PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: codeine and morphine pharmacodynamics pathway
Accession: PW:0001246
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Definition: The pathway of codeine/morphine-target interaction and of the biochemical or physiological responses to drug. The drugs are potential ligands for the mu-opioid receptor, a class of opioid receptor. Opioid receptors are G-protein coupled receptors (GPCR) activated by endogenous and also exogenous opioids. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms: related_synonym: SMP:00405; SMP:00406
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Adra1a
adrenoceptor alpha 1A
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500
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Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837
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Atp1a2
ATPase Na+/K+ transporting subunit alpha 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544
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Atp1a3
ATPase Na+/K+ transporting subunit alpha 3
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:80,572,796...80,601,918
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Atp1a4
ATPase Na+/K+ transporting subunit alpha 4
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr13:87,216,139...87,252,155
Ensembl chr13:84,683,768...84,719,687
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Atp1b1
ATPase Na+/K+ transporting subunit beta 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr13:79,319,708...79,340,226
Ensembl chr13:76,786,578...76,807,459
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Atp1b2
ATPase Na+/K+ transporting subunit beta 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr10:54,817,473...54,823,708
Ensembl chr10:54,318,701...54,324,933
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Atp1b3
ATPase Na+/K+ transporting subunit beta 3
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 8:105,789,824...105,821,151
Ensembl chr 8:96,910,309...96,941,598 Ensembl chr 8:96,910,309...96,941,598
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Atp1b4
ATPase Na+/K+ transporting family member beta 4
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr X:117,087,284...117,108,023
Ensembl chr X:117,057,423...117,108,020
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Cacna1a
calcium voltage-gated channel subunit alpha1 A
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr19:40,425,560...40,724,810
Ensembl chr19:23,520,741...23,823,225
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Cacna2d2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 8:116,950,860...117,082,159
Ensembl chr 8:108,072,454...108,203,173
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Cacnb1
calcium voltage-gated channel auxiliary subunit beta 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr10:83,494,509...83,515,164
Ensembl chr10:82,998,182...83,018,694
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
ISO
SMPDB
SMP:00405
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
ISO
SMPDB
SMP:00405
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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Dnajb11
DnaJ heat shock protein family (Hsp40) member B11
ISO
SMPDB
SMP:00406
NCBI chr11:91,656,334...91,672,800
Ensembl chr11:78,150,429...78,180,407
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Drd1
dopamine receptor D1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002
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Erp29
endoplasmic reticulum protein 29
ISO
SMPDB
SMP:00406
NCBI chr12:40,750,177...40,756,607
Ensembl chr12:35,089,707...35,096,376
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Fxyd2
FXYD domain-containing ion transport regulator 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 8:54,609,658...54,616,788
Ensembl chr 8:45,712,903...45,720,203
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Grin1
glutamate ionotropic receptor NMDA type subunit 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603
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Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637
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Grin3a
glutamate ionotropic receptor NMDA type subunit 3A
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 5:68,802,333...69,001,880
Ensembl chr 5:64,009,980...64,206,085
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Hsp90b1
heat shock protein 90 beta family member 1
ISO
SMPDB
SMP:00406
NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788
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Hspa5
heat shock protein family A (Hsp70) member 5
ISO
SMPDB
SMP:00406
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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Htr1a
5-hydroxytryptamine receptor 1A
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442
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Hyou1
hypoxia up-regulated 1
ISO
SMPDB
SMP:00406
NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:44,706,263...44,718,186
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Kcnd2
potassium voltage-gated channel subfamily D member 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:49,776,246...50,277,728
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Kcnip2
potassium voltage-gated channel interacting protein 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 1:254,590,172...254,614,437
Ensembl chr 1:244,641,150...244,664,874
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Oprm1
opioid receptor, mu 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409
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Pcsk2
proprotein convertase subtilisin/kexin type 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:130,880,422...131,183,127
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Pdia2
protein disulfide isomerase family A, member 2
ISO
SMPDB
SMP:00406
NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
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Pdia4
protein disulfide isomerase family A, member 4
ISO
SMPDB
SMP:00406
NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:76,803,198...76,822,107
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Pdia6
protein disulfide isomerase family A, member 6
ISO
SMPDB
SMP:00406
NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:40,062,926...40,080,613
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Pomc
proopiomelanocortin
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
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Ppib
peptidylprolyl isomerase B
ISO
SMPDB
SMP:00406
NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:66,603,861...66,630,428
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Scn10a
sodium voltage-gated channel alpha subunit 10
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:119,350,724...119,462,614
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Scn1b
sodium voltage-gated channel beta subunit 1
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 1:95,481,298...95,491,211
Ensembl chr 1:86,353,917...86,363,739
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Sdf2l1
stromal cell-derived factor 2-like 1
ISO
SMPDB
SMP:00406
NCBI chr11:97,376,878...97,379,120
Ensembl chr11:83,872,659...83,874,902
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Slc6a2
solute carrier family 6 member 2
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr19:30,183,289...30,228,292
Ensembl chr19:14,010,386...14,050,357
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Slc6a3
solute carrier family 6 member 3
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413
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Slc6a4
solute carrier family 6 member 4
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
ISO
SMPDB
SMP:00406
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
ISO
SMPDB
SMP:00406
NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a8
UDP glucuronosyltransferase family 1 member A8
ISO
SMPDB
SMP:00406
NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b7
UDP glucuronosyltransferase family 2 member B7
ISO
SMPDB
SMP:00405 SMP:00406
NCBI chr14:21,251,535...21,274,451
Ensembl chr14:20,896,682...20,919,604
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all