PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: irinotecan pharmacodynamics pathway
Accession: PW:0001226
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Definition: The pathway of irinotecan-target interactions and of the biochemical or physiological responses to drug. Irinotecan is a DNA topoisomerase I inhibitor used in the treatment of several types of cancer. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms: related_synonym: SMP:00433
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Abcb1a
ATP binding cassette subfamily B member 1A
ISO
SMPDB
SMP:00433
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Abcc1
ATP binding cassette subfamily C member 1
ISO
SMPDB
SMP:00433
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
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Abcc2
ATP binding cassette subfamily C member 2
ISO
SMPDB
SMP:00433
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
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Abcg2
ATP binding cassette subfamily G member 2
ISO
SMPDB
SMP:00433
NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
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Bche
butyrylcholinesterase
ISO
SMPDB
SMP:00433
NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148
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Ces1d
carboxylesterase 1D
ISO
SMPDB
SMP:00433
NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035
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Ces2h
carboxylesterase 2H
ISO
SMPDB
SMP:00433
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
ISO
SMPDB
SMP:00433
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
ISO
SMPDB
SMP:00433
NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422
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Dnajb11
DnaJ heat shock protein family (Hsp40) member B11
ISO
SMPDB
SMP:00433
NCBI chr11:91,656,334...91,672,800
Ensembl chr11:78,150,429...78,180,407
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Erp29
endoplasmic reticulum protein 29
ISO
SMPDB
SMP:00433
NCBI chr12:40,750,177...40,756,607
Ensembl chr12:35,089,707...35,096,376
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Hsp90b1
heat shock protein 90 beta family member 1
ISO
SMPDB
SMP:00433
NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788
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Hspa5
heat shock protein family A (Hsp70) member 5
ISO
SMPDB
SMP:00433
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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Hyou1
hypoxia up-regulated 1
ISO
SMPDB
SMP:00433
NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:44,706,263...44,718,186
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Pdia2
protein disulfide isomerase family A, member 2
ISO
SMPDB
SMP:00433
NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
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Pdia4
protein disulfide isomerase family A, member 4
ISO
SMPDB
SMP:00433
NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:76,803,198...76,822,107
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Pdia6
protein disulfide isomerase family A, member 6
ISO
SMPDB
SMP:00433
NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:40,062,926...40,080,613
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Ppib
peptidylprolyl isomerase B
ISO
SMPDB
SMP:00433
NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:66,603,861...66,630,428
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Sdf2l1
stromal cell-derived factor 2-like 1
ISO
SMPDB
SMP:00433
NCBI chr11:97,376,878...97,379,120
Ensembl chr11:83,872,659...83,874,902
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Top1
DNA topoisomerase I
ISO
SMPDB
SMP:00433
NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:149,293,403...149,376,623
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
ISO
SMPDB
SMP:00433
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
ISO
SMPDB
SMP:00433
NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all