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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:mechanotransduction pathway
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Accession:PW:0001502 term browser browse the term
Definition:The mechanostransduction pathway involves the conversion of a mechanical stimulus into an electrical signal whose processing underlies proprioception, hearing, balance and touch. Auditory and cytoskeleton mechanotransduction are examples.


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altered integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ilk integrin-linked kinase ISO RGD PMID:18772397 RGD:5490966 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Itga1 integrin subunit alpha 1 IMP RGD PMID:10536667 RGD:1302875 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421
JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:67,566,874...67,683,973
Ensembl chr 8:67,615,635...67,683,973
JBrowse link
G Itga4 integrin subunit alpha 4 IMP
ISO
RGD PMID:11782963, PMID:18772397 RGD:1302879, RGD:5490966 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Itga5 integrin subunit alpha 5 ISS RGD PMID:10536667 RGD:1302875 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itga8 integrin subunit alpha 8 IMP RGD PMID:10504498 RGD:633055 NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:127,271,029...127,576,709
Ensembl chr 8:127,271,289...127,572,988
JBrowse link
G Itgb1 integrin subunit beta 1 ISS RGD PMID:9633916 RGD:1302874 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
auditory mechanotransduction pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta ISO RGD PMID:20624897 RGD:8547669 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actg1 actin, gamma 1 ISO RGD PMID:20624897 RGD:8547669 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Adgrv1 adhesion G protein-coupled receptor V1 ISO RGD PMID:20624897 RGD:8547669 NCBI chr 2:8,926,843...9,504,455
Ensembl chr 2:8,926,850...9,504,134
JBrowse link
G Cdh23 cadherin-related 23 ISO RGD PMID:19804752, PMID:22177415 RGD:8547667, RGD:8547671 NCBI chr20:29,857,018...30,263,758
Ensembl chr20:29,857,637...29,990,111
JBrowse link
G Espn espin ISO RGD PMID:19804752, PMID:20624897 RGD:8547667, RGD:8547669 NCBI chr 5:169,293,356...169,331,338
Ensembl chr 5:169,293,904...169,331,163
JBrowse link
G Myo15a myosin XVA ISO RGD PMID:19804752 RGD:8547667 NCBI chr10:46,840,098...46,897,362
Ensembl chr10:46,840,113...46,896,054
JBrowse link
G Myo1c myosin 1C ISO RGD PMID:19804752 RGD:8547667 NCBI chr10:63,803,311...63,819,614
Ensembl chr10:63,803,309...63,819,614
JBrowse link
G Myo3a myosin IIIA ISO RGD PMID:19804752 RGD:8547667 NCBI chr17:88,952,635...89,167,538
Ensembl chr17:88,963,981...89,167,018
JBrowse link
G Myo6 myosin VI ISO RGD PMID:20624897, PMID:22715884 RGD:8547669, RGD:8547672 NCBI chr 8:87,583,649...87,731,271
Ensembl chr 8:87,630,916...87,731,269
JBrowse link
G Myo7a myosin VIIA ISO RGD PMID:19804752, PMID:22177415 RGD:8547667, RGD:8547671 NCBI chr 1:163,001,313...163,071,545
Ensembl chr 1:163,001,875...163,071,508
JBrowse link
G Otof otoferlin ISO RGD PMID:22715884 RGD:8547672 NCBI chr 6:27,328,343...27,424,864
Ensembl chr 6:27,328,406...27,424,864
JBrowse link
G Pcdh15 protocadherin related 15 ISO RGD PMID:19804752, PMID:22177415 RGD:8547667, RGD:8547671 NCBI chr20:14,952,213...15,334,745
Ensembl chr20:14,952,213...15,334,745
JBrowse link
G Pls1 plastin 1 ISO RGD PMID:20624897 RGD:8547669 NCBI chr 8:103,557,361...103,659,625
Ensembl chr 8:103,557,364...103,608,913
JBrowse link
G Pls3 plastin 3 ISO RGD PMID:20624897 RGD:8547669 NCBI chr  X:119,030,311...119,124,268
Ensembl chr  X:119,030,419...119,124,250
JBrowse link
G Ptprq protein tyrosine phosphatase, receptor type, Q ISO RGD PMID:20624897 RGD:8547669 NCBI chr 7:49,763,657...50,034,932
Ensembl chr 7:49,763,657...50,034,932
JBrowse link
G Slc17a8 solute carrier family 17 member 8 ISO RGD PMID:22715884 RGD:8547672 NCBI chr 7:30,215,231...30,274,993
Ensembl chr 7:30,216,104...30,274,984
JBrowse link
G Ush1c USH1 protein network component harmonin ISO RGD PMID:19804752, PMID:22177415 RGD:8547667, RGD:8547671 NCBI chr 1:102,207,096...102,256,779
