PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: codeine and morphine pharmacodynamics pathway
Accession: PW:0001246
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Definition: The pathway of codeine/morphine-target interaction and of the biochemical or physiological responses to drug. The drugs are potential ligands for the mu-opioid receptor, a class of opioid receptor. Opioid receptors are G-protein coupled receptors (GPCR) activated by endogenous and also exogenous opioids. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms: related_synonym: SMP:00405; SMP:00406
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ADRA1A
adrenoceptor alpha 1A
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 8:24,884,187...24,985,824
Ensembl chr 8:24,885,741...24,983,125
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ATP1A1
ATPase Na+/K+ transporting subunit alpha 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr20:17,319,440...17,351,054
Ensembl chr20:17,315,117...17,351,054
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ATP1A2
ATPase Na+/K+ transporting subunit alpha 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr20:3,801,044...3,828,680
Ensembl chr20:3,802,887...3,828,692
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ATP1A3
ATPase Na+/K+ transporting subunit alpha 3
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 6:36,166,586...36,195,343
Ensembl chr 6:36,166,262...36,195,363
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ATP1A4
ATPase Na+/K+ transporting subunit alpha 4
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr20:3,759,509...3,794,106
Ensembl chr20:3,759,597...3,793,980
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ATP1B1
ATPase Na+/K+ transporting subunit beta 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr25:59,898,745...59,925,166
Ensembl chr25:59,895,341...59,925,522
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ATP1B2
ATPase Na+/K+ transporting subunit beta 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr16:7,030,016...7,035,620
Ensembl chr16:7,030,055...7,037,754
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ATP1B3
ATPase Na+/K+ transporting subunit beta 3
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr15:48,691,224...48,742,336
Ensembl chr15:48,690,667...48,742,385
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ATP1B4
ATPase Na+/K+ transporting family member beta 4
ISO
SMPDB
SMP:00405 SMP:00406
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CACNA1A
calcium voltage-gated channel subunit alpha1 A
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 6:11,883,353...12,307,023
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CACNA2D2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr22:11,751,026...11,891,407
Ensembl chr22:11,749,727...11,890,924
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CACNB1
calcium voltage-gated channel auxiliary subunit beta 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr16:66,971,379...66,994,031
Ensembl chr16:66,971,459...66,996,095
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CHRNA4
cholinergic receptor nicotinic alpha 4 subunit
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 2:851,790...862,685
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CHRNB2
cholinergic receptor nicotinic beta 2 subunit
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr20:9,245,803...9,255,430
Ensembl chr20:9,247,231...9,253,795
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CYP2D6
cytochrome P450 family 2 subfamily D member 6
ISO
SMPDB
SMP:00405
NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513
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DNAJB11
DnaJ heat shock protein family (Hsp40) member B11
ISO
SMPDB
SMP:00406
NCBI chr15:2,841,377...2,858,192
Ensembl chr15:2,841,255...2,858,202
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DRD1
dopamine receptor D1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr23:77,587,340...77,591,434
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ERP29
endoplasmic reticulum protein 29
ISO
SMPDB
SMP:00406
NCBI chr11:107,244,359...107,255,293
Ensembl chr11:107,244,335...107,256,499
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FXYD2
FXYD domain containing ion transport regulator 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 1:109,187,301...109,199,729
Ensembl chr 1:109,186,886...109,198,267
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GRIN1
glutamate ionotropic receptor NMDA type subunit 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr12:1,020,556...1,050,568
Ensembl chr12:1,019,263...1,050,231
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GRIN2A
glutamate ionotropic receptor NMDA type subunit 2A
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 5:9,233,028...9,707,322
Ensembl chr 5:9,286,775...9,462,828
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GRIN3A
glutamate ionotropic receptor NMDA type subunit 3A
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr12:37,700,311...37,865,390
Ensembl chr12:37,701,039...37,867,041
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HSP90B1
heat shock protein 90 beta family member 1
ISO
SMPDB
SMP:00406
NCBI chr11:99,119,268...99,139,988
Ensembl chr11:99,119,224...99,139,722
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HSPA5
heat shock protein family A (Hsp70) member 5
ISO
SMPDB
SMP:00406
NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431
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HTR1A
5-hydroxytryptamine receptor 1A
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 4:60,159,542...60,162,947
Ensembl chr 4:60,159,944...60,161,212
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HYOU1
hypoxia up-regulated 1
ISO
SMPDB
SMP:00406
NCBI chr 1:110,418,497...110,431,636
Ensembl chr 1:110,417,942...110,431,590
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KCND2
potassium voltage-gated channel subfamily D member 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr21:89,091,939...89,575,464
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KCNIP2
potassium voltage-gated channel interacting protein 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 9:94,854,024...94,873,655
Ensembl chr 9:94,855,403...94,873,312
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LOC103246766
cytochrome P450 3A8
ISO
SMPDB
SMP:00405
NCBI chr28:13,297,566...13,330,023
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OPRM1
opioid receptor mu 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr13:81,568,295...81,650,005
Ensembl chr13:81,568,732...81,625,088
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PCSK2
proprotein convertase subtilisin/kexin type 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 2:46,293,983...46,548,902
Ensembl chr 2:46,294,005...46,549,609
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PDIA2
protein disulfide isomerase family A member 2
ISO
SMPDB
SMP:00406
NCBI chr 5:229,523...233,298
Ensembl chr 5:229,607...233,200
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PDIA4
protein disulfide isomerase family A member 4
ISO
SMPDB
SMP:00406
NCBI chr21:117,574,932...117,601,896
Ensembl chr21:117,574,427...117,601,960
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PDIA6
protein disulfide isomerase family A member 6
ISO
SMPDB
SMP:00406
NCBI chr14:96,801,327...96,828,325
Ensembl chr14:96,801,349...96,828,716
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POMC
proopiomelanocortin
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr14:82,491,296...82,499,289
Ensembl chr14:82,494,323...82,499,447
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PPIB
peptidylprolyl isomerase B
ISO
SMPDB
SMP:00406
NCBI chr26:19,380,496...19,399,596
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SCN10A
sodium voltage-gated channel alpha subunit 10
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr15:624,962...724,018
Ensembl chr15:625,742...721,963
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SCN1B
sodium voltage-gated channel beta subunit 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 6:29,962,993...29,972,845
Ensembl chr 6:29,962,843...29,973,325
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SDF2L1
stromal cell derived factor 2 like 1
ISO
SMPDB
SMP:00406
NCBI chr19:4,465,795...4,467,882
Ensembl chr19:4,465,797...4,467,761
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SLC6A2
solute carrier family 6 member 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 5:41,434,004...41,482,568
Ensembl chr 5:41,435,387...41,483,643
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SLC6A3
solute carrier family 6 member 3
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 4:1,209,013...1,258,797
Ensembl chr 4:1,209,019...1,258,866
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SLC6A4
solute carrier family 6 member 4
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr16:23,929,196...23,969,665
Ensembl chr16:23,927,311...23,955,616
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all