PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: ibuprofen pharmacodynamics pathway
Accession: PW:0001470
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Definition: The pathway of ibuprofen-target interaction and of the biochemical or physiological responses to drug. Ibuprofen is an inhibitor of cyclooxygenase enzymes used in the treatment of pain and inflammation. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms: related_synonym: SMP:00086
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ALOX12
arachidonate 12-lipoxygenase, 12S type
ISO
SMPDB
SMP:00086
NCBI chr16:6,355,795...6,370,051
Ensembl chr16:6,356,058...6,369,738
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ALOX12B
arachidonate 12-lipoxygenase, 12R type
ISO
SMPDB
SMP:00086
NCBI chr16:7,454,950...7,470,949
Ensembl chr16:7,455,044...7,469,934
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ALOX15
arachidonate 15-lipoxygenase
ISO
SMPDB
SMP:00086
NCBI chr16:4,112,795...4,121,764
Ensembl chr16:4,111,151...4,121,645
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ALOX15B
arachidonate 15-lipoxygenase type B
ISO
SMPDB
SMP:00086
NCBI chr16:7,425,533...7,435,896
Ensembl chr16:7,425,990...7,435,327
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ALOX5
arachidonate 5-lipoxygenase
ISO
SMPDB
SMP:00086
NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331
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CYP2B6
cytochrome P450 family 2 subfamily B member 6
ISO
SMPDB
SMP:00086
NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106
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CYP2C19
cytochrome P450 family 2 subfamily C member 19
ISO
SMPDB
SMP:00086
NCBI chr 9:87,981,300...88,025,007
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CYP2C8
cytochrome P450 family 2 subfamily C member 8
ISO
SMPDB
SMP:00086
NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458
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CYP2C9
cytochrome P450 family 2 subfamily C member 9
ISO
SMPDB
SMP:00086
NCBI chr 9:88,082,124...88,125,390
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CYP2E1
cytochrome P450 family 2 subfamily E member 1
ISO
SMPDB
SMP:00086
NCBI chr26:53,390,054...53,403,309
Ensembl chr26:53,390,089...53,404,211
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CYP2J2
cytochrome P450 family 2 subfamily J member 2
ISO
SMPDB
SMP:00086
NCBI chr20:73,083,312...73,115,174
Ensembl chr20:73,083,389...73,115,077
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CYP2U1
cytochrome P450 family 2 subfamily U member 1
ISO
SMPDB
SMP:00086
NCBI chr 7:55,859,669...55,880,266
Ensembl chr 7:55,859,849...55,879,280
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CYP4F3
cytochrome P450 family 4 subfamily F member 3
ISO
SMPDB
SMP:00086
NCBI chr 6:14,241,352...14,260,799
Ensembl chr 6:14,241,409...14,263,494
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CYP4F8
cytochrome P450 family 4 subfamily F member 8
ISO
SMPDB
SMP:00086
NCBI chr 6:14,211,899...14,229,793
Ensembl chr 6:14,215,337...14,229,509
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DNAJB11
DnaJ heat shock protein family (Hsp40) member B11
ISO
SMPDB
SMP:00086
NCBI chr15:2,841,377...2,858,192
Ensembl chr15:2,841,255...2,858,202
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EPHX2
epoxide hydrolase 2
ISO
SMPDB
SMP:00086
NCBI chr 8:25,603,668...25,659,232
Ensembl chr 8:25,603,735...25,659,345
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ERP29
endoplasmic reticulum protein 29
ISO
SMPDB
SMP:00086
NCBI chr11:107,244,359...107,255,293
Ensembl chr11:107,244,335...107,256,499
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GGT1
gamma-glutamyltransferase 1
ISO
SMPDB
SMP:00086
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GPX1
glutathione peroxidase 1
ISO
SMPDB
SMP:00086
NCBI chr22:10,754,976...10,756,617
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HSP90B1
heat shock protein 90 beta family member 1
ISO
SMPDB
SMP:00086
NCBI chr11:99,119,268...99,139,988
Ensembl chr11:99,119,224...99,139,722
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HSPA5
heat shock protein family A (Hsp70) member 5
ISO
SMPDB
SMP:00086
NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431
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HYOU1
hypoxia up-regulated 1
ISO
SMPDB
SMP:00086
NCBI chr 1:110,418,497...110,431,636
Ensembl chr 1:110,417,942...110,431,590
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LOC103218526
carbonyl reductase [NADPH] 1
ISO
SMPDB
SMP:00086
NCBI chr 2:80,096,743...80,099,982
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LOC103246766
cytochrome P450 3A8
ISO
SMPDB
SMP:00086
NCBI chr28:13,297,566...13,330,023
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LTA4H
leukotriene A4 hydrolase
ISO
SMPDB
SMP:00086
NCBI chr11:91,371,383...91,413,396
Ensembl chr11:91,371,383...91,406,542
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LTC4S
leukotriene C4 synthase
ISO
SMPDB
SMP:00086
NCBI chr23:81,523,784...81,526,297
Ensembl chr23:81,523,775...81,526,179
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PDIA2
protein disulfide isomerase family A member 2
ISO
SMPDB
SMP:00086
NCBI chr 5:229,523...233,298
Ensembl chr 5:229,607...233,200
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PDIA4
protein disulfide isomerase family A member 4
ISO
SMPDB
SMP:00086
NCBI chr21:117,574,932...117,601,896
Ensembl chr21:117,574,427...117,601,960
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PDIA6
protein disulfide isomerase family A member 6
ISO
SMPDB
SMP:00086
NCBI chr14:96,801,327...96,828,325
Ensembl chr14:96,801,349...96,828,716
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PLA2G4B
phospholipase A2 group IVB
ISO
SMPDB
SMP:00086
NCBI chr26:41,137,643...41,147,384
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PPIB
peptidylprolyl isomerase B
ISO
SMPDB
SMP:00086
NCBI chr26:19,380,496...19,399,596
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PRXL2B
peroxiredoxin like 2B
ISO
SMPDB
SMP:00086
NCBI chr20:128,964,750...128,969,469
Ensembl chr20:128,964,987...128,967,620
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PTGDS
prostaglandin D2 synthase
ISO
SMPDB
SMP:00086
NCBI chr12:1,210,567...1,214,631
Ensembl chr12:1,211,487...1,214,531
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PTGES
prostaglandin E synthase
ISO
SMPDB
SMP:00086
NCBI chr12:8,393,462...8,408,441
Ensembl chr12:8,393,550...8,408,435
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PTGIS
prostaglandin I2 synthase
ISO
SMPDB
SMP:00086
NCBI chr 2:14,420,318...14,484,667
Ensembl chr 2:14,441,983...14,488,264
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PTGS1
prostaglandin-endoperoxide synthase 1
ISO
SMPDB
SMP:00086
NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
SMPDB
SMP:00086
NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429
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SDF2L1
stromal cell derived factor 2 like 1
ISO
SMPDB
SMP:00086
NCBI chr19:4,465,795...4,467,882
Ensembl chr19:4,465,797...4,467,761
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SLC22A6
solute carrier family 22 member 6
ISO
SMPDB
SMP:00086
NCBI chr 1:10,918,081...10,926,790
Ensembl chr 1:10,918,770...10,925,983
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SLC22A8
solute carrier family 22 member 8
ISO
SMPDB
SMP:00086
NCBI chr 1:10,885,895...10,909,739
Ensembl chr 1:10,886,690...10,910,546
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TBXAS1
thromboxane A synthase 1
ISO
SMPDB
SMP:00086
NCBI chr21:108,584,458...108,779,357
Ensembl chr21:108,628,570...108,779,163
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all