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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:paracetamol drug pathway
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Accession:PW:0001524 term browser browse the term
Definition:The pharmacokinetics/pharmacodynamics of paracetamol, a widely used analgesic, known as acetaminophen (APAP). The analgesic effect is believed to be due to the inhibition of prostaglandins biosynthesis. Paracetamol overdose is associated with hepatic toxicity and a leading cause of liver failure. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
Synonyms:exact_synonym: acetaminophen drug pathway
 related_synonym: SMP:00710
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paracetamol drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00710 NCBI chrNW_004624786:9,542,966...9,555,235
Ensembl chrNW_004624786:9,542,970...9,555,214 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00710 NCBI chrNW_004624786:10,647,450...10,659,301
Ensembl chrNW_004624786:10,647,175...10,659,337 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00710 NCBI chrNW_004624966:168,244...220,430
Ensembl chrNW_004624966:168,250...220,522 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO SMPDB SMP:00710 NCBI chrNW_004624758:22,216,462...22,252,467
Ensembl chrNW_004624758:22,221,314...22,254,813 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00710 NCBI chrNW_004624747:10,030,034...10,048,554 JBrowse link
G Gpx1 glutathione peroxidase 1 ISO SMPDB SMP:00710 NCBI chrNW_004624730:3,313,773...3,314,870
Ensembl chrNW_004624730:3,313,972...3,314,626 		JBrowse link
G LOC101708291 cytochrome P450 2U1 ISO SMPDB SMP:00710 NCBI chrNW_004624830:1,470,186...1,485,804
Ensembl chrNW_004624830:1,469,868...1,485,804 		JBrowse link
G LOC101722366 cytochrome P450 2E1 ISO SMPDB SMP:00710 NCBI chrNW_004624737:12,335,733...12,345,278
Ensembl chrNW_004624737:12,335,681...12,345,514 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO SMPDB SMP:00710 NCBI chrNW_004624750:11,274,506...11,314,683
Ensembl chrNW_004624750:11,274,664...11,314,581 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO SMPDB SMP:00710 NCBI chrNW_004624733:42,668,963...42,673,385
Ensembl chrNW_004624733:42,670,632...42,672,846 		JBrowse link
G Pla2g4b phospholipase A2 group IVB ISO SMPDB SMP:00710 NCBI chrNW_004624804:9,017,154...9,026,977
Ensembl chrNW_004624804:9,016,487...9,026,621 		JBrowse link
G Prxl2b peroxiredoxin like 2B ISO SMPDB SMP:00710 NCBI chrNW_004624818:7,478,680...7,485,431
Ensembl chrNW_004624818:7,483,001...7,485,431 		JBrowse link
G Ptgds prostaglandin D2 synthase ISO SMPDB SMP:00710 NCBI chrNW_004624760:920,292...923,174
Ensembl chrNW_004624760:920,877...923,283 		JBrowse link
G Ptges prostaglandin E synthase ISO SMPDB SMP:00710 NCBI chrNW_004624760:5,643,549...5,653,747
Ensembl chrNW_004624760:5,643,501...5,654,475 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO SMPDB SMP:00710 NCBI chrNW_004624790:5,850,647...5,885,754
Ensembl chrNW_004624790:5,850,810...5,886,014 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO RGD
SMPDB		 PMID:23719833 RGD:8552695 SMP:00710 NCBI chrNW_004624760:12,917,244...12,937,858
Ensembl chrNW_004624760:12,915,206...12,937,824 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO SMPDB
RGD		 PMID:23719833 RGD:8552695 SMP:00710 NCBI chrNW_004624814:6,897,818...6,904,890
Ensembl chrNW_004624814:6,897,857...6,903,728 		JBrowse link
G Tbxas1 thromboxane A synthase 1 ISO SMPDB SMP:00710 NCBI chrNW_004624765:20,145,769...20,314,992
Ensembl chrNW_004624765:20,146,138...20,315,797 		JBrowse link
paracetamol pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00640 NCBI chrNW_004624782:449,217...590,306
Ensembl chrNW_004624782:449,288...591,310 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO RGD PMID:23462933 RGD:8552693 NCBI chrNW_004624737:11,593,701...11,686,790
Ensembl chrNW_004624737:11,593,864...11,688,460 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO RGD PMID:23462933 RGD:8552693 NCBI chrNW_004624795:6,516,384...6,558,332
Ensembl chrNW_004624795:6,516,224...6,557,892 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chrNW_004624879:1,811,686...2,060,221
Ensembl chrNW_004624879:1,811,651...2,060,099 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00640 NCBI chrNW_004624730:72,529,299...72,621,108
Ensembl chrNW_004624730:72,534,329...72,623,263 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00640 NCBI chrNW_004624730:70,173,024...70,185,492
Ensembl chrNW_004624730:70,170,003...70,186,031 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00640 NCBI chrNW_004624747:20,167,197...20,174,914
Ensembl chrNW_004624747:20,166,371...20,175,012 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00640 NCBI chrNW_004624750:4,738,563...4,752,227
Ensembl chrNW_004624750:4,737,894...4,752,221 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00640 NCBI chrNW_004624760:9,986,529...9,991,261
Ensembl chrNW_004624760:9,986,656...9,995,252 		JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00640 NCBI chrNW_004624784:14,427,297...14,439,027
Ensembl chrNW_004624784:14,427,130...14,439,038 		JBrowse link
G LOC101697399 sulfotransferase 1A1 ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chrNW_004624782:13,079,596...13,094,149 JBrowse link
G LOC101722366 cytochrome P450 2E1 ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chrNW_004624737:12,335,733...12,345,278
Ensembl chrNW_004624737:12,335,681...12,345,514 		JBrowse link
G Pdia2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00640 NCBI chrNW_004624913:1,135,498...1,138,900
Ensembl chrNW_004624913:1,135,536...1,138,819 		JBrowse link
G Pdia4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00640 NCBI chrNW_004624800:6,723,567...6,742,024
Ensembl chrNW_004624800:6,723,548...6,742,024 		JBrowse link
G Pdia6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00640 NCBI chrNW_004624865:4,695,178...4,711,029
Ensembl chrNW_004624865:4,695,220...4,710,680 		JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00640 NCBI chrNW_004624781:8,402,518...8,407,950
Ensembl chrNW_004624781:8,402,430...8,411,003 		JBrowse link
G Sdf2l1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00640 NCBI chrNW_004624747:1,195,043...1,197,105
Ensembl chrNW_004624747:1,195,055...1,197,105 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3916
    drug pathway 349
      nervous system drug pathway 146
        analgesic and/or antipyretic drug pathway 68
          paracetamol drug pathway 34
            paracetamol pharmacokinetics pathway 17
paths to the root