Ensembl chr 1:102,207,096...102,255,459
JBrowse link
G Ush1g USH1 protein network component sans ISO RGD PMID:22177415 RGD:8547671 NCBI chr10:103,866,566...103,873,416
Ensembl chr10:103,869,377...103,873,246
JBrowse link
G Ush2a usherin ISO RGD PMID:20624897 RGD:8547669 NCBI chr13:106,750,738...107,434,195
Ensembl chr13:106,751,625...107,427,329
JBrowse link
G Whrn whirlin ISO RGD PMID:19804752 RGD:8547667 NCBI chr 5:79,235,541...79,317,206
Ensembl chr 5:79,234,950...79,317,206
JBrowse link
integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein ISO RGD PMID:18363565 RGD:2300340 NCBI chr17:90,098,953...90,149,192
Ensembl chr17:90,099,025...90,149,894
JBrowse link
G Fabp3 fatty acid binding protein 3 ISO RGD PMID:23719537 RGD:7364738 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Fblim1 filamin binding LIM protein 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 5:160,122,466...160,158,921
Ensembl chr 5:160,122,425...160,158,386
JBrowse link
G Fermt1 fermitin family member 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 3:125,566,744...125,607,864
Ensembl chr 3:125,566,643...125,607,735
JBrowse link
G Fermt2 fermitin family member 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr15:19,807,806...19,876,557
Ensembl chr15:19,807,808...19,876,408
JBrowse link
G Fermt3 fermitin family member 3 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 1:222,254,183...222,272,775
Ensembl chr 1:222,254,184...222,272,285
JBrowse link
G Flna filamin A ISO RGD PMID:23719537 RGD:7364738 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245
JBrowse link
G Flnb filamin B ISO RGD PMID:23719537 RGD:7364738 NCBI chr15:18,750,152...18,883,019
Ensembl chr15:18,750,118...18,883,005
JBrowse link
G Flnc filamin C ISO RGD PMID:23719537 RGD:7364738 NCBI chr 4:56,710,934...56,738,779
Ensembl chr 4:56,711,049...56,738,791
JBrowse link
G Ilk integrin-linked kinase ISS
IMP
ISO
RGD PMID:11304546, PMID:12629168, PMID:16493410 RGD:633110, RGD:2302091, RGD:2300344 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase ISO RGD PMID:16493410 RGD:2300344 NCBI chr 9:98,514,599...98,536,586
Ensembl chr 9:98,514,584...98,536,581
JBrowse link
G Itga1 integrin subunit alpha 1 ISS
ISO
RGD PMID:2380249, PMID:17543136 RGD:729264, RGD:5135538 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421
JBrowse link
G Itga10 integrin subunit alpha 10 ISO RGD PMID:12297042, PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 2:198,772,937...198,792,253
Ensembl chr 2:198,772,937...198,792,253
JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:12297042, PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 8:67,566,874...67,683,973
Ensembl chr 8:67,615,635...67,683,973
JBrowse link
G Itga2 integrin subunit alpha 2 TAS
ISO
RGD PMID:12941079, PMID:17543136 RGD:1302878, RGD:5135538 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itga2b integrin subunit alpha 2b ISO based on Entrez HomoloGene, BLAST RGD PMID:17543136 RGD:5135538 NCBI chr10:90,397,960...90,416,550
Ensembl chr10:90,398,132...90,415,070
JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:12297042, PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itga4 integrin subunit alpha 4 TAS
ISO
RGD PMID:11782963, PMID:17543136 RGD:1302879, RGD:5135538 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Itga5 integrin subunit alpha 5 IDA
ISO
RGD PMID:12821041, PMID:17543136 RGD:1300196, RGD:5135538 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itga6 integrin subunit alpha 6 ISS
ISO
RGD PMID:12297042, PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Itga7 integrin subunit alpha 7 IDA
ISO
RGD PMID:1315319, PMID:17543136 RGD:70774, RGD:5135538 NCBI chr 7:3,355,079...3,383,886
Ensembl chr 7:3,355,116...3,384,675
JBrowse link
G Itga8 integrin subunit alpha 8 TAS
ISO
RGD PMID:10504498, PMID:17543136 RGD:633055, RGD:5135538 NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:12297042, PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 8:127,271,029...127,576,709
Ensembl chr 8:127,271,289...127,572,988
JBrowse link
G Itgad integrin subunit alpha D ISS
ISO
RGD PMID:12297042, PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 1:199,595,968...199,623,931
