PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: irinotecan pharmacodynamics pathway
Accession: PW:0001226
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Definition: The pathway of irinotecan-target interactions and of the biochemical or physiological responses to drug. Irinotecan is a DNA topoisomerase I inhibitor used in the treatment of several types of cancer. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms: related_synonym: SMP:00433
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Abcb1
ATP binding cassette subfamily B member 1
ISO
SMPDB
SMP:00433
NCBI chrNW_004955432:4,911,774...5,085,349
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Abcc1
ATP binding cassette subfamily C member 1 (ABCC1 blood group)
ISO
SMPDB
SMP:00433
NCBI chrNW_004955442:729,322...858,826
Ensembl chrNW_004955442:729,316...860,290
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Abcc2
ATP binding cassette subfamily C member 2
ISO
SMPDB
SMP:00433
NCBI chrNW_004955507:5,724,788...5,791,281
Ensembl chrNW_004955507:5,724,762...5,790,812
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Abcg2
ATP binding cassette subfamily G member 2 (JR blood group)
ISO
SMPDB
SMP:00433
NCBI chrNW_004955474:12,365,903...12,408,715
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Bche
butyrylcholinesterase
ISO
SMPDB
SMP:00433
NCBI chrNW_004955448:15,327,374...15,396,827
Ensembl chrNW_004955448:15,329,273...15,396,970
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Dnajb11
DnaJ heat shock protein family (Hsp40) member B11
ISO
SMPDB
SMP:00433
NCBI chrNW_004955420:21,097,292...21,113,053
Ensembl chrNW_004955420:21,097,941...21,112,792
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Erp29
endoplasmic reticulum protein 29
ISO
SMPDB
SMP:00433
NCBI chrNW_004955482:8,572,227...8,579,589
Ensembl chrNW_004955482:8,572,227...8,579,946
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Hsp90b1
heat shock protein 90 beta family member 1
ISO
SMPDB
SMP:00433
NCBI chrNW_004955405:38,629,691...38,645,202
Ensembl chrNW_004955405:38,629,691...38,645,202
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Hspa5
heat shock protein family A (Hsp70) member 5
ISO
SMPDB
SMP:00433
NCBI chrNW_004955419:3,055,420...3,060,208
Ensembl chrNW_004955419:3,055,420...3,062,131
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Hyou1
hypoxia up-regulated 1
ISO
SMPDB
SMP:00433
NCBI chrNW_004955412:20,149,104...20,161,378
Ensembl chrNW_004955412:20,148,953...20,161,172
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Pdia2
protein disulfide isomerase family A member 2
ISO
SMPDB
SMP:00433
NCBI chrNW_004955442:16,898,563...16,901,867
Ensembl chrNW_004955442:16,898,635...16,901,799
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Pdia4
protein disulfide isomerase family A member 4
ISO
SMPDB
SMP:00433
NCBI chrNW_004955491:4,344,874...4,360,205
Ensembl chrNW_004955491:4,344,874...4,360,205
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Pdia6
protein disulfide isomerase family A member 6
ISO
SMPDB
SMP:00433
NCBI chrNW_004955487:5,735,698...5,744,601
Ensembl chrNW_004955487:5,735,698...5,748,015
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Ppib
peptidylprolyl isomerase B
ISO
SMPDB
SMP:00433
NCBI chrNW_004955450:11,241,279...11,246,628
Ensembl chrNW_004955450:11,241,279...11,249,056
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Sdf2l1
stromal cell derived factor 2 like 1
ISO
SMPDB
SMP:00433
NCBI chrNW_004955442:17,468,302...17,470,296
Ensembl chrNW_004955442:17,468,302...17,470,296
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Top1
DNA topoisomerase I
ISO
SMPDB
SMP:00433
NCBI chrNW_004955445:15,834,017...15,922,785
Ensembl chrNW_004955445:15,834,017...15,922,785
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all