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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:codeine and morphine pharmacodynamics pathway
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Accession:PW:0001246 term browser browse the term
Definition:The pathway of codeine/morphine-target interaction and of the biochemical or physiological responses to drug. The drugs are potential ligands for the mu-opioid receptor, a class of opioid receptor. Opioid receptors are G-protein coupled receptors (GPCR) activated by endogenous and also exogenous opioids. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00405;   SMP:00406



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codeine and morphine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISO SMPDB SMP:00405 SMP:00406 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO SMPDB SMP:00405 SMP:00406 NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:80,572,796...80,601,918
JBrowse link
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 ISO SMPDB SMP:00405 SMP:00406 NCBI chr13:87,216,139...87,252,155
Ensembl chr13:84,683,768...84,719,687
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00405 SMP:00406 NCBI chr13:79,319,708...79,340,226
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00405 SMP:00406 NCBI chr10:54,817,473...54,823,708
Ensembl chr10:54,318,701...54,324,933
JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 8:105,789,824...105,821,151
Ensembl chr 8:96,910,309...96,941,598
Ensembl chr 8:96,910,309...96,941,598
JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00405 SMP:00406 NCBI chr  X:117,087,284...117,108,023
Ensembl chr  X:117,057,423...117,108,020
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO SMPDB SMP:00405 SMP:00406 NCBI chr19:40,425,560...40,724,810
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 8:116,950,860...117,082,159
Ensembl chr 8:108,072,454...108,203,173
JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00405 SMP:00406 NCBI chr10:83,494,509...83,515,164
Ensembl chr10:82,998,182...83,018,694
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit ISO SMPDB SMP:00405 SMP:00406 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO SMPDB SMP:00405 SMP:00406 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO SMPDB SMP:00405 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00405 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00406 NCBI chr11:91,656,334...91,672,800
Ensembl chr11:78,150,429...78,180,407
JBrowse link
G Drd1 dopamine receptor D1 ISO SMPDB SMP:00405 SMP:00406 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00406 NCBI chr12:40,750,177...40,756,607
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 8:54,609,658...54,616,788
Ensembl chr 8:45,712,903...45,720,203
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO SMPDB SMP:00405 SMP:00406 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A ISO SMPDB SMP:00405 SMP:00406 NCBI chr 5:68,802,333...69,001,880
Ensembl chr 5:64,009,980...64,206,085
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00406 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00406 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO SMPDB SMP:00405 SMP:00406 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00406 NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:44,706,263...44,718,186
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:49,776,246...50,277,728
JBrowse link
G Kcnip2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 1:254,590,172...254,614,437
Ensembl chr 1:244,641,150...244,664,874
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 ISO SMPDB SMP:00406 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 ISO SMPDB SMP:00406 NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:76,803,198...76,822,107
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 ISO SMPDB SMP:00406 NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:40,062,926...40,080,613
JBrowse link
G Pomc proopiomelanocortin ISO SMPDB SMP:00405 SMP:00406 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00406 NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:66,603,861...66,630,428
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:119,350,724...119,462,614
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 1:95,481,298...95,491,211
Ensembl chr 1:86,353,917...86,363,739
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 ISO SMPDB SMP:00406 NCBI chr11:97,376,878...97,379,120
Ensembl chr11:83,872,659...83,874,902
JBrowse link
G Slc6a2 solute carrier family 6 member 2 ISO SMPDB SMP:00405 SMP:00406 NCBI chr19:30,183,289...30,228,292
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO SMPDB SMP:00405 SMP:00406 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO SMPDB SMP:00405 SMP:00406 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 ISO SMPDB SMP:00406 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 ISO SMPDB SMP:00406 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 ISO SMPDB SMP:00406 NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 ISO SMPDB SMP:00405 SMP:00406 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      nervous system drug pathway 183
        analgesic and/or antipyretic drug pathway 97
          opioid drug pathway 55
            codeine and morphine drug pathway 46
              codeine and morphine pharmacodynamics pathway 46
paths to the root