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgae integrin subunit alpha E TAS
ISO
RGD PMID:9394838, PMID:17543136 RGD:633077, RGD:5135538 NCBI chr10:59,652,324...59,711,885
Ensembl chr10:59,539,405...59,711,874
JBrowse link
G Itgal integrin subunit alpha L ISS
ISO
RGD PMID:12297042, PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Itgam integrin subunit alpha M ISS
ISO
RGD PMID:12297042, PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgav integrin subunit alpha V ISO
IDA
RGD PMID:12297042, PMID:17543136, PMID:12639933 RGD:1358329, RGD:5135538, RGD:1625134 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgax integrin subunit alpha X ISO RGD PMID:17543136 RGD:5135538 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932
JBrowse link
G Itgb1 integrin subunit beta 1 ISS
ISO
IDA
RGD PMID:9633916, PMID:17543136, PMID:12639933 RGD:1302874, RGD:5135538, RGD:1625134 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 ISO RGD PMID:23860236, PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G Itgb2 integrin subunit beta 2 ISO RGD PMID:12297042, PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Itgb3 integrin subunit beta 3 ISS
ISO
IDA
RGD PMID:12600920, PMID:17543136, PMID:12639933 RGD:633129, RGD:5135538, RGD:1625134 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Itgb4 integrin subunit beta 4 TAS
ISO
RGD PMID:8026337, PMID:17543136 RGD:729025, RGD:5135538 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Itgb5 integrin subunit beta 5 ISS
ISO
RGD PMID:9531507, PMID:17543136 RGD:724441, RGD:5135538 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372
JBrowse link
G Itgb6 integrin subunit beta 6 ISS
ISO
RGD PMID:12297042, PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Itgb7 integrin subunit beta 7 TAS
ISO
RGD PMID:9233649, PMID:17543136 RGD:633040, RGD:5135538 NCBI chr 7:143,820,236...143,837,802
Ensembl chr 7:143,820,900...143,837,780
JBrowse link
G Itgb8 integrin subunit beta 8 ISO RGD PMID:12297042, PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813
JBrowse link
G Krit1 KRIT1, ankyrin repeat containing ISO RGD PMID:23860236, PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 4:27,438,609...27,473,150
Ensembl chr 4:27,438,609...27,473,150
JBrowse link
G Lims1 LIM zinc finger domain containing 1 ISO RGD PMID:16493410 RGD:2300344 NCBI chr20:27,895,981...28,004,767
Ensembl chr20:27,954,433...28,002,082
JBrowse link
G Lims2 LIM zinc finger domain containing 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr18:24,707,951...24,746,159
Ensembl chr18:24,708,115...24,746,159
JBrowse link
G Nck2 NCK adaptor protein 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Parva parvin, alpha ISO RGD PMID:16493410 RGD:2300344 NCBI chr 1:177,249,302...177,408,160
Ensembl chr 1:177,249,226...177,408,205
JBrowse link
G Parvb parvin, beta ISO RGD PMID:16493410 RGD:2300344 NCBI chr 7:125,189,827...125,275,977
Ensembl chr 7:125,189,827...125,277,689
JBrowse link
G Parvg parvin, gamma ISO RGD PMID:16493410 RGD:2300344 NCBI chr 7:125,288,081...125,307,587
Ensembl chr 7:125,288,081...125,306,976
JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO RGD PMID:15108811 RGD:2300402 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Pxn paxillin ISO RGD PMID:16493410 RGD:2300344 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Sharpin SHANK-associated RH domain interactor ISO RGD PMID:23860236, PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 7:117,413,151...117,417,455
Ensembl chr 7:117,413,152...117,417,363
JBrowse link
G Tln1 talin 1 ISO RGD PMID:18363565, PMID:23860236 RGD:2300340, RGD:7349373 NCBI chr 5:59,033,635...59,063,592
Ensembl chr 5:59,033,636...59,063,592
JBrowse link
G Tln2 talin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 8:73,009,980...73,441,536
Ensembl chr 8:73,014,137...73,194,837
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6103
    signaling pathway 2646
      mechanotransduction pathway 70
        altered mechanotransduction pathway + 0
        auditory mechanotransduction pathway + 20
        integrin mediated signaling pathway + 50
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.