PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: doxorubicin pharmacokinetics pathway
Accession: PW:0001565
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Definition: The pathway of processing - absorption, distribution, metabolism or elimination - of doxorubicin. Doxorubicin is used as a chemotherapeutic agent for the treatment of various cancers. Its use is limited by the serious cardiotoxic side effects it exerts. Genetic variations can result in changes in the availability of the drug.
Synonyms: related_synonym: SMP:00650
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Abcb1a
ATP binding cassette subfamily B member 1A
ISO
SMPDB RGD
PMID:21048526
SMP:00650, RGD:10395261
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Abcc1
ATP binding cassette subfamily C member 1
ISO
SMPDB
SMP:00650
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
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Abcc2
ATP binding cassette subfamily C member 2
ISO
SMPDB RGD
PMID:21048526
SMP:00650, RGD:10395261
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
ISO
RGD
PMID:21048526
RGD:10395261
NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
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Abcg2
ATP binding cassette subfamily G member 2
ISO
SMPDB RGD
PMID:21048526
SMP:00650, RGD:10395261
NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
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Akr1a1
aldo-keto reductase family 1 member A1
ISO
SMPDB RGD
PMID:21048526 PMID:19442138
SMP:00650, RGD:10395261 , RGD:10395262
NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:130,092,732...130,113,674
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Akr1c3
aldo-keto reductase family 1, member C3
ISO
SMPDB RGD
PMID:21048526
SMP:00650, RGD:10395261
NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873
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Cbr1
carbonyl reductase 1
ISO
SMPDB RGD
PMID:21048526 PMID:19442138
SMP:00650, RGD:10395261 , RGD:10395262
NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cbr3
carbonyl reductase 3
ISO
SMPDB RGD
PMID:21048526 PMID:19442138
SMP:00650, RGD:10395261 , RGD:10395262
NCBI chr11:46,478,295...46,486,555
Ensembl chr11:33,008,615...33,016,875
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Ndufs2
NADH:ubiquinone oxidoreductase core subunit S2
ISO
SMPDB
SMP:00650
NCBI chr13:86,186,867...86,203,914
Ensembl chr13:83,654,406...83,671,420
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Ndufs3
NADH:ubiquinone oxidoreductase core subunit S3
ISO
SMPDB
SMP:00650
NCBI chr 3:97,332,477...97,339,654
Ensembl chr 3:76,876,646...76,883,824
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Ndufs7
NADH:ubiquinone oxidoreductase core subunit S7
ISO
SMPDB
SMP:00650
NCBI chr 7:10,103,226...10,110,862
Ensembl chr 7:9,450,392...9,460,195
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Nos3
nitric oxide synthase 3
ISO
SMPDB RGD
PMID:19442138
SMP:00650, RGD:10395262
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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Nqo1
NAD(P)H quinone dehydrogenase 1
ISO
SMPDB RGD
PMID:19442138
SMP:00650, RGD:10395262
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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Por
cytochrome p450 oxidoreductase
ISO
SMPDB
SMP:00650
NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
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Ralbp1
ralA binding protein 1
ISO
SMPDB RGD
PMID:21048526
SMP:00650, RGD:10395261
NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707
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Slc22a16
solute carrier family 22 member 16
ISO
SMPDB RGD
PMID:21048526
SMP:00650, RGD:10395261
NCBI chr20:45,527,275...45,647,675
Ensembl chr20:43,972,836...44,065,019
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Xdh
xanthine dehydrogenase
ISO
SMPDB RGD
PMID:19442138
SMP:00650, RGD:10395262
NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all