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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:paracetamol drug pathway
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Accession:PW:0001524 term browser browse the term
Definition:The pharmacokinetics/pharmacodynamics of paracetamol, a widely used analgesic, known as acetaminophen (APAP). The analgesic effect is believed to be due to the inhibition of prostaglandins biosynthesis. Paracetamol overdose is associated with hepatic toxicity and a leading cause of liver failure. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
Synonyms:exact_synonym: acetaminophen drug pathway
 related_synonym: SMP:00710
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paracetamol drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c18 aldo-keto reductase family 1, member C18 ISO SMPDB SMP:00710 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase ISO SMPDB SMP:00710 NCBI chr11:70,132,283...70,146,206
Ensembl chr11:70,132,283...70,146,179 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00710 NCBI chr11:69,047,898...69,060,617
Ensembl chr11:69,047,815...69,060,618 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00710 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00710 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Alox8 arachidonate 8-lipoxygenase ISO SMPDB SMP:00710 NCBI chr11:69,074,711...69,088,669
Ensembl chr11:69,074,758...69,088,669 		JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB SMP:00710 NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 ISO SMPDB SMP:00710 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 ISO SMPDB SMP:00710 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO SMPDB SMP:00710 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 ISO SMPDB SMP:00710 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 ISO SMPDB SMP:00710 NCBI chr 3:131,084,140...131,097,806
Ensembl chr 3:131,082,090...131,096,876 		JBrowse link
G Cyp4a31 cytochrome P450, family 4, subfamily a, polypeptide 31 ISO SMPDB SMP:00710 NCBI chr 4:115,420,824...115,436,212
Ensembl chr 4:115,420,846...115,436,212 		JBrowse link
G Cyp4f13 cytochrome P450, family 4, subfamily f, polypeptide 13 ISO SMPDB SMP:00710 NCBI chr17:33,143,662...33,166,389
Ensembl chr17:33,143,662...33,166,376 		JBrowse link
G Cyp4f16 cytochrome P450, family 4, subfamily f, polypeptide 16 ISO SMPDB SMP:00710 NCBI chr17:32,755,517...32,770,772
Ensembl chr17:32,755,532...32,770,772 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 ISO SMPDB SMP:00710 NCBI chr 8:72,742,326...72,763,512
Ensembl chr 8:72,742,326...72,763,470 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic ISO SMPDB SMP:00710 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00710 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO SMPDB SMP:00710 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO SMPDB SMP:00710 NCBI chr10:93,289,258...93,320,758
Ensembl chr10:93,289,273...93,320,737 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO SMPDB SMP:00710 NCBI chr11:50,127,288...50,129,378
Ensembl chr11:50,127,288...50,129,443 		JBrowse link
G Prxl2b peroxiredoxin like 2B ISO SMPDB SMP:00710 NCBI chr 4:154,980,884...154,983,522
Ensembl chr 4:154,979,961...154,983,592 		JBrowse link
G Ptgds prostaglandin D2 synthase (brain) ISO SMPDB SMP:00710 NCBI chr 2:25,356,723...25,360,080
Ensembl chr 2:25,356,721...25,360,058 		JBrowse link
G Ptges prostaglandin E synthase ISO SMPDB SMP:00710 NCBI chr 2:30,779,483...30,793,309
Ensembl chr 2:30,779,483...30,819,875 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase ISO SMPDB SMP:00710 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO SMPDB
RGD		 PMID:23719833 SMP:00710, RGD:8552695 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO SMPDB
RGD		 PMID:23719833 SMP:00710, RGD:8552695 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Tbxas1 thromboxane A synthase 1, platelet ISO SMPDB SMP:00710 NCBI chr 6:38,817,897...39,061,524
Ensembl chr 6:38,852,338...39,061,519 		JBrowse link
paracetamol pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A ISO SMPDB SMP:00640 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 ISO SMPDB SMP:00640 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family C member 2 TAS RGD PMID:23462933 RGD:8552693 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 TAS RGD PMID:23462933 RGD:8552693 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 TAS
ISO 		SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcc5 ATP-binding cassette, sub-family C member 5 ISO SMPDB SMP:00640 NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) TAS
ISO 		SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO SMPDB SMP:00640 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 ISO SMPDB SMP:00640 NCBI chr 7:26,006,617...26,014,513
Ensembl chr 7:26,006,594...26,014,513 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 ISO SMPDB SMP:00640 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 ISO SMPDB SMP:00640 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 TAS
ISO 		SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 ISO SMPDB SMP:00640 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00640 NCBI chr16:22,676,595...22,698,384
Ensembl chr16:22,676,595...22,698,384 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00640 NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 ISO SMPDB SMP:00640 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 ISO SMPDB SMP:00640 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418 		JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 ISO SMPDB SMP:00640 NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373 		JBrowse link
G Hspa5 heat shock protein 5 ISO SMPDB SMP:00640 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00640 NCBI chr 9:44,290,840...44,303,662
Ensembl chr 9:44,290,787...44,303,666 		JBrowse link
G Pdia2 protein disulfide isomerase associated 2 ISO SMPDB SMP:00640 NCBI chr17:26,414,973...26,418,108
Ensembl chr17:26,414,973...26,418,061 		JBrowse link
G Pdia4 protein disulfide isomerase associated 4 ISO SMPDB SMP:00640 NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364 		JBrowse link
G Pdia6 protein disulfide isomerase associated 6 ISO SMPDB SMP:00640 NCBI chr12:17,316,590...17,334,786
Ensembl chr12:17,316,546...17,334,771 		JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00640 NCBI chr 9:65,967,451...65,973,911
Ensembl chr 9:65,967,504...65,973,905 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 ISO SMPDB SMP:00640 NCBI chr16:16,948,002...16,950,247
Ensembl chr16:16,948,002...16,950,247 		JBrowse link
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 ISO SMPDB SMP:00640 NCBI chr 7:126,272,042...126,289,615
Ensembl chr 7:126,272,037...126,275,604 		JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 ISO SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453 		JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 ISO SMPDB SMP:00640 NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 ISO SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a6a UDP glucuronosyltransferase 1 family, polypeptide A6A ISO RGD PMID:23462933 RGD:8552693 NCBI chr 1:88,062,531...88,147,724
Ensembl chr 1:88,062,531...88,146,719 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B ISO SMPDB SMP:00640 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 ISO SMPDB SMP:00640 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6071
    drug pathway 402
      nervous system drug pathway 190
        analgesic and/or antipyretic drug pathway 103
          paracetamol drug pathway 59
            paracetamol pharmacokinetics pathway 32
paths to the root