subfamily B member 1
ISO
SMPDB RGD
PMID:21048526
RGD:10395261 SMP:00650
NCBI chrNW_004955432:4,911,774...5,085,349
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Abcc1
ATP binding cassette subfamily C member 1 (ABCC1 blood group)
ISO
SMPDB
SMP:00650
NCBI chrNW_004955442:729,322...858,826
Ensembl chrNW_004955442:729,316...860,290
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Abcc2
ATP binding cassette subfamily C member 2
ISO
SMPDB RGD
PMID:21048526
RGD:10395261 SMP:00650
NCBI chrNW_004955507:5,724,788...5,791,281
Ensembl chrNW_004955507:5,724,762...5,790,812
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Abcc3
ATP binding cassette subfamily C member 3
ISO
RGD
PMID:21048526
RGD:10395261
NCBI chrNW_004955451:11,087,246...11,130,108
Ensembl chrNW_004955451:11,087,570...11,130,482
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Abcg2
ATP binding cassette subfamily G member 2 (JR blood group)
ISO
SMPDB RGD
PMID:21048526
RGD:10395261 SMP:00650
NCBI chrNW_004955474:12,365,903...12,408,715
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Akr1a1
aldo-keto reductase family 1 member A1
ISO
SMPDB RGD
PMID:19442138 PMID:21048526
RGD:10395261 RGD:10395262 SMP:00650
NCBI chrNW_004955464:12,715,238...12,729,034
Ensembl chrNW_004955464:12,714,717...12,729,662
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Cbr1
carbonyl reductase 1
ISO
SMPDB RGD
PMID:19442138 PMID:21048526
RGD:10395261 RGD:10395262 SMP:00650
NCBI chrNW_004955407:35,351,601...35,354,510
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Cbr3
carbonyl reductase 3
ISO
SMPDB RGD
PMID:19442138 PMID:21048526
RGD:10395261 RGD:10395262 SMP:00650
NCBI chrNW_004955407:35,419,674...35,428,270
Ensembl chrNW_004955407:35,419,674...35,428,270
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Ndufs2
NADH:ubiquinone oxidoreductase core subunit S2
ISO
SMPDB
SMP:00650
NCBI chrNW_004955468:12,961,873...12,971,278
Ensembl chrNW_004955468:12,961,915...12,971,095
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Ndufs3
NADH:ubiquinone oxidoreductase core subunit S3
ISO
SMPDB
SMP:00650
NCBI chrNW_004955422:713,370...717,926
Ensembl chrNW_004955422:709,784...717,926
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Ndufs7
NADH:ubiquinone oxidoreductase core subunit S7
ISO
SMPDB
SMP:00650
NCBI chrNW_004955495:6,540,360...6,548,072
Ensembl chrNW_004955495:6,540,450...6,547,975
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Nos3
nitric oxide synthase 3
ISO
SMPDB RGD
PMID:19442138
RGD:10395262 SMP:00650
NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
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Nqo1
NAD(P)H quinone dehydrogenase 1
ISO
SMPDB RGD
PMID:19442138
RGD:10395262 SMP:00650
NCBI chrNW_004955484:7,012,373...7,028,182
Ensembl chrNW_004955484:7,012,506...7,027,604
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Por
P450 (cytochrome) oxidoreductase
ISO
SMPDB
SMP:00650
NCBI chrNW_004955456:14,698,589...14,748,520
Ensembl chrNW_004955456:14,698,589...14,748,520
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Ralbp1
ralA binding protein 1
ISO
SMPDB RGD
PMID:21048526
RGD:10395261 SMP:00650
NCBI chrNW_004955402:2,571,672...2,616,040
Ensembl chrNW_004955402:2,569,637...2,616,040
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all