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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:doxorubicin pharmacokinetics pathway
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Accession:PW:0001565 term browser browse the term
Definition:The pathway of processing - absorption, distribution, metabolism or elimination - of doxorubicin. Doxorubicin is used as a chemotherapeutic agent for the treatment of various cancers. Its use is limited by the serious cardiotoxic side effects it exerts. Genetic variations can result in changes in the availability of the drug.
Synonyms:related_synonym: SMP:00650

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doxorubicin pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 ISO SMPDB
RGD
PMID:21048526 RGD:10395261 SMP:00650 NCBI chrNW_004955432:4,911,774...5,085,349 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00650 NCBI chrNW_004955442:729,322...858,826
Ensembl chrNW_004955442:729,316...860,290
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB
RGD
PMID:21048526 RGD:10395261 SMP:00650 NCBI chrNW_004955507:5,724,788...5,791,281
Ensembl chrNW_004955507:5,724,762...5,790,812
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO RGD PMID:21048526 RGD:10395261 NCBI chrNW_004955451:11,087,246...11,130,108
Ensembl chrNW_004955451:11,087,570...11,130,482
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB
RGD
PMID:21048526 RGD:10395261 SMP:00650 NCBI chrNW_004955474:12,365,903...12,408,715 JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 ISO SMPDB
RGD
PMID:19442138 PMID:21048526 RGD:10395261 RGD:10395262 SMP:00650 NCBI chrNW_004955464:12,715,238...12,729,034
Ensembl chrNW_004955464:12,714,717...12,729,662
JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB
RGD
PMID:19442138 PMID:21048526 RGD:10395261 RGD:10395262 SMP:00650 NCBI chrNW_004955407:35,351,601...35,354,510 JBrowse link
G Cbr3 carbonyl reductase 3 ISO SMPDB
RGD
PMID:19442138 PMID:21048526 RGD:10395261 RGD:10395262 SMP:00650 NCBI chrNW_004955407:35,419,674...35,428,270
Ensembl chrNW_004955407:35,419,674...35,428,270
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 ISO SMPDB SMP:00650 NCBI chrNW_004955468:12,961,873...12,971,278
Ensembl chrNW_004955468:12,961,915...12,971,095
JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 ISO SMPDB SMP:00650 NCBI chrNW_004955422:713,370...717,926
Ensembl chrNW_004955422:709,784...717,926
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 ISO SMPDB SMP:00650 NCBI chrNW_004955495:6,540,360...6,548,072
Ensembl chrNW_004955495:6,540,450...6,547,975
JBrowse link
G Nos3 nitric oxide synthase 3 ISO SMPDB
RGD
PMID:19442138 RGD:10395262 SMP:00650 NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 ISO SMPDB
RGD
PMID:19442138 RGD:10395262 SMP:00650 NCBI chrNW_004955484:7,012,373...7,028,182
Ensembl chrNW_004955484:7,012,506...7,027,604
JBrowse link
G Por P450 (cytochrome) oxidoreductase ISO SMPDB SMP:00650 NCBI chrNW_004955456:14,698,589...14,748,520
Ensembl chrNW_004955456:14,698,589...14,748,520
JBrowse link
G Ralbp1 ralA binding protein 1 ISO SMPDB
RGD
PMID:21048526 RGD:10395261 SMP:00650 NCBI chrNW_004955402:2,571,672...2,616,040
Ensembl chrNW_004955402:2,569,637...2,616,040
JBrowse link

Term paths to the root
Path 1
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  pathway 3924
    drug pathway 348
      antineoplastic and immunomodulatory drug pathway 129
        antineoplastic drug pathway 128
          doxorubicin drug pathway 17
            doxorubicin pharmacokinetics pathway 15
paths to the root