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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:ibuprofen pharmacodynamics pathway
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Accession:PW:0001470 term browser browse the term
Definition:The pathway of ibuprofen-target interaction and of the biochemical or physiological responses to drug. Ibuprofen is an inhibitor of cyclooxygenase enzymes used in the treatment of pain and inflammation. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00086


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ibuprofen pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00086 NCBI chr16:6,355,795...6,370,051
Ensembl chr16:6,356,058...6,369,738
JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00086 NCBI chr16:7,454,950...7,470,949
Ensembl chr16:7,455,044...7,469,934
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00086 NCBI chr16:4,112,795...4,121,764
Ensembl chr16:4,111,151...4,121,645
JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B ISO SMPDB SMP:00086 NCBI chr16:7,425,533...7,435,896
Ensembl chr16:7,425,990...7,435,327
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00086 NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO SMPDB SMP:00086 NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 ISO SMPDB SMP:00086 NCBI chr 9:87,981,300...88,025,007 JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 ISO SMPDB SMP:00086 NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 ISO SMPDB SMP:00086 NCBI chr 9:88,082,124...88,125,390 JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO SMPDB SMP:00086 NCBI chr26:53,390,054...53,403,309
Ensembl chr26:53,390,089...53,404,211
JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 ISO SMPDB SMP:00086 NCBI chr20:73,083,312...73,115,174
Ensembl chr20:73,083,389...73,115,077
JBrowse link
G CYP2U1 cytochrome P450 family 2 subfamily U member 1 ISO SMPDB SMP:00086 NCBI chr 7:55,859,669...55,880,266
Ensembl chr 7:55,859,849...55,879,280
JBrowse link
G CYP4F3 cytochrome P450 family 4 subfamily F member 3 ISO SMPDB SMP:00086 NCBI chr 6:14,241,352...14,260,799
Ensembl chr 6:14,241,409...14,263,494
JBrowse link
G CYP4F8 cytochrome P450 family 4 subfamily F member 8 ISO SMPDB SMP:00086 NCBI chr 6:14,211,899...14,229,793
Ensembl chr 6:14,215,337...14,229,509
JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00086 NCBI chr15:2,841,377...2,858,192
Ensembl chr15:2,841,255...2,858,202
JBrowse link
G EPHX2 epoxide hydrolase 2 ISO SMPDB SMP:00086 NCBI chr 8:25,603,668...25,659,232
Ensembl chr 8:25,603,735...25,659,345
JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00086 NCBI chr11:107,244,359...107,255,293
Ensembl chr11:107,244,335...107,256,499
JBrowse link
G GGT1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00086
G GPX1 glutathione peroxidase 1 ISO SMPDB SMP:00086 NCBI chr22:10,754,976...10,756,617 JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00086 NCBI chr11:99,119,268...99,139,988
Ensembl chr11:99,119,224...99,139,722
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00086 NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431
JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00086 NCBI chr 1:110,418,497...110,431,636
Ensembl chr 1:110,417,942...110,431,590
JBrowse link
G LOC103218526 carbonyl reductase [NADPH] 1 ISO SMPDB SMP:00086 NCBI chr 2:80,096,743...80,099,982 JBrowse link
G LOC103246766 cytochrome P450 3A8 ISO SMPDB SMP:00086 NCBI chr28:13,297,566...13,330,023 JBrowse link
G LTA4H leukotriene A4 hydrolase ISO SMPDB SMP:00086 NCBI chr11:91,371,383...91,413,396
Ensembl chr11:91,371,383...91,406,542
JBrowse link
G LTC4S leukotriene C4 synthase ISO SMPDB SMP:00086 NCBI chr23:81,523,784...81,526,297
Ensembl chr23:81,523,775...81,526,179
JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00086 NCBI chr 5:229,523...233,298
Ensembl chr 5:229,607...233,200
JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00086 NCBI chr21:117,574,932...117,601,896
Ensembl chr21:117,574,427...117,601,960
JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00086 NCBI chr14:96,801,327...96,828,325
Ensembl chr14:96,801,349...96,828,716
JBrowse link
G PLA2G4B phospholipase A2 group IVB ISO SMPDB SMP:00086 NCBI chr26:41,137,643...41,147,384 JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00086 NCBI chr26:19,380,496...19,399,596 JBrowse link
G PRXL2B peroxiredoxin like 2B ISO SMPDB SMP:00086 NCBI chr20:128,964,750...128,969,469
Ensembl chr20:128,964,987...128,967,620
JBrowse link
G PTGDS prostaglandin D2 synthase ISO SMPDB SMP:00086 NCBI chr12:1,210,567...1,214,631
Ensembl chr12:1,211,487...1,214,531
JBrowse link
G PTGES prostaglandin E synthase ISO SMPDB SMP:00086 NCBI chr12:8,393,462...8,408,441
Ensembl chr12:8,393,550...8,408,435
JBrowse link
G PTGIS prostaglandin I2 synthase ISO SMPDB SMP:00086 NCBI chr 2:14,420,318...14,484,667
Ensembl chr 2:14,441,983...14,488,264
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00086 NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00086 NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429
JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00086 NCBI chr19:4,465,795...4,467,882
Ensembl chr19:4,465,797...4,467,761
JBrowse link
G SLC22A6 solute carrier family 22 member 6 ISO SMPDB SMP:00086 NCBI chr 1:10,918,081...10,926,790
Ensembl chr 1:10,918,770...10,925,983
JBrowse link
G SLC22A8 solute carrier family 22 member 8 ISO SMPDB SMP:00086 NCBI chr 1:10,885,895...10,909,739
Ensembl chr 1:10,886,690...10,910,546
JBrowse link
G TBXAS1 thromboxane A synthase 1 ISO SMPDB SMP:00086 NCBI chr21:108,584,458...108,779,357
Ensembl chr21:108,628,570...108,779,163
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    drug pathway 383
      cardiovascular system drug pathway 178
        ibuprofen drug pathway 41
          ibuprofen pharmacodynamics pathway 41
Path 2
Term Annotations click to browse term
  pathway 4028
    drug pathway 383
      nervous system drug pathway 173
        analgesic and/or antipyretic drug pathway 89
          ibuprofen drug pathway 41
            ibuprofen pharmacodynamics pathway 41
paths to the root