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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:platinum (Pt) containing drug pathway
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Accession:PW:0001507 term browser browse the term
Definition:The pharmacokinetics/pharmacodynamics of platinum (Pt) containing drugs, widely used in the treatment of cancer. These drugs introduce intra- and inter-strand DNA breaks. The DNA lesion and responses it triggers is toxic to tumor cells. However, it can also exert toxic side effects. Three Pt-containing drugs are being used and they vary in their efficacy and toxicity. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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cisplatin drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atox1 antioxidant 1 copper chaperone ISO RGD PMID:23936210 RGD:8548474 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950 		JBrowse link
G Atp7a ATPase copper transporting alpha ISO RGD PMID:22796517 RGD:8548473 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atp7b ATPase copper transporting beta ISO RGD PMID:22796517 RGD:8548473 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Hmgb1 high mobility group box 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 ISO
IDA 		RGD PMID:22796517 PMID:23123662 RGD:8548473, RGD:8549769 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Ssrp1 structure specific recognition protein 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr 3:70,124,371...70,134,481
Ensembl chr 3:70,118,655...70,134,482 		JBrowse link
G Tbp TATA box binding protein ISO RGD PMID:20046924 RGD:8548475 NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:56,463,618...56,510,016 		JBrowse link
G Ubtf upstream binding transcription factor ISO RGD PMID:20046924 RGD:8548475 NCBI chr10:87,258,217...87,274,291
Ensembl chr10:87,258,217...87,272,969 		JBrowse link
G Ybx1 Y box binding protein 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr 5:132,882,137...132,898,885
Ensembl chr 5:132,882,145...132,898,862 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      antineoplastic and immunomodulatory drug pathway 156
        antineoplastic drug pathway 154
          platinum (Pt) containing drug pathway 9
            carboplatin drug pathway 0
            cisplatin drug pathway 9
            oxaliplatin drug pathway 0
paths to the root