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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:paracetamol drug pathway
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Accession:PW:0001524 term browser browse the term
Definition:The pharmacokinetics/pharmacodynamics of paracetamol, a widely used analgesic, known as acetaminophen (APAP). The analgesic effect is believed to be due to the inhibition of prostaglandins biosynthesis. Paracetamol overdose is associated with hepatic toxicity and a leading cause of liver failure. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
Synonyms:exact_synonym: acetaminophen drug pathway
 related_synonym: SMP:00710
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paracetamol drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00710 NCBI chrNW_004955467:8,876,186...8,887,980
Ensembl chrNW_004955467:8,876,027...8,888,033 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00710 NCBI chrNW_004955467:10,032,792...10,039,789
Ensembl chrNW_004955467:10,032,792...10,039,323 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase type B ISO SMPDB SMP:00710 NCBI chrNW_004955467:8,896,740...8,906,032
Ensembl chrNW_004955467:8,895,095...8,906,009 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00710 NCBI chrNW_004955546:2,495,226...2,550,909
Ensembl chrNW_004955546:2,494,819...2,550,909 		JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB SMP:00710 NCBI chrNW_004955407:35,351,601...35,354,510
Ensembl chrNW_004955407:35,349,330...35,354,403 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO SMPDB SMP:00710 NCBI chrNW_004955403:49,999,563...50,038,800
Ensembl chrNW_004955403:49,999,563...50,041,572 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00710 NCBI chrNW_004955455:8,082,578...8,099,523
Ensembl chrNW_004955455:8,068,710...8,099,584 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO SMPDB SMP:00710 NCBI chrNW_004955532:1,298,336...1,298,830 JBrowse link
G LOC102026028 cytochrome P450 2E1 ISO SMPDB SMP:00710 NCBI chrNW_004955507:6,293,162...6,303,255
Ensembl chrNW_004955507:6,289,576...6,304,193 		JBrowse link
G LOC102028874 cytochrome P450 2U1 ISO SMPDB SMP:00710 NCBI chrNW_004955496:1,873,031...1,887,840
Ensembl chrNW_004955496:1,875,401...1,882,542 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO SMPDB SMP:00710 NCBI chrNW_004955405:32,345,005...32,377,685
Ensembl chrNW_004955405:32,344,925...32,378,384 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO SMPDB SMP:00710 NCBI chrNW_004955408:788,856...791,505 JBrowse link
G Pla2g4b phospholipase A2 group IVB ISO SMPDB SMP:00710 NCBI chrNW_004955416:8,633,249...8,643,219
Ensembl chrNW_004955416:8,634,184...8,642,833 		JBrowse link
G Prxl2b peroxiredoxin like 2B ISO SMPDB SMP:00710 NCBI chrNW_004955486:8,663,708...8,666,369
Ensembl chrNW_004955486:8,663,595...8,666,469 		JBrowse link
G Ptgds prostaglandin D2 synthase ISO SMPDB SMP:00710 NCBI chrNW_004955513:5,009,530...5,012,781
Ensembl chrNW_004955513:5,009,625...5,012,781 		JBrowse link
G Ptges prostaglandin E synthase ISO SMPDB SMP:00710 NCBI chrNW_004955445:10,053,745...10,056,981 JBrowse link
G Ptgis prostaglandin I2 synthase ISO SMPDB SMP:00710 NCBI chrNW_004955445:8,624,228...8,663,385
Ensembl chrNW_004955445:8,623,430...8,677,658 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO SMPDB
RGD		 PMID:23719833 RGD:8552695 SMP:00710 NCBI chrNW_004955419:5,678,750...5,699,305
Ensembl chrNW_004955419:5,678,694...5,699,305 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO SMPDB
RGD		 PMID:23719833 RGD:8552695 SMP:00710 NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171 		JBrowse link
G Tbxas1 thromboxane A synthase 1 ISO SMPDB SMP:00710 NCBI chrNW_004955494:3,161,032...3,321,974
Ensembl chrNW_004955494:3,160,653...3,334,411 		JBrowse link
paracetamol pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00640 NCBI chrNW_004955432:4,911,774...5,085,349
Ensembl chrNW_004955432:4,912,184...5,007,188 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00640 NCBI chrNW_004955442:729,322...858,826
Ensembl chrNW_004955442:729,316...860,290 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO RGD PMID:23462933 RGD:8552693 NCBI chrNW_004955507:5,724,788...5,791,281
Ensembl chrNW_004955507:5,724,762...5,790,812 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO RGD PMID:23462933 RGD:8552693 NCBI chrNW_004955451:11,087,246...11,130,108
Ensembl chrNW_004955451:11,087,570...11,130,482 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chrNW_004955404:14,700,808...14,927,944
Ensembl chrNW_004955404:14,700,808...14,928,617 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00640 NCBI chrNW_004955420:23,447,920...23,522,732
Ensembl chrNW_004955420:23,447,920...23,522,732 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chrNW_004955474:12,365,903...12,408,715
Ensembl chrNW_004955474:12,355,731...12,408,969 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00640 NCBI chrNW_004955420:21,097,292...21,113,053
Ensembl chrNW_004955420:21,097,941...21,112,792 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00640 NCBI chrNW_004955482:8,572,227...8,579,589
Ensembl chrNW_004955482:8,572,227...8,579,946 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO SMPDB SMP:00640 NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00640 NCBI chrNW_004955405:38,629,691...38,645,202
Ensembl chrNW_004955405:38,629,691...38,645,202 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00640 NCBI chrNW_004955419:3,055,420...3,060,208
Ensembl chrNW_004955419:3,055,420...3,062,131 		JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00640 NCBI chrNW_004955412:20,149,104...20,161,378
Ensembl chrNW_004955412:20,148,953...20,161,172 		JBrowse link
G LOC102010322 cytochrome P450 1A2 ISO SMPDB SMP:00640 NCBI chrNW_004955450:3,165,107...3,171,894
Ensembl chrNW_004955450:3,165,106...3,171,942 		JBrowse link
G LOC102026028 cytochrome P450 2E1 ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chrNW_004955507:6,293,162...6,303,255
Ensembl chrNW_004955507:6,289,576...6,304,193 		JBrowse link
G Pdia2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00640 NCBI chrNW_004955442:16,898,563...16,901,867
Ensembl chrNW_004955442:16,898,635...16,901,799 		JBrowse link
G Pdia4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00640 NCBI chrNW_004955491:4,344,874...4,360,205
Ensembl chrNW_004955491:4,344,874...4,360,205 		JBrowse link
G Pdia6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00640 NCBI chrNW_004955487:5,735,698...5,744,601
Ensembl chrNW_004955487:5,735,698...5,748,015 		JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00640 NCBI chrNW_004955450:11,241,279...11,246,628
Ensembl chrNW_004955450:11,241,279...11,249,056 		JBrowse link
G Sdf2l1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00640 NCBI chrNW_004955442:17,468,302...17,470,296
Ensembl chrNW_004955442:17,468,302...17,470,296 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3923
    drug pathway 348
      nervous system drug pathway 151
        analgesic and/or antipyretic drug pathway 72
          paracetamol drug pathway 39
            paracetamol pharmacokinetics pathway 20
paths to the root