Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:ibuprofen pharmacodynamics pathway
go back to main search page
Accession:PW:0001470 term browser browse the term
Definition:The pathway of ibuprofen-target interaction and of the biochemical or physiological responses to drug. Ibuprofen is an inhibitor of cyclooxygenase enzymes used in the treatment of pain and inflammation. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00086


show annotations for term's descendants           Sort by:
ibuprofen pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 ISO SMPDB SMP:00086 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00086 NCBI chr10:55,456,923...55,469,239
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00086 NCBI chr10:54,361,898...54,373,776
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00086 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B ISO SMPDB SMP:00086 NCBI chr10:54,391,331...54,400,648
Ensembl chr10:53,892,466...53,901,812 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00086 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB SMP:00086 NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 ISO SMPDB SMP:00086 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 ISO SMPDB SMP:00086 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 ISO SMPDB SMP:00086
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO SMPDB SMP:00086 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 ISO SMPDB SMP:00086 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 ISO SMPDB SMP:00086 NCBI chr 2:222,523,516...222,541,055
Ensembl chr 2:219,849,407...219,866,882 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00086 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 ISO SMPDB SMP:00086 NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,707,317...17,804,940 		JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 ISO SMPDB SMP:00086 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00086 NCBI chr11:91,656,334...91,672,800
Ensembl chr11:78,150,429...78,180,407 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO SMPDB SMP:00086 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00086 NCBI chr12:40,750,177...40,756,607
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00086 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO SMPDB SMP:00086 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00086 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00086 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00086 NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO SMPDB SMP:00086 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO SMPDB SMP:00086 NCBI chr10:35,060,002...35,066,466
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 ISO SMPDB SMP:00086 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 ISO SMPDB SMP:00086 NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 ISO SMPDB SMP:00086 NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Pla2g4b phospholipase A2 group IVB ISO SMPDB SMP:00086 NCBI chr 3:127,458,022...127,467,637
Ensembl chr 3:107,005,489...107,013,853 		JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00086 NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:66,603,861...66,630,428 		JBrowse link
G Prxl2b peroxiredoxin like 2B ISO SMPDB SMP:00086 NCBI chr 5:170,744,953...170,747,556 JBrowse link
G Ptgds prostaglandin D2 synthase ISO SMPDB SMP:00086 NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptges prostaglandin E synthase ISO SMPDB SMP:00086 NCBI chr 3:34,575,643...34,586,987 JBrowse link
G Ptgis prostaglandin I2 synthase ISO SMPDB SMP:00086 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00086 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00086 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 ISO SMPDB SMP:00086 NCBI chr11:97,376,878...97,379,120
Ensembl chr11:83,872,659...83,874,902 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 ISO SMPDB SMP:00086 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 ISO SMPDB SMP:00086 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Tbxas1 thromboxane A synthase 1 ISO SMPDB SMP:00086 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 ISO SMPDB SMP:00086 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 ISO SMPDB SMP:00086 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 ISO SMPDB SMP:00086 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 ISO SMPDB SMP:00086 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      cardiovascular system drug pathway 184
        ibuprofen drug pathway 45
          ibuprofen pharmacodynamics pathway 45
Path 2
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      nervous system drug pathway 183
        analgesic and/or antipyretic drug pathway 97
          ibuprofen drug pathway 45
            ibuprofen pharmacodynamics pathway 45
paths to the root