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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:doxorubicin pharmacokinetics pathway
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Accession:PW:0001565 term browser browse the term
Definition:The pathway of processing - absorption, distribution, metabolism or elimination - of doxorubicin. Doxorubicin is used as a chemotherapeutic agent for the treatment of various cancers. Its use is limited by the serious cardiotoxic side effects it exerts. Genetic variations can result in changes in the availability of the drug.
Synonyms:related_synonym: SMP:00650

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doxorubicin pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB
RGD
PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00650 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB
RGD
PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO RGD PMID:21048526 RGD:10395261 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 ISO SMPDB
RGD
PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 ISO SMPDB
RGD
PMID:21048526 PMID:19442138 SMP:00650, RGD:10395261, RGD:10395262 NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 ISO SMPDB
RGD
PMID:21048526 SMP:00650, RGD:10395261 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB
RGD
PMID:21048526 PMID:19442138 SMP:00650, RGD:10395261, RGD:10395262 NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Cbr3 carbonyl reductase 3 ISO SMPDB
RGD
PMID:21048526 PMID:19442138 SMP:00650, RGD:10395261, RGD:10395262 NCBI chr11:46,478,295...46,486,555
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 ISO SMPDB SMP:00650 NCBI chr13:86,186,867...86,203,914
Ensembl chr13:83,654,406...83,671,420
JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 ISO SMPDB SMP:00650 NCBI chr 3:97,332,477...97,339,654
Ensembl chr 3:76,876,646...76,883,824
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 ISO SMPDB SMP:00650 NCBI chr 7:10,103,226...10,110,862
Ensembl chr 7:9,450,392...9,460,195
JBrowse link
G Nos3 nitric oxide synthase 3 ISO SMPDB
RGD
PMID:19442138 SMP:00650, RGD:10395262 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 ISO SMPDB
RGD
PMID:19442138 SMP:00650, RGD:10395262 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Por cytochrome p450 oxidoreductase ISO SMPDB SMP:00650 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ralbp1 ralA binding protein 1 ISO SMPDB
RGD
PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707
JBrowse link
G Slc22a16 solute carrier family 22 member 16 ISO SMPDB
RGD
PMID:21048526 SMP:00650, RGD:10395261 NCBI chr20:45,527,275...45,647,675
Ensembl chr20:43,972,836...44,065,019
JBrowse link
G Xdh xanthine dehydrogenase ISO SMPDB
RGD
PMID:19442138 SMP:00650, RGD:10395262 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      antineoplastic and immunomodulatory drug pathway 156
        antineoplastic drug pathway 154
          doxorubicin drug pathway 20
            doxorubicin pharmacokinetics pathway 18
paths to the root