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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:doxorubicin drug pathway
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Accession:PW:0001455 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of doxorubicin, a streptomyces metabolite used as a chemotherapeutic agent used in the treatment of cancers. However, its use is limited by the serious cardiotoxic side effects. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
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doxorubicin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Top2a DNA topoisomerase II alpha ISO RGD PMID:25895646 RGD:10395260 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Top2b DNA topoisomerase II beta ISO RGD PMID:25895646 RGD:10395260 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
doxorubicin pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB
RGD		 PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00650 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB
RGD		 PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO RGD PMID:21048526 RGD:10395261 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 ISO SMPDB
RGD		 PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 ISO SMPDB
RGD		 PMID:21048526 PMID:19442138 SMP:00650, RGD:10395261, RGD:10395262 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 ISO SMPDB
RGD		 PMID:21048526 SMP:00650, RGD:10395261 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB
RGD		 PMID:21048526 PMID:19442138 SMP:00650, RGD:10395261, RGD:10395262 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cbr3 carbonyl reductase 3 ISO SMPDB
RGD		 PMID:21048526 PMID:19442138 SMP:00650, RGD:10395261, RGD:10395262 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 ISO SMPDB SMP:00650 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 ISO SMPDB SMP:00650 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824 		JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 ISO SMPDB SMP:00650 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO SMPDB
RGD		 PMID:19442138 SMP:00650, RGD:10395262 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 ISO SMPDB
RGD		 PMID:19442138 SMP:00650, RGD:10395262 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Por cytochrome p450 oxidoreductase ISO SMPDB SMP:00650 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ralbp1 ralA binding protein 1 ISO SMPDB
RGD		 PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707 		JBrowse link
G Slc22a16 solute carrier family 22 member 16 ISO SMPDB
RGD		 PMID:21048526 SMP:00650, RGD:10395261 NCBI chr20:43,972,808...44,068,447
Ensembl chr20:43,972,836...44,065,019 		JBrowse link
G Xdh xanthine dehydrogenase ISO SMPDB
RGD		 PMID:19442138 SMP:00650, RGD:10395262 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      antineoplastic and immunomodulatory drug pathway 156
        antineoplastic drug pathway 154
          doxorubicin drug pathway 20
            doxorubicin pharmacodynamics pathway 2
            doxorubicin pharmacokinetics pathway 18
paths to the root