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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:paracetamol drug pathway
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Accession:PW:0001524 term browser browse the term
Definition:The pharmacokinetics/pharmacodynamics of paracetamol, a widely used analgesic, known as acetaminophen (APAP). The analgesic effect is believed to be due to the inhibition of prostaglandins biosynthesis. Paracetamol overdose is associated with hepatic toxicity and a leading cause of liver failure. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
Synonyms:exact_synonym: acetaminophen drug pathway
 related_synonym: SMP:00710
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paracetamol drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 ISO SMPDB SMP:00710 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00710 NCBI chr10:55,456,923...55,469,239
Ensembl chr10:55,456,928...55,469,199 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00710 NCBI chr10:54,361,898...54,373,776
Ensembl chr10:54,361,898...54,373,776 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00710 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B ISO SMPDB SMP:00710 NCBI chr10:54,391,331...54,400,648
Ensembl chr10:54,391,302...54,400,648 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00710 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126 		JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB SMP:00710 NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 ISO SMPDB SMP:00710 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 ISO SMPDB SMP:00710
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO SMPDB SMP:00710 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 ISO SMPDB SMP:00710 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042 		JBrowse link
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 ISO SMPDB SMP:00710 NCBI chr 2:222,523,516...222,541,055
Ensembl chr 2:222,523,518...222,541,124 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 ISO SMPDB SMP:00710 NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,740,001...17,838,958 		JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 ISO SMPDB SMP:00710 NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,680,806...12,708,402 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO SMPDB SMP:00710 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00710 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO SMPDB SMP:00710 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO SMPDB SMP:00710 NCBI chr 7:29,856,846...29,888,642
Ensembl chr 7:29,856,802...29,888,641 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO SMPDB SMP:00710 NCBI chr10:35,060,002...35,066,466
Ensembl chr10:35,061,437...35,063,768 		JBrowse link
G Pla2g4b phospholipase A2 group IVB ISO SMPDB SMP:00710 NCBI chr 3:127,458,022...127,467,637
Ensembl chr 3:127,459,273...127,467,637 		JBrowse link
G Prxl2b peroxiredoxin like 2B ISO SMPDB SMP:00710 NCBI chr 5:170,744,953...170,747,556
Ensembl chr 5:170,744,953...170,747,556 		JBrowse link
G Ptgds prostaglandin D2 synthase ISO SMPDB SMP:00710 NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978 		JBrowse link
G Ptges prostaglandin E synthase ISO SMPDB SMP:00710 NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO SMPDB SMP:00710 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO SMPDB
RGD		 PMID:23719833 SMP:00710, RGD:8552695 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO SMPDB
RGD		 PMID:23719833 SMP:00710, RGD:8552695 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Tbxas1 thromboxane A synthase 1 ISO SMPDB SMP:00710 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969 		JBrowse link
paracetamol pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB SMP:00640 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00640 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 TAS RGD PMID:23462933 RGD:8552693 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 TAS RGD PMID:23462933 RGD:8552693 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 TAS
ISO 		SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00640 NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 TAS
ISO 		SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO SMPDB SMP:00640 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO SMPDB SMP:00640 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00640 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00640 NCBI chr11:91,656,334...91,672,800
Ensembl chr11:91,656,335...91,672,800 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00640 NCBI chr12:40,750,177...40,756,607
Ensembl chr12:40,750,314...40,757,010 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO SMPDB SMP:00640 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO SMPDB SMP:00640 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00640 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00640 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00640 NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:53,602,604...53,614,997 		JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 ISO SMPDB SMP:00640 NCBI chr10:15,720,301...15,723,386
Ensembl chr10:15,720,301...15,723,396 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 ISO SMPDB SMP:00640 NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:78,134,144...78,153,191 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 ISO SMPDB SMP:00640 NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091 		JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00640 NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:75,498,797...75,504,847 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 ISO SMPDB SMP:00640 NCBI chr11:97,376,878...97,379,120
Ensembl chr11:97,376,878...97,379,120 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 ISO SMPDB SMP:00640 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 ISO SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 ISO SMPDB SMP:00640 NCBI chr 1:84,582,011...84,639,001 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 ISO SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a6a UDP glucuronosyltransferase family 1 member A6a ISO SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 ISO SMPDB SMP:00640 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6090
    drug pathway 397
      nervous system drug pathway 183
        analgesic and/or antipyretic drug pathway 97
          paracetamol drug pathway 55
            paracetamol pharmacokinetics pathway 29
paths to the root