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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:paracetamol drug pathway
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Accession:PW:0001524 term browser browse the term
Definition:The pharmacokinetics/pharmacodynamics of paracetamol, a widely used analgesic, known as acetaminophen (APAP). The analgesic effect is believed to be due to the inhibition of prostaglandins biosynthesis. Paracetamol overdose is associated with hepatic toxicity and a leading cause of liver failure. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
Synonyms:exact_synonym: acetaminophen drug pathway
 related_synonym: SMP:00710
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paracetamol drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C1 aldo-keto reductase family 1, member C1 ISO SMPDB SMP:00710 NCBI chr10:65,580,297...65,594,998
Ensembl chr10:65,576,464...65,678,248 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00710 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,401,810...52,414,903 		JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00710 NCBI chr12:53,292,530...53,302,850
Ensembl chr12:53,292,526...53,302,993 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00710 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,287,160...52,295,871 		JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B ISO SMPDB SMP:00710 NCBI chr12:53,259,867...53,281,127
Ensembl chr12:53,271,583...53,281,123 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00710 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,019...90,907,090 		JBrowse link
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B ISO SMPDB SMP:00710 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO SMPDB SMP:00710 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G CYP2U1 cytochrome P450 family 2 subfamily U member 1 ISO SMPDB SMP:00710 NCBI chr 8:114,016,915...114,035,905
Ensembl chr 8:114,011,304...114,035,357 		JBrowse link
G EPHX2 epoxide hydrolase 2 ISO SMPDB SMP:00710 NCBI chr14:11,217,125...11,293,018
Ensembl chr14:11,216,978...11,293,410 		JBrowse link
G GPX1 glutathione peroxidase 1 ISO SMPDB SMP:00710 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G LOC110255237 cytochrome P450 4F6-like ISO SMPDB SMP:00710 NCBI chr 2:61,893,963...61,917,944
Ensembl chr 2:61,889,495...61,917,929 		JBrowse link
G LOC110256483 carbonyl reductase [NADPH] 1-like ISO SMPDB SMP:00710 NCBI chr13:199,713,741...199,719,535 JBrowse link
G LOC110259329 docosahexaenoic acid omega-hydroxylase CYP4F3-like ISO SMPDB SMP:00710 NCBI chr 2:61,863,378...61,884,717
Ensembl chr 2:61,864,575...61,984,903 		JBrowse link
G LOC110261221 cytochrome P450 2J2-like ISO SMPDB SMP:00710 NCBI chr 6:152,321,816...152,358,179
Ensembl chr 6:152,321,848...152,648,979 		JBrowse link
G LTA4H leukotriene A4 hydrolase ISO SMPDB SMP:00710 NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515 		JBrowse link
G LTC4S leukotriene C4 synthase ISO SMPDB SMP:00710 NCBI chr 2:78,799,446...78,802,281
Ensembl chr 2:78,799,449...78,802,285 		JBrowse link
G PLA2G4B phospholipase A2 group IVB ISO SMPDB SMP:00710 NCBI chr 1:129,514,801...129,524,365
Ensembl chr 1:129,514,346...129,524,313 		JBrowse link
G PRXL2B peroxiredoxin like 2B ISO SMPDB SMP:00710 NCBI chr 6:64,432,187...64,435,328
Ensembl chr 6:64,432,148...64,435,320 		JBrowse link
G PTGDS prostaglandin D2 synthase ISO SMPDB SMP:00710
G PTGES prostaglandin E synthase ISO SMPDB SMP:00710 NCBI chr 1:269,911,785...269,924,481
Ensembl chr 1:269,911,789...269,924,462 		JBrowse link
G PTGIS prostaglandin I2 synthase ISO SMPDB SMP:00710 NCBI chr17:51,153,151...51,200,515
Ensembl chr17:51,153,154...51,200,300 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO SMPDB
RGD		 PMID:23719833 RGD:8552695 SMP:00710 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO SMPDB
RGD		 PMID:23719833 RGD:8552695 SMP:00710 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G TBXAS1 thromboxane A synthase 1 ISO SMPDB SMP:00710 NCBI chr18:9,717,291...9,886,699
Ensembl chr18:9,717,294...9,886,681 		JBrowse link
paracetamol pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO SMPDB SMP:00640 NCBI chr 9:93,049,955...93,146,469
Ensembl chr 9:93,050,111...93,146,467 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00640 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO RGD PMID:23462933 RGD:8552693 NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO RGD PMID:23462933 RGD:8552693 NCBI chr12:26,920,764...26,978,389
Ensembl chr12:26,920,821...26,979,602 		JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chr11:64,089,149...64,309,831 JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00640 NCBI chr13:121,868,614...121,957,901
Ensembl chr13:121,869,600...121,926,071 		JBrowse link
G ABCG2A ATP binding cassette subfamily G member 2A ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,775,444...130,945,393 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 ISO SMPDB SMP:00640 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO SMPDB SMP:00640 NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,642 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00640 NCBI chr13:124,387,921...124,409,967
Ensembl chr13:124,390,970...124,413,200 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00640 NCBI chr14:39,687,028...39,695,748
Ensembl chr14:39,687,000...39,695,752 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00640 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00640 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00640 NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,933...46,276,995 		JBrowse link
G LOC100515741 UDP-glucuronosyltransferase 2B31 ISO SMPDB SMP:00640 NCBI chr 8:66,251,785...66,297,861 JBrowse link
G LOC100738425 multidrug resistance-associated protein 4 ISO RGD PMID:23462933 RGD:8552693 NCBI chr11:64,861,069...64,996,684 JBrowse link
G LOC100739508 glutathione S-transferase P-like ISO SMPDB SMP:00640 NCBI chr 2:5,005,498...5,009,247 JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00640 NCBI chr 3:41,394,267...41,397,547
Ensembl chr 3:41,394,058...41,397,687 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00640 NCBI chr 9:109,260,850...109,280,256
Ensembl chr 9:109,252,011...109,280,247 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00640 NCBI chr 3:125,752,079...125,774,225
Ensembl chr 3:125,751,978...125,776,077 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00640 NCBI chr 1:107,886,663...107,893,155
Ensembl chr 1:107,886,658...107,893,253 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00640 NCBI chr14:50,249,607...50,251,636
Ensembl chr14:50,246,710...50,251,642 		JBrowse link
G SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chr 8:66,811,536...66,838,181
Ensembl chr 8:66,811,550...66,834,473 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 ISO SMPDB SMP:00640 NCBI chr 6:53,525,496...53,536,723
Ensembl chr 6:53,524,787...53,536,718 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4043
    drug pathway 384
      nervous system drug pathway 173
        analgesic and/or antipyretic drug pathway 89
          paracetamol drug pathway 49
            paracetamol pharmacokinetics pathway 25
paths to the root