Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:irinotecan pharmacodynamics pathway
go back to main search page
Accession:PW:0001226 term browser browse the term
Definition:The pathway of irinotecan-target interactions and of the biochemical or physiological responses to drug. Irinotecan is a DNA topoisomerase I inhibitor used in the treatment of several types of cancer. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00433



show annotations for term's descendants           Sort by:
irinotecan pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB SMP:00433 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00433 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00433 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 ISO SMPDB SMP:00433 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Bche butyrylcholinesterase ISO SMPDB SMP:00433 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Ces1d carboxylesterase 1D ISO SMPDB SMP:00433 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces2h carboxylesterase 2H ISO SMPDB SMP:00433 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00433 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 ISO SMPDB SMP:00433 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00433 NCBI chr11:91,656,334...91,672,800
Ensembl chr11:78,150,429...78,180,407
JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00433 NCBI chr12:40,750,177...40,756,607
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00433 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00433 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00433 NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:44,706,263...44,718,186
JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 ISO SMPDB SMP:00433 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 ISO SMPDB SMP:00433 NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:76,803,198...76,822,107
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 ISO SMPDB SMP:00433 NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:40,062,926...40,080,613
JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00433 NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:66,603,861...66,630,428
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 ISO SMPDB SMP:00433 NCBI chr11:97,376,878...97,379,120
Ensembl chr11:83,872,659...83,874,902
JBrowse link
G Top1 DNA topoisomerase I ISO SMPDB SMP:00433 NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 ISO SMPDB SMP:00433 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 ISO SMPDB SMP:00433 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      antineoplastic and immunomodulatory drug pathway 156
        antineoplastic drug pathway 154
          irinotecan drug pathway 22
            irinotecan pharmacodynamics pathway 22
paths to the root