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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:irinotecan pharmacodynamics pathway
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Accession:PW:0001226 term browser browse the term
Definition:The pathway of irinotecan-target interactions and of the biochemical or physiological responses to drug. Irinotecan is a DNA topoisomerase I inhibitor used in the treatment of several types of cancer. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00433


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irinotecan pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00433 NCBI chrNW_004955432:4,911,774...5,085,349 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00433 NCBI chrNW_004955442:729,322...858,826
Ensembl chrNW_004955442:729,316...860,290
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00433 NCBI chrNW_004955507:5,724,788...5,791,281
Ensembl chrNW_004955507:5,724,762...5,790,812
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB SMP:00433 NCBI chrNW_004955474:12,365,903...12,408,715 JBrowse link
G Bche butyrylcholinesterase ISO SMPDB SMP:00433 NCBI chrNW_004955448:15,327,374...15,396,827
Ensembl chrNW_004955448:15,329,273...15,396,970
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00433 NCBI chrNW_004955420:21,097,292...21,113,053
Ensembl chrNW_004955420:21,097,941...21,112,792
JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00433 NCBI chrNW_004955482:8,572,227...8,579,589
Ensembl chrNW_004955482:8,572,227...8,579,946
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00433 NCBI chrNW_004955405:38,629,691...38,645,202
Ensembl chrNW_004955405:38,629,691...38,645,202
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00433 NCBI chrNW_004955419:3,055,420...3,060,208
Ensembl chrNW_004955419:3,055,420...3,062,131
JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00433 NCBI chrNW_004955412:20,149,104...20,161,378
Ensembl chrNW_004955412:20,148,953...20,161,172
JBrowse link
G Pdia2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00433 NCBI chrNW_004955442:16,898,563...16,901,867
Ensembl chrNW_004955442:16,898,635...16,901,799
JBrowse link
G Pdia4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00433 NCBI chrNW_004955491:4,344,874...4,360,205
Ensembl chrNW_004955491:4,344,874...4,360,205
JBrowse link
G Pdia6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00433 NCBI chrNW_004955487:5,735,698...5,744,601
Ensembl chrNW_004955487:5,735,698...5,748,015
JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00433 NCBI chrNW_004955450:11,241,279...11,246,628
Ensembl chrNW_004955450:11,241,279...11,249,056
JBrowse link
G Sdf2l1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00433 NCBI chrNW_004955442:17,468,302...17,470,296
Ensembl chrNW_004955442:17,468,302...17,470,296
JBrowse link
G Top1 DNA topoisomerase I ISO SMPDB SMP:00433 NCBI chrNW_004955445:15,834,017...15,922,785
Ensembl chrNW_004955445:15,834,017...15,922,785
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3924
    drug pathway 348
      antineoplastic and immunomodulatory drug pathway 129
        antineoplastic drug pathway 128
          irinotecan drug pathway 16
            irinotecan pharmacodynamics pathway 16
paths to the root